Cannabis Less Harmful Than Current Drug Therapies?

Many when faced with a serious illness fight for their life but ironically are prescribed medications that in fact not only cause harm but also are capable of taking their life.  Many prescription side effects are quite lengthy.  Those that are on prescriptions long-term end up requiring even more medication down the line to combat the side effects from the first drug.  With all that in mind patients are looking for a safer alternative solution.

From cancers to anxiety many prescribed therapies are not only dangerous but can cause death.  Chemotherapy has come a long way from the early days but it is still a drug that ravages the body.  By contrast research has shown that cannabinoid therapies induce programmed cell death in cancerous cells.  Cannabinoids as is widely known are praised for their ability to alleviate without any reported deaths throughout its historic, several thousand year use.

Although the official stance from the government is that cannabis has no accepted medical value science tells us otherwise.  Below you will see a study that weighs the harm of accepted drug therapies such as opioids.  As always I encourage all to do their own research and please feel free to share ~ Cherry Girl

Prescribing Cannabis For Harm Reduction 2012
Neuropathic pain affects between 5% and 10% of the US population and can be refractory to treatment. Opioids may be recommended as a second-line pharmacotherapy but have risks including overdose and death. Cannabis has been shown to be effective for treating nerve pain without the risk of fatal poisoning. The author suggests that physicians who treat neuropathic pain with opioids should evaluate their patients for a trial of cannabis and prescribe it when appropriate prior to using opioids. This harm reduction strategy may reduce the morbidity and mortality rates associated with prescription pain medications.

Cannabis Has Cancer In The Cross-Hairs. Utilizing The Endocannabinoid System To Kill Cancer

It seems that these days the word cancer is everywhere.  From billboards encouraging donations to charities to news headlines to loved one effected by cancer most people are familiar.  There are more than 200 different types of cancer that can develop in over 60 different organs in the body.  Current therapies include poisoning the body in hopes that it will also kill the cancer.  Cannabis is used to help counteract the side effects of these therapies.  However new research points to cannabis as the compounds that can actually cause cancer cell death, essentially curing cancer.  There are countless studies that have been published showing the benefits of using the endocannabinoid system to target cancer cells with cannabinoids.  From that research we have found where using the endocannabinoid system has proven vital in fighting cancer.  Below you will see several studies that show how using the endocannabinoid system can be used in targeting cancer.  Please feel free to share and help others see that using cannabis is beyond the smoke.  I encourage all to do their own research as well ~ Cherry Girl

The Endocannabinoid System in Cancer-Potential Therapeutic Target?
Endogenous arachidonic acid metabolites with properties similar to compounds of Cannabis sativa Linnaeus, the so-called endocannabinoids, have effects on various types of cancer.    Remarkably, these effects may be selective for the cancer cells, while normal cells and tissues are spared. Such apparent tumor cell selectivity makes the endocannabinoid system an attractive potential target for cancer therapy.

Targeting the Endocannabinoid System For the Treatment of Cancer–A Practical View
In recent years, considerable interest has been generated by findings that cannabinoids not only have useful palliative effects, but also can affect the viability and invasivity of a variety of different cancer cells.   It is concluded that cannabinoids (or agents modulating the endogenous cannabinoid system) are an attractive target for drug development in the cancer area….

The Endocannabinoid System As A Target For the Development of New Drugs For Cancer Therapy
Studies on the main bioactive components of Cannabis sativa, the cannabinoids, and particularly (THC), led to the discovery of a new endogenous signalling system that controls several physiological and pathological conditions: the endocannabinoid system. Recently, evidence has accumulated indicating that stimulation of cannabinoid receptors by either THC or the endocannabinoids influence the intracellular events controlling the proliferation and apoptosis(cell death) of numerous types of cancer cells, thereby leading to anti-tumour effects both in vitro and in vivo. This evidence is reviewed here and suggests that future anti-cancer therapy might be developed from our knowledge of how the endocannabinoid system controls the growth and metastasis of malignant cells.

