Prevention and Treatment of Alzheimer’s Disease With Cannabis


It is estimated that 5.1 million Americans may have Alzheimer’s disease. Alzheimer’s disease is an irreversible, progressive brain disease that slowly destroys memory and thinking skills, and eventually even the ability to carry out the simplest tasks.  Alzheimer’s disease is the most common cause of dementia among older people. Dementia is the loss of cognitive functioning—thinking, remembering, and reasoning—and behavioral abilities.  Scientists have been working on finding a cure for this debilitating disease.  One option was cannabis.  Below you will find several studies where cannabis was studied for Alzheimer’s Disease please share the truth about the CURE ~ Cherry Girl

Alzheimer’s Disease; Taking the Edge Off With Cannabinoids?
Manipulation of the cannabinoid pathway offers a novel pharmacological approach for the treatment of AD that may be more efficacious than current treatment regimes. Cannabinoids can reduce the oxidative stress, neuroinflammation and apoptosis that is evoked by Aβ, while promoting the brain’s intrinsic repair mechanisms.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190031/?tool=pubmed

Multi-Target-Directed Ligands in Alzheimer’s Disease Treatment.
AD is related to increased levels of the amyloid β peptide (A β) and the hyperphosphorylated tau protein, along with loss of neurons and synapses. Moreover, there is some evidence pointing to the role of oxidative stress, metal ion deregulation, inflammation and cell cycle regulatory failure in its pathogenesis. There are many attractive targets for the development of anti-AD drugs, and the multi-factor nature of this disease calls for multi-target-directed compounds which can be beneficial for AD treatment.
http://www.ncbi.nlm.nih.gov/pubmed/22050745

The Endocannabinoid System and Alzheimer’s Disease.
If you want to understand why CANNABINOIDS CURE, you need to know about the endoCANNABINOID SYSTEM. Cannabinoids CURE because of cannabinoid receptors and the endoCANNABINOID SYSTEM. Cannabis CURES ALzheimer’s and more, via the endoCANNABINOID SYSTEM: “Data obtained for this disease and in human samples seem to corroborate the notion that the activation of the ECS, through the use of agonists or by enhancing the endogenous cannabinoid tone, may induce beneficial effects on the evolution of this disease.
http://www.ncbi.nlm.nih.gov/pubmed/17952652

Cannabinoid System in Neurodegeneration: New Perspectives In Alzheimer’s Disease 
Alzheimer’s disease is a chronic and progressive neurodegenerative disorder. The presence of functional cannabinoid CB2 receptors in central nervous system (CNS) has provoked that this receptor and its agonist ligands are now considered as promising pharmacological targets for neurological diseases.
http://www.ncbi.nlm.nih.gov/pubmed/19456285

Cannabinoids As Therapeutic Agents For Ablating Neuroinflammatory Disease
Ablate means to remove or destroy biologically. Keep that in mind when reading this: “Cannabinoids may serve as ideal agents for adjunct treatment of pathological processes that have a neuroinflammatory component.As highly lipophilic molecules, they readily access the brain.Furthermore, they have relatively low toxicity and can be engineered to selectively target cannabinoid receptors. The cannabinoid-cannabinoid receptor system may prove therapeutically manageable in ablating neuropathogenic disorders such as Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis, HIV encephalitis, closed head injury, and granulomatous amebic encephalitis.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750822/?tool=pubmed

The Role of the Endocannabinoid System in Alzheimer’s Disease: Facts and Hypotheses
There is evidence, from in vivo studies on beta-amyloid-induced neurotoxicity, also for a possible causative role of endocannabinoids in the impairment in memory retention, which is typical of AD. This might open the way to the use of cannabinoid receptor antagonists as therapeutic drugs for the treatment of cognitive deficits in the more advanced phases of this disorder. The scant, but nevertheless important literature on the regulation and role of the endocannabinoid system in AD, and on the potential treatment of this disorder with cannabinoids and endocannabinoid-based drugs, are discussed in this mini-review.
http://www.ncbi.nlm.nih.gov/pubmed/18781980

Role of CB2 Receptors in Neuroprotective Effects of Cannabinoids
Given the lack of psychoactivity demonstrated by selective CB2 receptor agonists, this receptor becomes an interesting target for the treatment of neurological diseases, in particular, certain neurodegenerative disorders in which induction/up-regulation of CB2 receptors has been demonstrated. These disorders include Alzheimer’s disease and others. In experimental models, the activation of CB2 receptors has been related to a delayed progression of neurodegenerative events. The present article will review the evidence supporting that CB2 receptors might represent a key element in the endogenous response against different types of cytotoxic events, and that this receptor type may be a clinically promising target for the control of brain damage in neurodegenerative disorders.
http://www.ncbi.nlm.nih.gov/pubmed/18291574

