Save Your Ass, Smoke Some Grass


When people think of grass, weed, pot or cannabis they think of hippies and parties.  What most people don’t think about is that cannabis is showing real promise, on the molecular level, in fighting cancers.  People of all walks have been touched by cancer.  Most people know of someone, has had a loved one go through it or they themselves have experienced cancer.  It is no wonder then that science and medicine have been working hard to find a cure.  Cannabis research has been taking notice especially for its anti-cancer discoveries.   Over 140,000 new cases were reported for colon and rectal cancers with 51,000 reported deaths.  Below you will see studies where cannabis has been examined in the context of colorectal cancers.  As always please feel free to share and I encourage all to do their own research as well ~ Cherry Girl

Single Nucleotide Change in the Cannabinoid Receptor-1 (CNR1) Gene in Colorectal Cancer Outcome
The cannabinoid receptor-1 (CNR-1) and endogenous agonists of this receptor are present in the central and peripheral nervous systems including the gastrointestinal nervous system.Indeed nontumor paired colorectal tissues showed nucleotide change. A large number of patients with mutation in the CNR1 gene were observed. These preliminary findings highlight the importance of further studies in the use of cannabinoid analogs as receptor ligands to analyze potential therapeutic effects.

Cannabinoid Receptor Activation Induces Apoptosis(programmed cell death) through Tumor Necrosis Factor α–Mediated Ceramide De novo Synthesis in Colon Cancer Cells
We show that the CB1 receptor was mainly expressed in human normal colonic epithelium whereas tumor tissue was strongly positive for the CB2 receptor.  The present study shows that either CB1 or CB2 receptor activation induces apoptosis through ceramide de novo synthesis in colon cancer cells. Our data unveiled, for the first time, that TNF-α acts as a link between cannabinoid receptor activation and ceramide production.

Apoptosis: Programmed Cell Death At A Molecular Level
Balanced apoptosis is crucial in development and homeostasis, and all multicellular organisms have a physiologically programmed continuum of pathways to apoptotic cell death. Further studies of the control at the molecular level of key components and promoters/suppressors of apoptosis may provide better approaches to treatment of autoimmune diseases, malignancies, and neurodegenerative disorders. Many important questions remain regarding the advantages of modifying apoptotic programs in clinical situations.

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