Endocannabinoid System Modulation In Cancer Biology and Therapy
Endocannabinoid system modulation in cancer biology and therapy. The discovery of the endocannabinoid system… led to the development of therapeutic agents related to either the stimulation or antagonism of CB1 and CB2 cannabinoid receptors… evidence suggests that agonists of cannabinoid receptors, which share the useful property to discern between tumor cells and their non-transformed counterparts, could represent novel tumor-selective tools to treat cancer in addition to their already exploited use as palliative drugs.

Use of Cannabinoid Receptor Agonists In Cancer Therapy As Palliative and Curative Agents
“Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents… Cannabinoids (the active components of Cannabis sativa)… development, exploration and use of cannabinoid agonists for cancer therapy, not only as palliative but also as curative drugs.

Changes in the Endocannabinoid System May Give Insight into new and Effective Treatments for Cancer
Marijuana and its derivatives have been used in medicine for centuries… cannabinoids might be effective anti-tumoral agents because of their ability to inhibit the growth of various types of cancer… Evidence suggests that the endocannabinoid system may be dysregulated in a number of cancers… the endocannabinoid system exerts a myriad of effects on tumor cell growth, progression, angiogenesis, and migration. With a notable few exceptions, targeting the endocannabinoid system with agents that activate cannabinoid receptors or increase the endogenous levels of AEA may prove to have therapeutic benefit in the treatment of various cancers.

Save Your Ass, Smoke Some Grass

When people think of grass, weed, pot or cannabis they think of hippies and parties.  What most people don’t think about is that cannabis is showing real promise, on the molecular level, in fighting cancers.  People of all walks have been touched by cancer.  Most people know of someone, has had a loved one go through it or they themselves have experienced cancer.  It is no wonder then that science and medicine have been working hard to find a cure.  Cannabis research has been taking notice especially for its anti-cancer discoveries.   Over 140,000 new cases were reported for colon and rectal cancers with 51,000 reported deaths.  Below you will see studies where cannabis has been examined in the context of colorectal cancers.  As always please feel free to share and I encourage all to do their own research as well ~ Cherry Girl

Single Nucleotide Change in the Cannabinoid Receptor-1 (CNR1) Gene in Colorectal Cancer Outcome
The cannabinoid receptor-1 (CNR-1) and endogenous agonists of this receptor are present in the central and peripheral nervous systems including the gastrointestinal nervous system.Indeed nontumor paired colorectal tissues showed nucleotide change. A large number of patients with mutation in the CNR1 gene were observed. These preliminary findings highlight the importance of further studies in the use of cannabinoid analogs as receptor ligands to analyze potential therapeutic effects.

Cannabinoid Receptor Activation Induces Apoptosis(programmed cell death) through Tumor Necrosis Factor α–Mediated Ceramide De novo Synthesis in Colon Cancer Cells
We show that the CB1 receptor was mainly expressed in human normal colonic epithelium whereas tumor tissue was strongly positive for the CB2 receptor.  The present study shows that either CB1 or CB2 receptor activation induces apoptosis through ceramide de novo synthesis in colon cancer cells. Our data unveiled, for the first time, that TNF-α acts as a link between cannabinoid receptor activation and ceramide production.

Apoptosis: Programmed Cell Death At A Molecular Level
Balanced apoptosis is crucial in development and homeostasis, and all multicellular organisms have a physiologically programmed continuum of pathways to apoptotic cell death. Further studies of the control at the molecular level of key components and promoters/suppressors of apoptosis may provide better approaches to treatment of autoimmune diseases, malignancies, and neurodegenerative disorders. Many important questions remain regarding the advantages of modifying apoptotic programs in clinical situations.

