Cannabis Kicking Breast Cancer’s Ass

Understanding how cannabis therapy relates to your disease can be very daunting.  Our knowledge of breast cancer is actually quite expansive but we are still in the infancy of fully understanding why and how it grows as well as how we can cure or prevent it.  Breast cancer is widely researched from private enterprises to corporations and non-profits.  We see and hear about it all the time and know that billions are spent funding the research.  Cannabis therapy has been one such subject.  We know that cannabis has a wide range of uses medicinally.

Breast cancer has been studied in regards to the actual cancer cells being treated with cannabinoids.  When looking at most cannabis research you will notice it is not just cannabis as a whole but specific compounds found within certain cannabis strains.  This is important to remember when trying to use cannabis on your illness or affliction.  Finding the right strain that contains the right compounds is what will bring the desired effects.  Cannabinoids have been found to have anti-cancer properties.  Science has found that cannabinoids target cancer cells and induce cell death.  This is exciting news as current therapies are equivilant to a carpet bomb destroying more than just cancer cells and notorious for leaving behind a shell of a person.

Many in that situation have turned to cannabis to relieve the constant nausea and pain associated with cancer and current therapies.  Cannabinoids on the other hand have been found to actually protect and repair the body as well as destroy cancer cells.  Our system naturally works well with cannabis.  Our endocannabinoid system was discovered in the 60s and since then science has been trying to figure out how to use that system to help cure diseases.

Below you will see studies that show how breast cancer cells are targeted using the the endocannabinoid system specifically receptors and cannabis compounds.  A few are for background on how they relate.  As always I encourage all to do their own research as well and discuss all options with their doctor.  Cannabis therapies have developed beyond smoke and now include tinctures, honey, oils, topical ointments, edibles, Rick Simpson Method Oil, capsules and many more.  Please feel free to share ~ Cherry Girl

Pathways Mediating the Effects of Cannabidiol on the Reduction of Breast Cancer Cell Proliferation, Invasion, and Metastasis – 2011
Invasion and metastasis of aggressive breast cancer cells are the final and fatal steps during cancer progression. Clinically, there are still limited therapeutic interventions for aggressive and metastatic breast cancers available.   We previously reported that cannabidiol (CBD), a cannabinoid with a low toxicity profile, down-regulated Id-1 gene expression in aggressive human breast cancer cells in culture. Using cell proliferation and invasion assays, cell flow cytometry to examine cell cycle and the formation of reactive oxygen species, and Western analysis, we determined pathways leading to the down-regulation of Id-1 expression by CBD and consequently to the inhibition of the proliferative and invasive phenotype of human breast cancer cells.  The results have the potential to lead to the development of novel non-toxic compounds for the treatment of breast cancer metastasis…..

Role of Id-2 in the Maintenance of a Differentiated and Noninvasive Phenotype in Breast Cancer Cells
Id proteins are inhibitors of basic helix-loop-helix transcription factors and generally stimulate cell proliferation and inhibit differentiation.  We also show that Id-2 expression is inversely correlated with the rate of proliferation in murine mammary epithelial cells and that Id-2 is expressed at a higher level in differentiated human breast cancer cells in comparison with very aggressive and metastatic cells.

The Multiple Roles of Id-1 in Cancer Progression
Id-1 (Inhibitor of differentiation/DNA binding) is a member of the helix-loop-helix protein family expressed in actively proliferating cells.  A close association between Id-1 expression and angiogenesis has also been demonstrated recently in both normal and cancer cells. Accordingly, in prostate cancer cells, expression of Id-1 was able to activate EGF-R and nuclear factor-kappaB activities and resulted in progression to androgen independence. In addition, in both nasopharyngeal carcinoma and prostate cancer cells, Id-1 expression was found to protect the cells from chemotherapeutic drug-induced apoptosis(programmed cell death)…

Cannabidiol As A Novel Inhibitor of Id-1 Gene Expression In Aggressive Breast Cancer Cells
Invasion and metastasis of aggressive breast cancer cells is the final and fatal step during cancer progression, and is the least understood genetically. Clinically, there are still limited therapeutic interventions for aggressive and metastatic breast cancers available.  The CBD concentrations effective at inhibiting Id-1 expression correlated with those used to inhibit the proliferative and invasive phenotype of breast cancer cells. CBD was able to inhibit Id-1 expression at the mRNA and protein level in a concentration-dependent fashion. These effects seemed to occur as the result of an inhibition of the Id-1 gene at the promoter level. Importantly, CBD did not inhibit invasiveness in cells that ectopically expressed Id-1. In conclusion, CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells…..

