It is estimated that 17.6 million Americans have a problem with Alcohol. This problem can lead to all sorts of problems with work, family and friends just to name a few. One side effect of alcohol is liver damage. Alcohol can damage or destroy liver cells. Scientists have been hard at work looking for ways to repair liver cells. Below you will find studies involving cannabis and the liver. Please feel free to share the TRUTH ~ Cherry Girl
Alcohol and Substance Abuse (Background On Liver Damage)
Alcoholic liver disease is an important cause of cirrhosis, liver-associated death, and need for liver transplant. Up to 50% of recipients use some alcohol, and perhaps 10% drink addictively. Careful evaluation by an addiction medicine specialist is the best predictive instrument before transplant surgery, whereas the 6-month rule lacks sensitivity and specificity. Addictive drinking, but not minor slips, is associated with increased mortality. There is no standard therapy for alcoholism in alcoholics waiting for a transplant or for those who have undergone a transplant. Stably abstinent, methadone-maintained opiate-dependent patients should continue methadone; are generally good candidates for liver transplant; and show low relapse rates. Pre- and post-transplant smoking rates are high and cause significant morbidity and mortality. Transplant teams should encourage smoking cessation treatments. Marijuana use in liver transplant recipients is common, although risks associated with this practice are unknown.
Hyperactivation of Anandamide Synthesis and Regulation of Cell-Cycle Progression Via Cannabinoid Type 1 (CB1) Receptors In the Regenerating Liver
The mammalian liver regenerates upon tissue loss… Endocannabinoids acting via cannabinoid type 1 receptors (CB(1)R) promote neural progenitor cell proliferation, and in the liver they promote lipogenesis. These findings suggest the involvement of CB(1)R in the control of liver regeneration.”
The Endocannabinoid System As A Key Mediator During Liver Diseases: New Insights and Therapeutic Openings
Cannabinoid receptor 1 (CB(1)) receptors have been implicated in the pathogenesis of several lesions such as alcoholic and metabolic steatosis, liver fibrogenesis, or circulatory failure associated with cirrhosis. data obtained with peripherally restricted CB(1) antagonists give real hopes in the development of active CB(1) molecules devoid of central adverse effects. CB(2) -selective molecules may also offer novel perspectives for the treatment of liver diseases, and their clinical development is clearly awaited. Whether combined treatment with a peripherally restricted CB(1) antagonist and a CB(2) agonist might result in an increased therapeutic potential will warrant further investigation.”
Beneficial Paracrine Effects of Cannabinoid Receptor 2 On Liver Injury and Regeneration
”Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration…CB2 receptors reduce liver injury and promote liver regeneration following acute insult, via distinct paracrine mechanisms involving hepatic myofibroblasts. These results suggest that CB2 agonists display potent hepatoprotective (protects liver) properties, in addition to their antifibrogenic effects.”
Cannabinoid CB2 Receptors Protect Against Alcoholic Liver Disease By Regulating Kupffer Cell Polarization In Mice.
”Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice…These data identify CB2 agonists as potential therapeutic agents for the management of alcoholic liver disease.”
Annabinoids and Capsaicin Improve Liver Function Following Thioacetamide-Induced Acute Injury In Mice
”We have shown the beneficial effects of cannabinoids in a murine model of hepatic encephalopathy following thioacetamide and now report their effects on the liver injury.The similar pattern found between the effect of cannabinoids and their antagonists on brain and liver indicated that the therapeutic effect might be directed by the improvement in both organs through CB2 receptors and/or TRPV1 receptors. Modulation of these systems may have therapeutic potential.”