Cannabis: Your Heart Hero

More and more Americans are being classified as obese.  With obesity comes other complications such as cardiovascular disease.  Cardiovascular disease refers to any disease that affects the cardiovascular system, principally cardiac disease, vascular diseases of the brain and kidney, and peripheral arterial disease.  The causes of cardiovascular disease are diverse but atherosclerosis and/or hypertension are the most common.  It is estimated that one-third of Americans die from cardiovascular disease so it is no wonder that scientists have been hard at work trying to find a cure.   Below you will see studies where science has looked at cannabis compounds when applied to CVD.  Please feel free to share and I encourage all do their own research as well ~ Cherry Girl

Targeting Cannabinoid Receptor CB(2 ) in Cardiovascular Disorders: Promises and Controversies
“Cardiovascular disease is the leading cause of death and disability worldwide, which can be largely attributed to atherosclerosis, a chronic inflammation of the arteries… the lipid endocannabinoid system has emerged as a new therapeutic target in variety of disorders associated with inflammation and tissue injury, including those of the cardiovascular system. The discovery that delta-9-tetrahydrocannabinol (Δ9-THC), the main active constituent of marijuana, inhibited atherosclerotic plaque progression via a cannabinoid 2 (CB(2) ) receptor-dependent anti-inflammatory mechanism.

Endocannabinoid System in Cardiovascular Disorders – New Pharmacotherapeutic Opportunities
The evidence so far gathered shows that the modulation of ECS (as agonism or antagonism of its receptors) is an enormous potential field for research and intervention in multiple areas of human pathophysiology. The development of selective drugs for the CB1 and CB2 receptors may open a door to new therapeutic regimens.

Never Fear Cannabis Is Here! How Cannabis Can Help With Fear, Anxiety, and Other Psychiatric Disorders

Nearly 19 million Americans suffer from a  psychiatric disorder which could include disorders such as specific phobias, generalized anxiety disorder, social anxiety disorder, panic disorder, agoraphobia, obsessive-compulsive disorder and post-traumatic stress disorder.  Many veterans returning from war have found cannabis to be a relief from PTSD.  Below you will studies where science has studied the effects of cannabis compounds when applied to psychiatric disorders.  Please feel free to share and I encourage all to do their own research as well ~ Cherry Girl

The Endocannabinoid System in the Processing of Anxiety and Fear and How CB1 Receptors May Modulate Fear Extinction 
The endocannabinoid system recently emerged as an important modulator of many neuronal functions. Among them, the control of anxiety and acquired fear represents nowadays one of the most interesting fields of research.  Finally, a neurobiological model possibly able to implement the role of the endocannabinoid system in these processes will be proposed.

CB1 Cannabinoid Receptors Modulate Kinase and Phosphatase Activity During Extinction of Conditioned Fear in Mice
Cannabinoid receptors type 1 (CB1) play a central role in both short-term and long-term extinction of auditory-cued fear memory.  We propose that the endogenous cannabinoid system modulates extinction of aversive memories, at least in part via regulation of the activity of kinases and phosphatases in a brain structure-dependent manner.

Extinction of Emotional Response As A Novel Approach of Pharmacotherapy of Anxiety Disorders 
The patogenesis of anxiety may be related to the process of an extinction of aversive memories… Studies on molecular and cellular mechanisms responsible for individual fear extinction may serve as the basis of search for more effective forms of clinical treatment… ligands stimulating endogenous cannabinoid system… these substances stimulate different central mechanisms, they appear to act synergistically, to improve the behavioural therapy.

Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear
the findings in the present study suggest that augmenting eCB-mediated neurotransmission by inhibition of eCB transport or breakdown may provide a novel mechanism for enhancing the extinction of fear. As such, eCB reuptake inhibitors may serve as useful adjuncts in the treatment of anxiety disorders (such as PTSD, panic disorder, and OCD) as well as drug addiction and other disorders that respond to behavioral treatments utilizing extinction processes.

The Endogenous Cannabinoid System Controls Extinction of Aversive Memories
Acquisition and storage of aversive memories is one of the basic principles of central nervous systems throughout the animal kingdom. In the absence of reinforcement, the resulting behavioural response will gradually diminish to be finally extinct.  We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala.