Id-1 As A Molecular Target In Therapy For Breast Cancer Cell Invasion and Metastasis
Mammary epithelial cells constitutively expressing Id-1 protein are unable to differentiate, acquire the ability to proliferate, and invade the extracellular matrix.  We demonstrate significant reduction of both Id-1 and MT1-MMP expressions as well as the metastatic spread of 4T1 breast cancer cells in syngeneic BALB/c mice. In conclusion, our studies have identified Id-1 as a critical regulator of breast cancer progression and suggest the feasibility of developing novel therapeutic approaches to target Id-1 expression to reduce breast cancer metastasis in humans…..

Inhibition of Tumor Angiogenesis By Cannabinoids
Inhibition of tumor angiogenesis may allow new strategies for the design of cannabinoid-based antitumoral therapies” and “The non-psychoactive cannabinoid….

Cannabidiol Inhibits Angiogenesis By Multiple Mechanisms
Several studies demonstrated anti-proliferative and pro-apoptotic actions of cannabinoids on several tumours, together with their anti-angiogenic properties.

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12 thoughts on “Cannabis Kicking Breast Cancer’s Ass

  1. Cherry, I have been using Rick Simpson oil for more than 3 years and my cancer has progressed quite a bit during that time. I have used bud oil, whole plant, and trim oils trying to find the right bullet. Otoh, I should’ve been dead more than 4 years ago so I totally credit the cannabis for that. Doctors sure can’t explain it. But not cured … What are your thoughts on that? God knows I have eaten that stuff every which way but no joy. I was reading about blocked receptors but I todo green tea and fish oil out the wazoo trying to reactivate them if they were blocked. No joy there either. Care to opine? 🙂

    • Without knowing specifics I can not help much. What we do know is that using the right strain is key. Science has found that by using the right compounds found within specific cannabis strains people have found relief or cure from illnesses including cancer. When using the RSO is it always the same strain or different ones? If you are lucky enough to be able to work with others or a collective/dispensary you may find more guidance as to what works better for you type. The type of cancer, how aggressive it is and what your genetic make up can all effect the outcome. Here is some more info and if you need more help please feel free to contact me ~ Cherry Girl

  2. Melissa, I think it is important that while substances in Cannabis can and do kill cancer cells in vitro and in vivo, we cannot say that Cannabis cures cancer, as cancer is a heterogenous disease. Certainly, Cannabis protects against the development of cancer as illustrated by Dr Tashkin, but like you said, while it might slow the growth of a large tumor, cannabis might not necrose and eliminate it. What kind of tumor are you talking about? Have you looked into cannabis juicing? Like you must know, when living with cancer, the other effects cannabis has on mood and appetite and outlook are also very valuable. Good luck and Blessings on you

  3. @Nagmas I disagree there are many more studies that show that cannabinoids cause cancer cell death. There are thousands more that can attest to the fact that cannabis has helped them get rid of their cancer. Cash Hyde is one such patient as are many more Unfortunately cannabis can not save everyone….yet. Science has not gotten to the point where we know all there is about cannabinoids or cancers. We are on our own right now to discover which will actually help us which for those that are short on time can be very unsettling. This is one reason why I fight for legalization so that patients can at least try to save themselves even when doctors say there is nothing more that they personally can do for the patient. More cannabis research is definitely needed. ~Cherry Girl

