Endocannabinoid System, Cannabinoid Receptors, and Cannabinoids CURING Cancer

Cannabis holds many healing properties that are slowly being unraveled.  Since the 60’s it has been known that the human body contains an Endocannabinoid system that interacts with cannabis.  Since then science has discovered many things and continues in the search for the key to unlocking the cure.  Many believe in the power of cannabis to cure many things including cancer.  Scientists are hard at work trying to prove the very same thing.  Below you will see studies that show how science has unlocked some mysteries.  These are valid published medical studies dealing with out endocannabinoid system please feel free to share ~ Cherry Girl

Cannabinoids In the Treatment of Cancer
Cannabinoids, the active components of the hemp plant Cannabis sativa, along with their endogenous counterparts and synthetic derivatives, have elicited anti-cancer effects in many different in vitro and in vivo models of cancer. While the various cannabinoids have been examined in a variety of cancer models, recent studies have focused on the role of cannabinoid receptor agonists (both CB(1) and CB(2)) in the treatment of estrogen receptor-negative breast cancer. This review will summarize the anti-cancer properties of the cannabinoids, discuss their potential mechanisms of action, as well as explore controversies surrounding the results.

Changes In the Endocannabinoid System May Give Insight Into New and Effective Treatments For Cancer
Marijuana and its derivatives have been used in medicine for centuries, however, it was not until the isolation of the psychoactive component of Cannabis sativa (Δ9-tetrahydrocannabinol; Δ9-THC) and the subsequent discovery of the endogenous cannabinoid signaling system that research into the therapeutic value of this system reemerged. Ongoing research is determining that regulation of theendocannabinoid system may be effective in the treatment of pain, glaucoma, and neurodegenerative disorders such as Parkinson’s disease and multiple sclerosis. In addition, cannabinoids might be effective anti-tumoral agents because of their ability to inhibit the growth of various types of cancer cell lines.   In conclusion, the endocannabinoid system exerts a myriad of effects on tumor cell growth, progression, angiogenesis, and migration. With a notable few exceptions, targeting the endocannabinoid system with agents that activate cannabinoid receptors or increase the endogenous levels of AEA may prove to have therapeutic benefit in the treatment of various cancers. Further studies into the downstream consequences of AEA treatment are required and may illuminate other potential therapeutic targets.

The Endocannabinoid System and Cancer: Therapeutic Implication
Identification of safe and effective treatments to manage and improve cancer therapy is critical to improve quality of life and reduce unnecessary suffering in cancer patients. In this regard, cannabis-like compounds offer therapeutic potential for the treatment of breast, prostate and bone cancer in patients.

Endocannabinoids As Emerging Suppressors of Angiogenesis and Tumor Invasion
The medicinal properties of extracts from the hemp plant Cannabis sativa have been known for centuries but only in the 90s membrane receptors for the Cannabis major principle were discovered in mammalian cells…endocannabinoids are now emerging as suppressors of angiogenesis and tumor spreading since they have been reported to inhibit angiogenesis, cell migration and metastasis in different types of cancer, pointing to a potential role of the endocannabinoid system as a target for a therapeutic approach of such malignant diseases. The potential use of cannabinoids to retard tumor growth and spreading is even more appealing considering that they show a good safety profile, regarding toxicity, and are already used in cancer patients as palliatives to stimulate appetite and to prevent devastating effects such as nausea, vomiting and pain.

Therapeutic Target-In-Waiting
CB(2) cannabinoid receptor agonists hold promise as a new class of therapeutics for indications as diverse as pain, neuroinflammation, immune suppression and osteoporosis. These potential indications are supported by strong preliminary data from multiple investigators using diverse preclinical models.

Cannabidiol Inhibits Lung Cancer Cell Invasion and Metastasis Via Intercellular Adhesion Molecule-1
Overall, our data indicate that cannabinoids induce ICAM-1, thereby conferring TIMP-1 induction and subsequent decreased cancer cell invasiveness.

Cannabinoid Receptor 1 is A Potential Drug Target For Treatment of Translocation-Positive Rhabdomyosarcoma
Because cannabinoid receptor agonists are capable of reducing proliferation and inducing apoptosis in diverse cancer cells such as glioma, breast cancer, and melanoma, we evaluated whether CB1 is a potential drug target in rhabdomyosarcoma.Our study shows that treatment with the cannabinoid receptor agonists HU210 and Delta(9)-tetrahydrocannabinol lowers the viability of translocation-positive rhabdomyosarcoma cells through the induction of apoptosis.These results support the notion that cannabinoid receptor agonists represent a novel targeted approach for treatment of translocation-positive rhabdomyosarcoma.

PAX3-FOXO1 Induces Cannabinoid Receptor 1 to Enhance Cell Invasion and Metastasis
Alveolar rhabdomyosarcoma (ARMS) is a muscle-derived childhood tumor characterized by production of oncogenic PAX3/7-FOXO1 chimeric transcription factors…Genetic or pharmacologic abrogation of (Cnr1/Cb1) inhibited the enhanced basement membrane invasion induced by PAX3-FOXO1. Cnr1 loss by either route also dramatically reduced lung metastasis formation. Taken together, our findings strongly implicate Cnr1 as a novel tractable target to inhibit ARMS invasion and metastasis.

The Endocannabinoid System In Cancer-Potential Therapeutic Target?
Endogenous arachidonic acid metabolites with properties similar to compounds of Cannabis sativa Linnaeus, the so-called endocannabinoids, have effects on various types of cancer. Although endocannabinoids and synthetic cannabinoids may have pro-proliferative effects, predominantly inhibitory effects on tumor growth, angiogenesis, migration and metastasis have been described. Remarkably, these effects may be selective for the cancer cells, while normal cells and tissues are spared. Such apparent tumor cell selectivity makes the endocannabinoid system an attractive potential target for cancer therapy.

 

 

Christmas Extra Jolly Fudge

A quick Thank You to all my readers!  I just wanted to wish everyone a Merry Christmas and A Happy New Year!  I hope everyone is blessed with the opportunity to spend time with the ones they love.  I also hope you get time to bake!  Here is a fudge recipe that will keep you Jolly all night.

Santa’s Secret Jolly Fudge
Ingredients

  • 1-1/2 teaspoons plus 1/4 cup cannabutter, softened, divided
  • 2 cups sugar
  • 1/2 cup sour cream
  • 12 ounces white baking chocolate, chopped
  • 1 jar (7 ounces) marshmallow creme
  • 1/2 cup crushed peppermint candy
  • 1/2 teaspoon peppermint extract

Directions

  • Line a 9-in. square pan with foil. Grease the foil with 1-1/2 teaspoons butter; set aside.
  • In a large heavy saucepan, combine the sugar, sour cream and remaining butter. Cook and stir over medium heat until sugar is dissolved. Bring to a rapid boil; cook and stir until a candy thermometer reads 234° (soft-ball stage), about 5 minutes.
  • Remove from the heat; stir in white chocolate and marshmallow creme until melted. Fold in peppermint candy and extract. Pour into prepared pan. Chill until firm.
  • Using foil, lift fudge out of pan. Gently peel off foil; cut fudge into 1-in. squares. Store in the refrigerator. Yield: 2 pounds.

 And To All A Good Night!

Breaking News: Louisiana’s Neti Pot Brain-Eating Amoeba and Cannabis

This week Louisiana issued a warning about using tap water and neti pots.  The amoeba, formally known as the Naegleria fowleri, can be fatal when it is introduced into the body through the nasal cavity.  It must enter the body through the nasal cavity; it cannot be ingested through drinking water.  It is recommended that neti pot users strictly use sterile water and not tap water.

Susceptibility of Naegleria fowleri to A9-Tetrahydrocannabinol
Nature holds many mysteries and one is how this brain eating amoeba is susceptible to THC.  Although it does not stop their movement it does inhibit growth of the pathogenic amoeboflagellate Naegleria fowleri. THC is amoebostatic at 5 to 50 micrograms/ml. delta 9-THC prevents enflagellation and encystment.  When there are concentrations of A9-THC. N. fowleri will not grow in standard mammalian cell cultures.

