Times have changed, Yet some things are still the same….

#DWTS_Tommy_Chong

Tommy’s prison sentence, the result of the War on Drugs.

Tonight I happened to catch a clip of dancing with the stars which featured Tommy Chong.  I was sad to be reminded yet again how much our government that is supposed to be working for the good of the people has actually done to us.  We have two states that have legalized cannabis for recreation use but we still have states where people are being locked up. In states that have legalized for medical use we have patients that are having a hard time accessing medicine while others are facing sanctions and bans at the county and city levels.

California, the first state to legalize, has been one example where county after county fought to ban sales and growth altogether.  Redding in the north part of the state is currently trying to ban the outdoor grows and going so far as to stipulate the type of building, how far from your residence the approved outbuilding can be

and other intrusions.  After so many fought hard to make cannabis available to patients we still see where many are forced to drive hours including experiencing dangerous driving conditions during the winter because of these local bans.

The Federal government has backed down from its hay day of no-knock-raids and busting down doors of cancer patients but we still see families broken and lives shattered because of over zealous local authorities that want to win elections.  We see legal shops set up where adults 21 and over can purchase cannabis for their own personal use but we still see irresponsible behavior solely attributed to cannabis as apposed to the person’s stupidity and lack of experience with cannabis supported with antiquated reefer madness logic of “ban it all”.

2014 has been full of advancements but it is almost over and it will be 15 years into the new millennium, can we say we are making the progress we should be?  Unfortunately we still see too much of the same mentality-harsh punishment-that has been proven to be costly both economically and socially.  Thankfully more people are knowledgeable about the benefits of cannabis and its legalization than ever before.  We have made a lot of strides in understanding the plant and all its compounds in relation to our bodies.  With more and more patients along with cannabis supporters coming forward we are starting to see bigger changes happen.

With elections coming up we all know the spam mail, ads and people accosting us on the street for their causes come with the pumpkin spice season.  While keeping our eye on the larger issues it would be wise to make sure that we are not losing our rights locally.  Tommy Chong, Marc Emery and millions more are a stark reminder of times past and unfortunately for some, present, that we are still not free from the fear of our freedom being taken away.

While we can revel in the success of our victories in some states let us not lose the fire to continue our battle for all to be free.  We cannot live in a world where a person looking death in the face has to worry about being raided and locked up or where people’s lives are destroyed for nothing more than enjoying cannabis.  Our vote is our voice and it is important that we make sure it is heard loud and clear.  Let us make loss of freedom a thing of the past for all.

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Happy 420!

Today as we enjoy the day that people worldwide celebrate cannabis let us not forget how far we have come.  Today is a day to give thanks to so many before us that have given up their freedom and in some cases their life so that we can enjoy the freedoms we do have today.  There are still far too many that are not free and we must not forget how far we still need to go.  But today is a day to just sit back, relax and let the plant work its magic.  Happy 420 to everyone!

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A Happy New Year and A New Beginning

A new year is upon us and with it comes new possibilities. This year we will discover even more miraculous properties of cannabis. From cancers to other ailments we already know the capabilities that cannabinoids possess. We have seen two states move forward beyond medical needs and legalize for recreational use. With that comes the hope that it will make it easier for patients to obtain the necessary strains they require.
We need to keep in mind that it is not simply using cannabis but using it correctly that will achieve desired results. As we have discussed before each strain possess different compounds or cannabinoids. We have already seen 3 strains genetically mapped, discovering a variety of previously unknown compounds and it will be exciting to see more added to the list.
We have seen so many advances in the delivery methods used for patients. We are no longer only left with smoking. For patients there are very real solutions.
We have seen countless stories of patients who were unable to eat, unable to control their shaking or seizures who have taken only a small amount of cannabis and have been able to control their symptoms. We have also seen in studies where cannabis has slowed or stopped cancer growth. It is no longer deniable that cannabis has real medical use.
I am hopeful that with the advancement of Washington and Colorado’s legislation as well as the other states that have set up medical provisions that we will continue to see the path cleared for all states and ultimately all patients to have access to not only cannabis but quality and variety of strains. Individualized care is key and will only come about for the masses if it becomes legally available. We have suffered for too long. We have lost too many loved ones unnecessarily. Now is the time to act! Call, e-mail or write your representatives and urge them to work towards the common goal of providing for all a safe natural alternative to big Pharma’s poison.

Alcoholism Liver Damage and Cannabis: A Natural Way to Heal the Liver

It is estimated that 17.6 million Americans have a problem with Alcohol.  This problem can lead to all sorts of problems with work, family and friends just to name a few.  One side effect of alcohol is liver damage.  Alcohol can damage or destroy liver cells.  Scientists have been hard at work looking for ways to repair liver cells.  Below you will find studies involving cannabis and the liver.  Please feel free to share the TRUTH ~ Cherry Girl

Alcohol and Substance Abuse (Background On Liver Damage)
Alcoholic liver disease is an important cause of cirrhosis, liver-associated death, and need for liver transplant. Up to 50% of recipients use some alcohol, and perhaps 10% drink addictively. Careful evaluation by an addiction medicine specialist is the best predictive instrument before transplant surgery, whereas the 6-month rule lacks sensitivity and specificity. Addictive drinking, but not minor slips, is associated with increased mortality. There is no standard therapy for alcoholism in alcoholics waiting for a transplant or for those who have undergone a transplant. Stably abstinent, methadone-maintained opiate-dependent patients should continue methadone; are generally good candidates for liver transplant; and show low relapse rates. Pre- and post-transplant smoking rates are high and cause significant morbidity and mortality. Transplant teams should encourage smoking cessation treatments. Marijuana use in liver transplant recipients is common, although risks associated with this practice are unknown.

Hyperactivation of Anandamide Synthesis and Regulation of Cell-Cycle Progression Via Cannabinoid Type 1 (CB1) Receptors In the Regenerating Liver
The mammalian liver regenerates upon tissue loss… Endocannabinoids acting via cannabinoid type 1 receptors (CB(1)R) promote neural progenitor cell proliferation, and in the liver they promote lipogenesis. These findings suggest the involvement of CB(1)R in the control of liver regeneration.”

The Endocannabinoid System As A Key Mediator During Liver Diseases: New Insights and Therapeutic Openings
Cannabinoid receptor 1 (CB(1)) receptors have been implicated in the pathogenesis of several lesions such as alcoholic and metabolic steatosis, liver fibrogenesis, or circulatory failure associated with cirrhosis. data obtained with peripherally restricted CB(1) antagonists give real hopes in the development of active CB(1) molecules devoid of central adverse effects. CB(2) -selective molecules may also offer novel perspectives for the treatment of liver diseases, and their clinical development is clearly awaited. Whether combined treatment with a peripherally restricted CB(1) antagonist and a CB(2) agonist might result in an increased therapeutic potential will warrant further investigation.”

Beneficial Paracrine Effects of Cannabinoid Receptor 2 On Liver Injury and Regeneration
‎”Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration…CB2 receptors reduce liver injury and promote liver regeneration following acute insult, via distinct paracrine mechanisms involving hepatic myofibroblasts. These results suggest that CB2 agonists display potent hepatoprotective (protects liver) properties, in addition to their antifibrogenic effects.”

Cannabinoid CB2 Receptors Protect Against Alcoholic Liver Disease By Regulating Kupffer Cell Polarization In Mice.
‎”Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice…These data identify CB2 agonists as potential therapeutic agents for the management of alcoholic liver disease.”

