Cannabinoid Receptors: Key To Cannabis’ Healing Success

Since the discovery of the endocannabinoid system in the 60’s science has been hard at work trying to unlock the mysteries surrounding cannabis and the interaction of the human body.  For thousands of years cannabis has been used for medicinal, religious and recreation purposes.  Below you will see studies that explain a little as to why cannabis works the way it does within our system.  You will see how CB1 and   CB2 receptors interact with cannabis and how they play a key role in its therapeutic properties.   I encourage all to do their own research and seek out the truth please feel free to share ~ Cherry Girl

The CB(2) Cannabinoid Receptor Controls Myeloid Progenitor Trafficking: Involvement In the Pathogenesis of An Animal Model of Multiple Sclerosis
These findings demonstrate the protective role of CB(2) receptors in experimental autoimmune encephalomyelitis EAE pathology; provide evidence for a new site of CB(2) receptor action, namely the targeting of myeloid progenitor trafficking and its contribution to microglial activation; and support the potential use of non-psychoactive CB(2) agonists in therapeutic strategies for multiple sclerosis and other neuroinflammatory disorders.

Transcriptional Regulation of the Cannabinoid Receptor Type 1 Gene In T Cells By Cannabinoids
Effects of cannabinoids (CBs) are mediated by two types of receptors, CB1 and CB2. In this report, we investigated whether CBs regulate gene expression of their cognate receptors in T cells and studied underlying mechanisms in CD4+ Jurkat T cells.  In summary, up-regulation of CB1 in T lymphocytes in response to CBs themselves may facilitate or enhance the various immunomodulatory effects related to CBs.

Therapeutic Action of Cannabinoids In A Murine Model of Multiple Sclerosis
Cannabinoids may act as immunosuppressive compounds that have shown therapeutic potential in chronic inflammatory disorders… Overall, the data presented may have potential therapeutic implications in demyelinating pathologies such as MS; in particular, the involvement of cannabinoid receptor CB2 would enable nonpsychoactive therapy suitable for long-term use.

The Human Eye Expresses High Levels of CB1 Cannabinoid Receptor mRNA and Protein
These results further support the proposed role of the CB1 receptor in controlling intraocular pressure, helping to explain the antiglaucoma properties of marijuana.

CB1 and CB2 Receptor mRNA Expression In Human Peripheral Blood Mononuclear Cells (PBMC) From Various Donor Types
Marijuana cannabinoid receptors (CBR), CB1 and CB2, are G protein-coupled receptors… expressed in brain as well as cells of the periphery…results suggest that CBR expression is relatively constant across the human population.

Cannabinoid-receptor 1 Null Mice Are Susceptible To Neurofilament Damage and Caspase 3 Activation
Administered cannabinoids have been shown to ameliorate signs of CNS inflammatory disease in a number of animal models, including allergic encephalomyelitis. More recently, neuroprotective actions have been attributed to activation of the cannabinoid 1 receptor in a number of in vitro and in vivo models…The data presented further strengthen the hypothesis of neuroprotection elicited via cannabinoid receptor 1 signaling.

Detailed Characterization of CB2 Receptor Protein Expression In Peripheral Blood Immune Cells From Healthy Human Volunteers Using Flow Cytometry
These data provide the first detailed analysis of CB2 protein levels in blood leukocyte subsets from healthy donors and identifies the cell types which could be targeted with CB-mimetic drugs in humans.

Cannabinoid-Induced Immune Suppression and Modulation of Antigen-Presenting Cells
The study of marijuana cannabinoid biology has led to many important discoveries in neuroscience and immunology. These studies have uncovered a new physiological system, the endocannabinoid system, which operates in the regulation of not only brain function but also the regulation of the immune system. Studies examining the effect of cannabinoid-based drugs on immunity have shown that many cellular and cytokine mechanisms are suppressed by these agents leading to the hypothesis that these drugs may be of value in the management of chronic inflammatory diseases. In this report, we review current information on cannabinoid ligand and receptor biology, mechanisms involved in immune suppression by cannabinoids with emphasis on antigen-presenting cells, and preclinical and clinical models analyzing the therapeutic potential of cannabinoid-based drugs.

Immunoregulation of A CB2 Receptor Agonist In A Murine Model of NeuroAIDS
Chronic HIV-1 infection commonly affects behavioral, cognitive, and motor functions in the infected human host and is commonly referred to as HIV-1-associated neurocognitive disorders (HAND)…Our results support the notion that CB2 receptor agonists may be a viable therapeutic candidate for HAND.

Anandamide Prior To Sensitization Increases Cell-Mediated Immunity In Mice
The endocannabinoid system has become a topic of great interest in pharmacology due to its remarkable distribution in mammal organisms and capacity to play a modulatory role on several physiological systems, including modulation of immunity. Many studies have shown that administration of cannabinoids causes inhibitory effects on immune cells, including decreased proliferation and antigen-presenting cell (APC) co-stimulatory activity. In contrast, other groups have shown that some cannabinoids might present stimulatory actions on macrophage activity and T cell activation…Anandamide prior to sensitization increases cell-mediated immunity in mice.

Endogenous Modulators of Synaptic Transmission: Cannabinoid Regulation In the Supraoptic Nucleus
The magnocellular neurons of the hypothalamic supraoptic nucleus (SON) are a major source of both systemic and central release of the neurohypophyseal peptides, oxytocin (OXT) and arginine-vasopressin (AVP).  Further study of eCB signalling in the SON, including its interaction with AVP neurons, promises to extend our understanding of the synaptic regulation of SON physiological function.

 

 

Breaking News: CA Police Visits

Received the following message from ASA for an alert for people regarding the Siskiyou county area.

Unfortunately, Americans for Safe Access (“ASA”) has heard reports from Siskiyou County that its Sheriff’s Department has compiled a “list” of medical marijuana patients and are visiting them to ensure compliance with California’s medical marijuana laws.  While ASA expects to put an end to this unlawful practice, it imparts the following information to medical marijuana patients throughout the State who are confronted by the police at their home.  First, do not let the police into your home without a warrant.  You should always be polite, but do not let them into your home without a warrant.  Second, there is no reason for you to present the officers with your physician’s recommendation, unless they have probable cause.  Based on the reports ASA has received, officers in Siskiyou County are asking for recommendations, even without probable cause that any crime has been committed under California law.  Lastly, try to get the names of the officers and, if they have cards, get them as well.  They will likely not give you their first names, but, if this question is asked appropriately, it may create a more professional environment for all involved.

If you have had an encounter with the Siskiyou Sheriff’s Department because you were on their list of medical marijuana patients, we encourage you to contact ASA at(510) 251-1856 ext. 304.  You can read more about medical cannabis compliance checks by clicking here.

Citizens Drive, Consume Alcohol, Use Tobacco And Take Prescriptions So Why Not Cannabis?

With all the heated debates over cannabis legalization going on around the country one would wonder why there is so much buzz over a plant.  Cannabis, specifically medical cannabis, has been at the forefront of discussions all around the country.  The federal government has continued its harsh stance against legalization despite the mounting evidence of its benefits, as backed up by the Vice President’s actions in Latin America this week.

We have looked at the issue of legalization in many lights but one way that has not been discussed is that of the individual.  Legally we are given responsibility for our actions and our bodies when we drive, consume alcohol, tobacco or prescriptions despite deaths each year.  Most of us are reasonably responsible adults who are depended upon to carry out many important tasks and make many important decisions including raising children.  Doctors are entrusted with our lives including cancer treatments and brain surgeries but they are not trusted to prescribe cannabis medicinally.

We are each supposed to be responsible for ourselves including the care of our bodies.  With this it would naturally be assumed that one would also have control of what goes into one’s body and what treatments or relaxations methods one chooses to use.  Americans range from lawyers, doctors, congresspeople, CEO s, mothers or any other law abiding citizens.  Why are we not trusted to make a responsible decision when it comes to cannabis?