Targeting Our Endocannabinoid System:Search For Nature’s Cure

The endocannabinoid system was discovered in the 1960’s and since then scientists have been hard at work trying to unravel the mysteries.  Below you will see studies showing how the endocannabinoid system within the human body is at the center for learning how to treat many illnesses and diseases. Please feel free to share the truth about the CURE ~ Cherry Girl

Endocannabinoids In The Immune System and Cancer
Although its action as an immunomodulatory molecule requires further characterization, modulation of the endocannabinoid system interferes with cancer cell proliferation either by inhibiting mitogenic autocrine/paracrine loops or by directly inducing apoptosis.   In conclusion, further investigations are needed to elucidate the function of endocannabinoids as immunosuppressant and antiproliferative/cytotoxic agents. The experimental evidence reviewed in this article argues in favor of the therapeutic potential of these compounds in immune disorders and cancer.

Endocannabinoid System Modulation In Cancer Biology and Therapy
The discovery of the endocannabinoid system and the recognition of its impact in a plethora of pathological conditions, led to the development of therapeutic agents related to either the stimulation or antagonism of CB1 and CB2 cannabinoid receptors…Endocannabinoid-related agents have been reported to affect multiple signaling pathways and biological processes involved in the development of cancer, displaying an interesting anti-proliferative, pro-apoptotic, anti-angiogenic and anti-metastatic activity both in vitro and in vivo in several models of cancer. Emerging evidence suggests that agonists of cannabinoid receptors, which share the useful property to discern between tumor cells and their non-transformed counterparts, represent novel tumor-selective tools to treat cancer in addition to their already exploited use as palliative drugs to treat chemotherapy-induced nausea, pain and anorexia/weight loss in cancer patients.

Possible Endocannabinoid Control Of Colorectal Cancer Growth
CONCLUSIONS: Endocannabinoid levels are enhanced in transformed colon mucosa cells possibly to counteract proliferation via CBRs. Inhibitors of endocannabinoid inactivation may prove useful anticancer agents

Cannabinoids, Endocannabinoids, and Cancer
Modulation of the endocannabinoid system by pharmacological agents in various cancer types reveals that it can mediate antiproliferative and apoptotic effects by both cannabinoid receptor-dependent and -independent pathways…the endocannabinoid system is a promising target for the development of novel chemotherapeutics to treat cancer.

The Endocannabinoid System As A Target For The Development Of New Drugs For Cancer Therapy
stimulation of cannabinoid receptors by either THC or the endocannabinoids influence the intracellular events controlling the proliferation and apoptosis of numerous types of cancer cells, thereby leading to anti-tumour effects both in vitro and in vivo

2012 Is It Really The End Of The World?

The way that the world used to be is forever changing.  Maybe thats what the Mayans were talking about.   Archaeologists have said that the Mayan calendar predicts the end of the world on Dec 23, 2012.  Some believe that their translation does not actually mean a physical end of the world but a global shift, one that will forever change the course of history and the world as we know it.

The way that the world used to be was relatively the same up until the 1900’s when the car was introduced and took over the use of horses which had been around for centuries.  Now we have the digital age where everything is rapidly changing.  No where else in history do we have record of this kind of global change.  The technology era of today has effected the entire globe and beyond.  They are right.  The way of the world as it used to be will never be again; we are definitely in the dawn of a new age.

The way we parent, interact, communicate and so much more is touched by technology and modern society.  Even remote places of the globe are being touched by technology.  People around the globe are hard at work using technology to unravel the mysteries of the Earth and beyond.  Many aspects of our lives have come leaps and bounds from where they would have been only a few generations ago.

Parenting today is mainly done by the immediate family only with occasional interaction with the extended family.  Primarily children grew up in more of a group setting with grandparents, aunts, uncles and cousins playing an active role in their lives.  Today many families live apart and only get to visit on holidays.  Compounded with limited influence of the extended family is that many children today grow up in a broken home.  The divorce rate is near 50% leaving children to learn balance between two households.

Children today are also being raised to be more aware of their emotional self.  They are being taught to use your words not your fists; leaving you to wonder if this influence will be seen in the future when this generation begins to govern.  Will they be able to be more diplomatic, possibly saving lives through preventing wars?

We have the IPhone, IPad, cell phones, tablets and much more that connect us to the rest of the world.  Unfortunately because these conveniences can be found just about anywhere we also have the problem of being distracted while being in the company of real people.  Too many times people will be talking but they are distracted by their phone or other device and lose out on quality time.  Even young children are handed a phone or IPad to keep them busy instead of parental interaction.  This too will have an effect on this generation.

Many parents today do not have the luxury of their parents where they had a one person working household.  With both parents exhausted from working and the pressures of life, children are feeling the effects.  Many times they are left in the care of a sitter, older sibling or after school program.  With less quality face time with their parents and even less with those that have both parents in one household, children grow up being shaped by with their peers or television project.

A recent study analyzed popular programs on MTV among 12-17 year olds and found them to be primarily promoting negativity.  Looking at it from the surface these shows seem harmless but without parental balance to teach them what is right, wrong and fake, children grow up affected.  Looking at TV, Movies, Music and Advertising in general it is not hard to see that we, as a society, have lowered are standards.  What are children are exposed to today would horrify our grandparents.

One has to wonder whether this new found movement for “he who has the most money calls the shots” will spur a damaging trend in society?  It seems as if we have been hijacked and our kids are just thrown to the wind as collateral damage.  Commercials today that are risque are aired in the middle of the afternoon.  Even PG-13 movies of today are what R movies were of yesteryear.   Standards keep getting lowered so that another dollar can be made.

With all these changes in society’s standards and the shift in the way children are being raised one has to wonder what the ultimate effects of this will be on society.  Will this be a dawn of a new age of mankind or will it be our ultimate demise?  Technology and people are slowly merging together as they forge ahead into this new century we have just begun.  Even as the world changes quickly before our eyes; let us not forget the importance of quality personal human interaction and how it has an effect on society.

Finding Pain Relief In Cannabis

This last weekend was supposed to be a mini-vacation while I Christmas shopped.  I was to stay the night in a hotel and I envisioned a fun day looking at all the Christmas displays.  In reality I was in so much pain all week I was just hoping I would be able to make it to a few stores.  My entire body was in pain with a horrible headache that radiated through my upper body.  It was hard to be in the Christmas spirit.

Fortunately by Friday I had the opportunity to visit a dispensary and picked up a new strain I had only heard about.  When I got home I was able to use some of my medicine.  I have been testing out different strains for awhile now and most I have found will give me some pain relief or complete pain relief but only briefly.  When I used the new strain I got complete pain relief for hours.  I wanted to cry.

I realized that it has been the entire year that I have spent in pain.  The year has seem to fly by and I can not believe that it is December.  It feel like it should still be early fall and I have more time left in the year.  Each month I would research more medical studies, strain lists, talk with dispensary owners, read books and test out the strains myself in search of pain relief.  Some I found would give me the giggles, make me tired, make me sick, ease anxiety, help with insomnia and now finally give me full pain relief.

It was such a strange feeling being able to enjoy the moment without trying to ignore pain.I realized how long it had been since I felt this way.  Each day I get up feeling nauseous and then a headache will set in.  Sometimes they are dull and sometimes the pain is so bad its like seeing stars before you black out.  I have not found a prescription that fully takes away the pain, doesn’t give me horrible side effects or turns me into a zombie.  I have only found that in cannabis.

This year has been a long journey that I know is just begining.  I have learned so much about cannabis and have met so many wonderful people that are doing great things for the community.  Looking back over this year I am amazed at how much I know now.  All the reading and learning that I have done has ignited a fire in me that gives me passion about this subject.  I see so many people that are suffering, that like myself, have found pain relief in cannabis.  After getting a taste of what life without pain feels like I was suddenly brought back down to earth with the realization that it could all be taken away.