Annabinoids and Capsaicin Improve Liver Function Following Thioacetamide-Induced Acute Injury In Mice
‎”We have shown the beneficial effects of cannabinoids in a murine model of hepatic encephalopathy following thioacetamide and now report their effects on the liver injury.The similar pattern found between the effect of cannabinoids and their antagonists on brain and liver indicated that the therapeutic effect might be directed by the improvement in both organs through CB2 receptors and/or TRPV1 receptors. Modulation of these systems may have therapeutic potential.”

Becky’s Story

It started out as coming home from Calif. as my kids were grown and I was sick. I had done Infer-on treatments twice, once with UNC Clinical trial then in Calif. I did 54 weeks started in 2010. It about killed my mind, body and soul. Luckily being Calif. it was no problem smoking or eating the Cannabis. I ended up on IV’s fluids for almost 4 yrs. most were in an infusion center at our local Hospital in Calif. I remember my nurse Abby well. Spent Christmas eve, New years Eve together. My Belly had been scarred bad. I couldn’t drink water for years. We drove me back in my rig in 09. My father had a set up for me to finally relax and heal me. Landed in the hospital 5 hours from home bad angina attack. Finally made it here on April 19th 2009. I even had to leave my 17 yr. Homecoming Queen, I missed so much. Cancer struck my Father Sam Haines Ret. Navy, Magna Cum Laude Honor Student Psychology, Master Gardner, Herbologist, and many other things a few months later. He always said the absetos from the Subs. would take him out. He didn’t want money for that, I respect it. He loved his USA. We lost him 3 months after I came home. A few months later I felt a sharp pain in my left lower belly it took me to the ER 24 hrs. later. Was the first time I had ever heard the word Cancer for me. It was a mass about the size of an Apple on my left Ovary. Six weeks later it had grown to 2 lbs. Took blood no Ovarian Cancer I was found, my OB did some major surgery to remove it and other organs. I woke up hearing it was bad, rare they had to send it to Duke the pathology. That is where my night mare begin as I was pretty much on my own here.
Came home, paid someone to bring me with 34 staples in my gut and a backed up septic tank, still have leach line issues. 3 weeks later I finally get a call. Musinous Adenocarcinoma 2 lb. Mass and Unknown Primary. Very Rare only 600 cases in the States a year. I found only 2 hospitals treated this one in San Diego and Wake Forest. Thought I was in, emailed Dr. Levine my Pathology, he quickly replied stated yes they do treat it, not mine, I was co-morbid. A term for med-care. If a person has 2 or more chronic conditions they won’t put the money in them. The Surgery was called MOAS a 23 hr. surgery cutting out 1/2 colon, 1/2 intestines and all lump nodes appendix and also HEPIC chemo. where they run warm chemo. in your guts sew you up and leave it for a few hrs. this giving me maybe 5 yrs to live. Duke jumped in, it was my CEA’s that were elevated the marker for Colon Cancer. Did a round, it about killed of Taxol. I lost my in home care I had since 2001 to the NC’s health plan. I did eat cannabis and smoke the whole time during the chemo. I could eat a chili dog had weird cravings while others were puking. Did have the water issue and my belly I had to look out for dehydration, I don’t think right when it happens those around me have signs. It didn’t get caught quite a few times, once I laid in my bed devacating on myself for 5 days, had Kloe looking out the window , I remember I thought it was snowing and no one could see us in here dying, wow. Sad looking back. My family tried , came in washed me up, bless their hearts. at one tine I even told Sam to get Kloe she had been eating chemo and was glowing green, he did it. I can give instructions. We got through it.
I had researched the Cannabis Oil as a cure, I believe in our science of Plants and it has always been a big part of my life, my father shared the history and health with me. Many other things but that is another story, If I remember right he was one of the Original ones in the first NORML he believed it should have been free, he fought for it. I’m no activist always;ys felt it was a gift to us, I choose to live off Grid I’ll get there again. I lost that in 99 due to Hurricane Floyd the flood. The oil I knew it would work, my children they only science they believed in was mans, I was forced into the chemo. it did no good on the numbers came back a tad more elevated. I did a search of the property as Dad told me he had material for bakeables wow was I surprised there was my oil meds. He had grew it he was going to compost, I told him to save it til I got back there ..lol..I guess it was part of my inheritence. Some one showed up from NCCPN she runs a differnt one now CCC I believe. Spent the first 3 months in a good Cannabis coma almost finally had a little help to feed me, I could rest, Rick Said that for it to work I must rest. I gave in. I have a list of 20 Chronic Conditions I have been pinned with. I knew the endocanabonoid system but had no idea I could feel this dang good.
Within 6 weeks I could tell a difference in my eating and resting I was able to shower again on a regular basis eating well. I took a lot of oil! Tumors started leaving I had nodules unknown stuff in my lungs they cleared. The drs. were amazed as we sat there and giggled they were lost to this science, I told them the whole time what I was doing, we preached Cannabis at Duke, eating my little green cookies everywhere . Around 6 months ago I had been studying food a long time, believe in our organics was almost there once, then got sick. I started this little crazy diet a friend mentioned also tips from my friend Tamara she cleared her Cancer through foods just wrote a book the fist print sold out, Alternative Health Solutions. I’ll post a link with this. 12 colors a day, it was simple to me, I needed simplicity. Lost so much, reading, writing, seeing, driving, etc. The GMOs are killing us also, I hope to climate all one day, also I’ll wear only hemp once I can shop for my clothes again, using 7th generation Baby products for the skin and clothes washing, dish washing all natural stuff. There were so many scripts I had been on since the Interferon treatment. I was ready for the pills to be gone too. I became quiet good at the oil , good shit, I jacked up my dose to detox off this stuff processed foods and the rest of the meds. I was on. I didn’t think I had to tell anyone what I was doing, it was my world here. The family reacted quite different to the natural healing. They had never heard me talk about Jesus before, I dig him. What happened to my health is short of a miracle all conditions cleared, Cancer, Fibro. Chronic Pain, Fatique, high blood pressure, high sugar, Epstien Barre, angina, spastic esophagus, chronic thrush had took my taste, also candida bad on my skin, Ptsd, Anxiety, Hyper-activity I’ll get that list there are more, even have chronic marijuana abuse, I’ll keep that one. There are 2 pills I have to take, I tested it, for hyperprotienlypidemia 4, a genetic blood disorder. The only meds .I will take, or my trich
Around 2 months ago I stepped out in our World, got my hair done, new clothes, the bloat from treatments just fell off with the oil like magic! I had no idea what would come of me coming out of this Corporate Greed. I ended up with an infection, it started a change for me with our local Hospital who I had standing orders for fluids at. I usually carry a book so they can see my condition if they can’t understand me, I come around after a bag or 2. I said ” I’m not from around here, I need fluids my family has sucked me dry.” Next thing I know I was being stripped of clothes and rights, the infection or fluids not treated. They shot me up with dope and knocked me out. I awoke in what they call here the observatory, wow, worse then jail, been there one night..lol. they see if you need to be in psych. took me 2 days to get my I rights back. I cleared the infection with the veggies and water brought to me in there I made them wait on my ass hand and foot, since they had me. I had to take a drug called Septra for Schizophrenia and shut up for 3 hrs before they let me out the door I conformed. I knew an injustice had been done I was going to let it go, but they got me again.
On Dec. 2nd, my daughter, she got worried, so was I. I had did so much of my oil i need to get some more done, no one understood what I was up against, I didn’t feel I had to explain myself as long as I was getting better. The Fytanal patches, celexa they gave me for crying during chemo. , the lortabs, Valiums I was ready to get them out of my system for good. I don’t need a pain pill today for the fibromyalgia. i did show my ass, I can’t rest with knots in my gut, things I need to get out with the family and community, no one fully understand how close I’ve been to death quite many times done with that shit. Autumn hadn’t seen me since we got me thru the chemo. Placed a 911 call to my ass to check on my welfare. I was already set and at the beach with my stuff getting ready to rent a place and relax a month, yes they found me there too 4 cops and ambulance pulled in the yard. The law can do that if they feel you have a mental heath, Holistic healing is not heard here, hardly. I told that Dr. Hussini, I had stepped out of the medical society I only suffer from PTSD as far as my head is concerned. He told me I could no step out of their system. watch me.
I’m really grasping what happened next. I’ll go into more detail later but it still hurts as I saw so much brutality. I was driven and handed over to the the psych. ward. 6 cops and 2 attented to tie me down in a seclusion room and shoot me up with drugs. This went on till the 20 of Dec. I fought that stuff hard. I would no conform. I wore my Army Creed shirt, taught everyone to say Pledge allienge I had to draw it out. Talked about the Cannabis the medical bill, they lock folks in our county up if they have a narcotic benzo or cannabis in your system and dry you out. When I left there the recovery counselor who was tough..lo. I heard tell our people yes smoke a joint, its ok, That felt good, things did change up there. I did finally conform as I wasn’t going to get out, took their drugs and the lituim this time they said I was bi-polar. no labels here, a little eccentric they thought I had grandiose ideas, which I don’t think anything is impossible. We are going to free our weed in the South. I feel it. I had to eat their foods, made me sick, sleep so many hours, I’m on my own schedule is my right. I have been court ordered to take the meds. After my release 2 days later I went back. I wanted them not to keep me on those drugs, I was able to release with my signature that Observatory on the 23rd of this month with my own signature yes. I won that mess. I do feel that the Hospital will be in my lawsuit pending the county. Here is what happened while I was away from my home.
Since I wasn’t home they bursted right in my door. I don’t worry about my cannabis here, or my guns or anything for that matter I did nothing wrong. I had my Christmas weed out, maybe 10 grams, I had left buckets soaking in the bathroom, the didn’t mess with that, they were kind of freaked on my big vial of left over oil. It was empty. Many drugs in the house, a grow room my dad grew veggies in, many guns, I had my tax money put up , they took all my stuff while they figured out I was no harm to a soul not a grower or dealer of any kind. Robeson here wants this Cannabis free, its taking up their courts and recovery for the real addicts and Alcoholics. We had yet to clean out my house from all the scripts. As I sit now I’m ok with what it took to get me here. I gotta go to court to get my stuff back my guns and money. My cable which was my connection to the world all cut turned off someone didn’t pay my bills, I came home to my car egged with my own eggs, inside and out that one bit I know who did it. My dang Kloe, I lost her, 2 of my hens, I’ve been having to be on-line outside I have enjoyed the freedom.
I’d like to get the ball started rolling on education here , in my side of the State 75% are stil without internet. We have to get something to them. I was going to front this part my self financially I had 2 land sales going on. I lost them both with my phone. HB 577 needs to be in every ones face if its going to pass in a year. It should have already been 3 years ago. I have been begging for help. We are going to run a fund for now. I’m putting in about my last 100 bucks to get it rolling. That way I can get the printed material they have been begging for in their hands at least in my county Columbus and Brunswick any others can contact me. I hope to have a link for those pamphlets soon. I can’t create them on my puter don’t have the program but have help for that once I get or info. more narrow down, Also putting in about those foods and gmos just a little ed. its not available here. Very sweet runs thru veins here, dying of Cancer all over the place Genocide is what I call it. I’m leaving on that one. Have a Bless day. Peace be with you all. yes, my medicine, my Cannabis OIL! I had enough to last me for a year, til it was free to grown my own weed! My friend Donnie destroyed all for my protection. Dang, I feel I may could have beat the case and won that shit back. Out of my hands I’m ok. The foods and I smoke and eat my cookies still. Spaz is a nervous little thing she suffers from PTSD also. Do be careful with that watched a video last night out of Co. they are rushing knocked out stoned dogs to the Vets.
Magic Carpet Ride
http://www.youtube.com