The Endocannabinoid system and Extinction Learning
As several human psychiatric disorders, such as phobia, generalized anxiety disorders, and posttraumatic stress disorder (PTSD) appear to involve aberrant memory processing and impaired adaptation to changed environmental conditions, the hope has been fuelled that the endocannabinoid system might be a valuable therapeutic target for the treatment of these disorders.

Bringing the War Back Home: Mental Health Disorders Among 103,788 US Veterans Returning From Iraq and Afghanistan Seen at Department of Veterans Affairs Facilities
Co-occurring mental health diagnoses and psychosocial problems were detected early and in primary care medical settings in a substantial proportion of OEF/OIF veterans seen at VA facilities. Targeted early detection and intervention beginning in primary care settings are needed to prevent chronic mental illness and disability.

Psychosis and Trauma. Theorical Links Between Post-Traumatic and Psychotic Symptoms
The links between psychotic and psycho-traumatic symptoms are complex and multidirectional; this co-occurrence is a factor of seriousness. The clinician, while paying attention to these symptoms, has to distinguish the structure of the personality of the subject to articulate the psychotherapy and the pharmacological treatment. Further investigational studies may determine whether antipsychotics will enhance treatment response in PTSD patients with psychotic features.

The Human Prenatal Endocannabinoid System

Since the discovery of the human endocannabinoid system science has been busy trying to unlock the mysteries of this complex system.  Science has uncovered many interesting features of this system.  This includes the presence of this multi-function system in fetuses.   Below you will see studies on how science has uncovered in-dept knowledge of the endocannabinoid system in pre and post natal subjects.  I encourage all to do their own research and please feel free to share the TRUTH ~ Cherry Girl

Multiple Roles For the Endocannabinoid System During the Earliest Stages Of Life: Pre- and Postnatal Development
The endocannabinoid system, including its receptors (CB(1) and CB(2)), endogenous ligands (‘endocannabinoids’), synthesising and degrading enzymes, as well as transporter molecules, has been detected from the earliest stages of embryonic development and throughout pre- and postnatal development.  Multiple roles for the endocannabinoid system during the earliest stages of life: pre- and postnatal development…the endocannabinoid system appears to play an essential role for development and survival… the endocannabinoid system plays several key roles in pre- and postnatal development. Future studies should further clarify the mechanisms involved… in order to design strategies for the treatment of conditions such as infertility, mental retardation and failure-to-thrive.

The Endocannabinoid-CB Receptor System: Importance For Development and In Pediatric Disease
The endocannabinoid-CB receptor system: Importance for development and in pediatric disease… it is suggested that children may respond positively to medicinal applications of cannabinoids without undesirable central effects. Excellent clinical results have previously been reported in pediatric oncology and in case studies of children with severe neurological disease or brain trauma. We suggest cannabinoid treatment for children or young adults with cystic fibrosis in order to achieve an improvement of their health condition including improved food intake and reduced inflammatory exacerbations.

On the Application of Cannabis In Paediatrics and Epileptology
An initial report on the therapeutic application of delta 9-THC (THC) (Dronabinol, Marinol) in 8 children resp. adolescents suffering from the following conditions, is given: neurodegenerative disease, mitochondriopathy, posthypoxic state, epilepsy, posttraumatic reaction. THC effected reduced spasticity, improved dystonia, increased initiative, increased interest in the surroundings, and anticonvulsive action…possibility that THC-induced effects on ion channels and transmitters may explain its therapeutic activity seen in epileptic patients.

The Endocannabinoid-CB(1) Receptor System In Pre- and Postnatal Life
The endocannabinoid-CB(1) receptor system in pre- and postnatal life.. CB(1) receptors display a transient presence in white matter areas of the pre- and postnatal nervous system, suggesting a role for CB(1) receptors in brain development…Further observations suggest that children may be less prone to psychoactive side effects of Delta(9)-tetrahydrocannabinol or endocannabinoids than adults. The medical implications of these novel developments are far reaching and suggest a promising future for cannabinoids in pediatric medicine for conditions including “non-organic failure-to-thrive” and cystic fibrosis.