This leaves one to wonder in regards to cannabis when did the government decide we were incapable of making such a personal decision?  When did they decide that they know more about whats better for each of us individually than we do ourselves?  It is insulting when you look at it in this light; that the government does not feel that each of us are capable of self-control.  As a parent I am insulted that they question my parenting abilities to raise a competent person capable of choosing wisely for themselves including refraining from letting cannabis “take over their lives” as the government wants us to believe happens all the time.  In reality each of us are capable of deciding how to, when to and how much to use cannabis if at all.  Each of us are capable of researching and talking with our doctors to see if cannabis is right for us.

The government allows drivers 16 and older to get behind the wheel of a car despite the harm drivers cause all across the nation.  There are over 40,000 deaths a year as a result of vehicles and their drivers.  People now more than ever are distracted with texting, videos, talking, browsing and more making them even more dangerous.

The government also allows for adults 21 and older to consume alcohol even though it causes over 750,000 deaths a year, domestic violence, rise in crime rates, child abuse, liver damage and many more tragedies.  The government feels that you can responsibly use and monitor your consumption of alcohol even though there are over 17 million alcoholics in the US.

The government allow adults 18 and older to use tobacco even after concrete evidence that it causes cancer and death not only to the user but those around them that are exposed.  Cigarettes have been linked to lung cancer, emphysema and more.  Each year it is estimated that 443,000 die from tobacco related issues.

Each year over 100,000 Americans die from medication by overdose, interactions or other medication related issues.  Citizens are entrusted with sometimes fatal medications monitored only by themselves and some doctor supervision.  Doctors on the whole still do not have sophisticated systems between themselves and pharmacies to prevent drug interactions or overdose.

There are many larger responsibilities we handle than a personal choice of using cannabis or not.  Even legally we are given much larger responsibilities so with that in mind the obvious question is why would using this plant in a responsible manner not be one our responsibilities as well?

Despite all the mounting evidence of the beneficial properties of cannabis and the fact there has never been a reported case of overdose, the government refuses to recognize that Americans are responsible enough and should have control over their decision concerning cannabis.  The decision to use or not to use cannabis is a personal choice and one that should be used with facts in hand and government nowhere in sight.

Although cannabis does not cause death, people still do.  People need to live up to that responsibility by using cannabis wisely and responsibly.  We shouldn’t have to prove anything to the government but if we are going to change things in this country being a good example is the first step.  This includes responsibly using cannabis and restricting access to children.

Educating others is the second step.  We need to show others that cannabis is not the evil drug that the government has made it out to be but instead a healing plant.  It can be used responsibly to wind down at the end of a long day much like wine or beer or in more potent version medicinally for patients.  In the end this is just a plant and one that can be used naturally without changing its form which can not be said for many other drugs legal or not.

Educating others is key to our success in legalization.  Others need to know the truth and I encourage all to go out and seek the truth.  Learn the real facts of cannabis.  Then contact your representative and ask for their support in repealing cannabis prohibition.  There are several pending legislation all over the country.  Help 2012 be a monumental year, one that we reach our goal!

The Many Functions of the Human Endocannabinoid System And How Cannabis Can Help

The endocannabinoid system was discovered in the 60’s and since then scientists have been trying to unravel the mysteries surrounding this system.  At first some thought it was merely the receptors for the cannabis plant but we soon found that the endocannabinoid system is tied to several functions throughout the human body and in recent years become a target for therapies.  Below you will find studies that show how the endocannabinoid system is involved in many functions.  Please share with all and I encourage you to do your own research seeking out the TRUTH ~ Cherry Girl

The Endocannabinoid System: A Revolving Plate In Neuro-Immune Interaction In Health and Disease 2012
The cannabinoid system has been shown to be involved in regulating the immune system. Studies examining the effect of cannabinoid-based drugs on immunity have shown that many cellular and cytokine mechanisms are modulated by these agents, thus raising the hypothesis that these compounds may be of value in the management of chronic inflammatory diseases. The special properties of endocannabinoids as neurotransmitters, their pleiotropic effects and the impact on immune function show that the endocannabinoid system represents a revolving plate of neural and immune interactions.

Endocannabinoid Signaling As A Synaptic Circuit Breaker In Neurological Disease
Cannabis sativa is one of the oldest herbal plants in the history of medicine. It was used in various therapeutic applications from pain to epilepsy… renewed interest has been fueled by major discoveries revealing that cannabis-derived compounds act through a signaling pathway in the human body. Here we review recent advances showing that endocannabinoid signaling is a key regulator of synaptic communication throughout the central nervous system. Its underlying molecular architecture is highly conserved in synapses from the spinal cord to the neocortex, and as a negative feed-back signal, it provides protection against excess presynaptic activity. The endocannabinoid signaling machinery operates on demand in a synapse-specific manner; therefore, its modulation offers new therapeutic opportunities for the selective control of deleterious neuronal activity in several neurological disorders…Endocannabinoid signaling as a synaptic circuit breaker in neurological disease.

The Endogenous Cardiac Cannabinoid System: A New Protective Mechanism Against Myocardial Ischemia
The pharmacological (and recreational) effects of cannabis have been known for centuries. However, it is only recently that one has identified two subtypes of G-protein-coupled receptors, namely CB1 and CB2-receptors, which mediate the numerous effects of delta9-tetrahydrocannabinol and other cannabinoids. Logically, the existence of cannabinoid-receptors implies that endogenous ligands for these receptors (endocannabinoids) exist and exert a physiological role. Thus, the endogenous cardiac cannabinoid system, through activation of CB2-receptors, appears to be an important mechanism of protection against myocardial ischemia.

The Endocannabinoid Nervous System: Unique Opportunities For Therapeutic Intervention
The active principle in marijuana, Delta(9)-tetrahydrocannabinol (THC), has been shown to have wide therapeutic application for a number of important medical conditions… Delta(9)-THC binds to and activates two known cannabinoid receptors found in mammalian tissue, CB1 and CB2. The development of cannabinoid-based therapeutics has focused predominantly on the CB1 receptor, based on its predominant and abundant localization in the CNS.. cannabinoid agonists are relatively safe and provide therapeutic efficacy, but that they also induce psychotropic side effects… This review attempts to link current understanding of the basic biology of the endocannabinoid nervous system to novel opportunities for therapeutic intervention. This new knowledge may facilitate the development of cannabinoid receptor-targeted therapeutics with improved safety and efficacy profiles.
A Critical Review Of The Cannabinoid Receptor As A Drug Target For Obesity Management
The discovery of cannabinoids, with the well-known stimulatory effect of Cannabis sativa on appetite, has offered a new drug target for obesity treatment. Cannabinoids act on two different receptors: CB1 receptors which are sited in the brain and many peripheral tissues, and CB2 receptors which are primarily found in immune system cells. Cannabinoid receptor antagonists act centrally by blocking CB1 receptors, thereby reducing food intake…This review discusses how close cannabinoid receptor antagonists are to the IDEAL ANTI-OBESITY DRUG, with respect to their mechanisms of action, clinical effectiveness and safety.


American Medical Association 1937 Defense For Cannabis Use

Below is the defense given from the American Medical Association in 1937.

American Medical Association Opposes the Marijuana Tax Act of 1937

American Medical Association
Bureau of Legal Medicine and Legislation
Chicago, July 10, 1937
Hon. Pat Harrison
Chairman, Committee on Finance, United States Senate
Washington D.C.

SIR: I have been instructed by the board of trustees of the American Medical Association to protest on behalf of the association against the enactment in its present form of so much of H.R. 6906 as relates to the medicinal use of cannabis and its preparations and derivatives. The act is entitled “An Act to impose an occupational excise tax upon certain dealers in marihuana, to impose a transfer tax upon certain dealings in marihuana, and to safeguard the revenue therefrom by registry and recording.”

Cannabis and its preparations and derivatives are covered in the bill by the term “marihuana” as that term is defined in section 1, paragraph (b). There is no evidence, however, that the medicinal use of these drugs has caused or is causing cannabis addiction. As remedial agents, they are used to an inconsiderable extent, and the obvious purpose and effect of this bill is to impose so many restrictions on their use as to prevent such use altogether. Since the medicinal use of cannabis has not caused and is not causing addiction, the prevention of the use of the drug for medicinal purposes can accomplish no good end whatsoever. How far it may serve to deprive the public of the benefits of a drug that on further research may prove to be of substantial value, it is impossible to foresee.