Currently in California, city by city, government is banning cannabis dispensaries because of the federal crackdown that happened this year.  Real people experiencing real pain not only have to brace themselves for daily life but for the realization that they very well could be without their pain relief.  They also must face the fact that their option may be going to the corner drug dealer where no questions are asked and its a gamble of what you are actually getting.

In the country we have a very heated debate on the size of the government. We have the federal government that is imposing its view on the states.  The citizens of California voted to allow for cannabis use by patients.  In 1996 most knew of cannabis use for cancer but at that time it was not publically known to help with many other illnesses.

Now in 2011, with ABC, NBC, CNN, FOX and many other mainstream media outlets as well as organizations like NORML speaking out about the many benefits of cannabis we have a more educated public.  We still hear how California is a joke because anyone can get a recommendation for cannabis.  The truth is that many people benefit from cannabis beyond those with cancer and AIDS.

Cannabis can help from a headache, to nausea, to body aches.  It can help with many different illnesses and modern science is confirming on a continual basis the new uses for cannabis.  Many different diseases that plague millions of Americans are being treated in labs around the world with cannabis.  Scientists are hard at work to unlock the cure for cancer, Alzheimer’s, Parkinson’s, obesity, migraines, to name a few and many are finding that it may be cannabis.

Many people are starting to see the harm that prescriptions are starting to have on our bodies, our society and our government.  When looking at the side effects and the drug recalls that are regulated through the FDA we wonder why a natural plant is so evil.  We are now dealing with big drug companies controlling legislation and officials in our government.  We see users of a natural plant in its natural form imprisoned.   We see families broken up and tax payer money used against them.  We also see a rise in over use of prescription drugs and addiction and what that is doing to society.

We see what the War on Drugs has done to our society as well.  Not only has it broken families, forced those arrested to a lower standard of life but also burdened the American people with a costly system of punishment for use of a natural plant. With the raids in California we saw stories of children being awakened by DEA agents busting through their front doors and shoving a gun in their parent’s face.

We also see the black market side of things heating up.  There needs to be a balance and restoring of order.  Responsible adults should be allowed to make their own medical decisions for themselves and their family.  We should not have the federal government or any government dictating how to treat our illnesses or our bodies.  We need the black market taken down and cleaned up and the legitimate legal market allowed to flourish.

The cannabis community wants to be out in the open legally operating and paying taxes.  We want a system that supports responsible use and regulation.  We want to know that we can have safe access to safe medicine.  We want to know that we have a reliable legitimate source of pain relief.  Every citizen has the right to treat their body as they see fit. They also should have the option to treat their body with natural herbs.  As a human on this Earth we have the right to use what the planet gives us.  We have the right to use nature responsibly.

It is time that we start being a more courageous nation and stand up for what is right.  We need to voice our opinions and start working together to solve these issues.  Turn off the TV, look away from the IPhone and start talking to one another to begin the repair work for this country.  We need responsibility put back on the shoulders of the American people.  We need to roll up our sleeves and get the job done.  The government is not the answer, we are.  2012 is only weeks away how will you make a difference?

Treating Obesity and Diabetes With Cannabis

It is estimated that about one-third of Americans are clinically obese, with 25.8 million diagnosed with diabetes.  It is no secret that the American culture has encouraged obesity and as a result reported cases of diabetes is on the rise.

Scientists are still hard at work looking for a cure to both epidemics.  One therapy looked at is using cannabinoids.  Below you will see studies that back up the strongly held belief that cannabis is a natural cure to many illnesses that should be legalized for all.  Please feel free to spread the truth ~ Cherry Girl

The Endocannabinoid System As A Target For Obesity Treatment 
Overweight and obesity are major factors contributing to the development of type 2 diabetes mellitus (DM) and cardiovascular disease (CVD)… researchers and clinicians continue to explore pharmacotherapy, with intense efforts being directed toward the development of agents that will reduce weight and simultaneously reduce or eliminate modifiable cardiovascular and metabolic risk factors. Amongthe promising new agents are the CB(1) receptor antagonists. These agents target receptors of the endocannabinoid system, a neuromodulatory system recently found to influence energy balance, eating behavior, and metabolic homeostasis via central and peripheral mechanisms. In animal and clinical studies, antagonism of CB(1) receptors has resulted in meaningful weight loss and improvement of lipid and glycemic profiles.

ANTIOBESITY EFFICACY OF LH-21, A CANNABINOID CB(1) RECEPTOR ANTAGONIST WITH POOR BRAIN PENETRATION, IN DIET-INDUCED OBESE RATS
The peripheral blockade of cannabinoid CB(1) receptors has been proposed as a safe and effective therapy against obesity, putatively devoid of the adverse psychiatric side effects…Conclusions and implications: These results support the hypothesis that the treatment with the peripherally neutral acting cannabinoid CB(1) receptor antagonist, LH-21, may promote weight loss through modulation of visceral adipose tissue.

The Endocannabinoid System: A Promising Target For The Management Of Type 2 Diabetes
The endoCANNABINOID system “regulates the intake of nutrients through central mechanisms located within the hypothalamus and limbic area, but also intervenes in transport, metabolism and deposit of the nutrients in the digestive tract, liver, adipose tissue, skeletal muscle, and possibly pancreas. Activation of both central and peripheral CB1 receptors promotes weight gain and associated metabolicchanges. Conversely, selective CB(1) receptor antagonists, have been shown to reduce body weight, waist circumference, triglycerides, blood pressure, insulin resistance and C-reactive protein levels, and to increase HDL cholesterol and adiponectin concentrations in both non-diabetic and diabetic overweight/obese patients.

The Implication of CNR1 Gene’s Polymorphisms In The Modulation Of Endocannabinoid System Effects
The endocannabinoid system (ECS) represents one of the most important physiologic systems involved in organism homeostasis…The discovery of ECS and its signaling pathways opens a door towards the understanding of several important physiologic processes regarding appetite, food intake, metabolism, weight gain, motor control, memory, learning, drug addiction and nociception. The detailed analysis and validation of the ECS functioning can bring us very close to the discovery of new diagnosis and treatment methods for obesity, drugs abuse and numerous psychic diseases.

Rehashing Endocannabinoid Antagonists: Can We Selectively Target The Periphery To Safely Treat Obesity And Type 2 Diabetes?
A growing body of evidence supports an important role for the endocannabinoid system as a regulator of appetite, body weight, and systemic metabolism, which is overactive in obesity and type 2 diabetes. While initial attempts to target this system using rimonabant were successful in producing weight loss and improving obesity-related metabolic complications in humans, adverse central nervous system side effects precluded introduction of this drug into clinical practice. However, new data, presented by Tam and colleagues, demonstrate that selective blockade of peripheral cannabinoid receptors may be a novel successful therapeutic approach.

Pharmacotherapeutic Targeting Of The Endocannabinoid Signaling System: Drugs For Obesity And The Metabolic Syndrome.
Endogenous signaling lipids (“endocannabinoids”) functionally related to Delta(9)-tetrahydrocannabinol, the psychoactive ingredient of marijuana (Cannabis), are important biomediators and metabolic regulators critical to mammalian (patho)physiology.More recent data support the concept that the endocananbinoid system may be modulated for therapeutic gain at discrete pharmacological targets with safety and efficacy.Pressing worldwide healthcare needs and increasing appreciation of endocannabinoid biology make the rational design and refinement of targeted CB1 receptor modulators a promising route to future medications with significant therapeutic impact against overweight, obesity, obesity-related cardiometabolic dysregulation, and, more generally, maladies having a reward-supported appetitive component.

Cannabis As A Treatment Option and Cure For Epilepsy and Seizures

3 Million Americans suffer each year from seizures.  One disorder that causes seizures is Epilepsy.  Epilepsy produces seizures affecting a variety of mental and physical functions. It is also called a seizure disorder. Seizures happen when clusters of nerve cells in the brain signal abnormally, which may briefly alter a person’s consciousness, movements or actions.

