Understanding how cannabis therapy relates to your disease can be very daunting. Our knowledge of breast cancer is actually quite expansive but we are still in the infancy of fully understanding why and how it grows as well as how we can cure or prevent it. Breast cancer is widely researched from private enterprises to corporations and non-profits. We see and hear about it all the time and know that billions are spent funding the research. Cannabis therapy has been one such subject. We know that cannabis has a wide range of uses medicinally.
Breast cancer has been studied in regards to the actual cancer cells being treated with cannabinoids. When looking at most cannabis research you will notice it is not just cannabis as a whole but specific compounds found within certain cannabis strains. This is important to remember when trying to use cannabis on your illness or affliction. Finding the right strain that contains the right compounds is what will bring the desired effects. Cannabinoids have been found to have anti-cancer properties. Science has found that cannabinoids target cancer cells and induce cell death. This is exciting news as current therapies are equivilant to a carpet bomb destroying more than just cancer cells and notorious for leaving behind a shell of a person.
Many in that situation have turned to cannabis to relieve the constant nausea and pain associated with cancer and current therapies. Cannabinoids on the other hand have been found to actually protect and repair the body as well as destroy cancer cells. Our system naturally works well with cannabis. Our endocannabinoid system was discovered in the 60s and since then science has been trying to figure out how to use that system to help cure diseases.
Below you will see studies that show how breast cancer cells are targeted using the the endocannabinoid system specifically receptors and cannabis compounds. A few are for background on how they relate. As always I encourage all to do their own research as well and discuss all options with their doctor. Cannabis therapies have developed beyond smoke and now include tinctures, honey, oils, topical ointments, edibles, Rick Simpson Method Oil, capsules and many more. Please feel free to share ~ Cherry Girl
Pathways Mediating the Effects of Cannabidiol on the Reduction of Breast Cancer Cell Proliferation, Invasion, and Metastasis – 2011
Invasion and metastasis of aggressive breast cancer cells are the final and fatal steps during cancer progression. Clinically, there are still limited therapeutic interventions for aggressive and metastatic breast cancers available. We previously reported that cannabidiol (CBD), a cannabinoid with a low toxicity profile, down-regulated Id-1 gene expression in aggressive human breast cancer cells in culture. Using cell proliferation and invasion assays, cell flow cytometry to examine cell cycle and the formation of reactive oxygen species, and Western analysis, we determined pathways leading to the down-regulation of Id-1 expression by CBD and consequently to the inhibition of the proliferative and invasive phenotype of human breast cancer cells. The results have the potential to lead to the development of novel non-toxic compounds for the treatment of breast cancer metastasis…..
Role of Id-2 in the Maintenance of a Differentiated and Noninvasive Phenotype in Breast Cancer Cells
Id proteins are inhibitors of basic helix-loop-helix transcription factors and generally stimulate cell proliferation and inhibit differentiation. We also show that Id-2 expression is inversely correlated with the rate of proliferation in murine mammary epithelial cells and that Id-2 is expressed at a higher level in differentiated human breast cancer cells in comparison with very aggressive and metastatic cells.
The Multiple Roles of Id-1 in Cancer Progression
Id-1 (Inhibitor of differentiation/DNA binding) is a member of the helix-loop-helix protein family expressed in actively proliferating cells. A close association between Id-1 expression and angiogenesis has also been demonstrated recently in both normal and cancer cells. Accordingly, in prostate cancer cells, expression of Id-1 was able to activate EGF-R and nuclear factor-kappaB activities and resulted in progression to androgen independence. In addition, in both nasopharyngeal carcinoma and prostate cancer cells, Id-1 expression was found to protect the cells from chemotherapeutic drug-induced apoptosis(programmed cell death)…
Cannabidiol As A Novel Inhibitor of Id-1 Gene Expression In Aggressive Breast Cancer Cells
Invasion and metastasis of aggressive breast cancer cells is the final and fatal step during cancer progression, and is the least understood genetically. Clinically, there are still limited therapeutic interventions for aggressive and metastatic breast cancers available. The CBD concentrations effective at inhibiting Id-1 expression correlated with those used to inhibit the proliferative and invasive phenotype of breast cancer cells. CBD was able to inhibit Id-1 expression at the mRNA and protein level in a concentration-dependent fashion. These effects seemed to occur as the result of an inhibition of the Id-1 gene at the promoter level. Importantly, CBD did not inhibit invasiveness in cells that ectopically expressed Id-1. In conclusion, CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells…..
Id-1 As A Molecular Target In Therapy For Breast Cancer Cell Invasion and Metastasis
Mammary epithelial cells constitutively expressing Id-1 protein are unable to differentiate, acquire the ability to proliferate, and invade the extracellular matrix. We demonstrate significant reduction of both Id-1 and MT1-MMP expressions as well as the metastatic spread of 4T1 breast cancer cells in syngeneic BALB/c mice. In conclusion, our studies have identified Id-1 as a critical regulator of breast cancer progression and suggest the feasibility of developing novel therapeutic approaches to target Id-1 expression to reduce breast cancer metastasis in humans…..
Inhibition of Tumor Angiogenesis By Cannabinoids
Inhibition of tumor angiogenesis may allow new strategies for the design of cannabinoid-based antitumoral therapies” and “The non-psychoactive cannabinoid….
Cannabidiol Inhibits Angiogenesis By Multiple Mechanisms
Several studies demonstrated anti-proliferative and pro-apoptotic actions of cannabinoids on several tumours, together with their anti-angiogenic properties.