May They All Rest In Peace.

The world collectively felt a pain in their heart.  That moment when time stops for the moment is too overwhelming to comprehend. Where your mind swirls losing touch with the world only to be quickly sucked back to the reality of the gaping hole in our lives. To know that innocence was taken from us. To know that bright smiles and the rosy cheeks that were lovingly held in their mother’s hands will not be in their beds tonight. No gleeful screams of delight on Christmas morning as they jump out of bed rushing to see what Santa brought them. This Christmas we should take a moment for the little ones who will not be with us and the heroes who gave their life so that others could live. Let us focus on the important things in life rather than materials. Let us remember the names of the victims and forget that of the monster’s. 

You Will Be Missed

On Wed Nov 14th we lost a little boy who gave many hope and inspired the world. Cashy beat cancer two times but the third time it came back too aggressively. Cashy and his family became widely know when the Hyde’s started treating their toddler son with cannabis oil through his feeding tube. Soon Cashy started bouncing back to life and actually having an appetite. The case was widely watched and discussed. The Hyde family has bought a humanity to the discussion of what should be allowed to be a private choice. Cashy has forever left his mark on the world and our hearts. Though most did not have the privilege of meeting Cashy we were all behind him cheering him on. May we never forget his valiant fight nor the Hyde family who had to make an unimaginable decision to break the law or save their son. May we not give up the fight for legalization until all are freely able to make that personal choice without fear nor concern.
May you rest in peace little buddy you will be missed! ONE LOVE

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Cannabis Less Harmful Than Current Drug Therapies?

Many when faced with a serious illness fight for their life but ironically are prescribed medications that in fact not only cause harm but also are capable of taking their life.  Many prescription side effects are quite lengthy.  Those that are on prescriptions long-term end up requiring even more medication down the line to combat the side effects from the first drug.  With all that in mind patients are looking for a safer alternative solution.

From cancers to anxiety many prescribed therapies are not only dangerous but can cause death.  Chemotherapy has come a long way from the early days but it is still a drug that ravages the body.  By contrast research has shown that cannabinoid therapies induce programmed cell death in cancerous cells.  Cannabinoids as is widely known are praised for their ability to alleviate without any reported deaths throughout its historic, several thousand year use.

Although the official stance from the government is that cannabis has no accepted medical value science tells us otherwise.  Below you will see a study that weighs the harm of accepted drug therapies such as opioids.  As always I encourage all to do their own research and please feel free to share ~ Cherry Girl

Prescribing Cannabis For Harm Reduction 2012
Neuropathic pain affects between 5% and 10% of the US population and can be refractory to treatment. Opioids may be recommended as a second-line pharmacotherapy but have risks including overdose and death. Cannabis has been shown to be effective for treating nerve pain without the risk of fatal poisoning. The author suggests that physicians who treat neuropathic pain with opioids should evaluate their patients for a trial of cannabis and prescribe it when appropriate prior to using opioids. This harm reduction strategy may reduce the morbidity and mortality rates associated with prescription pain medications.