The American Medical Association has no objection to any reasonable regulation of the medicinal use of cannabis and its preparations and derivatives. It does protest, however, against being called upon to pay a special tax, to use special order forms in order to procure the drug, to keep special records concerning its professional use and to make special returns to the Treasury Department officials, as a condition precedent to the use of cannabis in the practice of medicine. in the several States, all separate and apart from the taxes, order forms, records, and reports required under the Harrison Narcotics Act with reference to opium and coca leaves and their preparations and derivatives.

If the medicinal use of cannabis calls for Federal legal regulation further than the legal regulation that now exists, the drug can without difficulty be covered under the provisions of the Harrison Narcotics Act by a suitable amendment. By such a procedure the professional use of cannabis may readily be controlled as effectively as are the professional uses of opium and coca leaves, with less interference with professional practice and less cost and labor on the part of the Treasury Department.

It has been suggested that the inclusion of cannabis into the Harrison Narcotics Act would jeopardize the constitutionality of that act, but that suggestion has been supported by no specific statements of its legal basis or citations of legal authorities.

Wm. C. Woodward,
Legislative Counsel {American Medical Assn}


 

Why We Should Pay Attention….At Least Some Of The Time

I remember as a child my grandpa talking with me about the politics of the U.S. and around the world.  I remember him rattling off different names of important people and all the scandalous things happening at the time.  My grandfather was born in 1938 and has seen a lot change in this world.  He’s followed politics longer than I have been alive and yet this passionate subject, for him, did absolutely nothing for me and felt more like a foreign language.  Once I moved out on my own and got my first real taste of freedom I thought I was free to do as I pleased.  I continued that blissful thought until my late twenties where I discovered cannabis.

I went through life not paying any attention to what was going on in politics because it wasn’t effecting me.  Then I started getting blinding intense pain headaches.  I went through a series of doctors, specialists, tests, machines, naturalists, chiropractors, medications, diets and supplements as well as a few other treatments.  For 4 years I sought out a treatment, a cause and a relief from the pain!  I subjected myself to all kinds of different prescriptions some that made my brain feel like it was on fire, made my body numb and on one occasion a near blackout on I-5 in the middle of Seattle from one drug that was supposedly safe.

It was then while at a party I discovered cannabis and all its natural benefits.  After finding cannabis I finally found relief.  I found something that not only took away the pain but lifted my spirits.  In one aspect it was a huge relief that I was not looking at a life where I had to constantly remind myself not to think of the pain always keeping myself busy to distract myself.  In the other aspect cannabis’ natural compounds helped with the depression that set in from being in pain for 4 years.  It really was a prayer answered.

I was fortunate enough to live in a state that had legalized medical marijuana so I was able to obtain a doctor’s recommendation that allowed me to purchase or grow cannabis.  It wasn’t until I walked into my first dispensary and started really talking to the cannabis community that I realized I actually needed to pay attention to politics.  Having control over your treatment, over your medication is priceless.  Having an option that is not fatal, that is natural and affordable is something everyone should enjoy.

Before legalization patients had to obtain their cannabis from the streets or risk growing it themselves.  If you buy on the black market you do not always have control over what you get and typically can not ask what strain it is, does it have molds, pests, chemicals or if its organic.  The streets also do not care if you are 37 or 15 only if you have cash.  On the other hand if a patient decides to grow they risk life as they know it.  If they are caught citizens face all kinds of situations from large legal bills, jail or prison time, losing their kids, job, house or assets as well as a stigma from society being labeled as a criminal.  Even being raided by the police is very tramatizing to the family as they typically break down the door and treat you like armed drug lords, drawing their weapons on your family.

This is why Californians passed prop 215 and later SB420.  This is just one reason why its important to at the very least check in on politics and whats going on in the world at least once in awhile.  While I was out searching for a cure to my pain trying all different kinds of legal chemical narcotics millions of Americans were being shuffled through the justice system for using, possessing or growing a plant.  Even after those two legislation were passed California patients are still having issues from the government with 2011 proving to be an aggressive year for the federal raids on patients.  

It wasn’t until I started researching cannabis that I suddenly realized we are not free at all.  When the government dictates what your medical treatment is and is not instead of you and your doctor, when they take your freedom of choice away that is not freedom and we need to ask ourselves “How can we stand by and allow it to happen?”  We as citizens need to come together and demand our freedom back.  It seems a little comical, if not for all the appalling tragedies, that we are fighting for our right to use a natural plant, one that has been used safely throughout the world for thousands of years.

I will probably never be like my grandfather rattling off names like baseball stats but I have learned to pay better attention to whats going on around me.  Financial crisis, unrest among the people in countries all over the world, everyday living prices soaring, budget cuts are everywhere and raids and arrests for simple possession of a plant are abundant.  2012 is a year to pay attention and get involved.  This year we could seize the opportunity to educate others and push for legalization and an end to this failed, immoral and unconstitutional War on Drugs.  it is time we take back our choice, our freedom, our government!  Contact your Representative or the White House and tell them its time for a real change.  Spread the word Legalization is on the horizon!

Breaking News: Cashy Hyde Free From Cancer

The Cashy Hyde case has been one that has been closely followed by many in the cannabis community that believe in the healing power of cannabis.  Below is the breaking news released yesterday.

On Wednesday, February 22, 2012 Cash Michael Hyde was in Salt Lake City for a follow up MRI to check the status of his brain tumor. A PNET brain tumor he has been battling for almost 2 years.

For the second time in a row, Cashy has beat his tumor, and is in remission.

The Boy of Steel is Cancer Free!

How many people do you know that beat cancer once, nonetheless twice?

At THREE years of age?

Congratulations and hugest of blessing upon his parents Mike and Kalli for being the strong parents they are, and fighting so diligently to save their son’s life with an alternative option.

Thank heavens for the cannabis oil that saves Cashy’s life.

Be vigilant in your duties Pioneers……your efforts are important to people just like Cashy and his family EVERY day! Act responsibly! Keep up the great work!

And to all the politicians out there…….please support the Hyde family, and many other families out there just like them.

We are here to save children’s lives, not take them away.

Love and blessings to all…..I’m off to celebrate on the ride back to Montana with the Hyde’s.

I love them all so very much. Better be a BIG box of Kleenex on board as we will all be so HAPPY!

For more information please view original source or visit The Cash Hyde Foundation.

Children’s Cancer and Cannabis

The words children and cannabis sound very uncomfortable to many but to parents who want to see their child thrive, for some, it sounds like a prayer answered.  It is a very controversial subject but a very important one to discuss.  In the United States over 10,000 children under the age of 15 are diagnosed with cancer each year.  One of the most famous cases of a child with cancer being treated with cannabis is Cashy Hyde.  Many know the story of how the frail little boy bounced back with the help of Rick Simpson Oil.  Below you will see studies on how cannabis has been looked at for childhood cancers.  I encourage all to do their own research and seek out the truth! ~ Cherry Girl

An Efficient New Cannabinoid Antiemetic in Pediatric Oncology
An efficient new cannabinoid antiemetic in pediatric oncology…Delta-8-tetrahydrocannabinol (delta-8-THC), a cannabinoid with lower psychotropic potency than the main Cannabis constituent, delta-9-tetrahydrocannabinol (delta-9-THC), was administered to eight children, aged 3-13 years with various hematologic cancers, treated with different antineoplastic drugs… The THC treatment started two hours before each antineoplastic treatment… Vomiting was completely prevented.

Cannabis-Induced Cytotoxicity in Leukemic Cell Lines: The Role of the Cannabinoid Receptors and the MAPK Pathway
Delta9-Tetrahydrocannabinol (THC) is the active metabolite of cannabis… We investigated the role of the CB-Rs (cannabinoid receptors) in mediating apoptosis (cell death) in 3 leukemic cell lines… We have shown that THC is a potent inducer of apoptosis (cell death/cell suicide)…Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway.

Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of P22phox and Nox4 Expression
2006: “Cannabidiol-induced apoptosis (cell death) in human leukemia cells… results from this study reveal that cannabidiol, acting through CB2 and regulation of Nox4 and p22(phox) expression, may be a novel and highly selective treatment for leukemia.”— I believe cannabidiol is a non-psychoactive cannabinoid from cannabis.

