The Miraculous Human CB1 Receptor

For over 50 years we have known of the human endocannabinoid system and with that the discovery of the CB1 receptor.  The CB1 receptor is found in the brain and is involved in a lot of functions.  Below you will see studies on the CB1 receptor and how they function within the body and with cannabis.  I encourage all to do their own research and seek out the truth.  Please feel free to share ~ Cherry Girl

Mitochondrial CB(1) Receptors Regulate Neuronal Energy Metabolism
The mammalian brain is one of the organs with the highest energy demands, and mitochondria are key determinants of its functions. Thus, mtCB(1) receptors directly modulate neuronal energy metabolism, revealing a new mechanism of action of G protein-coupled receptor signaling in the brain.

Cannabinoid Receptor 1 Trafficking and the Role of the Intracellular Pool: Implications For Therapeutics
Cannabinoid Receptor 1 (CB(1)), an abundant G-protein coupled receptor in the CNS, is currently of significant interest as a therapeutic target.  These findings have significant implications for the interpretation of CB(1) biochemical studies and the design and application of cannabinoid therapeutics.

Cannabinoid Receptor Trafficking In Peripheral Cells Is Dynamically Regulated By A Binary Biochemical Switch 2012
The cannabinoid G protein-coupled receptors (GPCRs) CB(1) and CB(2) are expressed in different peripheral cells.  This study describes, for the first time, the dynamic nature of CB receptor trafficking in the context of a biochemical switch, which may have implications for studies on the cell-type specific effects of cannabinoids and our understanding of the regulation of CB receptor cell surface expression.

Cannabinoid Receptors: Key To Cannabis’ Healing Success

Since the discovery of the endocannabinoid system in the 60’s science has been hard at work trying to unlock the mysteries surrounding cannabis and the interaction of the human body.  For thousands of years cannabis has been used for medicinal, religious and recreation purposes.  Below you will see studies that explain a little as to why cannabis works the way it does within our system.  You will see how CB1 and   CB2 receptors interact with cannabis and how they play a key role in its therapeutic properties.   I encourage all to do their own research and seek out the truth please feel free to share ~ Cherry Girl

The CB(2) Cannabinoid Receptor Controls Myeloid Progenitor Trafficking: Involvement In the Pathogenesis of An Animal Model of Multiple Sclerosis
These findings demonstrate the protective role of CB(2) receptors in experimental autoimmune encephalomyelitis EAE pathology; provide evidence for a new site of CB(2) receptor action, namely the targeting of myeloid progenitor trafficking and its contribution to microglial activation; and support the potential use of non-psychoactive CB(2) agonists in therapeutic strategies for multiple sclerosis and other neuroinflammatory disorders.

Transcriptional Regulation of the Cannabinoid Receptor Type 1 Gene In T Cells By Cannabinoids
Effects of cannabinoids (CBs) are mediated by two types of receptors, CB1 and CB2. In this report, we investigated whether CBs regulate gene expression of their cognate receptors in T cells and studied underlying mechanisms in CD4+ Jurkat T cells.  In summary, up-regulation of CB1 in T lymphocytes in response to CBs themselves may facilitate or enhance the various immunomodulatory effects related to CBs.

Therapeutic Action of Cannabinoids In A Murine Model of Multiple Sclerosis
Cannabinoids may act as immunosuppressive compounds that have shown therapeutic potential in chronic inflammatory disorders… Overall, the data presented may have potential therapeutic implications in demyelinating pathologies such as MS; in particular, the involvement of cannabinoid receptor CB2 would enable nonpsychoactive therapy suitable for long-term use.

The Human Eye Expresses High Levels of CB1 Cannabinoid Receptor mRNA and Protein
These results further support the proposed role of the CB1 receptor in controlling intraocular pressure, helping to explain the antiglaucoma properties of marijuana.

CB1 and CB2 Receptor mRNA Expression In Human Peripheral Blood Mononuclear Cells (PBMC) From Various Donor Types
Marijuana cannabinoid receptors (CBR), CB1 and CB2, are G protein-coupled receptors… expressed in brain as well as cells of the periphery…results suggest that CBR expression is relatively constant across the human population.