Cannabis Kicking Breast Cancer’s Ass

Understanding how cannabis therapy relates to your disease can be very daunting.  Our knowledge of breast cancer is actually quite expansive but we are still in the infancy of fully understanding why and how it grows as well as how we can cure or prevent it.  Breast cancer is widely researched from private enterprises to corporations and non-profits.  We see and hear about it all the time and know that billions are spent funding the research.  Cannabis therapy has been one such subject.  We know that cannabis has a wide range of uses medicinally.

Breast cancer has been studied in regards to the actual cancer cells being treated with cannabinoids.  When looking at most cannabis research you will notice it is not just cannabis as a whole but specific compounds found within certain cannabis strains.  This is important to remember when trying to use cannabis on your illness or affliction.  Finding the right strain that contains the right compounds is what will bring the desired effects.  Cannabinoids have been found to have anti-cancer properties.  Science has found that cannabinoids target cancer cells and induce cell death.  This is exciting news as current therapies are equivilant to a carpet bomb destroying more than just cancer cells and notorious for leaving behind a shell of a person.

Many in that situation have turned to cannabis to relieve the constant nausea and pain associated with cancer and current therapies.  Cannabinoids on the other hand have been found to actually protect and repair the body as well as destroy cancer cells.  Our system naturally works well with cannabis.  Our endocannabinoid system was discovered in the 60s and since then science has been trying to figure out how to use that system to help cure diseases.

Below you will see studies that show how breast cancer cells are targeted using the the endocannabinoid system specifically receptors and cannabis compounds.  A few are for background on how they relate.  As always I encourage all to do their own research as well and discuss all options with their doctor.  Cannabis therapies have developed beyond smoke and now include tinctures, honey, oils, topical ointments, edibles, Rick Simpson Method Oil, capsules and many more.  Please feel free to share ~ Cherry Girl

Pathways Mediating the Effects of Cannabidiol on the Reduction of Breast Cancer Cell Proliferation, Invasion, and Metastasis – 2011
Invasion and metastasis of aggressive breast cancer cells are the final and fatal steps during cancer progression. Clinically, there are still limited therapeutic interventions for aggressive and metastatic breast cancers available.   We previously reported that cannabidiol (CBD), a cannabinoid with a low toxicity profile, down-regulated Id-1 gene expression in aggressive human breast cancer cells in culture. Using cell proliferation and invasion assays, cell flow cytometry to examine cell cycle and the formation of reactive oxygen species, and Western analysis, we determined pathways leading to the down-regulation of Id-1 expression by CBD and consequently to the inhibition of the proliferative and invasive phenotype of human breast cancer cells.  The results have the potential to lead to the development of novel non-toxic compounds for the treatment of breast cancer metastasis…..

Role of Id-2 in the Maintenance of a Differentiated and Noninvasive Phenotype in Breast Cancer Cells
Id proteins are inhibitors of basic helix-loop-helix transcription factors and generally stimulate cell proliferation and inhibit differentiation.  We also show that Id-2 expression is inversely correlated with the rate of proliferation in murine mammary epithelial cells and that Id-2 is expressed at a higher level in differentiated human breast cancer cells in comparison with very aggressive and metastatic cells.

The Multiple Roles of Id-1 in Cancer Progression
Id-1 (Inhibitor of differentiation/DNA binding) is a member of the helix-loop-helix protein family expressed in actively proliferating cells.  A close association between Id-1 expression and angiogenesis has also been demonstrated recently in both normal and cancer cells. Accordingly, in prostate cancer cells, expression of Id-1 was able to activate EGF-R and nuclear factor-kappaB activities and resulted in progression to androgen independence. In addition, in both nasopharyngeal carcinoma and prostate cancer cells, Id-1 expression was found to protect the cells from chemotherapeutic drug-induced apoptosis(programmed cell death)…

Cannabidiol As A Novel Inhibitor of Id-1 Gene Expression In Aggressive Breast Cancer Cells
Invasion and metastasis of aggressive breast cancer cells is the final and fatal step during cancer progression, and is the least understood genetically. Clinically, there are still limited therapeutic interventions for aggressive and metastatic breast cancers available.  The CBD concentrations effective at inhibiting Id-1 expression correlated with those used to inhibit the proliferative and invasive phenotype of breast cancer cells. CBD was able to inhibit Id-1 expression at the mRNA and protein level in a concentration-dependent fashion. These effects seemed to occur as the result of an inhibition of the Id-1 gene at the promoter level. Importantly, CBD did not inhibit invasiveness in cells that ectopically expressed Id-1. In conclusion, CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells…..

Id-1 As A Molecular Target In Therapy For Breast Cancer Cell Invasion and Metastasis
Mammary epithelial cells constitutively expressing Id-1 protein are unable to differentiate, acquire the ability to proliferate, and invade the extracellular matrix.  We demonstrate significant reduction of both Id-1 and MT1-MMP expressions as well as the metastatic spread of 4T1 breast cancer cells in syngeneic BALB/c mice. In conclusion, our studies have identified Id-1 as a critical regulator of breast cancer progression and suggest the feasibility of developing novel therapeutic approaches to target Id-1 expression to reduce breast cancer metastasis in humans…..

Inhibition of Tumor Angiogenesis By Cannabinoids
Inhibition of tumor angiogenesis may allow new strategies for the design of cannabinoid-based antitumoral therapies” and “The non-psychoactive cannabinoid….

Cannabidiol Inhibits Angiogenesis By Multiple Mechanisms
Several studies demonstrated anti-proliferative and pro-apoptotic actions of cannabinoids on several tumours, together with their anti-angiogenic properties.

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U.S. Government Destroying History: Why We Must Save Cannabis Plant Genetics From Extinction

Strains such as Kush have been made notorious through songs and celebrities professing their love for the strain.  Those that have experienced Kush know why it is so famous.  From Tahoe OG Kush to Afghan Kush the high is memorable.  Cannabis is not a new plant created in a lab but rather has been used for centuries as medicine, religious herb and for recreation.  Research proves more every day how vital plant genetics are in finding the right compounds to combat illnesses and find cures.  Genetics is something that isn’t often thought of when discussing the War on Drugs but it has definitely been affected by it.

Some cannabis genetics are thought to have come from Providences in China and spread throughout the Silk Road while others originate in the Middle East.  There of course was the large movement through the 60s and 70s that helped spread and create new cannabis strains through people exchanging seeds and ganja.

With new genetics infiltrating the gene pool in the States new plant strains emerged.  Hybrids also came out of the mix.  People discovered that by crossing different strains they could breed out the undesirable traits while promoting higher potency and better growth stamina.  By cross breeding not only Indica with Indica but breeding for balance we have seen hybrid strains that have the pain relief of an Indica but with the “upper” functioning high of a Sativa.  Genetics play a role in growth, mold/pest resistance and of course potency.  

Blueberry strains are known for their social anxiety and pain relief as well as helping with digestive disorders and have spawned notorious strains like Blue Cheese, Blue Dream, Old-Time Moonshine and Blue Haze .  DJ Short created the Blueberry strain by crossing his Afghani Indica, brought by some growers from California and his Purple Thai.  The female pedigree of his Purple Thai is his highly potent all-around champion, “Juicy Fruit” Highland Thai female. It packed a very sweet tropical punch and an intense high that lasted for many hours. The second plant was a Purple Thai out of Oregon, Ohio. This plant was a cross between an outstanding Highland Oaxaca Gold and a very freaky Chocolate Thai. The hybrid was very dark colored and would express a deep royal purple color at the slightest exposure to cold. The finished product was equally tasty and strong as the Juicy Fruit female.