The CB2 Cannabinoid Receptor Signals Apoptosis Via Ceramide-Dependent Activation of the Mitochondrial Intrinsic Pathway
2006: “Delta9-tetrahydrocannabinol and other cannabinoids exert pro-apoptotic actions in tumor cells via the CB2 cannabinoid receptor… the molecular mechanism involved in this effect has remained elusive. Here we used the human leukemia cell line Jurkat-that expresses CB2 as the unique CB receptor-to investigate this mechanism…results presented here show that CB2 receptor activation signals apoptosis (cell death).

Medical Marijuana: Should Minors Have the Same Rights As Adults?
“Failure to give an effective therapy to seriously ill patients, either adults or children, violates the core principles of both medicine and ethics. Medically, to deny physicians the right to prescribe to their patients a therapy that relieves pain and suffering violates the physician-patient relationship. Ethically, failure to offer an available therapy that has proven to be effective violates the basic ethical principle of nonmaleficence, which prohibits the infliction of harm, injury, or death and is related to the maxim primum non nocere (‘above all, or first, do no harm’)… Therefore, in the patient’s best interest, patients and parents/surrogates, have the right to request medical marijuana under certain circumstances and physicians have the duty to disclose medical marijuana as an option and prescribe it when appropriate. The right to an effective medical therapy, whose benefits clearly outweigh the burdens, must be available to all patients including children. To deny children the use of medical marijuana when appropriate is a grave injustice which violates the basic foundational beliefs of both medicine and… ” — ethics?

Breaking News: CO Legalization Ballot Initiative Likely To Be On November Ballot

CO: The proponents of a Colorado initiative to Regulate Marijuana Like Alcohol turned in more than 14,000 additional voter signatures Friday in a last bid to qualify for the November ballot. The initiative needs only 2,400 valid signatures to qualify, meaning a whopping four out of five signatures handed in would have to be invalidated to keep the measure off the ballot.

The campaign had earlier turned in 159,000 signatures, nearly twice the 86,000 needed to qualify. But on examining the signatures, state election officials found that nearly half were invalid, an usually high percentage.

Other similar initiatives are in the works across the country.  To get involved contact your representative and urge them to support the end of cannabis prohibtion.

It Is Time, This Is Our Moment

Throughout history there are those moments in time that forever change our course.  Great moments where heroes stood up, fought back, and changed our destinies.  Many led ordinary lives but in that moment found the courage to do what’s right even in the face of adversity.

I believe we are at a very unique point in time.  All over the globe are seeing people wake up to the idea of a more involved society, one that gives them a voice.  We are starting to see the corruption that has been allowed to take hold.  Thanks to instant and world-wide communications we all can share an abundance of information.  The message is clear: People want freedom!

The thought of freedom of self is spreading.  People realize they have a choice.  They can be free to be responsible for themselves and their government.  With God-given free will people are seeking out the truths.  One truth that has frequently come into the spotlight, all over the globe is cannabis.  People are starting to see through the “reefer madness” and seek out the truths not only of its healing powers but of its actual harms.

The U.S. government has wasted trillions of tax-payer’s dollars pursuing a plant put here on earth for humans to use.  Beyond all its myriad of health benefits including exciting research pointing towards curing cancer, cannabis in its natural form can be looked at in the same light as drinking a beer or having a glass of wine.  Many Americans drink at the end of their day to unwind and relax from the day’s activities.  Millions of Americans use cannabis in the same way including using forms such as oils, juices, edibles and tinctures.

It is time to start taking a more serious look at what the real dangers are of cannabis prohibition.  Cannabis does not cause death, is more beneficial and is less harmful than alcohol which is a legal drug for Americans 21 and older.  We need to look at the practicality of prohibition on a national level. This is a serious issue that has devastating effects on millions of Americans.  An issue that breaks up families, bankrupts countless people, destroys American rights, costs trillions of tax-payer dollars and ruins society demands that we take a serious look at this situation and what its doing to this country.

These are the moments that history is made of.  Moments that show of courage and strength.  Times were we came together and fought back.  We need to make our voices heard loud and clear: Its time to talk about the end of prohibition!  We need to tell our representatives that its time to reschedule cannabis and repeal the prohibition.  We need to educate others on the truths.  When people see the truth we will have freedom.  This is our moment will you have the courage to change history?

Urge Congress to Co-Sponsor HR1983: The States’ Medical Marijuana Patient Protection Act!

Today is the second day of Medical Marijuana Week, and ASA’s National Week of Actions continues by targeting congress.  Help stop attacks on medical cannabis by urging your representative to sign onto HR1983.  Because of the increase in DEA raids and other tactics used by the federal government to interfere with medical cannabis across the country, our allies in Congress have introduced critical bipartisan legislation to protect medical cannabis patients and providers. But they need your help to get it passed. Take a minute to urge your Representative in the House to cosponsor the HR1983, the States’ Medical Marijuana Patient Protection Act today!  To read ASA’s blog about the need for HR 1983, click here. 

If passed, HR 1983 will essentially end federal interference in state sanctioned programs, provide patients and providers with a defense in federal court, and, most importantly, reclassify cannabis to Schedule III under the Controlled Substance Act.  This reclassification will recognize the medicinal value of cannabis, open doors to critical medical research, and create access for people in need across the country!  

Call your representative today; ask him or her to cosponsor HR1983, the States’ Medical Marijuana Patient Protection Act, today!

To find your representative, click here.  

Representative  _____________________________

HR1983 has an eye toward ending the current conflict between federal and state laws respect to medical cannabis by providing a comprehensive system of protections for medical cannabis patients, providers, and their physicians.  It would also reschedule cannabis to the appropriate schedule that upholds its medical value and open the door for medical research.  These protections are absolutely necessary to ensure safe access, and would allow states the autonomy envisioned by the Constitution.  HR1983 will bring us one step closer to ending the federal conflict with state-sanctioned medical cannabis programs.  Your support will help ensure the rights of medical cannabis patients and providers, and help create policies that work.

Thank you.  

National Medical Marijuana Week – Please Contact the White House Today!

Today is the start of Medical Marijuana Week, and Americans for Safe Access has created a week of action for you to participate in to save safe access.  Today’s target is Obama.

Despite his indication to take a more reasonable approach to medical cannabis, President Obama and his Administration have become more aggressive towards our community.  In addition to raids, the Obama Administration has launched a variety of new tactics including patient privacy violations, seizing and shutting down of medical cannabis related bank accounts, manipulation of the tax code, threats to government officials and landlords, and interfering with medical cannabis patients’ Right to Bear Arms.  To read more about Obama’s mistreatment of our community, click here.  

Our voice must be heard!  Ask Obama to work with our community in order to develop policies that work!  Rather than using scarce federal resources to interfere with state sanctioned medical cannabis laws, urge Obama to work with state officials to harmonize state and federal law thereby legitimizing the medical cannabis community.

Call the White House switchboard today, and tell Obama to end federal interference in state sanctioned medical cannabis programs!  Dial 202-456-1414 and use the following script to help save safe access

President Obama–

As a candidate and our President, you indicated that you would take a more reasonable approach to medical cannabis; however, your administration has done just the opposite! Your administration’s interference with medical cannabis laws is jeopardizing people’s lives who rely on a variety of access models to acquire their doctor recommended medication!  Stop wasting scarce federal resources to circumvent state laws.  Instead, work with lawmakers to develop new policies that will harmonize federal law with states that work hard to provide safe access of medical cannabis to qualifying patients.  End the federal attack on the medical cannabis community today! 

After you take action, please share our blog post by copying the blog’s URL and encourage your friends and family to take action by posting it Facebook, Twitter and other social networking sites.

Thank you for taking a stand for safe access.  Keep and eye out for information related to tomorrow’s action targeting congress to sign onto HR1983: The State’s Medical Marijuana Patient Protection Act, and click here to view actions you can take all week!

Thank you!

Why the Prohibition of Cannabis Should End

We are witnessing the emergence of an oppressed part of society.  A community that had repeatedly been laughed at and pushed aside.  But in the last decade we have seen many breakthroughs and milestones reached.   We have also seen a very aggressive push back from the government on the fight for legalization.