Epilepsy is the third most common neurological disorder in the U.S. after Alzheimer’s disease and stroke. Its prevalence is greater than cerebral palsy, multiple sclerosis and Parkinson’s disease combined. Despite how common it is and major advances in diagnosis and treatment, epilepsy is among the least understood of major chronic medical conditions.

While medications and other treatments help many people of all ages who live with epilepsy, more than a million people continue to have seizures that can severely limit their school achievements, employment prospects and participation in all of life’s experiences.

Below you will see studies that show cannabis as a treatment option as well as a possible cure.  Please share the truth about the cure ~ Cherry Girl

The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy
Several lines of evidence suggest that cannabinoid compounds are anticonvulsant. Here we show that the marijuana extract Delta9-tetrahydrocannabinol completely abolished spontaneous epileptic seizures. These data indicate not only anticonvulsant activity of exogenously applied cannabinoids but also suggest that endogenous cannabinoid tone modulates seizure termination and duration through activation of the CB1 receptor.
http://www.ncbi.nlm.nih.gov/pubmed/12954810

Changes in the Cannabinoid (CB1) Receptor Expression Level and G-protein Activation in Kainic Acid Induced Seizures 2011
It has been known for centuries that exogenous cannabinoids, such as tetrahydrocannabinol have anticonvulsant activity. Recent studies have advanced our understanding of the endogenous cannabinoid system and renewed the interest in cannabinoids as a potential treatment for epilepsy.
http://www.ncbi.nlm.nih.gov/pubmed/22079489

Endocannabinoids and Their Implications For Epilepsy
Activation of cannabinoid receptors has been implicated in neuroprotection against excitotoxicity and can help explain the anticonvulsant properties of cannabinoids that have been known since antiquity.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1176361/?tool=pubmed

Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus
Cannabinoids have been shown to have anticonvulsant properties, but no studies have evaluated the effects of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy (AE) and status epilepticus (SE).The results from this study show CB1 receptor-mediated anticonvulsant effects of the cannabimimetic WIN 55,212-2 (THC) against both SRED and low Mg2+-induced SE in primary hippocampal neuronal cultures and show that these in vitro models of AE and SE may represent powerful tools to investigate the molecular mechanisms mediating the effects of cannabinoids on neuronal excitability.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2617751/?tool=pubmed

Assessment of the Role of CB1 Receptors in Cannabinoid Anticonvulsant Effects 
Cannabinoid compounds like delta9-tetrahydrocannabinol and cannabidiol have been shown to be anticonvulsant in maximal electroshock…This study establishes a role for the cannabinoid CB1 receptor in modulating seizure activity in a whole animal model.
http://www.ncbi.nlm.nih.gov/pubmed/11779037

Biomedical Benefits of Cannabinoids? 
Cannabinoids appear to be of therapeutic value as antiemetics, antispasmodics, analgesics and appetite stimulants and may have potential uses in epilepsy, glaucoma and asthma.The place of cannabinoids in modern medicine remains to be properly evaluated, but present evidence suggests that they could be valuable, particularly as adjuvants, for symptom control in a range of conditions for which standard drugs are not fully satisfactory.
http://www.ncbi.nlm.nih.gov/pubmed/20575778

On the application of Cannabis in Paediatrics and Epileptology
In the US over 300,000 children are affected with epilepsy.
An initial report on the therapeutic application of delta 9-THC (THC) (Dronabinol, Marinol) in 8 children suffering from the following conditions, is given: neurodegenerative disease, mitochondriopathy, posthypoxic state, epilepsy, posttraumatic reaction. THC effected reduced spasticity, improved dystonia, increased initiative (with low dose), increased interest in the surroundings, and anticonvulsive action. In several cases treatment was discontinued and in none of them discontinuing resulted in any problems. The possibility that THC-induced effects on ion channels and transmitters may explain its therapeutic activity seen in epileptic patients is discussed.
http://www.ncbi.nlm.nih.gov/pubmed/15159680

Brain Cannabinoid Systems As Targets For the Therapy of Neurological Disorders 
Unprecedented developments in cannabinoid research within the past decade include discovery of a brain (CB1) and peripheral (CB2) receptor; endogenous ligands, anandamide, and 2-arachidonylglycerol; cannabinoid drug-induced partial and inverse agonism at CB1 receptors, antagonism of NMDA receptors and glutamate, and antioxidant activity; and preferential CB1 receptor localization in areas subserving spasticity, pain, abnormal involuntary movements, seizures, and amnesia. These endogenous structures and chemicals and mechanisms are potentially new pathophysiologic substrates, and targets for novel cannabinoid treatments, of several neurological disorders.
http://www.ncbi.nlm.nih.gov/pubmed/9974182

Downregulation of the CB1 Cannabinoid Receptor and Related Molecular Elements of the Endocannabinoid System in Epileptic Human Hippocampus 
These findings show that a neuroprotective machinery involving endocannabinoids is impaired in epileptic human hippocampus and imply that downregulation of CB(1) receptors and related molecular components of the endocannabinoid system may facilitate the deleterious effects of increased network excitability.
http://www.ncbi.nlm.nih.gov/pubmed/18354002

Cannabidiol Displays Antiepileptiform and Antiseizure Properties in Vitro and in Vivo
These findings suggest that CBD acts, potentially in a CB(1) receptor-independent manner, to inhibit epileptiform activity in vitro and seizure severity in vivo. Thus, we demonstrate the potential of CBD as a novel antiepileptic drug in the unmet clinical need associated with generalized seizures.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819831/?tool=pubmed

Cannabinoid Receptor Activation Reverses Kainate-Induced Synchronized Population Burst Firing in Rat
Cannabinoids have been shown to possess anticonvulsant properties in whole animal models of epilepsy. The present results indicate that cannabinoids exert their antiepileptic effects by impeding pathological synchronization of neuronal networks in the hippocampus.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701678/?tool=pubmed

Chronic Headaches and Cannabis: Finding A Natural Relief

It is estimated that there are over 45 million Americans that suffer from chronic headaches.  This can include tension, migraine and cluster headaches.  Most of the population knows what its like to have a headache once in awhile but millions of Americans face severe pain on a regular basis which can be difficult.  The other problem that chronic pain suffers face is that the medication they are prescribed stops working after building up a tolerance.

Many of the choices for headaches can have scary side effects.  Many patients seek a natural option.  It is important to look at all your treatment options as well as thoroughly knowing your illness.  Please feel free to share the truth with not only your friends but your doctor as well.  Many are not trained in the science of cannabis and do not realize what studies have already been conducted.  ~ Cherry Girl

Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
Migraine has numerous relationships to endocannabinoid function. Anandamide (AEA) potentiates 5-HT1A and inhibits 5-HT2A receptors supporting therapeutic efficacy in acute and preventive migraine treatment. Cannabinoids also demonstrate dopamine-blocking and anti-inflammatory effects. AEA is tonically active in the periaqueductal gray matter, a migraine generator. THC modulates glutamatergic neurotransmission via NMDA receptors. Fibromyalgia is now conceived as a central sensitization state with secondary hyperalgesia. Cannabinoids have similarly demonstrated the ability to block spinal, peripheral and gastrointestinal mechanisms that promote pain in headache, fibromyalgia, IBS and related disorders. The past and potential clinical utility of cannabis-based medicines in their treatment is discussed, as are further suggestions for experimental investigation of CECD via CSF examination and neuro-imaging.
CONCLUSION:
Migraine, fibromyalgia, IBS and related conditions display common clinical, biochemical and pathophysiological patterns that suggest an underlying clinical endocannabinoid deficiency that may be suitably treated with cannabinoid medicines.
http://www.ncbi.nlm.nih.gov/pubmed/18404144

