Human Endocannabinoid System: Science’s Target For New Therapies

Since the discovery of the human endocannabinoid system science has had it in its cross hairs for many potential therapies as well as a better understanding of how our body works within systems.  We have found that the endocannabinoid system has a role in many functions throughout the body.  Below you will see studies where the endocannabinoid system was targeted for therapies with promising outcomes.  Please feel free to share this information with others and your doctor when deciding which treatment options are best for you.  Keep in mind that cannabis is all natural and is used in its natural form.  There are many options when choosing cannabis for a treatment option and goes beyond just smoked cannabis.  I encourage all to do their own research and seek out the truth about cannabis ~ Cherry Girl

Possible Endocannabinoid Control of Colorectal Cancer Growth (2003)
Possible endocannabinoid control of colorectal cancer growth…Anandamide, 2-AG, and… CBR agonist… potently inhibit cell proliferation. This effect is blocked by the CB(1) antagonist, but not by the CB(2) antagonist, and is mimicked by CB(1)-selective, but not CB(2)-selective, agonists… both CB(1) and CB(2) receptors mediate inhibition of proliferation. Inhibitors of endocannabinoid inactivation enhance endocannabinoid levels and block cell proliferation.

The Endocannabinoid System In Amyotrophic Lateral Sclerosis (2008)
The endocannabinoid system in amyotrophic lateral sclerosis…Currently the only licensed therapy available for the treatment of ALS is the anti-glutamatergic agent Riluzole, which has limited therapeutic effects. However, there is increasing evidence that cannabinoids and manipulation of the endocannabinoid system may have therapeutic value in ALS, in addition to other neurodegenerative conditions. Cannabinoids exert anti-glutamatergic and anti-inflammatory actions through activation of the CB(1) and CB(2) receptors, respectively. Activation of CB(1) receptors therefore inhibit glutamate release… Meanwhile, CB(2) receptors influence inflammation, whereby receptor activation reduces microglial activation, resulting in a decrease in neurotoxic mediators. Finally, cannabinoid agents may also exert anti-oxidant actions by a receptor-independent mechanism. Therefore the ability of cannabinoids to target multiple neurotoxic pathways in different cell populations increase their therapeutic potential in the treatment of ALS. Recent studies investigating this potential in models of ALS, in particular those that focus on strategies that activate CB(2) receptors, are discussed.

Interaction of Endocannabinoid System and Steroid Hormones In the Control of Colon Cancer Cell Growth (2012)
Interaction of endocannabinoid system and steroid hormones in the control of colon cancer cell growth…Our results partially elucidated the role of EC system in the molecular mechanisms enrolled by steroids in the inhibition of colon cancer cell growth and strongly suggested that targeting the EC system represent a promising tool to improve the efficacy of CRC (colorectal cancer cell) treatments.

The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications (2011)
The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications…The modulation of the activity of this system holds tremendous therapeutic potential in a wide range of diseases, ranging from cancer, pain, neurodegenerative, and cardiovascular diseases to obesity and metabolic syndrome, diabetes, and diabetic complications… the role of the endocannabinoid system in primary diabetes…therapeutic potential of targeting the endocannabinoid system… certain plant-derived cannabinoids… possess potent anti-inflammatory and/or antioxidant properties.

The Endocannabinoid System In Ageing: A New Target For Drug Development (2006)
The endocannabinoid system in ageing: a new target for drug development…. Anandamide (N-arachidonoylethanolamine; AEA) and 2-arachidonoylglycerol are the main endogenous agonists of cannabinoid receptors able to mimic several pharmacological effects of Delta(9)-tetrahydrocannabinol, the active principle of Cannabis sativa preparations like hashish and marijuana. AEA is released “on demand”…. Together with AEA and congeners, the proteins which bind, synthesize, transport and hydrolyze AEA form the “endocannabinoid system”. Endogenous cannabinoids are present in the central nervous system and in peripheral tissues, suggesting… therapeutic potential… drugs able to modulate the endocannabinoid tone for the treatment of ageing and age-related human pathologies.

Endocannabinoid System In Cardiovascular Disorders – New Pharmacotherapeutic Opportunities (2011)
Endocannabinoid system in cardiovascular disorders – new pharmacotherapeutic opportunities.The long history of Cannabis sativa had its development oriented for medicine after the discovery and chemical characterization of its main active ingredient, the 9-tetrahydrocannabinol (9-THC). Consequently, a binding site for 9-THC was identified in and the first cannabinoid receptor (CB1) was cloned, followed by the CB2 and by the discover of two endogenous agonists: anandamide and 2-arachidonoyl glycerol. Cannabinoid receptors, endocannabinoids and the enzymes that catalyze its synthesis and degradation constitute the endocannabinoid system (ECS), which plays an important role in the cardiovascular system…The evidence so far gathered shows that the modulation of ECS (as agonism or antagonism of its receptors) is an enormous potential field for research and intervention in multiple areas of human pathophysiology. The development of selective drugs for the CB1 and CB2 receptors may open a door to new therapeutic regimens.

The Endogenous Cannabinoid System. Therapeutic Implications For Neurologic and Psychiatric Disorders (2005)
The endogenous cannabinoid system. Therapeutic implications for neurologic and psychiatric disorders. For about 5,000 years, cannabis has been used as a therapeutic agent. There has been growing interest in the medical use of cannabinoids. This is based on the discovery that cannabinoids act with specific receptors (CB1 and CB2). CB1 receptors are located in specific brain areas and CB2 receptors on cells of the immune system… findings could possibly lead to the use of synthetic and natural cannabinoids as therapeutic agents in various areas.

