The Many Functions of the Human Endocannabinoid System And How Cannabis Can Help


The endocannabinoid system was discovered in the 60’s and since then scientists have been trying to unravel the mysteries surrounding this system.  At first some thought it was merely the receptors for the cannabis plant but we soon found that the endocannabinoid system is tied to several functions throughout the human body and in recent years become a target for therapies.  Below you will find studies that show how the endocannabinoid system is involved in many functions.  Please share with all and I encourage you to do your own research seeking out the TRUTH ~ Cherry Girl

The Endocannabinoid System: A Revolving Plate In Neuro-Immune Interaction In Health and Disease 2012
The cannabinoid system has been shown to be involved in regulating the immune system. Studies examining the effect of cannabinoid-based drugs on immunity have shown that many cellular and cytokine mechanisms are modulated by these agents, thus raising the hypothesis that these compounds may be of value in the management of chronic inflammatory diseases. The special properties of endocannabinoids as neurotransmitters, their pleiotropic effects and the impact on immune function show that the endocannabinoid system represents a revolving plate of neural and immune interactions.

Endocannabinoid Signaling As A Synaptic Circuit Breaker In Neurological Disease
Cannabis sativa is one of the oldest herbal plants in the history of medicine. It was used in various therapeutic applications from pain to epilepsy… renewed interest has been fueled by major discoveries revealing that cannabis-derived compounds act through a signaling pathway in the human body. Here we review recent advances showing that endocannabinoid signaling is a key regulator of synaptic communication throughout the central nervous system. Its underlying molecular architecture is highly conserved in synapses from the spinal cord to the neocortex, and as a negative feed-back signal, it provides protection against excess presynaptic activity. The endocannabinoid signaling machinery operates on demand in a synapse-specific manner; therefore, its modulation offers new therapeutic opportunities for the selective control of deleterious neuronal activity in several neurological disorders…Endocannabinoid signaling as a synaptic circuit breaker in neurological disease.

The Endogenous Cardiac Cannabinoid System: A New Protective Mechanism Against Myocardial Ischemia
The pharmacological (and recreational) effects of cannabis have been known for centuries. However, it is only recently that one has identified two subtypes of G-protein-coupled receptors, namely CB1 and CB2-receptors, which mediate the numerous effects of delta9-tetrahydrocannabinol and other cannabinoids. Logically, the existence of cannabinoid-receptors implies that endogenous ligands for these receptors (endocannabinoids) exist and exert a physiological role. Thus, the endogenous cardiac cannabinoid system, through activation of CB2-receptors, appears to be an important mechanism of protection against myocardial ischemia.

The Endocannabinoid Nervous System: Unique Opportunities For Therapeutic Intervention
The active principle in marijuana, Delta(9)-tetrahydrocannabinol (THC), has been shown to have wide therapeutic application for a number of important medical conditions… Delta(9)-THC binds to and activates two known cannabinoid receptors found in mammalian tissue, CB1 and CB2. The development of cannabinoid-based therapeutics has focused predominantly on the CB1 receptor, based on its predominant and abundant localization in the CNS.. cannabinoid agonists are relatively safe and provide therapeutic efficacy, but that they also induce psychotropic side effects… This review attempts to link current understanding of the basic biology of the endocannabinoid nervous system to novel opportunities for therapeutic intervention. This new knowledge may facilitate the development of cannabinoid receptor-targeted therapeutics with improved safety and efficacy profiles.
A Critical Review Of The Cannabinoid Receptor As A Drug Target For Obesity Management
The discovery of cannabinoids, with the well-known stimulatory effect of Cannabis sativa on appetite, has offered a new drug target for obesity treatment. Cannabinoids act on two different receptors: CB1 receptors which are sited in the brain and many peripheral tissues, and CB2 receptors which are primarily found in immune system cells. Cannabinoid receptor antagonists act centrally by blocking CB1 receptors, thereby reducing food intake…This review discusses how close cannabinoid receptor antagonists are to the IDEAL ANTI-OBESITY DRUG, with respect to their mechanisms of action, clinical effectiveness and safety.


14 thoughts on “The Many Functions of the Human Endocannabinoid System And How Cannabis Can Help

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