Degradation of Endocannabinoids in Chronic Migraine and Medication Overuse Headache
Chronic migraine (CM) is frequently associated with medication overuse headache (MOH). The endocannabinoid system plays a role in modulating pain including headache and is involved in the common neurobiological mechanism underlying drug addiction and reward system. Anandamide (AEA) and 2-arachidonoylglycerol are the most biologically active endocannabinoids, which bind to both central and peripheral cannabinoid receptors. The level of AEA in the extracellular space is controlled by cellular uptake via a specific AEA membrane transporter (AMT), followed by intracellular degradation by the enzyme AEA hydrolase (fatty acid amide hydrolase, FAAH). AMT and FAAH have also been characterized in human platelets. We assayed the activity of AMT and of FAAH in platelets isolated from four groups of subjects: MOH, CM without MOH, episodic migraine and controls. AMT and FAAH were significantly reduced in CM and MOH, compared to either controls or episodic migraine group. This latter finding was observed in both males and females with CM and MOH. Changes observed in the biochemical mechanisms degrading endogenous cannabinoids may reflect an adaptative behaviour induced by chronic headache and/or drug overuse.
http://www.ncbi.nlm.nih.gov/pubmed/18358734

Endocannabinoids in Chronic Migraine: CSF Findings Suggest A System Failure 
Based on experimental evidence of the antinociceptive action of endocannabinoids and their role in the modulation of trigeminovascular system activation, we hypothesized that the endocannabinoid system may be dysfunctional in chronic migraine (CM). We examined whether the concentrations of N-arachidonoylethanolamide (anandamide, AEA), palmitoylethanolamide (PEA), and 2-arachidonoylglycerol (2-AG) in the CSF of patients with CM and with probable CM and probable analgesic-overuse headache (PCM+PAOH) are altered compared with control subjects. The above endocannabinoids were measured by high-performance liquid chromatography (HPLC), and quantified by isotope dilution gas-chromatography/mass-spectrometry. Calcitonin gene-related peptide (CGRP) levels were also determined by RIA method and the end products of nitric oxide (NO), the nitrites, by HPLC. CSF concentrations of AEA were significantly lower and those of PEA slightly but significantly higher both in patients with CM and PCM+PAOH than in nonmigraineur controls (p<0.01 and p<0.02, respectively). A negative correlation was found between AEA and CGRP levels in CM and PCM+PAOH patients (r=0.59, p<0.01 and r=-0.65, p<0.007; respectively). A similar trend was observed between this endocannabinoid and nitrite levels. Reduced levels of AEA in the CSF of CM and PCM+PAOH patients may reflect an impairment of the endocannabinoid system in these patients, which may contribute to chronic head pain and seem to be related to increased CGRP and NO production. These findings support the potential role of the cannabinoid (CB)1 receptor as a possible therapeutic target in CM.
http://www.ncbi.nlm.nih.gov/pubmed/17119542 

The Endocannabinoid System and Migraine
In this review we shall describe experimental and clinical data that, intriguingly, demonstrate the link between endocannabinoids and migraine, a neurovascular disorder characterized by recurrent episodic headaches and caused by abnormal processing of sensory information due to peripheral and/or central sensitization. Although the exact ECS-dependent mechanisms underlying migraine are not fully understood, the available results strongly suggest that activation of ECS could represent a promising therapeutical tool for reducing both the physiological and inflammatory components of pain that are likely involved in migraine attacks.
http://www.ncbi.nlm.nih.gov/pubmed/20353780

Cannabinoid (CB1) Receptor Activation Inhibits Trigeminovascular Neurons
Migraine is a common and disabling neurological disorder that involves activation or the perception of activation of the trigeminovascular system.  The data suggest that Cannabinoid receptors may have therapeutic potential in migraine, cluster headache, or other primary headaches, although the potential hazards of psychoactive side effects that accompany cannabinoid treatments may be complex to overcome.
http://www.ncbi.nlm.nih.gov/pubmed/17018694

Interictal Type 1 Cannabinoid Receptor Binding is Increased in Female Migraine Patients
It has been suggested that endocannabinoid deficiency may play a role in the pathophysiology of migraine. Conclusion: The increased interictal CB1R binding, especially in brain regions that exert top-down influences to modulate pain, supports the idea that endocannibinoid deficiency is present in female patients suffering from episodic migraine.
http://www.ncbi.nlm.nih.gov/pubmed/22077199

Cluster Attacks Responsive to Recreational Cannabis and Dronabinol
Pharmacological preparations of cannabinoid compounds have a variety of therapeutic uses in medicine, including different pain syndromes…We present a patient with cluster headache who was refractory to multiple acute and preventive medications but successfully aborted his attacks with recreational marijuana use. The beneficial effect may be related to the high concentration of cannabinoid receptors in the hypothalamus, which has been implicated as a site of dysfunction in neuroimaging studies of patients with cluster headache.
http://www.ncbi.nlm.nih.gov/pubmed/19220500

Cannabinoid Deficiency: Is It the Source of Your Illness?

Millions of Americans suffer from chronic illnesses many of those with painful side effects.  Drugs that are prescribed to patients can compound this with their side effects to the body.  Many seek a treatment option that is natural.   It is important to know your illness and all your treatment options.  Below you will see studies on cannabis as a treatment option for several illnesses as well as cannabinoid deficiency as a cause.  Please feel free to share the truth with not only your friends but your doctor as well.  Many are not trained in the science of cannabis and do not realize what studies have already been conducted.  ~ Cherry Girl

Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
Migraine has numerous relationships to endocannabinoid function. Anandamide (AEA) potentiates 5-HT1A and inhibits 5-HT2A receptors supporting therapeutic efficacy in acute and preventive migraine treatment. Cannabinoids also demonstrate dopamine-blocking and anti-inflammatory effects. AEA is tonically active in the periaqueductal gray matter, a migraine generator. THC modulates glutamatergic neurotransmission via NMDA receptors. Fibromyalgia is now conceived as a central sensitization state with secondary hyperalgesia. Cannabinoids have similarly demonstrated the ability to block spinal, peripheral and gastrointestinal mechanisms that promote pain in headache, fibromyalgia, IBS and related disorders. The past and potential clinical utility of cannabis-based medicines in their treatment is discussed, as are further suggestions for experimental investigation of CECD via CSF examination and neuro-imaging.
CONCLUSION:
Migraine, fibromyalgia, IBS and related conditions display common clinical, biochemical and pathophysiological patterns that suggest an underlying clinical endocannabinoid deficiency that may be suitably treated with cannabinoid medicines.
http://www.ncbi.nlm.nih.gov/pubmed/18404144

Cannabis Fluid Extract Recipe 1898

I found this article and had to share…maybe great great grandma had more in common with us than we thought ha ha.  Cannabis has been around for a long time and that is something that CANNOT be said for a lot of legal and illegal drugs. ~ Cherry Girl

Cannabis fluid extract recipe (1898)

King’s American Dispensatory.
by Harvey Wickes Felter, M.D., and John Uri Lloyd, Phr. M., Ph. D., 1898.

Extractum Cannabis Indicae (U. S. P.)—Extract of Indian Cannabis.

Related entry: Cannabis Indica (U. S. P.)—Indian Cannabis – Extracts and Fluid Extracts
Other tomes

SYNONYM: Extract of Indian hemp.

Preparation.—”Indian cannabis, in No. 20 powder, one thousand grammes (1000 Gm.) [2 lbs. av., 3 ozs., 120 grs.]; alcohol, a sufficient quantity. Moisten the powder with three hundred cubic centimeters (300 Cc.) [10 fl, 69] of alcohol, and pack it firmly in a cylindrical percolator; then add enough alcohol to saturate the powder and leave a stratum above it. When the liquid begins to drop from the percolator, close the lower orifice, and, having closely covered the percolator, macerate for 48 hours. Then allow the percolation to proceed, gradually adding alcohol, until the cannabis is exhausted. Distill off the alcohol from the tincture by means of a water-bath, and evaporate the residue in a porcelain capsule, on a water-bath, to a pilular consistence “—(U. S. P.).