Cannabinoid-receptor 1 Null Mice Are Susceptible To Neurofilament Damage and Caspase 3 Activation
Administered cannabinoids have been shown to ameliorate signs of CNS inflammatory disease in a number of animal models, including allergic encephalomyelitis. More recently, neuroprotective actions have been attributed to activation of the cannabinoid 1 receptor in a number of in vitro and in vivo models…The data presented further strengthen the hypothesis of neuroprotection elicited via cannabinoid receptor 1 signaling.

Detailed Characterization of CB2 Receptor Protein Expression In Peripheral Blood Immune Cells From Healthy Human Volunteers Using Flow Cytometry
These data provide the first detailed analysis of CB2 protein levels in blood leukocyte subsets from healthy donors and identifies the cell types which could be targeted with CB-mimetic drugs in humans.

Cannabinoid-Induced Immune Suppression and Modulation of Antigen-Presenting Cells
The study of marijuana cannabinoid biology has led to many important discoveries in neuroscience and immunology. These studies have uncovered a new physiological system, the endocannabinoid system, which operates in the regulation of not only brain function but also the regulation of the immune system. Studies examining the effect of cannabinoid-based drugs on immunity have shown that many cellular and cytokine mechanisms are suppressed by these agents leading to the hypothesis that these drugs may be of value in the management of chronic inflammatory diseases. In this report, we review current information on cannabinoid ligand and receptor biology, mechanisms involved in immune suppression by cannabinoids with emphasis on antigen-presenting cells, and preclinical and clinical models analyzing the therapeutic potential of cannabinoid-based drugs.

Immunoregulation of A CB2 Receptor Agonist In A Murine Model of NeuroAIDS
Chronic HIV-1 infection commonly affects behavioral, cognitive, and motor functions in the infected human host and is commonly referred to as HIV-1-associated neurocognitive disorders (HAND)…Our results support the notion that CB2 receptor agonists may be a viable therapeutic candidate for HAND.

Anandamide Prior To Sensitization Increases Cell-Mediated Immunity In Mice
The endocannabinoid system has become a topic of great interest in pharmacology due to its remarkable distribution in mammal organisms and capacity to play a modulatory role on several physiological systems, including modulation of immunity. Many studies have shown that administration of cannabinoids causes inhibitory effects on immune cells, including decreased proliferation and antigen-presenting cell (APC) co-stimulatory activity. In contrast, other groups have shown that some cannabinoids might present stimulatory actions on macrophage activity and T cell activation…Anandamide prior to sensitization increases cell-mediated immunity in mice.

Endogenous Modulators of Synaptic Transmission: Cannabinoid Regulation In the Supraoptic Nucleus
The magnocellular neurons of the hypothalamic supraoptic nucleus (SON) are a major source of both systemic and central release of the neurohypophyseal peptides, oxytocin (OXT) and arginine-vasopressin (AVP).  Further study of eCB signalling in the SON, including its interaction with AVP neurons, promises to extend our understanding of the synaptic regulation of SON physiological function.

 

 

Newly Released Studies That Show Medical Value Of Cannabis 2011

As we see this year come to a close it is time to look back over 2011 and view the studies that were released this year that show cannabis to be a treatment option or a cure for an illness.  Please share the truth about cannabis ~ Cherry Girl

Cannabinoid Receptor Type 1 (CB1) Activation Inhibits Small GTPase RhoA Activity and Regulates Motility of Prostate Carcinoma Cells 
Cannabinoid receptor 1 activation stops and controls the growth of prostate cancer cells.

Cannabinoid Receptor 1 Gene is Associated With Alcohol Dependence
Cannabinoid receptor 1 is involved in alcoholism. CB1 is the target for treatment.

CB(1) Receptor Activation Inhibits Neuronal and Astrocytic Intermediary Metabolism in the Rat Hippocampus
In conclusion, CB(1)Rs are able to control hippocampal intermediary metabolism in both neuronal and glial compartments, which suggests new alternative mechanisms by which CB(1)Rs control cell physiology and afford neuroprotection.