Times have changed, Yet some things are still the same….

#DWTS_Tommy_Chong

Tommy’s prison sentence, the result of the War on Drugs.

Tonight I happened to catch a clip of dancing with the stars which featured Tommy Chong.  I was sad to be reminded yet again how much our government that is supposed to be working for the good of the people has actually done to us.  We have two states that have legalized cannabis for recreation use but we still have states where people are being locked up. In states that have legalized for medical use we have patients that are having a hard time accessing medicine while others are facing sanctions and bans at the county and city levels.

California, the first state to legalize, has been one example where county after county fought to ban sales and growth altogether.  Redding in the north part of the state is currently trying to ban the outdoor grows and going so far as to stipulate the type of building, how far from your residence the approved outbuilding can be

and other intrusions.  After so many fought hard to make cannabis available to patients we still see where many are forced to drive hours including experiencing dangerous driving conditions during the winter because of these local bans.

The Federal government has backed down from its hay day of no-knock-raids and busting down doors of cancer patients but we still see families broken and lives shattered because of over zealous local authorities that want to win elections.  We see legal shops set up where adults 21 and over can purchase cannabis for their own personal use but we still see irresponsible behavior solely attributed to cannabis as apposed to the person’s stupidity and lack of experience with cannabis supported with antiquated reefer madness logic of “ban it all”.

2014 has been full of advancements but it is almost over and it will be 15 years into the new millennium, can we say we are making the progress we should be?  Unfortunately we still see too much of the same mentality-harsh punishment-that has been proven to be costly both economically and socially.  Thankfully more people are knowledgeable about the benefits of cannabis and its legalization than ever before.  We have made a lot of strides in understanding the plant and all its compounds in relation to our bodies.  With more and more patients along with cannabis supporters coming forward we are starting to see bigger changes happen.

With elections coming up we all know the spam mail, ads and people accosting us on the street for their causes come with the pumpkin spice season.  While keeping our eye on the larger issues it would be wise to make sure that we are not losing our rights locally.  Tommy Chong, Marc Emery and millions more are a stark reminder of times past and unfortunately for some, present, that we are still not free from the fear of our freedom being taken away.

While we can revel in the success of our victories in some states let us not lose the fire to continue our battle for all to be free.  We cannot live in a world where a person looking death in the face has to worry about being raided and locked up or where people’s lives are destroyed for nothing more than enjoying cannabis.  Our vote is our voice and it is important that we make sure it is heard loud and clear.  Let us make loss of freedom a thing of the past for all.

A Happy New Year and A New Beginning

A new year is upon us and with it comes new possibilities. This year we will discover even more miraculous properties of cannabis. From cancers to other ailments we already know the capabilities that cannabinoids possess. We have seen two states move forward beyond medical needs and legalize for recreational use. With that comes the hope that it will make it easier for patients to obtain the necessary strains they require.
We need to keep in mind that it is not simply using cannabis but using it correctly that will achieve desired results. As we have discussed before each strain possess different compounds or cannabinoids. We have already seen 3 strains genetically mapped, discovering a variety of previously unknown compounds and it will be exciting to see more added to the list.
We have seen so many advances in the delivery methods used for patients. We are no longer only left with smoking. For patients there are very real solutions.
We have seen countless stories of patients who were unable to eat, unable to control their shaking or seizures who have taken only a small amount of cannabis and have been able to control their symptoms. We have also seen in studies where cannabis has slowed or stopped cancer growth. It is no longer deniable that cannabis has real medical use.
I am hopeful that with the advancement of Washington and Colorado’s legislation as well as the other states that have set up medical provisions that we will continue to see the path cleared for all states and ultimately all patients to have access to not only cannabis but quality and variety of strains. Individualized care is key and will only come about for the masses if it becomes legally available. We have suffered for too long. We have lost too many loved ones unnecessarily. Now is the time to act! Call, e-mail or write your representatives and urge them to work towards the common goal of providing for all a safe natural alternative to big Pharma’s poison.