Description, Medical Uses, and Dosage.—This forms a dark, dull-green extract, having the well-marked odor of hemp resin, is soluble in strong alcohol, ether, chloroform, olive oil, and oil of turpentine, the latter solution depositing minute, scaly crystals on standing; almost wholly soluble in benzol; not affected by alkalies; and with cold nitric acid, sp. gr. 1.38, it is slowly acted on, evolving red fumes, being converted into an orange-red resinoid substance, about as abundant as the resin treated, and which, when washed with water and dried, resemble minute fragments of gamboge (W. Procter, Jr., Proc. Amer. Pharm. Assoc., 1864, pp. 246-7). Much of the drug, cannabis indica, is moldy, partly decayed, and unfit for use. As a. rule, this extract of cannabis is dull in color, and inferior to the extract purified according to the following method, which yields a deep-green, alcohol-soluble preparation. Uses, those of cannabis. Dose, 1/4 grain, increased gradually until its effects are produced. On account of the variability of the preparation, the dose is not definitely established.

Related Preparation.—The following is Prof. Procter’s method of preparing Purified extract of Indian hemp: EXTRACTUM CANNABIS PURIFICATUM, Extract of Indian hemp, purified.—Take of the green extract of Indian hemp, imported from India, 1 1/2 troy ounces; triturate it thoroughly with alcohol, sp. gr. 0.820, 1 1/2 fluid ounces; and then add to it of the same alcohol, 9 fluid ounces. Let the whole macerate for 36 hours, filter, and, while on the filter, add more alcohol until the extract is thoroughly exhausted. Evaporate the filtrate to dryness in a waterbath, at a temperature not exceeding 65.5° C. (150° F.). The uses are the same as stated under Cannabis. This extract, being purified, and possessing greater uniformity of strength than the ordinary commercial extract, should be administered in somewhat smaller doses. For making chlorodyne, this preparation is to be preferred to the extract made of the herb by the preceding process.

Extractum Cannabis Indicae Fluidum (U. S. P.)—Fluid Extract of Indian Cannabis.

SYNONYM: Fluid extract of Indian hemp.

Preparation.—”Indian cannabis, in No. 20 powder, one thousand grammes (1000 Gm.) [2 lbs. av., 3 ozs., 120 grs.]; alcohol, a sufficient quantity, to make one thousand cubic centimeters (1000 Cc.) [33 fl, 391]. Moisten the powder with three hundred cubic centimeters (300 Cc.) [10 fl, 69] of alcohol, and pack it firmly in a cylindrical percolator; then add enough alcohol to saturate the powder and leave a stratum above it. When the liquid begins to drop from the percolator, close the lower orifice, and, having closely covered the percolator, macerate for 48 hours. Then allow the percolation to proceed, gradually adding alcohol until the Indian cannabis is exhausted. Reserve the first nine hundred cubic centimeters (900 Cc.) [30 fl, 208] of the percolate. Distill off the alcohol from the remainder by means of a water-bath, and evaporate the residue, in a porcelain capsule, to a soft extract; dissolve this in the reserved portion, and add enough alcohol to make the fluid extract measure one thousand cubic centimeters (1000 Cc.) [33 fl, 391]”—(U. S. P.).

Description, Medical Uses, and Dosage.—(See Cannabis). A deep-green fluid. Dose, 1/2 to 10 minims. In our opinion, a fluid extract made by dissolving a given amount of the purified extract of the preceding formula in official alcohol, is to be preferred to the foregoing.

Read more: http://www.drugs-for…3#ixzz1O9diesw5

Thank You

This week it is hard not to think of all the things I am thankful for.  During these hard times when so many things are going on in the world it can be hard to see that ray of sunshine; that something to be thankful for.  Sometimes we get an entire day of sun and sometimes we only get a glimpse but either way it is important to treasure each moment.  Looking back over this year I see all the battles we fought and the progress we have made.  I also see the set backs and the tearful defeats.  Through all that I am thankful that I have found my passion.  Through this new adventure I have met many new friends along the way and strengthened old relationships.  I have found so many new things that have opened up a curiosity and thirst for more knowledge.  I have read countless stories of patient’s battling illnesses and they still shine.  I am thankful that those patients have discovered cannabis and have found a peace from the pain that haunts them.  I am thankful for those angels out there that put themselves on the line for the good of all of us.  For all the men and women  who are diligently working to give us all freedom of choice I am thankful.  For the powerful voice of NORML who tirelessly works to spread the word and to the angles like David Worrell who spreads the truth to all he meets I am thankful.  I am thankful to all my readers who take time to visit.  I hope that during this holiday season we all find that ray of sunshine I wish peace and happiness to all my readers ~ Cherry Girl

Making It A Happy Thanksgiving: How To Cook A Cannabis Thanksgiving Dinner

Happy Thanksgiving to everyone out there.  I hope that everyone is able to be with their family during this holiday season.  I also hope that those that are suffering from a number of different illness also find peace and some relief.  Below you will find a video on how to make cannabutter.  Once you have made that you can turn any recipe into a cannabis infused dish!  Please share these recipes and bring joy to others ~ Cherry Girl

Cannabutter (can be used in any recipe)
http://www.youtube.com/watch?v=M90mAWrI_58
http://www.420magazine.com/forums/420-kitchen/37701-cannabutter-7-easy-steps.html

CannaCandied Yams

Yields about 8 servings.

Ingredients:

* ¼ cup canabutter
* ½ cup light brown sugar
* ¼ cup chopped pecans
* 1 large (40-ounce) cans large yams or sweet potatoes, drained
* 1 teaspoon ground cinnamon
* 1 teaspoon ground nutmeg
* Mini marshmallows for topping

Directions

1. Preheat oven to 325 degrees F
2. In a saucepan, melt pot butter over medium heat. Add brown sugar and pecans, simmering for a few minutes
3. In a large bowl, mash yams with a potato masher until you reach desired consistency.
4. Add sugar/pecan mixture, cinnamon and nutmeg, and mix thoroughly.
5. Transfer yam mixture to a metal pie pan and cover with marshmallows.
6. Bake for 15-20 minutes at 325 degrees F.
7. Remove from the oven and place under the broiler until the marshmallows are lightly browned.

Greenbud Green Bean Casserole

Cooking time 30 mins, Serves 10 – 12

Ingredients:

• 2 cans Condensed Cream of Mushroom Soup
• 1 cup milk (fat free or 2%)
• One onion finely diced
• 2 tablespoons of Cannabutter
• ¼ teaspoon of salt
• 1/4 teaspoon ground black pepper
• 8 cups cooked cut green beans
• 1 cup of French Fried Onions

Directions:

1. Preheat oven to 375 degrees.
2. In a large skillet sauté the chopped onion in a little cannabutter over medium heat for a few minutes until cooked.
3. Stir in the canned mushroom soup, milk, salt and pepper, green beans and 1 table spoon of cannabutter and mix well until its all warmed through.
4. Using the left over cannabutter grease the casserole dish.
5. Transfer to the casserole dish, sprinkle with French Fried Onions and bake for 15 mins or until hot and bubbling.

 Cannabis Pumpkin Pie

Ingredients:

* 1 8-ounce package cream cheese, softened
* 2 cups canned pumpkin, mashed
* 1 cup sugar
* 1/4 teaspoon salt
* 2 eggs, slightly beaten
* 1 cup half-and-half
* 1/3 cup marijuana butter, melted
* 1 tsp vanilla extract
* 1/2 tsp ground cinnamon
* 1/4 tsp ground ginger
* 1/4 tsp nutmeg
* 1 (9-inch) unbaked pastry shell
* Whipped cannabis cream, for topping

Directions:

1. Preheat the oven to 350 degrees F.
2. In a large mixing bowl, beat the cream cheese with a hand mixer. Add the pumpkin and beat until combined.
3. Add the sugar and salt, and beat until combined.
4. Add the eggs, half-and-half, and melted cannabis butter, and beat until combined.
5. Add the vanilla, cinnamon, and ginger, and beat until combined.
6. Pour the filling into the pie crust and bake for 45-50 minutes, or until the center is set.
7. Allow pie to cool to room temperature and top each slice with a generous amount of cannabis whipped cream before serving.