Endocannabinoids and Food Intake: Newborn Suckling and Appetite Regulation In Adulthood
The appetite-stimulating effects of the cannabis plant (Cannabis sativa) have been known since ancient times, and appear to be effected through the incentive and rewarding properties of foods. Investigations into the biological basis of the multiple effects of cannabis have yielded important breakthroughs in recent years… exciting progress in the understanding of how the endocannabinoid CB receptor systems influence appetite and body weight is stimulating the development of therapeutic orexigenic and anorectic agents. Furthermore, the role of cannabinoid CB1 receptor activation for milk suckling in newborns may open new doors toward understanding nonorganic failure-to-thrive in infants, who display growth failure without known organic cause.

Ontogenetic Development of Cannabinoid Receptor Expression and Signal Transduction Functionality in the Human Brain
Previous evidence suggests that the endogenous cannabinoid system emerges relatively early during brain development in the rat. However, the pre- and postnatal pattern of appearance of CB1 cannabinoid receptors in humans has not been analysed in detail.   This early pattern of expression of functionally active cannabinoid receptors, along with the transient and atypical localization of these proteins in white matter areas during the prenatal stages, suggest an specific role of the endocannabinoid system in the events related to human neural development.

 

Ever Wonder If Your Illness Could Be Treated With Cannabis?

When I was first introduced to cannabis it was in a party setting.  I just knew that if I smoked it I would feel good.  The only way to get it was by calling up a guy who would bring you a plastic bag of green stuff.  There was no talk of what strain, how it was grown or where it came from.  Each week would be a surprise as to what you were going to get.  Sometimes it would make you sleepy, sometimes it would make you giggle till your sides hurt.

After dealing with debilitating headaches for a few years I decided to try cannabis as a treatment option.  I had a Dr. that was prescribing me medication after medication that would cause side effects like making my brain feel like it was on fire.  I was getting frustrated with reading all the side effects or worse feeling them.  I finally drew the line after they suggested that I try injections at the base of my head.  I knew I needed to find a safer, natural remedy.

Once I started doing research I learned that cannabis wasn’t green stuff in a bag but a natural wonder plant.  Not only was there more than one type but hundreds each with its own miracle properties.  Its not only the strain but the location of where or even how its grown that determines its usefulness.  When determining which strain is right for you there are some things to keep in mind.

There are two main categories that cannabis fall into although there are more.  Indica strains typically are the strains that will give you that drowsy body stoned feeling.  By contrast a sativa strain typically is a cerberal or head high.  Hybrids are quite common and depending on the percentage of indica to sativa can make a nice combination high.

There are strains that help with a variety of illnesses.  There are even studies that are suggesting that cannabis can reduce or shrink cancer cells.  Cancer patients find comfort from strains that aid with nausea and appetite while chronic pain sufferers find solace in it’s pain relief properties.

Cannabis needs to be grown properly and preferably by a quality grower who puts attention to detail as a priority.  One thing that should be on your mind when choosing cannabis is that you will be ingesting this product so why not know more about it?  Fertilizers and other chemicals being used during the growing process can effect the end product.  Even things like proper drying and handling can change how effective your medicine is.

One of the best ways to ensure that you are getting quality product is to grow it yourself.  There are plenty of books and online help to assist in growing your own medicine.  If growing is not an option the next best thing is buying your medicine through a dispensary or collective.  There you will have the option of choosing quality medicine that is safer.  If your state offers a medical marijuana program it is definitely worth the time to research and see if its an option for you.  So before passing off the option of using cannabis as a natural option do a little research and see that there is more to it than some green stuff in a bag.

We have selfless people who are willing to put in the time to compile a list of illness and their known treatments with cannabis as well as studies to back it up.  This is just a guide and as with anything you should seek professional opinions first.

Click Below to download PDF list
Granny Storm Crow’s MMJ Reference List- July 2011