The War on Drugs forced cannabis use underground.  Cannabis began being bred for bag appeal and what would bring the best sales.  Growers began looking for traits that would bring the biggest yield with the shortest flowering time.  Medicinal qualities were disregarded.    For decades it was thought that the compound THC was responsible for all of the effects cannabis provided.  We now know of CBD which is actually responsible for pain relief and has been found to help with insomnia, anxiety and Alzheimer’s.  CBD was another casualty of the war with most of today’s strains registering less than 0.5%.  With the War on Drugs ongoing for over 40 years countless plants have been destroyed with the government’s actions forever destroying precious genetics.

Although cannabis has been around for thousands of years it wasn’t until the summer of 2011 that the genetics of the cannabis Sativa and Indica were mapped.  We know that there are hundreds of strains that have come from the original heirloom landraces.  Today many patients and citizens alike have the option of what type of relief or high they are looking for.  From the euphoric highs of the Sativa to the amazing pain relief that Indicas bring the options are endless.

Everyday we have new research that is released that shows the anti-cancer properties of cannabinoids.  Now more than ever we understand why we need to preserve the genetics of all cannabis plants.  We know that we can use different strains to treat a wide range of illnesses and afflictions.  We also know that cannabis is not a one-size-fits-all type of plant.  You need to have the correct strain containing the right balance of compounds to reach the desired effects.

We have more proof than we have ever had before showing the medical benefits even on a molecular level.  We are beyond smoke when taking about cannabis therapies.  There are a wide range of options when talking about uses.  Tinctures, edibles, concentrates, oils, topical lotion, capsules, vaporizers and more.

Support is at an historic high with medical use over 75% and legalization for adults over 21 at 50%.  States that have enacted decriminalization have found favorable outcomes.  States that have enacted medical statues have found large increases in tax income as well as economic growth in the communities.

If cannabis is allowed to thrive imagine the possibilities.  Imagine 5, 10, 15 years from now how much we will know about genetics, compounds and treatments for cancers.  Imagine all the possibilities if we could openly and safely exchange genetics and end products.  How many people could find relief?  How many could save their life?

It is time that we stand up and protect cannabis genetics.  We need to stop the violent raids by government officials.  The government needs to change their stance on cannabis therapies.  Now more than ever it is time we stop the continual attacks on patients, crops and our heritage.  The War on Drugs needs to end.  It has been a failed war for over 40 years that has forever changed the history of cannabis.  Those that have kept cannabis genetics alive even in the face of persecution and imprisonment thus passing down history should be celebrated.  Urge your representative today to show support for ending the failed approach to dealing with cannabis.

Ganja For Your Guts: How Cannabis Can Help IBS

No one likes dealing with an upset stomach from taco night.  Those with Irritable Bowel Syndrome or IBS deal with those symptoms and more on a frequent basis.  It is estimated that 20% of the U.S. population has IBS.  It is no wonder then why scientists would be hard at work looking for a cure.  We are seeing more and more research targeting the human Endocannabinoid system to treat illnesses.  IBS is no exception.  Below you will see studies where science has researched the role of the Endocannabinoid system with IBS and how cannabis therapy could help patients.  As always I encourage all to do their own research and please feel free to share ~ Cherry Girl

The Role of the Endocannabinoid System in the Pathophysiology and Treatment of Irritable Bowel Syndrome
Activation of cannabinoid (CB)(1) and CB(2) receptors under various circumstances reduces motility, limits secretion and decreases hypersensitivity in the gut. Drugs that alter the levels of endocannabinoids in the gut also reduce motility and attenuate inflammation. In this review, we discuss the role of the endocannabinoid system in gastrointestinal physiology. We go on to consider the involvement of the endocannabinoid system in the context of symptoms associated with IBS and a possible role of this system in the pathophysiology and treatment of IBS.

Clinical Endocannabinoid Deficiency (CECD): Can This Concept Explain Therapeutic Benefits of Cannabis In Migraine, Fibromyalgia, Irritable Bowel Syndrome and Other Treatment-Resistant Conditions?
THC modulates glutamatergic neurotransmission via NMDA receptors. Fibromyalgia is now conceived as a central sensitization state with secondary hyperalgesia. Cannabinoids have similarly demonstrated the ability to block spinal, peripheral and gastrointestinal mechanisms that promote pain in headache, fibromyalgia, IBS and related disorders. The past and potential clinical utility of cannabis-based medicines in their treatment is discussed, as are further suggestions for experimental investigation of CECD via CSF examination and neuro-imaging.

Cannabinoids For Gastrointestinal Diseases: Potential Therapeutic Applications
A pharmacological modulation of the endogenous cannabinoid system could provide new therapeutics for the treatment of a number of gastrointestinal diseases, including nausea and vomiting, gastric ulcers, irritable bowel syndrome, Crohn’s disease, secretory diarrhoea, paralytic ileus and gastroesophageal reflux disease. Some cannabinoids are already in use clinically, for example, nabilone and delta(9)-tetrahydrocannabinol are used as antiemetics.

Cannabinoids and Gastrointestinal Motility: Animal and Human Studies
Activation of prejunctional CB1 receptors reduces excitatory enteric transmission (mainly cholinergic transmission) in different regions of the gastrointestinal tract. Consistently, in vivo studies have shown that cannabinoids reduce gastrointestinal transit in rodents through activation of CB1, but not CB2, receptors. However, in pathophysiological states, both CB1 and CB2 receptors could reduce the increase of intestinal motility induced by inflammatory stimuli. Cannabinoids also reduce gastrointestinal motility in randomized clinical trials. Overall, modulation of the gut endogenous cannabinoid system may provide a useful therapeutic target for disorders of gastrointestinal motility.

Alternative Targets Within the Endocannabinoid System for Future Treatment of Gastrointestinal Diseases
Of major therapeutic interest are nonpsychoactive cannabinoids or compounds that do not directly target cannabinoid receptors but still possess cannabinoid-like properties. Drugs that inhibit endocannabinoid degradation and raise the level of endocannabinoids are becoming increasingly promising alternative therapeutic tools to manipulate the ECS.

Irritable Bowel Syndrome: A Dysfunction of the Endocannabinoid System?

Cannabis, Cancer And Children:Why We Must Give Parents A Choice

There is something special about children that brings a smile.  Some parents wait a long time to be able to have that special time to cradle their child, gazing into their eyes.  Imagine being the parents faced with the reality that your child has cancer.  For over 10,000 parents each year that is the case.  Vigilantly staying by their child’s side through countless shots, painful procedures, body wrenching medications and worst of all watching as their child withers away before their eyes.  The spark slowly going out leaving behind a weak body.  Most would try anything to save their baby.  

Current therapies  such as chemotherapy are not precise measures.  Rates of success in comparisson with side effects make some wonder why alternatives are being stifled.    In contrast there is mounting evidence of the anti-tumor effects of cannabis compounds.  Cannabis has been praised for its large window of error since cannabis does not cause death.

Most in the cannabis community know who Cashy Hyde is.  He is the little boy who’s father treated him with cannabis oil and who today is cancer free.  Cashy has undergone extensive treatments that ravaged his tiny body.  His father watched as the light faded and decided to save his son.  He fed Cashy Rick Simpson Method Cannabis Oil through his feeding tube and miraculously watched his son bounce back to life.  Within days they noticed a difference.