Mary Jane’s Turkey

1 medium-sized (12- to 15-pound) turkey

*1/2 cup marijuana butter

¼ cup chicken broth

1 tablespoon lemon juice

1 teaspoon poultry seasoning

1 teaspoon sweet basil

1 teaspoon thyme leaves

1/2 teaspoon sage

Melt butter in a small saucepan over low heat and blend in remaining ingredients. Stuff turkey or season with salt and pepper, if desired. Make a small incision in skin of turkey, force a finger through the slit and break the contact between the skin and the meat. Using a meat injector, squirt half the butter mixture under the skin. Cook the turkey according to your favorite method, basting with the remaining butter mixture every half hour until done.

Ganja Gravy

Ingredients:

* Turkey, chicken or vegetable stock
* 6 Tbsp cannabutter
* 2 large onions, sliced thin
* 2 Tbsp chopped fresh rosemary
* 2 Tbsp chopped fresh sage
* 1/3 cup flour
* 1/2 cup balsamic vinegar
* Salt and pepper to taste
* ½ cup balsamic vinegar

Directions:

1. In a large skillet, melt canabutter over medium-high heat
2. Add sliced onions and sauté 10 minutes
3. Add rosemary and sage and sauté for 10 minutes
4. Add flour and whisk for 1 minute
5. Gradually whisk in stock and boil until gravy thickens, stirring frequently
6. In the pan that you baked the turkey in, pour the juices from pan into a large cup or bowl and spoon off fat. Add juices to the gravy.
7. Add vinegar to roasting pan. Bring vinegar to simmer over medium heat, scraping up browned bits. Pour mixture into heavy small saucepan.
8. Boil for about 3 minutes and add to gravy.
9. Season with salt and pepper.
10. Optional: If you are not cooking the turkey or are using the juices for a non-medicinal gravy, simply add the vinegar to the gravy and simmer for 10-15 minutes.

Newly Released Studies That Show Medical Value Of Cannabis 2011

As we see this year come to a close it is time to look back over 2011 and view the studies that were released this year that show cannabis to be a treatment option or a cure for an illness.  Please share the truth about cannabis ~ Cherry Girl

Cannabinoid Receptor Type 1 (CB1) Activation Inhibits Small GTPase RhoA Activity and Regulates Motility of Prostate Carcinoma Cells 
Cannabinoid receptor 1 activation stops and controls the growth of prostate cancer cells.

Cannabinoid Receptor 1 Gene is Associated With Alcohol Dependence
Cannabinoid receptor 1 is involved in alcoholism. CB1 is the target for treatment.

CB(1) Receptor Activation Inhibits Neuronal and Astrocytic Intermediary Metabolism in the Rat Hippocampus
In conclusion, CB(1)Rs are able to control hippocampal intermediary metabolism in both neuronal and glial compartments, which suggests new alternative mechanisms by which CB(1)Rs control cell physiology and afford neuroprotection.

Multiple Sclerosis and Cannabis: Finding a Natural Treatment Option

It is estimated that over 400,000 Americans suffer from Multiple sclerosis or MS.  MS is a chronic, often disabling disease that attacks the central nervous system (CNS), which is made up of the brain, spinal cord, and optic nerves. Symptoms may be mild, such as numbness in the limbs, or severe, such as paralysis or loss of vision.

The body’s own defense system attacks myelin, the fatty substance that surrounds and protects the nerve fibers in the central nervous system. The nerve fibers themselves can also be damaged. The damaged myelin forms scar tissue (sclerosis), which gives the disease its name. When any part of the myelin sheath or nerve fiber is damaged or destroyed, nerve impulses traveling to and from the brain and spinal cord are distorted or interrupted, producing the variety of symptoms that can occur.

Below you will see a study relating to cannabis as a therapeutic option for MS.  Please share the truth about the cure ~ Cherry Girl

Cannabinoids For Symptomatic Therapy of Multiple Sclerosis 2011
Treatment of spasticity remains difficult, which has prompted some patients to self-medicate with and perceive benefits from cannabis. Advances in the understanding of cannabinoid biology support these anecdotal observations. Various clinical reports as well as randomized, double-blind, placebo-controlled studies have now demonstrated clinical efficacy of cannabinoids for the treatment of spasticity in MS patients.

Breaking News

The FDA revoked approval of the use of a popular breast cancer drug Avastin.  It was found that Avastin exposed users to potentially harmful side effects such as severe high blood pressure and hemorrhaging.  Even with this news Avastin will remain on the market where Doctors can still prescribe it to breast cancer patients but with the revoking of FDA approval it will likely cost breast cancer patients $88,000 a year which would be too costly for most.
http://www.nytimes.com/2011/11/19/business/fda-revokes-approval-of-avastin-as-breast-cancer-drug.html?_r=1

Shocking news that scientists have caught up with the public they have found merit to medical marijuana.   The Institute of Medicine has published a study stating that they found merit to cannabis.  Just had to share please pass along.  The study is from 1999 so it is curious why the government still claims no medicinal value to cannabis.
IOM finds scientific merit to medical marijuana. Institute of Medicine

New Study Finds Cannabinoids Could Be A Beneficial Treatment Option For Parkinson’s Disease

Brand new science on Parkinson’s Disease Published 2011:

Cannabinoid Receptor Type 1 Protects Nigrostriatal Dopaminergic Neurons against MPTP Neurotoxicity by Inhibiting Microglial Activation
The present in vivo and in vitro findings clearly indicate that the CB(1) receptor possesses anti-inflammatory properties and inhibits microglia-mediated oxidative stress. Our results collectively suggest that the cannabinoid system is beneficial for the treatment of Parkinson’s disease and other disorders associated with neuroinflammation and microglia-derived oxidative damage.
Chung YC, Bok E, Huh SH, Park JY, Yoon SH, Kim SR, Kim YS, Maeng S, Hyun Park S, Jin BK.
SourceDepartment of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 130-701, Korea;

Abstract
This study examined whether the cannabinoid receptor type 1 (CB(1)) receptor contributes to the survival of nigrostriatal dopaminergic (DA) neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease. MPTP induced significant loss of nigrostriatal DA neurons and microglial activation in the substantia nigra (SN), visualized with tyrosine hydroxylase or macrophage Ag complex-1 immunohistochemistry. Real-time PCR, ELISA, Western blotting, and immunohistochemistry disclosed upregulation of proinflammatory cytokines, activation of microglial NADPH oxidase, and subsequent reactive oxygen species production and oxidative damage of DNA and proteins in MPTP-treated SN, resulting in degeneration of DA neurons. Conversely, treatment with nonselective cannabinoid receptor agonists (WIN55,212-2 and HU210) led to increased survival of DA neurons in the SN, their fibers and dopamine levels in the striatum, and improved motor function. This neuroprotection by cannabinoids was accompanied by suppression of NADPH oxidase reactive oxygen species production and reduced expression of proinflammatory cytokines from activated microglia. Interestingly, cannabinoids protected DA neurons against 1-methyl-4-phenyl-pyridinium neurotoxicity in cocultures of mesencephalic neurons and microglia, but not in neuron-enriched mesencephalic cultures devoid of microglia. The observed neuroprotection and inhibition of microglial activation were reversed upon treatment with CB(1) receptor selective antagonists AM251 and/or SR14,716A, confirming the involvement of the CB(1) receptor. The present in vivo and in vitro findings clearly indicate that the CB(1) receptor possesses anti-inflammatory properties and inhibits microglia-mediated oxidative stress. Our results collectively suggest that the cannabinoid system is beneficial for the treatment of Parkinson’s disease and other disorders associated with neuroinflammation and microglia-derived oxidative damage.
http://www.ncbi.nlm.nih.gov/pubmed/22079984

No Connection Found Between Marijuana and Cancer

This was an article I came across about a study done on the association of cannabis and cancer.

The largest study of its kind has unexpectedly concluded that smoking marijuana, even regularly and heavily, does not lead to lung cancer.

The new findings “were against our expectations,” said Donald Tashkin of the University of California at Los Angeles, a pulmonologist who has studied marijuana for 30 years.

“We hypothesized that there would be a positive association between marijuana use and lung cancer, and that the association would be more positive with heavier use,” he said. “What we found instead was no association at all, and even a suggestion of some protective effect.”