Stimulation of Cannabinoid Receptor 2 (CB2) Suppresses Microglial Activation
Activated microglial cells have been implicated in a number of neurodegenerative disorders, including Alzheimer’s disease (AD). Many data reveal that cannabinoids mediate suppression of inflammation in vitro and in vivo through stimulation of cannabinoid receptor 2 (CB2). These results provide mechanistic insight into beneficial effects provided by cannabinoid receptor CB2 modulation in neurodegenerative diseases, particularly AD.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1352348/?tool=pubmed

Effects of Cannabinoids on the Immune System and Central Nervous System: Therapeutic Implications
‎1999: “Cannabinoids possess immunomodulatory activity, are neuroprotective in vivo and in vitro and can modify the production of inflammatory mediators… Cannabinoid-induced immunosuppression may have implications for the treatment of neurological disorders that are associated with excess immunological activity, such as multiple sclerosis and Alzheimer’s disease.There is anecdotal evidence thatcannabis use improves the symptoms of multiple sclerosis, and studies with animal models are beginning to provide evidence for the mechanism of such effects. The development of nonpsychotropic cannabinoid analogues and modulators of the metabolism of endogenous cannabinoid ligands may lead to novel approaches to the treatment of neurodegenerative disorders.
http://www.ncbi.nlm.nih.gov/pubmed/18031185

A Molecular Link Between the Active Component of Marijuana and Alzheimer’s Disease Pathology
A link between the endocannabinoid system and Alzheimer’s disease has been discovered which has provided a new therapeutic target for the treatment of patients suffering from Alzheimer’s disease.New targets for this debilitating disease are critical as Alzheimer’s disease afflicts over 20 million people worldwide, with the number of diagnosed cases continuing to rise at an exponential rate.These studies have demonstrated the ability of cannabinoids to provide neuroprotection against β-amyloid peptide (Aβ) toxicity.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562334/?tool=pubmed

Cannabidiol: From An Inactive Cannabinoid to A Drug With Wide Spectrum of Action
The last five years have shown a remarkable increase in publications on cannabidiol mainly stimulated by the discovery of its anti-inflammatory, anti-oxidative and neuroprotective effects. Studies have suggested a wide range of therapeutic effects of cannabidiol on several conditions, including Alzheimer’s disease, cancer, etc…In the last 45 years it has been possible to demonstrate that CBD has a wide range of pharmacological effects, many of which being of great therapeutic interest, but still waiting to be confirmed by clinical trials.
http://www.ncbi.nlm.nih.gov/pubmed/18833429

Delta-9-tetrahydrocannabinol For Nighttime Agitation In Severe Dementia
Nighttime agitation occurs frequently in patients with dementia and represents the number one burden on caregivers today. Current treatment options are few and limited due to substantial side effects. CONCLUSIONS: The study suggests that THC (Dronabinol) was able to reduce nocturnal motor activity and agitation in severely demented patients. Thus, it appears that THC (Dronabinol) may be a safe new treatment option for behavioral and circadian disturbances in dementia.
http://www.ncbi.nlm.nih.gov/pubmed/16521031

The Seek of Neuroprotection: Introducing Cannabinoids
2007: The Endocannabinoid System (ECS) is emerging as a natural system of neuroprotection. This consideration is based on properties of cannabinoids as vasodilatory effect, inhibition of the release of excitotoxic amino acids and cytokines, and the modulation of oxidative stress and toxic production of nitric oxide. Such effects have been demonstrated in models of acute and chronic neurodegenerative conditions, and postulate cannabinoids as valuable neuroprotective agents. Patents related to cannabinoid receptors are also discussed.
http://www.ncbi.nlm.nih.gov/pubmed/18221224

CB2 Receptors in the Brain: Role in Central Immune Function – Cebral
The topic is neuroinflammation, which is relevant to Alzheimer’s and more. Ablation means removing or destroying biologically: “Selective targeting of the Cannabinoid Receptor 2 (CB2R) could lead to ablation of neuropathological processes while minimizing psychotropic effects that could be exerted by activation of the CB1R.
http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0707584/full

Cannabidiol and Other Cannabinoids Reduce Microglial Activation in Vitro and in Vivo: Relevance to Alzheimer’s Disease
Microglial activation is an invariant feature of Alzheimer’s disease (AD). It is noteworthy that cannabinoids are neuroprotective by preventing β-amyloid (Aβ)-induced microglial activation both in vitro and in vivo. CBD is able to modulate microglial cell function in vitro and induce beneficial effects in an in vivo model of AD. Given that CBD lacks psychoactivity, it may represent a novel therapeutic approach for this neurological disease.
http://www.ncbi.nlm.nih.gov/pubmed/21350020

Prevention of Alzheimer’s disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation
Cannabinoids prevent Alzheimer’s Disease: Cannabis protects the brain by blocking microglial activation. “Our results indicate that cannabinoid receptors are important in the pathology of AD and that cannabinoids succeed in preventing the neurodegenerative process occurring in the disease. Because cannabinoids combine both anti-inflammatory and neuroprotective actions, our findings may set the basis for the use of these compounds as a therapeutic approach for AD.
http://www.jneurosci.org/content/25/8/1904.long

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