Cannabis As A Treatment Option and Cure For Epilepsy and Seizures

3 Million Americans suffer each year from seizures.  One disorder that causes seizures is Epilepsy.  Epilepsy produces seizures affecting a variety of mental and physical functions. It is also called a seizure disorder. Seizures happen when clusters of nerve cells in the brain signal abnormally, which may briefly alter a person’s consciousness, movements or actions.

Epilepsy is the third most common neurological disorder in the U.S. after Alzheimer’s disease and stroke. Its prevalence is greater than cerebral palsy, multiple sclerosis and Parkinson’s disease combined. Despite how common it is and major advances in diagnosis and treatment, epilepsy is among the least understood of major chronic medical conditions.

While medications and other treatments help many people of all ages who live with epilepsy, more than a million people continue to have seizures that can severely limit their school achievements, employment prospects and participation in all of life’s experiences.

Below you will see studies that show cannabis as a treatment option as well as a possible cure.  Please share the truth about the cure ~ Cherry Girl

The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy
Several lines of evidence suggest that cannabinoid compounds are anticonvulsant. Here we show that the marijuana extract Delta9-tetrahydrocannabinol completely abolished spontaneous epileptic seizures. These data indicate not only anticonvulsant activity of exogenously applied cannabinoids but also suggest that endogenous cannabinoid tone modulates seizure termination and duration through activation of the CB1 receptor.

Changes in the Cannabinoid (CB1) Receptor Expression Level and G-protein Activation in Kainic Acid Induced Seizures 2011
It has been known for centuries that exogenous cannabinoids, such as tetrahydrocannabinol have anticonvulsant activity. Recent studies have advanced our understanding of the endogenous cannabinoid system and renewed the interest in cannabinoids as a potential treatment for epilepsy.

Endocannabinoids and Their Implications For Epilepsy
Activation of cannabinoid receptors has been implicated in neuroprotection against excitotoxicity and can help explain the anticonvulsant properties of cannabinoids that have been known since antiquity.

Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus
Cannabinoids have been shown to have anticonvulsant properties, but no studies have evaluated the effects of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy (AE) and status epilepticus (SE).The results from this study show CB1 receptor-mediated anticonvulsant effects of the cannabimimetic WIN 55,212-2 (THC) against both SRED and low Mg2+-induced SE in primary hippocampal neuronal cultures and show that these in vitro models of AE and SE may represent powerful tools to investigate the molecular mechanisms mediating the effects of cannabinoids on neuronal excitability.

Assessment of the Role of CB1 Receptors in Cannabinoid Anticonvulsant Effects 
Cannabinoid compounds like delta9-tetrahydrocannabinol and cannabidiol have been shown to be anticonvulsant in maximal electroshock…This study establishes a role for the cannabinoid CB1 receptor in modulating seizure activity in a whole animal model.

Biomedical Benefits of Cannabinoids? 
Cannabinoids appear to be of therapeutic value as antiemetics, antispasmodics, analgesics and appetite stimulants and may have potential uses in epilepsy, glaucoma and asthma.The place of cannabinoids in modern medicine remains to be properly evaluated, but present evidence suggests that they could be valuable, particularly as adjuvants, for symptom control in a range of conditions for which standard drugs are not fully satisfactory.

On the application of Cannabis in Paediatrics and Epileptology
In the US over 300,000 children are affected with epilepsy.
An initial report on the therapeutic application of delta 9-THC (THC) (Dronabinol, Marinol) in 8 children suffering from the following conditions, is given: neurodegenerative disease, mitochondriopathy, posthypoxic state, epilepsy, posttraumatic reaction. THC effected reduced spasticity, improved dystonia, increased initiative (with low dose), increased interest in the surroundings, and anticonvulsive action. In several cases treatment was discontinued and in none of them discontinuing resulted in any problems. The possibility that THC-induced effects on ion channels and transmitters may explain its therapeutic activity seen in epileptic patients is discussed.

Brain Cannabinoid Systems As Targets For the Therapy of Neurological Disorders 
Unprecedented developments in cannabinoid research within the past decade include discovery of a brain (CB1) and peripheral (CB2) receptor; endogenous ligands, anandamide, and 2-arachidonylglycerol; cannabinoid drug-induced partial and inverse agonism at CB1 receptors, antagonism of NMDA receptors and glutamate, and antioxidant activity; and preferential CB1 receptor localization in areas subserving spasticity, pain, abnormal involuntary movements, seizures, and amnesia. These endogenous structures and chemicals and mechanisms are potentially new pathophysiologic substrates, and targets for novel cannabinoid treatments, of several neurological disorders.

Downregulation of the CB1 Cannabinoid Receptor and Related Molecular Elements of the Endocannabinoid System in Epileptic Human Hippocampus 
These findings show that a neuroprotective machinery involving endocannabinoids is impaired in epileptic human hippocampus and imply that downregulation of CB(1) receptors and related molecular components of the endocannabinoid system may facilitate the deleterious effects of increased network excitability.

Cannabidiol Displays Antiepileptiform and Antiseizure Properties in Vitro and in Vivo
These findings suggest that CBD acts, potentially in a CB(1) receptor-independent manner, to inhibit epileptiform activity in vitro and seizure severity in vivo. Thus, we demonstrate the potential of CBD as a novel antiepileptic drug in the unmet clinical need associated with generalized seizures.

Cannabinoid Receptor Activation Reverses Kainate-Induced Synchronized Population Burst Firing in Rat
Cannabinoids have been shown to possess anticonvulsant properties in whole animal models of epilepsy. The present results indicate that cannabinoids exert their antiepileptic effects by impeding pathological synchronization of neuronal networks in the hippocampus.

7 thoughts on “Cannabis As A Treatment Option and Cure For Epilepsy and Seizures

  1. Pingback: Targeting Our Endocannabinoid System:Search For Nature’s Cure | Cherry Girl

  2. Pingback: Human Endocannabinoid System: Science’s Target For New Therapies | Cherry Girl

  3. Pingback: Children’s Cancer and Cannabis | Cherry Girl

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