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Federal health and drug enforcement officials have widely used Tashkin’s previous work on marijuana to make the case that the drug is dangerous. Tashkin said that while he still believes marijuana is potentially harmful, its cancer-causing effects appear to be of less concern than previously thought.

Earlier work established that marijuana does contain cancer-causing chemicals as potentially harmful as those in tobacco, he said. However, marijuana also contains the chemical THC, which he said may kill aging cells and keep them from becoming cancerous.

Tashkin’s study, funded by the National Institutes of Health’s National Institute on Drug Abuse, involved 1,200 people in Los Angeles who had lung, neck or head cancer and an additional 1,040 people without cancer matched by age, sex and neighborhood.

They were all asked about their lifetime use of marijuana, tobacco and alcohol. The heaviest marijuana smokers had lighted up more than 22,000 times, while moderately heavy usage was defined as smoking 11,000 to 22,000 marijuana cigarettes. Tashkin found that even the very heavy marijuana smokers showed no increased incidence of the three cancers studied.

“This is the largest case-control study ever done, and everyone had to fill out a very extensive questionnaire about marijuana use,” he said. “Bias can creep into any research, but we controlled for as many confounding factors as we could, and so I believe these results have real meaning.”

Tashkin’s group at the David Geffen School of Medicine at UCLA had hypothesized that marijuana would raise the risk of cancer on the basis of earlier small human studies, lab studies of animals, and the fact that marijuana users inhale more deeply and generally hold smoke in their lungs longer than tobacco smokers — exposing them to the dangerous chemicals for a longer time. In addition, Tashkin said, previous studies found that marijuana tar has 50 percent higher concentrations of chemicals linked to cancer than tobacco cigarette tar.

While no association between marijuana smoking and cancer was found, the study findings, presented to the American Thoracic Society International Conference this week, did find a 20-fold increase in lung cancer among people who smoked two or more packs of cigarettes a day.

The study was limited to people younger than 60 because those older than that were generally not exposed to marijuana in their youth, when it is most often tried.

http://www.washingtonpost.com/wp-dyn/content/article/2006/05/25/AR2006052501729.html

Neurodegeneration and Cannabis

Neurodegeneration effects millions of Americans.  Neurodegeneration is a broad term used for the progressive loss of structure or function of neurons, including death of neurons. Many neurodegenerative diseases including Parkinson’s,Alzheimer’s, and Huntington’s occur as a result of neurodegenerative processes.

The Endocannabinoid System in Neuropathological States
Among the group of brain disorders that have been associated with the endocannabinoid system, a special interest in various neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease and ischemia. These three disorders will be reviewed here from the perspective of the types of changes experienced by the cannabinoid signalling in humans and cellular or animal models, and from a possible usefulness of certain cannabinoid compounds to alleviate symptoms and/or to delay their progression.”—In other words: Because of the endocannabinoid system and cannabinoid receptors, cannabinoids could cure neurodegenerative diseases.
http://www.ncbi.nlm.nih.gov/pubmed/19367511

The Endocannabinoid System in Targeting Inflammatory Neurodegenerative Diseases 
Past posts have shown that there are functional cannabinoid receptors in the CNS and that Cannabinoids modulate the endocannabinoid system. This science says: “An early combination of neuroprotective and anti-inflammatory approaches to these disorders seems particularly desirable… We discuss the apparently unique opportunity to modify neurodegeneration and neuroinflammation simultaneously by pharmacological manipulation of the endocannabinoid system in the CNS and in peripheral immune cells.
http://www.ncbi.nlm.nih.gov/pubmed/17350694

Cannabinoid Receptors and Endocannabinoids: Role in Neuroinflammatory and Neurodegenerative Disorders
The receptors for Δ9-tetrahydrocannabinol, the major psychoactive principle of marijuana, are known as cannabinoid receptors of type 1 (CB1) and 2 (CB2) and play important functions in degenerative and inflammatory disorders of the central nervous system. We discuss plasticity of the endocannabinoid system during central nervous system disorders, as well as its dysregulation, both of which have opened the way to the use of either direct and indirect activators or blockers of CB1 and CB2 receptors for the treatment of the symptoms or progression of these diseases.”—Cannabinoids are direct activators and/or blockers of CB1 and CB2.
http://www.ncbi.nlm.nih.gov/pubmed/20632970

The Endocannabinoid System in Neurodegeneration
Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are the best studied endocannabinoids, and act as agonists of cannabinoid receptors. AEA and 2-AG mimic pharmacological effects of the exogenous cannabinoid delta9-tetrahydrocannabinol, the psychoactive principle of marijuana. Together with AEA, 2-AG and congeners, the proteins that bind, transport and metabolize these lipids form the “endocannabinoid system”. This new system will be presented in this review, in order to put in a better perspective the role of the endocannabinoid pathway in neurodegenerative disorders, like Parkinson’s disease, etc… In addition, the exploitation of antagonists of endocannabinoid receptors, or of inhibitors of endocannabinoid metabolism, as next-generation therapeutics will be discussed.
http://www.ncbi.nlm.nih.gov/pubmed/17274532

Cannabinoid Receptor Signalling in Neurodegenerative Diseases: A Potential Role For Membrane Fluidity Disturbance
Endocannabinoids (eCBs)’, belong to an ancient neurosignalling system that plays important functions in neurodegenerative and neuroinflammatory disorders like Alzheimer’s disease, Parkinson’s disease, etc…The results of these investigations might be exploited for the development of novel therapeutics able to combat disorders associated with abnormal activity of CB(1).
http://www.ncbi.nlm.nih.gov/pubmed/21323908

Cannabinoids and Neuroprotection in Motor-Related Disorders 
Neuroprotective properties of cannabinoids have been extensively studied in the last years in different neurodegenerative pathologies.This potential is based on the antioxidant, anti-inflammatory and anti-excitotoxic properties exhibited by these compounds that allow them to afford neuroprotection in different neurodegenerative disorders. In the review, we collect the latest advances in the knowledge of the cellular and molecular mechanisms through which cannabinoids arrest/delay the degeneration of specific neuronal subpopulations in these motor-related disorders. This should serve to encourage that the present promising evidence obtained mainly at the preclinical level might progress to a real exploitation of neuroprotective benefits of cannabinoid-based medicines.
http://www.ncbi.nlm.nih.gov/pubmed/18220777

Take Ownership of Your Body and Your Illness

On Oct 31st it was estimated that the 7 billionth person was born.  In the US the population is around 311 million and the number of doctors is about 661,400.  With that ratio it is not realistic for us to expect our doctor to be an expert on each one of us.  Therefore it is important for us to take ownership of our health and sometimes our illnesses as well.

Our body is something that we should be an expert on.  We should be informed of our illnesses so that we can make informed decisions with our doctors.  We should also be aware of all options for treatments as well.

One controversial treatment is cannabis.  The human body has an Endocannabinoid system that interacts with Cannabinoids found in the cannabis plant.  Cannabinoids have been found in numerous studies to help alleviate symptoms caused by illness or cure them completely. Despite this the US Federal government still denies any medicinal value.

There are several states that have enacted medical marijuana laws that were backed by the people.  California is one of them.  In California you can discuss cannabis as a treatment option with your doctor.  They in turn can write you a recommendation for cannabis which you can then grow or buy at a dispensary.  In any state you can inform your doctor that you are treating your illness with cannabis and have them document your progress. Be sure to weigh the options if your state does not offer protections.

This natural plant has been found to be of use in many ways including being a possible cure for cancer.  With cannabis proving time and again how beneficial it can be it is only a matter of time before America demands a stop to the prohibition of this miracle plant.  This natural medical miracle needs to be free for all people to use not locked into the pharmacutical bureaucratic mess.

My hope with this blog is to bring attention to all the benefits of cannabis.  I hope to show people how cannabis can relate to their disease or life in general.  I believe with education people will start to see the lies and corruption that surround this plant.  Please share the truth about cannabis and feel free to use this information in your fight against cannabis prohibition ~Cherry Girl