Cashy is not alone.  There are millions of others that have been helped and cured with cannabis.  The discussion of cannabis is beyond smoke.  Cannabis research has shown that by targeting the Endocannabinoid system with the right combinations of compounds you will receive the desired effects including inducing cell death in cancer.

With so much more scientific medical research as proof the majority of the country is asking why we still pursue prohibition with a vengeance.  California has been helping patients since 1996.  Last year we saw a flood of stories where federal agencies terrorized local communities with their SWAT style raids.  In doing so they cut off supply of much needed medicine for patients just like Cashy.

We must do something to give parents an option to save their children.  When parents are told there is nothing more that can be done should we really take away hope.  Should we incarcerate parents for possessing a plant, one that science proves is lifesaving?  We need to bring sanity back into the equation.  We must change the laws.  Me must challenge the “way its always been”.  It is time to allow parents the right to decide for their children.  Several states have proposed or pending legislation.  Contact your state representatives and urge them to help change the future for our children.

Newly Released Studies Show Protection and Regeneration of Brain Cells with Cannabis Therapies

There are over 1.7 million cases of severe brain injury that are reported each year.  These injuries can be life altering for many but thanks to the hard work from the science and medical communities we are learning more about new treatment options.  Cannabis has been discovered to help with cell regeneration and repair in the brain.  Below you will see newly published studies where  cannabis has been applied to help with brain injuries. Truly exciting!!   As always I encourage all to do their own research as well and please feel free to share ~ Cherry Girl

Early Survival of Comatose Patients After Severe Traumatic Brain Injury With the Dual Cannabinoid CB1/CB2 Receptor Agonist KN38-7271
Despite many drug trials, no substance has yet been identified that improves the outcome of severe head injury. The dual cannabinoid CB1/CB2 receptor agonist KN38-7271 mediates potent neuroprotection in animal models. We describe here the first randomized, double-blind, prospective, placebo-controlled clinical phase IIa proof-of-concept trial to investigate the safety, pharmacokinetics, and potential efficacy of a cannabinoid receptor agonist in humans.  Conclusions KN38-7271 appeared beneficial in the acute early phase of the comatose patient after a head injury. Its use was safe and well tolerated by patients.

Cannabinoids As Neuroprotective Agents In Traumatic Brain Injury
Cannabinoids of all classes have the ability to protect neurons from a variety of insults that are believed to underlie delayed neuronal death after traumatic brain injury (TBI), including excitotoxicity, calcium influx, free radical formation and neuroinflammation.

Cannabidiol Administration After Hypoxia-Ischemia To Newborn Rats Reduces Long-Term Brain Injury and Restores Neurobehavioral Function 2012
Cannabidiol (CBD) demonstrated short-term neuroprotective effects in the immature brain following hypoxia-ischemia (HI).   In conclusion, CBD administration after HI injury to newborn rats led to long-lasting neuroprotection, with the overall effect of promoting greater functional rather than histological recovery.

Cannabidiol Reduces Brain Damage and Improves Functional Recovery After Acute Hypoxia-Ischemia In Newborn Pigs 2011
Newborn piglets exposed to acute hypoxia-ischemia (HI) received i.v. cannabidiol (HI + CBD) or vehicle (HI + VEH). In HI + VEH, 72 h post-HI brain activity as assessed by amplitude-integrated EEG (aEEG) had only recovered to 42 ± 9% of baseline, near-infrared spectroscopy (NIRS) parameters remained lower than normal, and neurobehavioral performance was abnormal (27.8 ± 2.3 points, normal 36).   In conclusion, post-HI administration of CBD protects neurons and astrocytes, leading to histological, functional, biochemical, and neurobehavioral improvements.
 

Cannabis Has Cancer In The Cross-Hairs. Utilizing The Endocannabinoid System To Kill Cancer

It seems that these days the word cancer is everywhere.  From billboards encouraging donations to charities to news headlines to loved one effected by cancer most people are familiar.  There are more than 200 different types of cancer that can develop in over 60 different organs in the body.  Current therapies include poisoning the body in hopes that it will also kill the cancer.  Cannabis is used to help counteract the side effects of these therapies.  However new research points to cannabis as the compounds that can actually cause cancer cell death, essentially curing cancer.  There are countless studies that have been published showing the benefits of using the endocannabinoid system to target cancer cells with cannabinoids.  From that research we have found where using the endocannabinoid system has proven vital in fighting cancer.  Below you will see several studies that show how using the endocannabinoid system can be used in targeting cancer.  Please feel free to share and help others see that using cannabis is beyond the smoke.  I encourage all to do their own research as well ~ Cherry Girl

The Endocannabinoid System in Cancer-Potential Therapeutic Target?
Endogenous arachidonic acid metabolites with properties similar to compounds of Cannabis sativa Linnaeus, the so-called endocannabinoids, have effects on various types of cancer.    Remarkably, these effects may be selective for the cancer cells, while normal cells and tissues are spared. Such apparent tumor cell selectivity makes the endocannabinoid system an attractive potential target for cancer therapy.

Targeting the Endocannabinoid System For the Treatment of Cancer–A Practical View
In recent years, considerable interest has been generated by findings that cannabinoids not only have useful palliative effects, but also can affect the viability and invasivity of a variety of different cancer cells.   It is concluded that cannabinoids (or agents modulating the endogenous cannabinoid system) are an attractive target for drug development in the cancer area….

The Endocannabinoid System As A Target For the Development of New Drugs For Cancer Therapy
Studies on the main bioactive components of Cannabis sativa, the cannabinoids, and particularly (THC), led to the discovery of a new endogenous signalling system that controls several physiological and pathological conditions: the endocannabinoid system. Recently, evidence has accumulated indicating that stimulation of cannabinoid receptors by either THC or the endocannabinoids influence the intracellular events controlling the proliferation and apoptosis(cell death) of numerous types of cancer cells, thereby leading to anti-tumour effects both in vitro and in vivo. This evidence is reviewed here and suggests that future anti-cancer therapy might be developed from our knowledge of how the endocannabinoid system controls the growth and metastasis of malignant cells.

Endocannabinoid System Modulation In Cancer Biology and Therapy
Endocannabinoid system modulation in cancer biology and therapy. The discovery of the endocannabinoid system… led to the development of therapeutic agents related to either the stimulation or antagonism of CB1 and CB2 cannabinoid receptors… evidence suggests that agonists of cannabinoid receptors, which share the useful property to discern between tumor cells and their non-transformed counterparts, could represent novel tumor-selective tools to treat cancer in addition to their already exploited use as palliative drugs.

Use of Cannabinoid Receptor Agonists In Cancer Therapy As Palliative and Curative Agents
“Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents… Cannabinoids (the active components of Cannabis sativa)… development, exploration and use of cannabinoid agonists for cancer therapy, not only as palliative but also as curative drugs.

Changes in the Endocannabinoid System May Give Insight into new and Effective Treatments for Cancer
Marijuana and its derivatives have been used in medicine for centuries… cannabinoids might be effective anti-tumoral agents because of their ability to inhibit the growth of various types of cancer… Evidence suggests that the endocannabinoid system may be dysregulated in a number of cancers… the endocannabinoid system exerts a myriad of effects on tumor cell growth, progression, angiogenesis, and migration. With a notable few exceptions, targeting the endocannabinoid system with agents that activate cannabinoid receptors or increase the endogenous levels of AEA may prove to have therapeutic benefit in the treatment of various cancers.