The United States was attacked on Sept. 11, 2001 and since then laws and law enforcement agencies have changed.  Many expected changes but we did not expect our liberties to be eroded so much.  We have seen the militarization of local law enforcement increase with urgency.  We have seen the actions of these agencies change.

No community recognizes this more, surprisingly, than the cannabis community.  In 2011 alone thousands received threat letters from the DOJ.  Families, patients and caregivers were violently raided even though they were complying with state law.  Much of the legislation that was aimed at terrorists were actually used on Americans in the War on Drugs.  This costly war that has been going on for decades is not only a complete failure, it has misinformed millions and destroyed society.

They have squandered trillions of tax-payer dollars on this War on Drugs.  They have not only created a black market but allowed it to flourish.  Prohibition of alcohol created the rise in organized crime and prominent figures like Al Capone.  We saw prices go up, prescriptions for alcohol increase and speakeasies or clubs abound.  We have seen the same thing happen for over 75 years with cannabis with more recent increase in doctor recommendations, dispensaries in legal states and the head of a drug cartel listed on Forbes fortune 400 list.

With alcohol prohibition we saw a quicker end but we still saw the devastating effects it had in a short time.  We have had a longer period of time to take a look at the societal, emotional, economic, medical, environmental and many other impacts of prohibition and legalization.  For over 75 years we have seen families torn apart, parents lose children, people lose their wealth, their battle with their illness or their freedom.  We have seen the government tell us how cannabis is just as bad a heroin, worse than tobacco, alcohol and cocaine.  They have told us that cannabis holds no medical value.

With today’s access to information from all over the world and from many different sources many people should quickly see through the many lies of reefer madness.  There are countless medical studies backing up the medical potential of cannabis.  Last year the cannabis plants sativa and indica were genetically mapped enabling science to pinpoint the cannabinoids necessary to start using it as a therapy and cure.

With so much new data discovered, exciting breakthroughs on the horizon and the improved knowledge of society we too will see an end to cannabis prohibition.  Prohibition does not make sense as a policy or as a way to control society.  People are born with God-given free will and should be allowed to exercise it.  2012 can prove to be a momentous year if we make our voices heard.  Contact your representative today in support of legalization, rescheduling and responsible regulation.

How Technology and Medicine Are Coming Together To Legitimize Cannabis Use

In the last decade alone we have seen many advancements in technology as well as medicine.  We have seen the cell phone and subsequently smart phones and tablets held in the hands of the masses.  We have seen the access to information through use of the internet become available to the majority of the world even to far reaching places.  We have witnessed the advances in technology spill over to other industries such as medicine enabling breakthroughs.

Today with the help of technology the science, medical, technology and cannabis community are coming together.  We see doctors and scientists sharing information and ideas working collectively to cure and develop better therapies.  We see more informed patients who are working with doctors that have more access to their medical treatments (with electronic files implemented) helping to avoid the hundreds of millions of Americans that are sent to the hospital from drug reactions.

We have seen the technology that doctors use advance quickly enabling for a more pinpointed understanding of the ailment or even a patient’s specific body.  We have technology today that allows for the DNA sequencing of a cancer tumor, human and, thanks to Kevin McKernan and his team; cannabis Sativa and Indica.

In the Czech Republic they have been making advancements in the use of cannabis for medical use.  At the Konopi Je Lek (Cannabis Is Medicine) Clinic they have been working on exact strain-dependent therapeutic dosages of THC, CBD and CBN.  With the mapping of the cannabis plant along with the ability to map a human we can potentially have a quick way to match the right Cannabinoids for their particular ailment which is very exciting news.

There are millions of Americans that use cannabis in conjunction with their medication or instead of.  Many who know that cannabis works for them may not actually know why.  With the advancements in technology and medicine giving us those answers it is also making way for us to be able to better understand and therefore apply this for better therapy results.  Currently it can at times be a guessing game when trying to find the right strain or combination thereof when using cannabis therapy.  In the future you could make tinctures customized for your body.

Technology, Medicine, Science and Cannabis Community are showing people that cannabis therapy is beyond just the smoked version that comes up so frequently in debates.  Today’s cannabis therapy is far more advanced.  With British pharmaceutical products such Sativex (cannabis plant derived non-synthetic) that are seeking FDA approval it lends even more creditably to the medical uses of cannabis.  Many can see the future of cannabis as a therapy that will have legitimacy and will be taken seriously.

Just a few months ago we saw national support for medical legalization at 77%.  With more credible information available to the masses we see a shift in perception.  16 states along with D.C have enacted medical marijuana laws as well as several other states that have medical initiatives; with Washington, California and Colorado’s initiatives calling for legalization for adults over 21.

With the nation hurting financially it is time to look at our priorities.  So far the government has spent over $2 trillion on the war on drugs that has proven to be futile.  We need to look at reform and especially rescheduling cannabis.  This will only be accomplished if the people speak up.  We need to recognize that cannabis has medical value and that it should be decision made between a patient and doctor not the government.  Contact your local representative today and express your support for rescheduling and responsible legislation.  Many states have groups like NORML and ASA that are working on legislation so be sure to see if there is a current proposal in your state.  With everyone coming together we can see a bright future for the cannabis community as well as the nation.

Human Endocannabinoid System: Science’s Target For New Therapies

Since the discovery of the human endocannabinoid system science has had it in its cross hairs for many potential therapies as well as a better understanding of how our body works within systems.  We have found that the endocannabinoid system has a role in many functions throughout the body.  Below you will see studies where the endocannabinoid system was targeted for therapies with promising outcomes.  Please feel free to share this information with others and your doctor when deciding which treatment options are best for you.  Keep in mind that cannabis is all natural and is used in its natural form.  There are many options when choosing cannabis for a treatment option and goes beyond just smoked cannabis.  I encourage all to do their own research and seek out the truth about cannabis ~ Cherry Girl

Possible Endocannabinoid Control of Colorectal Cancer Growth (2003)
Possible endocannabinoid control of colorectal cancer growth…Anandamide, 2-AG, and… CBR agonist… potently inhibit cell proliferation. This effect is blocked by the CB(1) antagonist, but not by the CB(2) antagonist, and is mimicked by CB(1)-selective, but not CB(2)-selective, agonists… both CB(1) and CB(2) receptors mediate inhibition of proliferation. Inhibitors of endocannabinoid inactivation enhance endocannabinoid levels and block cell proliferation.

The Endocannabinoid System In Amyotrophic Lateral Sclerosis (2008)
The endocannabinoid system in amyotrophic lateral sclerosis…Currently the only licensed therapy available for the treatment of ALS is the anti-glutamatergic agent Riluzole, which has limited therapeutic effects. However, there is increasing evidence that cannabinoids and manipulation of the endocannabinoid system may have therapeutic value in ALS, in addition to other neurodegenerative conditions. Cannabinoids exert anti-glutamatergic and anti-inflammatory actions through activation of the CB(1) and CB(2) receptors, respectively. Activation of CB(1) receptors therefore inhibit glutamate release… Meanwhile, CB(2) receptors influence inflammation, whereby receptor activation reduces microglial activation, resulting in a decrease in neurotoxic mediators. Finally, cannabinoid agents may also exert anti-oxidant actions by a receptor-independent mechanism. Therefore the ability of cannabinoids to target multiple neurotoxic pathways in different cell populations increase their therapeutic potential in the treatment of ALS. Recent studies investigating this potential in models of ALS, in particular those that focus on strategies that activate CB(2) receptors, are discussed.

Interaction of Endocannabinoid System and Steroid Hormones In the Control of Colon Cancer Cell Growth (2012)
Interaction of endocannabinoid system and steroid hormones in the control of colon cancer cell growth…Our results partially elucidated the role of EC system in the molecular mechanisms enrolled by steroids in the inhibition of colon cancer cell growth and strongly suggested that targeting the EC system represent a promising tool to improve the efficacy of CRC (colorectal cancer cell) treatments.

The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications (2011)
The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications…The modulation of the activity of this system holds tremendous therapeutic potential in a wide range of diseases, ranging from cancer, pain, neurodegenerative, and cardiovascular diseases to obesity and metabolic syndrome, diabetes, and diabetic complications… the role of the endocannabinoid system in primary diabetes…therapeutic potential of targeting the endocannabinoid system… certain plant-derived cannabinoids… possess potent anti-inflammatory and/or antioxidant properties.

