Our Endocannabinoid System: Key To Understanding The Human Body

Since discovering the endocannabinoid system scientists have been using it as a target to cure or help many ailments.  When looking through the myriad of published medical studies one will quickly see this trend.  This is just one more reason why understanding the human endocannabinoid system is crucial.  Below you will see studies where the endocannabinoid system was targeted for therapies with promising outcomes.  Please feel free to share this information with others and your doctor when deciding which treatment options are best for you.  Keep in mind that cannabis is all natural and is used in its natural form.  There are many options when choosing cannabis for a treatment option and goes beyond just smoked cannabis.  I encourage all to do their own research and seek out the truth about cannabis ~ Cherry Girl

The Endocannabinoid System: Role In Energy Regulation (2012)
The endocannabinoid system: role in energy regulation. Cannabis sativa has been used since antiquity to treat many ailments… The primary psychoactive constituent of this plant, Δ(9) -tetrahydrocannabinol (THC) is an FDA approved medication… The effects of THC are mediated through the endocannabinoid system (ECS), which promotes a positive energy balance through stimulation of appetite as well as shifting homeostatic mechanisms toward energy storage… we discuss… the therapeutic potential of targeting this system.

Cannabis Sativa and the Endogenous Cannabinoid System: Therapeutic Potential For Appetite Regulation (2011)
Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation. The herb Cannabis sativa (C. sativa) has been used for thousands of years as a medicine…only recently has scientific endeavour begun to find valuable uses for either the whole plant or its individual components… we discuss evidence describing the endocannabinoid system, its endogenous and exogenous ligands and their varied effects… we also critically consider the mounting evidence which suggests non-Δ(9) tetrahydrocannabinol phytocannabinoids play a vital role in C. sativa-induced feeding pattern changes… given the wide range of phytocannabinoids present in Cannabis sativa… we demonstrate non-Δ(9) tetrahydrocannabinol phytocannabinoids retain an important and, as yet, untapped clinical potential.

The Endocannabinoid System and Prospects Her Stimulation In Clinical Medicine (2007)
The endocannabinoid system and prospects her stimulation in clinical medicine… The history of use by the man of plants of a sort Cannabis totals more than 4000 years… Cannabis sowing, named also “Indian” – cultural plant, which has set of applications. From it received fibres for hemp of ropes and make a fabric similar on linen. Its stalks went on manufacture glossy of a paper and building of plates… as fuel instead of diesel… The greatest popularity Cannabis has received as raw material for reception of products (marijuana, hashish etc) …Cannabis in the medical purposes: at migraine, spasmes, vomiting, pains of a different origin etc.

Cannabinoid System In the Skin – A Possible Target For future Therapies In Dermatology (2009)
Cannabinoid system in the skin -a possible target for future therapies in dermatology.Cannabinoids and their derivatives are group of more than 60 biologically active chemical agents, which have been used in natural medicine for centuries. The major agent of exogenous cannabinoids is Delta(9)-tetrahydrocannabinol (Delta(9)-THC), natural psychoactive ingredient of marijuana. However, psychoactive properties of these substances limited their use as approved medicines…cannabinoids are important mediators in the skin… we summarized the significant role of the cannabinoid system in the cutaneous physiology and pathology, pointing out possible future therapeutic targets.

Therapeutic Potential of the Endocannabinoid System In Perinatal Asphyxia (2011)
Therapeutic potential of the endocannabinoid system in perinatal asphyxia… Perinatal asphyxia is the most frequent cause of neonatal brain injury and, despite advances in neonatology, it has not been possible to reduce its incidence..it is necessary to find out new and more effective therapeutic strategies, appearing the use of cannabinoids as a promising one…The endocannabinoid system modulates a wide range of physiological processes in mammals… it has been considered as an endogenous neuroprotective system… modulation of the endocannabinoid system through the administration of cannabinoids and endocannabinoids has demonstrated neuroprotective effects both in vitro and in vivo… it seems to play an important role in the development of the central nervous system, as it appears in the fetal period since the beginning.
CONCLUSION: Modulation of the endocannabinoid system appears as a novel therapeutic strategy against neonatal hypoxic-ischemic brain injury.

The Role of the Endocannabinoid System In Islet Biology (2011)
The role of the endocannabinoid system in islet biology…It is now established that there is a functional endocannabinoid system in the pancreatic islet of Langerhans and that endocannabinoids are released concurrently with glucose-induced insulin secretion. The majority of the published papers show evidence of negative effects of the endocannabinoids on insulin secretion with antagonism of the cannabinoid 1 receptor improving beta cell function.

The Endocannabinoid System: A Promising Target For the Management of Type 2 Diabetes (2009)
The endocannabinoid system: a promising target for the management of type 2 diabetes…human observations suggest that the endocannabinoid (EC) system is overactivated in presence of abdominal obesity and/or diabetes, and contributes to disturbances of energy balance and metabolism… ECS regulates the intake of nutrients through central mechanisms located within the hypothalamus and limbic area, but also intervenes in transport, metabolism and deposit of the nutrients in the digestive tract, liver, adipose tissue, skeletal muscle, and pancreas. Activation of both central and peripheral CB1 receptors promotes weight gain… Conversely, selective CB(1) receptor antagonist in clinical use, has shown to reduce body weight, waist circumference, triglycerides, blood pressure, insulin resistance and C-reactive protein levels, and to increase HDL cholesterol and adiponectin concentrations in both non-diabetic and diabetic overweight/obese patients.

The Endocannabinoid System As A Target For Obesity Treatment (2008)
The endocannabinoid system as a target for obesity treatment…Among the promising new agents are the CB(1) receptor antagonists. These agents target receptors of the endocannabinoid system, a neuromodulatory system found to influence energy balance, eating behavior, and metabolic homeostasis via central and peripheral mechanisms…antagonism of CB(1) receptors has resulted in meaningful weight loss and improvement of lipid and glycemic profiles. Thus, these agents provide a rational and effective approach for the management of not only overweight and obesity but also their metabolic and cardiovascular sequelae.

Pharmacotherapeutic Targeting of the Endocannabinoid Signaling System: Drugs For Obesity and the Metabolic Syndrome (2008)
Pharmacotherapeutic targeting of the endocannabinoid signaling system: drugs for obesity and the metabolic syndrome…Endogenous signaling lipids (“endocannabinoids”) functionally related to Delta(9)-tetrahydrocannabinol, the psychoactive ingredient of marijuana (Cannabis), are important biomediators and metabolic regulators critical to mammalian (patho)physiology…The ubiquitous and diverse regulatory actions of the endocannabinoid system in health and disease have supported the regulatory approval of natural products and synthetic agents as drugs that alter endocannabinoid-system activity. More recent data support the concept that the endocananbinoid system may be modulated for therapeutic gain at discrete pharmacological targets with safety and efficacy. Potential medications based on the endocannabinoid system have thus become a central focus of contemporary translational research for varied indications with important unmet medical needs…selective CB1 cannabinoid receptor ligands to attenuate endocannabinoid signaling represents a state-of-the-art approach. 


9 thoughts on “Our Endocannabinoid System: Key To Understanding The Human Body

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  6. Pingback: The Human Prenatal Endocannabinoid System | Cherry Girl

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