Save Your Ass, Smoke Some Grass

When people think of grass, weed, pot or cannabis they think of hippies and parties.  What most people don’t think about is that cannabis is showing real promise, on the molecular level, in fighting cancers.  People of all walks have been touched by cancer.  Most people know of someone, has had a loved one go through it or they themselves have experienced cancer.  It is no wonder then that science and medicine have been working hard to find a cure.  Cannabis research has been taking notice especially for its anti-cancer discoveries.   Over 140,000 new cases were reported for colon and rectal cancers with 51,000 reported deaths.  Below you will see studies where cannabis has been examined in the context of colorectal cancers.  As always please feel free to share and I encourage all to do their own research as well ~ Cherry Girl

Single Nucleotide Change in the Cannabinoid Receptor-1 (CNR1) Gene in Colorectal Cancer Outcome
The cannabinoid receptor-1 (CNR-1) and endogenous agonists of this receptor are present in the central and peripheral nervous systems including the gastrointestinal nervous system.Indeed nontumor paired colorectal tissues showed nucleotide change. A large number of patients with mutation in the CNR1 gene were observed. These preliminary findings highlight the importance of further studies in the use of cannabinoid analogs as receptor ligands to analyze potential therapeutic effects.

Cannabinoid Receptor Activation Induces Apoptosis(programmed cell death) through Tumor Necrosis Factor α–Mediated Ceramide De novo Synthesis in Colon Cancer Cells
We show that the CB1 receptor was mainly expressed in human normal colonic epithelium whereas tumor tissue was strongly positive for the CB2 receptor.  The present study shows that either CB1 or CB2 receptor activation induces apoptosis through ceramide de novo synthesis in colon cancer cells. Our data unveiled, for the first time, that TNF-α acts as a link between cannabinoid receptor activation and ceramide production.

Apoptosis: Programmed Cell Death At A Molecular Level
Balanced apoptosis is crucial in development and homeostasis, and all multicellular organisms have a physiologically programmed continuum of pathways to apoptotic cell death. Further studies of the control at the molecular level of key components and promoters/suppressors of apoptosis may provide better approaches to treatment of autoimmune diseases, malignancies, and neurodegenerative disorders. Many important questions remain regarding the advantages of modifying apoptotic programs in clinical situations.

Beyond The Smoke: The Anticancer Properties Of Cannabis

Cannabis has many amazing healing properties that utilize the endocannabinoid system to reach target areas.  Scientists use this knowledge to target certain aspects of a condition depending on the symptoms.  It is well known that cannabis use can help cancer patients during the course of their battle, from increased appetite to pain relief.  Scientists have been uncovering cannabis’ anticancer effects as well.  This promising research is clearing the way so that one day we will fully understand this miracle plant.  Below are studies where science has looked at cannabis therapy when applied to cancer cells.  Please feel free to share and as always I encourage all to do their own research.  Please note that a lot of these are NEW 2012 released research which is really exciting! ~ Cherry Girl

CANNABIDIOL AS POTENTIAL ANTICANCER DRUG
Over the past years, several lines of evidence support an antitumorigenic effect of cannabinoids including Δ(9) -tetrahydrocannabinol (Δ(9) -THC), synthetic agonists, endocannabinoids and endocannabinoid transport or degradation inhibitors.

Non-THC Cannabinoids Counteract Prostate Carcinoma Growth In Vitro and In Vivo: Pro-Apoptotic Effects and Underlying Mechanisms 2012
Cannabinoid receptor activation induces prostate carcinoma cell…In LNCaP cells, the pro-apoptotic effect of CBD was only partly due to TRPM8 antagonism and was accompanied by down-regulation of AR, p53 activation and elevation of reactive oxygen species. LNCaP cells differentiated to androgen-insensitive neuroendocrine-like cells were more sensitive to CBD-induced apoptosis. Conclusions. These data support the clinical testing of CBD against prostate carcinoma.

Role of Lipid Rafts/Caveolae in the Anticancer Effect of Endocannabinoids 2012
The endocannabinoid system comprises the cannabinoid receptors type 1 (CB1) and type 2 (CB2), their endogenous ligands (endocannabinoids) and the whole apparatus… drugs targeting the endocannabinoid system might be used to retard or block cancer growth… Perturbation of lipid rafts/caveolae may in fact represent a useful tool for the development of a novel therapy for endocannabinoids-related diseases, such as cancer.

Update On the Endocannabinoid System As An Anticancer Target
Recent studies have shown that the endocannabinoid system (ECS) could offer an attractive antitumor target.  One direction that should be pursued in antitumor therapy is to select compounds with reduced psychoactivity. This is known to be connected to the CB1 receptor; thus, targeting the CB2 receptor is a popular objective. CB1 receptors could be maintained as a target to design new compounds, and mixed CB1-CB2 ligands could be effective if they are able to not cross the BBB. Furthermore, targeting the ECS with agents that activate cannabinoid receptors or inhibitors of endogenous degrading systems such as fatty acid amide hydrolase inhibitors may have relevant therapeutic impact on tumor growth. Additional studies into the downstream consequences of endocannabinoid treatment are required and may illuminate other potential therapeutic targets.

Use of Cannabinoid Receptor Agonists In Cancer Therapy As Palliative and Curative Agents
Emerging evidence suggests that agonists of cannabinoid receptors expressed by tumour cells may offer a novel strategy to treat cancer. In this chapter we review the more recent results generating interest in the field of cannabinoids and cancer, and provide novel suggestions for the development, exploration and use of cannabinoid agonists for cancer therapy, not only as palliative but also as curative drugs.

Inhibitory Effects of Cannabinoid CB1 Receptor Stimulation on Tumor Growth and Metastatic Spreading: Actions on Signals Involved in Angiogenesis and Metastasis
Stimulation of cannabinoid CB1 receptors by 2-methyl-arachidonyl-2′-fluoro-ethylamide (Met-F-AEA) inhibits the growth of a rat thyroid cancer cell-derived tumor in athymic mice by inhibiting the activity of the oncogene product p21ras.  Three weeks from the paw injection of 3LL cells, Met-F-AEA reduced significantly the number of metastatic nodes, in a way antagonized by SR141716A. Our findings indicate that CB1 receptor agonists might be used therapeutically to retard tumor growth in vivo by inhibiting at once tumor growth, angiogenesis, and metastasis.

Good News For CB1 Receptors: Endogenous Agonists Are in the Right Place
Good news for CB1 receptors: endogenous agonists are in the right place” and “CB1 receptor agonists might be used therapeutically to retard tumor growth in vivo by inhibiting at once tumor growth, angiogenesis, and metastasis.

Cannabis And Autism: We Need Your Help

NORML and the Unconventional Foundation for Autism has teamed up to bring awareness to the need for research and children with autism.  For more information please visit http://www.UF4A.org or http://www.NORML.org
Click Here for the survey

Over the last five years there have been numerous media reports about the anecdotal use of cannabis to help autistic children. Two brave women, one on the east coast the other the west, have been at the forefront of this effort to help scientifically explain why cannabis appears to be so helpful. Marie Myung-Ok Lee wrote about her experience in Rhode Island, a state with medical cannabis laws, in 2009. Soon after, inspired by Marie’s writings, Mieko Perez Hester and her son had a similarly positive experience with treating his autism in California. Mieko, soon after going public about their experience, was invited onto ABC’s Good Morning America.

The reply from parents around the country to these charter members of the NORML Women Alliance experience as parents using cannabis as a therapy for their autistic children has been overwhelming and inspired the need to perform proper scientific research to possibly develop cannabinoid-based treatments for autism in both children and adults.