Targeted Modulators of the Endogenous Cannabinoid System: Future Medications to Treat Addiction Disorders and Obesity (2007)
Targeted modulators of the endogenous cannabinoid system: future medications to treat addiction disorders and obesity…Pressing health care needs have made the rational design of targeted CB1 cannabinoid-receptor modulators a promising route to future medications with significant therapeutic impact.

The Importance of the Endogenous Cannabinoid System In Various Neuropsychiatric Disorders (2007)
The importance of the endogenous cannabinoid system in various neuropsychiatric disorders…The endogenous cannabinoid system was first described in 1988. There are two specific receptors, the CB2-receptor, located in the lymphatic system and the CB1-receptor occurring predominantly in the central nervous system…In 1992 endogenous ligands of the cannabinoid system were discovered for the first time (e.g. anandamide and 2-arachidonylglycerol)…A dysregulation in the endogenous cannabinoid/anandamide system could possibly play an import role in the etiology of Gilles de la Tourette syndrome and schizophrenic psychoses…administration of cannabinoids affects the symptoms of the Gilles de la Tourette syndrome positively… In ischaemic brain lesions cannabinoids seem to have a neuroprotective effect…interactions between the endogenous opioid system and the endogenous cannabainoid system are pointed out. This is of interest since it could be shown in experiments that the absence of CB1 receptors reduces the positive reinforcement of opiate administration.

Therapeutic Potential of the Endocannabinoid System in the Brain (2005)
Therapeutic potential of the endocannabinoid system in the brain. Cannabinoids… marijuana and other derivatives of Cannabis sativa… these compounds are now also considered for their therapeutic potential, since the term “cannabinoid” includes much more compounds than those present in Cannabis sativa derivatives… there are numerous synthetic cannabinoids obtained by modifications from plant-derived cannabinoids… All this boom of the cannabinoid pharmacology has an explanation in the discovery of the endocannabinoid signaling system, which plays a modulatory role… The objective of the article will be to review the advances in the study of the endocannabinoid system and their functions in the brain, as well as their alterations in a variety of pathologies and the proposed therapeutic benefits of novel cannabinoid-related compounds that improve the pharmacokinetic and pharmacodynamic properties of classic cannabinoids.

The Endocannabinoid Signaling System: A Marriage of PUFA and Musculoskeletal Health (2010)
The endocannabinoid signaling system: a marriage of PUFA and musculoskeletal health…The potential of dietary PUFA to regulate this signaling system to influence the metabolic and physiological outcomes favorable to musculoskeletal health is the purpose… we first introduce the EC agonists (ligands) and their receptors (CB1 and CB2) and the general actions of EC signaling in various organs and systems. Second, we describe EC signaling in bone and muscle and how dietary PUFA influence the levels of endogenous agonists. Third, we discuss the potential implications of how dietary PUFA impact this system to minimize muscle atrophy and osteopenia and support healthy muscle development and bone modeling.

The Endocannabinoid System: Physiology and Pharmacology (2005)
The endocannabinoid system: physiology and pharmacology…The endogenous cannabinoid system is an ubiquitous lipid signalling system that appeared early in evolution and which has important regulatory functions throughout the body in all vertebrates…Outside the brain, the endocannabinoid system is one of the crucial modulators of the autonomic nervous system, the immune system and microcirculation…Recent pharmacological advances have led to the synthesis of cannabinoid receptor agonists and antagonists, selective inhibitors of endocannabinoid degradation. These new tools have enabled the study of the physiological roles played by the endocannabinoids and have opened up new strategies in the treatment of pain, obesity, neurological diseases including multiple sclerosis, emotional disturbances such as anxiety and other psychiatric disorders including drug addiction. Recent advances have specifically linked the endogenous cannabinoid system to alcoholism, and cannabinoid receptor antagonism now emerges as a promising therapeutic alternative for alcohol dependence and relapse.”— I believe: since the endo-plant cannabinoid system can be the target for Big Pharma’s for-private-profit “treatments.

The Endocannabinoid System As An Emerging Target of Pharmacotherapy (2006)
The endocannabinoid system as an emerging target of pharmacotherapy. The recent identification of cannabinoid receptors and their endogenous lipid ligands has triggered an exponential growth of studies exploring the endocannabinoid system and its regulatory functions in health and disease…The growing number of preclinical studies and clinical trials with compounds that modulate the endocannabinoid system will probably result in novel therapeutic approaches in a number of diseases for which current treatments do not fully address the patients’ need. Here, we provide a comprehensive overview on the current state of knowledge of the endocannabinoid system as a target of pharmacotherapy.

The Endocannabinoid System: An Osteopathic Perspective (2008)
The endocannabinoid system consists of cannabinoid receptors, endogenous ligands, and ligand-metabolizing enzymes. The system exemplifies the osteopathic principle that the body possesses self-regulatory mechanisms that are self-healing in nature…The endocannabinoid system is a homeostatic mechanism that exemplifies the key osteopathic concepts of mind-body unity on a molecular level… osteopathic physicians may enhance endocannabinoid function in their patients…The plant Cannabis sativa, the source of cannabis (ie, marijuana, hashish), is native to central Asia. Several indigenous “traditional medicine” systems (eg, Ayurvedic medicine, Tibetan medicine, traditional Chinese medicine) evolved and make use of this substance.

7 thoughts on “Human Endocannabinoid System: Science’s Target For New Therapies

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