The Endocannabinoid System In Ageing: A New Target For Drug Development (2006)
The endocannabinoid system in ageing: a new target for drug development…. Anandamide (N-arachidonoylethanolamine; AEA) and 2-arachidonoylglycerol are the main endogenous agonists of cannabinoid receptors able to mimic several pharmacological effects of Delta(9)-tetrahydrocannabinol, the active principle of Cannabis sativa preparations like hashish and marijuana. AEA is released “on demand”…. Together with AEA and congeners, the proteins which bind, synthesize, transport and hydrolyze AEA form the “endocannabinoid system”. Endogenous cannabinoids are present in the central nervous system and in peripheral tissues, suggesting… therapeutic potential… drugs able to modulate the endocannabinoid tone for the treatment of ageing and age-related human pathologies.

Endocannabinoid System In Cardiovascular Disorders – New Pharmacotherapeutic Opportunities (2011)
Endocannabinoid system in cardiovascular disorders – new pharmacotherapeutic opportunities.The long history of Cannabis sativa had its development oriented for medicine after the discovery and chemical characterization of its main active ingredient, the 9-tetrahydrocannabinol (9-THC). Consequently, a binding site for 9-THC was identified in and the first cannabinoid receptor (CB1) was cloned, followed by the CB2 and by the discover of two endogenous agonists: anandamide and 2-arachidonoyl glycerol. Cannabinoid receptors, endocannabinoids and the enzymes that catalyze its synthesis and degradation constitute the endocannabinoid system (ECS), which plays an important role in the cardiovascular system…The evidence so far gathered shows that the modulation of ECS (as agonism or antagonism of its receptors) is an enormous potential field for research and intervention in multiple areas of human pathophysiology. The development of selective drugs for the CB1 and CB2 receptors may open a door to new therapeutic regimens.

The Endogenous Cannabinoid System. Therapeutic Implications For Neurologic and Psychiatric Disorders (2005)
The endogenous cannabinoid system. Therapeutic implications for neurologic and psychiatric disorders. For about 5,000 years, cannabis has been used as a therapeutic agent. There has been growing interest in the medical use of cannabinoids. This is based on the discovery that cannabinoids act with specific receptors (CB1 and CB2). CB1 receptors are located in specific brain areas and CB2 receptors on cells of the immune system… findings could possibly lead to the use of synthetic and natural cannabinoids as therapeutic agents in various areas.

Targeted Modulators of the Endogenous Cannabinoid System: Future Medications to Treat Addiction Disorders and Obesity (2007)
Targeted modulators of the endogenous cannabinoid system: future medications to treat addiction disorders and obesity…Pressing health care needs have made the rational design of targeted CB1 cannabinoid-receptor modulators a promising route to future medications with significant therapeutic impact.

The Importance of the Endogenous Cannabinoid System In Various Neuropsychiatric Disorders (2007)
The importance of the endogenous cannabinoid system in various neuropsychiatric disorders…The endogenous cannabinoid system was first described in 1988. There are two specific receptors, the CB2-receptor, located in the lymphatic system and the CB1-receptor occurring predominantly in the central nervous system…In 1992 endogenous ligands of the cannabinoid system were discovered for the first time (e.g. anandamide and 2-arachidonylglycerol)…A dysregulation in the endogenous cannabinoid/anandamide system could possibly play an import role in the etiology of Gilles de la Tourette syndrome and schizophrenic psychoses…administration of cannabinoids affects the symptoms of the Gilles de la Tourette syndrome positively… In ischaemic brain lesions cannabinoids seem to have a neuroprotective effect…interactions between the endogenous opioid system and the endogenous cannabainoid system are pointed out. This is of interest since it could be shown in experiments that the absence of CB1 receptors reduces the positive reinforcement of opiate administration.

Therapeutic Potential of the Endocannabinoid System in the Brain (2005)
Therapeutic potential of the endocannabinoid system in the brain. Cannabinoids… marijuana and other derivatives of Cannabis sativa… these compounds are now also considered for their therapeutic potential, since the term “cannabinoid” includes much more compounds than those present in Cannabis sativa derivatives… there are numerous synthetic cannabinoids obtained by modifications from plant-derived cannabinoids… All this boom of the cannabinoid pharmacology has an explanation in the discovery of the endocannabinoid signaling system, which plays a modulatory role… The objective of the article will be to review the advances in the study of the endocannabinoid system and their functions in the brain, as well as their alterations in a variety of pathologies and the proposed therapeutic benefits of novel cannabinoid-related compounds that improve the pharmacokinetic and pharmacodynamic properties of classic cannabinoids.

The Endocannabinoid Signaling System: A Marriage of PUFA and Musculoskeletal Health (2010)
The endocannabinoid signaling system: a marriage of PUFA and musculoskeletal health…The potential of dietary PUFA to regulate this signaling system to influence the metabolic and physiological outcomes favorable to musculoskeletal health is the purpose… we first introduce the EC agonists (ligands) and their receptors (CB1 and CB2) and the general actions of EC signaling in various organs and systems. Second, we describe EC signaling in bone and muscle and how dietary PUFA influence the levels of endogenous agonists. Third, we discuss the potential implications of how dietary PUFA impact this system to minimize muscle atrophy and osteopenia and support healthy muscle development and bone modeling.

The Endocannabinoid System: Physiology and Pharmacology (2005)
The endocannabinoid system: physiology and pharmacology…The endogenous cannabinoid system is an ubiquitous lipid signalling system that appeared early in evolution and which has important regulatory functions throughout the body in all vertebrates…Outside the brain, the endocannabinoid system is one of the crucial modulators of the autonomic nervous system, the immune system and microcirculation…Recent pharmacological advances have led to the synthesis of cannabinoid receptor agonists and antagonists, selective inhibitors of endocannabinoid degradation. These new tools have enabled the study of the physiological roles played by the endocannabinoids and have opened up new strategies in the treatment of pain, obesity, neurological diseases including multiple sclerosis, emotional disturbances such as anxiety and other psychiatric disorders including drug addiction. Recent advances have specifically linked the endogenous cannabinoid system to alcoholism, and cannabinoid receptor antagonism now emerges as a promising therapeutic alternative for alcohol dependence and relapse.”— I believe: since the endo-plant cannabinoid system can be the target for Big Pharma’s for-private-profit “treatments.

The Endocannabinoid System As An Emerging Target of Pharmacotherapy (2006)
The endocannabinoid system as an emerging target of pharmacotherapy. The recent identification of cannabinoid receptors and their endogenous lipid ligands has triggered an exponential growth of studies exploring the endocannabinoid system and its regulatory functions in health and disease…The growing number of preclinical studies and clinical trials with compounds that modulate the endocannabinoid system will probably result in novel therapeutic approaches in a number of diseases for which current treatments do not fully address the patients’ need. Here, we provide a comprehensive overview on the current state of knowledge of the endocannabinoid system as a target of pharmacotherapy.

The Endocannabinoid System: An Osteopathic Perspective (2008)
The endocannabinoid system consists of cannabinoid receptors, endogenous ligands, and ligand-metabolizing enzymes. The system exemplifies the osteopathic principle that the body possesses self-regulatory mechanisms that are self-healing in nature…The endocannabinoid system is a homeostatic mechanism that exemplifies the key osteopathic concepts of mind-body unity on a molecular level… osteopathic physicians may enhance endocannabinoid function in their patients…The plant Cannabis sativa, the source of cannabis (ie, marijuana, hashish), is native to central Asia. Several indigenous “traditional medicine” systems (eg, Ayurvedic medicine, Tibetan medicine, traditional Chinese medicine) evolved and make use of this substance.