    • Thanks for your efforts, I always enjoy your posts, and I appreciate what you do. Because I am a scientist as well as a healer, I must choose my language carefully depending on who I am speaking to. Because many scientists are sadly ignorant of the amazing properties of the Cannabis plant, I put a good deal of effort forth to educate and advocate for the cannabis plant. If I were to say Cannabis cures cancer, that would be call my credentials and judgement as a scientist into question. To start with, there is not single entity called “cancer.” To follow, what cures one “cancer” may not cure another. In some instances surgery “cures” cancer, but I would not say “surgery is a cure for cancer.”
      Cash Hyde is still battling cancer. If Cash has lived this long, cannabis has certainly helped, however, it has not “cured” Cash as any scientist would define a cure. Please go to the Cash Hyde Foundation web page you so kindly provided to see updates on Cash’s status.
      As a scientist I can confidently argue that if Cannabis is considered a medicine, (I believe it is a medicine and more) it is the safest medicine a patient can take, assuming the patient does so in a responsible and educated fashion. I believe the scientific evidence has clearly shown that compounds in cannabis act to kill cancer cells, and to prevent the development and growth of malignant cells in vitro and in vivo subsequent to carcinogen exposure.
      Cannabinoids are also being shown to have anti-amyloid properties, which means that smoking cannabis can possibly protect against the development of Alzheimer’s disease, or at least delay its appearance, or decrease its severity. When used properly, it probably also contributes to ongoing hippocampal neurogenesis and has centrally acting anti aging properties. I would not, however, say, “Cannabis cures Alzheimer’s disease”, or “Cannabis cures the CNS effect of aging.” I can confidently say and argue that Cannabis HELPS cure cancer, and that in the future, the more we learn, the more the Cannabis plant will continue to prove to have remarkable healing properties. Cannabis and compounds extracted from the Cannabis plant will continue to provide medicines which will have anti tumor properties, anti aging properties, anti inflammatory properties, anti nociceptive properties, anti schizophrenic properties, anti depressant properties and much more. I do not believe that any compound extracted from the Cannabis plant will be as safe, non-toxic and so broadly effective as the Cannabis plant itself. I hope that through the efforts of good people such as yourself Cannabis becomes widely available and legal so that people can continue to use it and discover it’s amazing properties free from fear of repression or harassment that is based on greed, ignorance and aversion.

      • Thank you for you clarifying. People have a hard time understanding how cannabis works. Many hear the word cannabis and shut down associating it with cartels and hippies. I hope to change people’s mind and enlighten them that there is much more beyond what the War on Drugs has created. When looking at the studies for the average person they seem daunting and overwhelming. Getting people to take notice and actually read a little further into the subject is a job unto itself. I feel that we are only at the beginning of understanding how cannabis works and how we can apply that to different illnesses. You are very right that what works for one will not work for another and that is what is key to understanding cannabis therapy. Science does not have a full grasp on cancers or other illnesses either which is a obstacle. I hope for the day when we can use cannabis therapies with confidence and achieve the desired effects with great outcomes for patients. There have been stories all over the world of people who were told there was nothing that could be done for them that turned to cannabis therapy and found relief of symptoms and their illness including cancer. I just think that they were lucky because as of now cannabis therapies are a shot in the dark. We do not have all strains mapped and therefore do not fully understand what we are dealing with. I really appreciate your input thank you for reading!

  4. Pingback: Cannabis Less Harmful Than Current Drug Therapies? | Cherry Girl

  5. Pingback: Detection of the Heterogeneous O-Glycosylation Profile of MT1-MMP Expressed in Cancer Cells by a Simple MALDI-MS Method – The Global Innovations

  6. Hi, I have been a breast cancer survivor for 18 months….however I’m a risk for it to come back. I was stage 1 with er- and pr- her2 postive…can you recommend a strain of marijuana that could be helpful for me…I live in Michigan…where medical marijuana is legal. Thanks for all your research…you are very helpful. Sue

    • You are so welcome. I hope you can find something that will help you. From what I have read and researched it is all dependent on having the right strain with the right compounds. The technology is there to DNA sequence your tumor and specifically apply the right cannabinoids to shrink or kill the cancer cells. We need to push for more research so that we can save more people, It is with individualized care that we will achieve the best results. We have DNA sequenced a couple of strains of the cannabis plant and have found wonders. In Israel or one of the other European countries are taking cancer patients and applying custom therapy with great results. It would be something to look into.

    • Sue, did you ever find the “right” strain? My wife has brain mets from BC. We are slowly ramping up “typical” Rick Simpson Oil. But we have not a single clue as to what we are doing.

  7. This was VERY informative thank you! Thank you to those who commented with informative well articulated comments..I did not know about the DNA sequencing to find the rt cannabis strain for your particular disease. That is awesome. I am part of the thousands in Ohio fighting for and depending on medical cannabis for Ohio in 2014. I am trying to educate myself and others as much as possible and articles like this and people like you make that possible. God bless you..

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