To help accomplish this Mieko established The Unconventional Foundation for Autism (UF4A), which is asking the NORML community of hundreds of thousands of cannabis consumers and patients to help with a scientific survey today.

The NORML community has joined UF4A in this remarkable journey and fight, and has offered to help solicit feedback through the survey.

Target: Persons on the autism spectrum currently using or interested in using cannabis as a safe and effective medication to treat autism.

With more than 1 in 88 children affected, autism is the fastest growing developmental disability in the United States. Currently, there is no medical detection or cure for autism; however, there are pharmaceutical and therapeutic treatments that have proven to be effective in treating the condition. Among the safest and most remarkable is the therapeutic use of medical cannabis.

Amidst a highly controversial setting, one California mother is sharing her autistic son’s triumphant and life-saving journey with the world. Single mother of three, Mieko Hester Perez was watching her young son, Joey, succumb to various combinations of 13 different prescription drugs that ravaged his body and internal organs. Joey weighed only 46 pounds, and was in a battle for his life.

In 2009, The Unconventional Foundation for Autism (UF4A) was formed. UF4A is lighting a path in hopes that others may benefit from alternative therapies that may be available to other families on the Autism Spectrum. Mieko helped create a survey to help solidify and amplify her results and the level of help the Foundation can provide.

At UF4A, we believe providing the most accurate information to medical professionals for research purposes will pave the way for clinical trials for unconventional treatments.

We seek to solidify and further the fundamental understanding we have in regards to the effectiveness of cannabis alleviating symptoms along the Autism Spectrum. The information collected in the survey will be used to further guide families, new patients, doctors and lawmakers in making informed and proper decisions for themselves and our community.

SURVEY LINK:
https://spreadsheets.google.com/spreadsheet/viewform?formkey=dG9wYmVjaVhQdXpXWVVYbUtjaDR0UGc6MQ

If this survey applicable to you or a loved one, we invite you or them to fill out the form UF4A Treatment of Persons on the Spectrum with Cannabis. To fill out the survey, click here.

-Allen St. Pierre
Executive Director
NORML

Cannabis: Your Heart Hero

More and more Americans are being classified as obese.  With obesity comes other complications such as cardiovascular disease.  Cardiovascular disease refers to any disease that affects the cardiovascular system, principally cardiac disease, vascular diseases of the brain and kidney, and peripheral arterial disease.  The causes of cardiovascular disease are diverse but atherosclerosis and/or hypertension are the most common.  It is estimated that one-third of Americans die from cardiovascular disease so it is no wonder that scientists have been hard at work trying to find a cure.   Below you will see studies where science has looked at cannabis compounds when applied to CVD.  Please feel free to share and I encourage all do their own research as well ~ Cherry Girl

Targeting Cannabinoid Receptor CB(2 ) in Cardiovascular Disorders: Promises and Controversies
“Cardiovascular disease is the leading cause of death and disability worldwide, which can be largely attributed to atherosclerosis, a chronic inflammation of the arteries… the lipid endocannabinoid system has emerged as a new therapeutic target in variety of disorders associated with inflammation and tissue injury, including those of the cardiovascular system. The discovery that delta-9-tetrahydrocannabinol (Δ9-THC), the main active constituent of marijuana, inhibited atherosclerotic plaque progression via a cannabinoid 2 (CB(2) ) receptor-dependent anti-inflammatory mechanism.

Endocannabinoid System in Cardiovascular Disorders – New Pharmacotherapeutic Opportunities
The evidence so far gathered shows that the modulation of ECS (as agonism or antagonism of its receptors) is an enormous potential field for research and intervention in multiple areas of human pathophysiology. The development of selective drugs for the CB1 and CB2 receptors may open a door to new therapeutic regimens.

Never Fear Cannabis Is Here! How Cannabis Can Help With Fear, Anxiety, and Other Psychiatric Disorders

Nearly 19 million Americans suffer from a  psychiatric disorder which could include disorders such as specific phobias, generalized anxiety disorder, social anxiety disorder, panic disorder, agoraphobia, obsessive-compulsive disorder and post-traumatic stress disorder.  Many veterans returning from war have found cannabis to be a relief from PTSD.  Below you will studies where science has studied the effects of cannabis compounds when applied to psychiatric disorders.  Please feel free to share and I encourage all to do their own research as well ~ Cherry Girl

The Endocannabinoid System in the Processing of Anxiety and Fear and How CB1 Receptors May Modulate Fear Extinction 
The endocannabinoid system recently emerged as an important modulator of many neuronal functions. Among them, the control of anxiety and acquired fear represents nowadays one of the most interesting fields of research.  Finally, a neurobiological model possibly able to implement the role of the endocannabinoid system in these processes will be proposed.

CB1 Cannabinoid Receptors Modulate Kinase and Phosphatase Activity During Extinction of Conditioned Fear in Mice
Cannabinoid receptors type 1 (CB1) play a central role in both short-term and long-term extinction of auditory-cued fear memory.  We propose that the endogenous cannabinoid system modulates extinction of aversive memories, at least in part via regulation of the activity of kinases and phosphatases in a brain structure-dependent manner.

Extinction of Emotional Response As A Novel Approach of Pharmacotherapy of Anxiety Disorders 
The patogenesis of anxiety may be related to the process of an extinction of aversive memories… Studies on molecular and cellular mechanisms responsible for individual fear extinction may serve as the basis of search for more effective forms of clinical treatment… ligands stimulating endogenous cannabinoid system… these substances stimulate different central mechanisms, they appear to act synergistically, to improve the behavioural therapy.

Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear
the findings in the present study suggest that augmenting eCB-mediated neurotransmission by inhibition of eCB transport or breakdown may provide a novel mechanism for enhancing the extinction of fear. As such, eCB reuptake inhibitors may serve as useful adjuncts in the treatment of anxiety disorders (such as PTSD, panic disorder, and OCD) as well as drug addiction and other disorders that respond to behavioral treatments utilizing extinction processes.

The Endogenous Cannabinoid System Controls Extinction of Aversive Memories
Acquisition and storage of aversive memories is one of the basic principles of central nervous systems throughout the animal kingdom. In the absence of reinforcement, the resulting behavioural response will gradually diminish to be finally extinct.  We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala.

The Endocannabinoid system and Extinction Learning
As several human psychiatric disorders, such as phobia, generalized anxiety disorders, and posttraumatic stress disorder (PTSD) appear to involve aberrant memory processing and impaired adaptation to changed environmental conditions, the hope has been fuelled that the endocannabinoid system might be a valuable therapeutic target for the treatment of these disorders.

Bringing the War Back Home: Mental Health Disorders Among 103,788 US Veterans Returning From Iraq and Afghanistan Seen at Department of Veterans Affairs Facilities
Co-occurring mental health diagnoses and psychosocial problems were detected early and in primary care medical settings in a substantial proportion of OEF/OIF veterans seen at VA facilities. Targeted early detection and intervention beginning in primary care settings are needed to prevent chronic mental illness and disability.

Psychosis and Trauma. Theorical Links Between Post-Traumatic and Psychotic Symptoms
The links between psychotic and psycho-traumatic symptoms are complex and multidirectional; this co-occurrence is a factor of seriousness. The clinician, while paying attention to these symptoms, has to distinguish the structure of the personality of the subject to articulate the psychotherapy and the pharmacological treatment. Further investigational studies may determine whether antipsychotics will enhance treatment response in PTSD patients with psychotic features.