Our Endocannabinoid System: Key To Understanding The Human Body

Since discovering the endocannabinoid system scientists have been using it as a target to cure or help many ailments.  When looking through the myriad of published medical studies one will quickly see this trend.  This is just one more reason why understanding the human endocannabinoid system is crucial.  Below you will see studies where the endocannabinoid system was targeted for therapies with promising outcomes.  Please feel free to share this information with others and your doctor when deciding which treatment options are best for you.  Keep in mind that cannabis is all natural and is used in its natural form.  There are many options when choosing cannabis for a treatment option and goes beyond just smoked cannabis.  I encourage all to do their own research and seek out the truth about cannabis ~ Cherry Girl

The Endocannabinoid System: Role In Energy Regulation (2012)
The endocannabinoid system: role in energy regulation. Cannabis sativa has been used since antiquity to treat many ailments… The primary psychoactive constituent of this plant, Δ(9) -tetrahydrocannabinol (THC) is an FDA approved medication… The effects of THC are mediated through the endocannabinoid system (ECS), which promotes a positive energy balance through stimulation of appetite as well as shifting homeostatic mechanisms toward energy storage… we discuss… the therapeutic potential of targeting this system.

Cannabis Sativa and the Endogenous Cannabinoid System: Therapeutic Potential For Appetite Regulation (2011)
Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation. The herb Cannabis sativa (C. sativa) has been used for thousands of years as a medicine…only recently has scientific endeavour begun to find valuable uses for either the whole plant or its individual components… we discuss evidence describing the endocannabinoid system, its endogenous and exogenous ligands and their varied effects… we also critically consider the mounting evidence which suggests non-Δ(9) tetrahydrocannabinol phytocannabinoids play a vital role in C. sativa-induced feeding pattern changes… given the wide range of phytocannabinoids present in Cannabis sativa… we demonstrate non-Δ(9) tetrahydrocannabinol phytocannabinoids retain an important and, as yet, untapped clinical potential.

The Endocannabinoid System and Prospects Her Stimulation In Clinical Medicine (2007)
The endocannabinoid system and prospects her stimulation in clinical medicine… The history of use by the man of plants of a sort Cannabis totals more than 4000 years… Cannabis sowing, named also “Indian” – cultural plant, which has set of applications. From it received fibres for hemp of ropes and make a fabric similar on linen. Its stalks went on manufacture glossy of a paper and building of plates… as fuel instead of diesel… The greatest popularity Cannabis has received as raw material for reception of products (marijuana, hashish etc) …Cannabis in the medical purposes: at migraine, spasmes, vomiting, pains of a different origin etc.

Cannabinoid System In the Skin – A Possible Target For future Therapies In Dermatology (2009)
Cannabinoid system in the skin -a possible target for future therapies in dermatology.Cannabinoids and their derivatives are group of more than 60 biologically active chemical agents, which have been used in natural medicine for centuries. The major agent of exogenous cannabinoids is Delta(9)-tetrahydrocannabinol (Delta(9)-THC), natural psychoactive ingredient of marijuana. However, psychoactive properties of these substances limited their use as approved medicines…cannabinoids are important mediators in the skin… we summarized the significant role of the cannabinoid system in the cutaneous physiology and pathology, pointing out possible future therapeutic targets.

Therapeutic Potential of the Endocannabinoid System In Perinatal Asphyxia (2011)
Therapeutic potential of the endocannabinoid system in perinatal asphyxia… Perinatal asphyxia is the most frequent cause of neonatal brain injury and, despite advances in neonatology, it has not been possible to reduce its incidence..it is necessary to find out new and more effective therapeutic strategies, appearing the use of cannabinoids as a promising one…The endocannabinoid system modulates a wide range of physiological processes in mammals… it has been considered as an endogenous neuroprotective system… modulation of the endocannabinoid system through the administration of cannabinoids and endocannabinoids has demonstrated neuroprotective effects both in vitro and in vivo… it seems to play an important role in the development of the central nervous system, as it appears in the fetal period since the beginning.
CONCLUSION: Modulation of the endocannabinoid system appears as a novel therapeutic strategy against neonatal hypoxic-ischemic brain injury.

The Role of the Endocannabinoid System In Islet Biology (2011)
The role of the endocannabinoid system in islet biology…It is now established that there is a functional endocannabinoid system in the pancreatic islet of Langerhans and that endocannabinoids are released concurrently with glucose-induced insulin secretion. The majority of the published papers show evidence of negative effects of the endocannabinoids on insulin secretion with antagonism of the cannabinoid 1 receptor improving beta cell function.

The Endocannabinoid System: A Promising Target For the Management of Type 2 Diabetes (2009)
The endocannabinoid system: a promising target for the management of type 2 diabetes…human observations suggest that the endocannabinoid (EC) system is overactivated in presence of abdominal obesity and/or diabetes, and contributes to disturbances of energy balance and metabolism… ECS regulates the intake of nutrients through central mechanisms located within the hypothalamus and limbic area, but also intervenes in transport, metabolism and deposit of the nutrients in the digestive tract, liver, adipose tissue, skeletal muscle, and pancreas. Activation of both central and peripheral CB1 receptors promotes weight gain… Conversely, selective CB(1) receptor antagonist in clinical use, has shown to reduce body weight, waist circumference, triglycerides, blood pressure, insulin resistance and C-reactive protein levels, and to increase HDL cholesterol and adiponectin concentrations in both non-diabetic and diabetic overweight/obese patients.

The Endocannabinoid System As A Target For Obesity Treatment (2008)
The endocannabinoid system as a target for obesity treatment…Among the promising new agents are the CB(1) receptor antagonists. These agents target receptors of the endocannabinoid system, a neuromodulatory system found to influence energy balance, eating behavior, and metabolic homeostasis via central and peripheral mechanisms…antagonism of CB(1) receptors has resulted in meaningful weight loss and improvement of lipid and glycemic profiles. Thus, these agents provide a rational and effective approach for the management of not only overweight and obesity but also their metabolic and cardiovascular sequelae.

Pharmacotherapeutic Targeting of the Endocannabinoid Signaling System: Drugs For Obesity and the Metabolic Syndrome (2008)
Pharmacotherapeutic targeting of the endocannabinoid signaling system: drugs for obesity and the metabolic syndrome…Endogenous signaling lipids (“endocannabinoids”) functionally related to Delta(9)-tetrahydrocannabinol, the psychoactive ingredient of marijuana (Cannabis), are important biomediators and metabolic regulators critical to mammalian (patho)physiology…The ubiquitous and diverse regulatory actions of the endocannabinoid system in health and disease have supported the regulatory approval of natural products and synthetic agents as drugs that alter endocannabinoid-system activity. More recent data support the concept that the endocananbinoid system may be modulated for therapeutic gain at discrete pharmacological targets with safety and efficacy. Potential medications based on the endocannabinoid system have thus become a central focus of contemporary translational research for varied indications with important unmet medical needs…selective CB1 cannabinoid receptor ligands to attenuate endocannabinoid signaling represents a state-of-the-art approach. 

 

Is A Win On the Horizon For the Cannabis Community?

When our parents took a stand against the government, the establishment, they had to grab the attention of the media to be heard.  They protested, burned bras and held demonstrations.  They too experienced police brutality but much of that was not covered.  They lived in a time when their generations was going through a transformation, a revolution.  As we look around today its hard not to draw parallels with where we are today.  We see critical shifts in society that give us hope for the future.  Some of these changes can be attributed to parental influence, more availability of information and a growth in enlightened thinking and perception.

The older generations who were indoctrinated with reefer madness are decreasing and we are now seeing the baby boomer generation head into the golden years.  Older Americans are finding that cannabis has come a long way from the “hippie” days and can be beneficial with ailments they are faced with today.  Discovering new methods such as edibles, tinctures and capsules spark a curiosity and give credibility to medicinal value for them.

We start to see a new generation emerge from this earlier shift in thinking and perception of the world resulting in a much more open-minded group.  With this shift in thinking we see more acceptance of non-traditional thinking, lifestyles and medical treatment options.   Along with the parental influence we see a huge influx of influence from technology and the information it provides.  This emerging group of people can search out for themselves the truth about cannabis including medicinal value.  People can connect with others, share information and even look up published medical studies.

Alternative, in some aspects, have almost become the norm.  Even something as simple as a grocery bag, ten years ago, would mostly have been used by “hippies” but now, at least on the west coast, it has become the norm.  With more education about our food and our planet we see more people choosing organic.  We are also seeing a sharp rise in acceptance and use of alternative medicine.  Polls in 2011 showed support for medical marijuana by Americans at 77%.

