Endocannabinoid System, Cannabinoid Receptors, and Cannabinoids CURING Cancer


Cannabis holds many healing properties that are slowly being unraveled.  Since the 60’s it has been known that the human body contains an Endocannabinoid system that interacts with cannabis.  Since then science has discovered many things and continues in the search for the key to unlocking the cure.  Many believe in the power of cannabis to cure many things including cancer.  Scientists are hard at work trying to prove the very same thing.  Below you will see studies that show how science has unlocked some mysteries.  These are valid published medical studies dealing with out endocannabinoid system please feel free to share ~ Cherry Girl

Cannabinoids In the Treatment of Cancer
Cannabinoids, the active components of the hemp plant Cannabis sativa, along with their endogenous counterparts and synthetic derivatives, have elicited anti-cancer effects in many different in vitro and in vivo models of cancer. While the various cannabinoids have been examined in a variety of cancer models, recent studies have focused on the role of cannabinoid receptor agonists (both CB(1) and CB(2)) in the treatment of estrogen receptor-negative breast cancer. This review will summarize the anti-cancer properties of the cannabinoids, discuss their potential mechanisms of action, as well as explore controversies surrounding the results.

Changes In the Endocannabinoid System May Give Insight Into New and Effective Treatments For Cancer
Marijuana and its derivatives have been used in medicine for centuries, however, it was not until the isolation of the psychoactive component of Cannabis sativa (Δ9-tetrahydrocannabinol; Δ9-THC) and the subsequent discovery of the endogenous cannabinoid signaling system that research into the therapeutic value of this system reemerged. Ongoing research is determining that regulation of theendocannabinoid system may be effective in the treatment of pain, glaucoma, and neurodegenerative disorders such as Parkinson’s disease and multiple sclerosis. In addition, cannabinoids might be effective anti-tumoral agents because of their ability to inhibit the growth of various types of cancer cell lines.   In conclusion, the endocannabinoid system exerts a myriad of effects on tumor cell growth, progression, angiogenesis, and migration. With a notable few exceptions, targeting the endocannabinoid system with agents that activate cannabinoid receptors or increase the endogenous levels of AEA may prove to have therapeutic benefit in the treatment of various cancers. Further studies into the downstream consequences of AEA treatment are required and may illuminate other potential therapeutic targets.

The Endocannabinoid System and Cancer: Therapeutic Implication
Identification of safe and effective treatments to manage and improve cancer therapy is critical to improve quality of life and reduce unnecessary suffering in cancer patients. In this regard, cannabis-like compounds offer therapeutic potential for the treatment of breast, prostate and bone cancer in patients.

Endocannabinoids As Emerging Suppressors of Angiogenesis and Tumor Invasion
The medicinal properties of extracts from the hemp plant Cannabis sativa have been known for centuries but only in the 90s membrane receptors for the Cannabis major principle were discovered in mammalian cells…endocannabinoids are now emerging as suppressors of angiogenesis and tumor spreading since they have been reported to inhibit angiogenesis, cell migration and metastasis in different types of cancer, pointing to a potential role of the endocannabinoid system as a target for a therapeutic approach of such malignant diseases. The potential use of cannabinoids to retard tumor growth and spreading is even more appealing considering that they show a good safety profile, regarding toxicity, and are already used in cancer patients as palliatives to stimulate appetite and to prevent devastating effects such as nausea, vomiting and pain.

Therapeutic Target-In-Waiting
CB(2) cannabinoid receptor agonists hold promise as a new class of therapeutics for indications as diverse as pain, neuroinflammation, immune suppression and osteoporosis. These potential indications are supported by strong preliminary data from multiple investigators using diverse preclinical models.

Cannabidiol Inhibits Lung Cancer Cell Invasion and Metastasis Via Intercellular Adhesion Molecule-1
Overall, our data indicate that cannabinoids induce ICAM-1, thereby conferring TIMP-1 induction and subsequent decreased cancer cell invasiveness.

Cannabinoid Receptor 1 is A Potential Drug Target For Treatment of Translocation-Positive Rhabdomyosarcoma
Because cannabinoid receptor agonists are capable of reducing proliferation and inducing apoptosis in diverse cancer cells such as glioma, breast cancer, and melanoma, we evaluated whether CB1 is a potential drug target in rhabdomyosarcoma.Our study shows that treatment with the cannabinoid receptor agonists HU210 and Delta(9)-tetrahydrocannabinol lowers the viability of translocation-positive rhabdomyosarcoma cells through the induction of apoptosis.These results support the notion that cannabinoid receptor agonists represent a novel targeted approach for treatment of translocation-positive rhabdomyosarcoma.

PAX3-FOXO1 Induces Cannabinoid Receptor 1 to Enhance Cell Invasion and Metastasis
Alveolar rhabdomyosarcoma (ARMS) is a muscle-derived childhood tumor characterized by production of oncogenic PAX3/7-FOXO1 chimeric transcription factors…Genetic or pharmacologic abrogation of (Cnr1/Cb1) inhibited the enhanced basement membrane invasion induced by PAX3-FOXO1. Cnr1 loss by either route also dramatically reduced lung metastasis formation. Taken together, our findings strongly implicate Cnr1 as a novel tractable target to inhibit ARMS invasion and metastasis.

The Endocannabinoid System In Cancer-Potential Therapeutic Target?
Endogenous arachidonic acid metabolites with properties similar to compounds of Cannabis sativa Linnaeus, the so-called endocannabinoids, have effects on various types of cancer. Although endocannabinoids and synthetic cannabinoids may have pro-proliferative effects, predominantly inhibitory effects on tumor growth, angiogenesis, migration and metastasis have been described. Remarkably, these effects may be selective for the cancer cells, while normal cells and tissues are spared. Such apparent tumor cell selectivity makes the endocannabinoid system an attractive potential target for cancer therapy.

 

 

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13 thoughts on “Endocannabinoid System, Cannabinoid Receptors, and Cannabinoids CURING Cancer

  1. Pingback: Monumental Achievement – Cannabis Plant Genetics Mapped | Cherry Girl

  2. Pingback: Our Endocannabinoid System: Key To Understanding The Human Body | Cherry Girl

  3. Pingback: Human Endocannabinoid System: Science’s Target For New Therapies | Cherry Girl

  4. Thanks a bunch for sharing this with all of us you actually know what you’re talking about! Bookmarked. Please also visit my website =). We could have a link exchange agreement between us!

  5. Pingback: Children’s Cancer and Cannabis | Cherry Girl

  6. Pingback: The Many Functions of the Human Endocannabinoid System And How Cannabis Can Help | Cherry Girl

  7. Pingback: Cannabinoid Receptors: Key To Cannabis’ Healing Success | Cherry Girl

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