In the last decade we have seen a national conversation about cannabis educate and enlighten countless people about the truths and fictions surrounding it.  We have seen 16 states and the District of Columbia enact medical marijuana laws and 6 states that have regulated legalization ballot initiatives underway for 2012.  With all this progress and exposure to the topic it has brought our society to a catalyst-like moment in history.  We see the struggle that has gone on in this country with prohibition for over 75 years.  This will not have the same outcome as earlier battles, this time is different.

The new life that has impassioned the movement and helped it to gain steam, especially in the last few years, has been remarkable.  We have farther to go and still need help from all of those who believe in their right of freedom of choice and free will.  Using our voice to stand up for whats right.  Just as we saw in earlier generations we too need to stand against the establishment and fight for our rights.  We should have a natural option.  The cannabis community has been ignored, has been laughed at, as we saw heightened last year fought with and now with hopeful hearts we hope to see a win on the horizon.

Video – Cannabis Botany of Desire

Short 8 minute video on cannabis and our Endocannabinoid system.

How the Government is Setting The Cannabis Community Up for Failure and How We Can Stop It

The U.S. has seen the cannabis industry booming in recent years much to the government’s dismay.  They have spread Reefer Madness, raided patients and dispensaries, threatened state government officials and much more.  In 2011 we saw the issue of medical marijuana and cannabis in general covered quite extensively in the mainstream media as well as online.

Federal law has put doctors, patients and state government officials in the middle of a chaotic mess.  Currently federal law dictates that marijuana is as harmful and addictive as heroin with no medical benefits. It is listed in the schedule 1 category from the Controlled Substance Act which is above other drugs like cocaine.  With the current federal law along with the aggressive actions of the D.O.J. towards California’s state medical marijuana program, the federal government has set the community up for failure.  State and city officials have been reluctant to stand up due to legal threats from the D.O.J.  Many have been too afraid to be caught in the middle of a legal mess.  This has left patients with an unregulated system.

Unfortunately the cannabis industry is still dealing with the black market, which brings along with it many problems.  One is that with the proliferation of legitimate dispensaries and business we also saw some that were just a cover for selling drugs.  In California, which has had a medical marijuana law on the books for over 15 years, we saw a large number of dispensaries open up in cities across the state.  Even smaller towns were not spared resulting in multiple shops opening up.

I personally visited several locations last year all over California and out of all my experiences more often than not they were uneducated pot peddlers, who rushed you in and out, instead of the informed caregivers many Californians had envisioned when they passed their compassion law.  I, thankfully, did find locations that were not only knowledgeable but had no problem in explaining to me each strain, how it could help my symptoms as well as any other questions I had.  I loved that they actually cared about what they were doing not only for me but the whole community.  The general public unfortunately does not see this side and that is a truly sad.

To those that were not involved in the cannabis industry or even had a clue one existed, were shocked to suddenly see so many shops pop up.  Along with the number inevitably came location issues.   There were reports of dispensaries opening up next door to daycares and schools were the smell of marijuana could be detected.  This of course put a black mark on the cannabis community as well in some cases shut it down all together.  In CA over 200 cities have banned dispensaries altogether.

What we saw first as our way to legalization has quickly gotten out of control and has threatened to destroy what many have worked so hard to achieve.  The government saw the opportunity to use the fear of people along with their lack of true knowledge about cannabis to shut down many cities across the state of California as well as other states.  As of today the D.O.J. has sent out many letters across the nation to city and state officials warning of aggressive actions to be taken.

Colorado has demonstrated forward thinking with the regulations they put in place.  Colorado’s system went a different route than California in saying that cannabis could be sold for profit.  What Colorado did was innovative in that they did not set up a guise of non-profit like California but heavily regulated the industry instead.  Now with local law enforcement and the state Medical Marijuana Enforcement division teamed up they can now weed out the legitimate businesses from the black market therefore avoiding harassment.  Many cannabis supporters welcomed it because as we have seen no regulations has led to chaos.

In 2010 there were 809 dispensaries, 321 infused product manufacturers and 1230 cultivators registered with the state of Colorado.  The state collected $7.34 million in licensing fees alone.  Although problems exist in the current laws and ideally we would like it legal for anyone this type of regulations, for now, is better than the alternative we see in CA.

With the booming cannabis industry we also saw the emergence of testing labs.  We not only got to see how much THC and CBD content a strain had but we also learned about important things like mold, disease and pest contaminates.  We quickly realized that although we love the freedom we currently have to run the cannabis industry it obviously needs regulations.  We need healthy, medical-grade (pest, disease and mold free) and a system that helps patients feel confident in their purchase.

If we can get responsible regulations, constructed by a partnership of the cannabis community and government, we will see a successful cannabis industry that could very well help save the budget in those states.  Most people today recognize that there are medical benefits to cannabis as well as it not being as harmful as those drugs it is currently listed with.  There is proposed legislation that has wide support calling for a rescheduling of cannabis so that states, and more importantly doctors and patients, can decided what is right for them.

Each of us, as citizens and as a person, have a duty to right wrongs.  For over 74 years we have seen the government tell us we cannot have safe access to a natural drug, one that has been used for thousands of years for hundreds of uses.  We each need to make a difference and stand up and say we will no longer stand for prohibition!  We need to reschedule cannabis and allow the states to decide.  This issue is a state issue and the 10th amendment should be respected.  Tell you representative today!

Monumental Achievement – Cannabis Plant Genetics Mapped

In 2011 we saw cannabis all over the news.  We saw raids, booming industries, more states push for and more doctors taking a stand for legalization.  Cannabis has been in use by humans since at least 2737 BCE with Chinese Emperor Shen-Nung recorded prescribing it for a number of ailments.

There are many mysteries and controversies surrounding the cannabis plant.  Science has been trying to unravel them for years.  In 2011 we had a monumental breakthrough that quite literally could change the course of history.

Kevin McKernan has stacked up a long list of big accomplishments at just 38.  He is the owner of Medicinal Genomics with a lab in Amsterdam for researchers to freely study the cannabis plant.  Kevin was part of the Human Genome Project for four years.  He also worked on a robotic system that could handle He also developed methods to process DNA 100,000 times faster.

With a man who’s resume is that impressive you have to ask yourself why would a guy like that get into the business of studying cannabis.  He did work on mapping tumors and after working with doctors and patients started to see that many cancer patients were using cannabis.  After looking into cannabis he saw that there was much more to this plant and that it did have medicinal value.

While working with oncologist he found that if you sequence a tumors DNA as well as the patient you will discover the differences which can then become a target for drug therapies.  With cannabis being mapped the same theory could apply, instead of using Big Pharma drugs you could use Cannabinoids.

With both the Indica and Cannabis plant genetics mapped science can now start to get a better grasp on how cannabinoids interact with our bodies.  When we can successfully target each person illness with specific cannabinoids we will effectively understand the science behind the curing powers of cannabis.

Science will finally be able to confirm what millions have known for thousands of years.  Today we know more about THC, the psychoactive ingredient and the CBD, non-psychoactive ingredient and how the synthases of each are the genes that code for an enzyme that helps fold the hydrocarbons into Cannabinoids.

What controls the other 83 cannabinoids and other hundreds of terpenes is still unknown.   Many genes that were bred out in search of higher THC content since the government prohibited cannabis use, will need to be brought back through selective breading.

This is one more step in our fight for legalization.  With scientific proof the government will have no choice but to recognize cannabis has medicinal value.

Even the national Cancer Institute briefly posted a page that listed cannabis as a pain reliever and anti-nausea as well as possible anti-tumor effects.  The government made them take it down since this has only been proven in cell cultures and rats although it is currently in human clinical trials.

When dealing with chemotherapeutic drugs there is a fine line between killing the tumor and killing the patient.  Whats exciting about cannabis is that it is not fatal and very few drug therapies have such a forgiving window.

With all this new data in the coming years we will see our knowledge grow and hopefully result in legalization.  It will take all of us making our voices heard, that we should have a natural choice when treating our illnesses.  Kevin and his team have posted their findings online for all to look at.  Please feel free to share ~ Cherry Girl