Becky’s Story

It started out as coming home from Calif. as my kids were grown and I was sick. I had done Infer-on treatments twice, once with UNC Clinical trial then in Calif. I did 54 weeks started in 2010. It about killed my mind, body and soul. Luckily being Calif. it was no problem smoking or eating the Cannabis. I ended up on IV’s fluids for almost 4 yrs. most were in an infusion center at our local Hospital in Calif. I remember my nurse Abby well. Spent Christmas eve, New years Eve together. My Belly had been scarred bad. I couldn’t drink water for years. We drove me back in my rig in 09. My father had a set up for me to finally relax and heal me. Landed in the hospital 5 hours from home bad angina attack. Finally made it here on April 19th 2009. I even had to leave my 17 yr. Homecoming Queen, I missed so much. Cancer struck my Father Sam Haines Ret. Navy, Magna Cum Laude Honor Student Psychology, Master Gardner, Herbologist, and many other things a few months later. He always said the absetos from the Subs. would take him out. He didn’t want money for that, I respect it. He loved his USA. We lost him 3 months after I came home. A few months later I felt a sharp pain in my left lower belly it took me to the ER 24 hrs. later. Was the first time I had ever heard the word Cancer for me. It was a mass about the size of an Apple on my left Ovary. Six weeks later it had grown to 2 lbs. Took blood no Ovarian Cancer I was found, my OB did some major surgery to remove it and other organs. I woke up hearing it was bad, rare they had to send it to Duke the pathology. That is where my night mare begin as I was pretty much on my own here.
Came home, paid someone to bring me with 34 staples in my gut and a backed up septic tank, still have leach line issues. 3 weeks later I finally get a call. Musinous Adenocarcinoma 2 lb. Mass and Unknown Primary. Very Rare only 600 cases in the States a year. I found only 2 hospitals treated this one in San Diego and Wake Forest. Thought I was in, emailed Dr. Levine my Pathology, he quickly replied stated yes they do treat it, not mine, I was co-morbid. A term for med-care. If a person has 2 or more chronic conditions they won’t put the money in them. The Surgery was called MOAS a 23 hr. surgery cutting out 1/2 colon, 1/2 intestines and all lump nodes appendix and also HEPIC chemo. where they run warm chemo. in your guts sew you up and leave it for a few hrs. this giving me maybe 5 yrs to live. Duke jumped in, it was my CEA’s that were elevated the marker for Colon Cancer. Did a round, it about killed of Taxol. I lost my in home care I had since 2001 to the NC’s health plan. I did eat cannabis and smoke the whole time during the chemo. I could eat a chili dog had weird cravings while others were puking. Did have the water issue and my belly I had to look out for dehydration, I don’t think right when it happens those around me have signs. It didn’t get caught quite a few times, once I laid in my bed devacating on myself for 5 days, had Kloe looking out the window , I remember I thought it was snowing and no one could see us in here dying, wow. Sad looking back. My family tried , came in washed me up, bless their hearts. at one tine I even told Sam to get Kloe she had been eating chemo and was glowing green, he did it. I can give instructions. We got through it.
I had researched the Cannabis Oil as a cure, I believe in our science of Plants and it has always been a big part of my life, my father shared the history and health with me. Many other things but that is another story, If I remember right he was one of the Original ones in the first NORML he believed it should have been free, he fought for it. I’m no activist always;ys felt it was a gift to us, I choose to live off Grid I’ll get there again. I lost that in 99 due to Hurricane Floyd the flood. The oil I knew it would work, my children they only science they believed in was mans, I was forced into the chemo. it did no good on the numbers came back a tad more elevated. I did a search of the property as Dad told me he had material for bakeables wow was I surprised there was my oil meds. He had grew it he was going to compost, I told him to save it til I got back there ..lol..I guess it was part of my inheritence. Some one showed up from NCCPN she runs a differnt one now CCC I believe. Spent the first 3 months in a good Cannabis coma almost finally had a little help to feed me, I could rest, Rick Said that for it to work I must rest. I gave in. I have a list of 20 Chronic Conditions I have been pinned with. I knew the endocanabonoid system but had no idea I could feel this dang good.
Within 6 weeks I could tell a difference in my eating and resting I was able to shower again on a regular basis eating well. I took a lot of oil! Tumors started leaving I had nodules unknown stuff in my lungs they cleared. The drs. were amazed as we sat there and giggled they were lost to this science, I told them the whole time what I was doing, we preached Cannabis at Duke, eating my little green cookies everywhere . Around 6 months ago I had been studying food a long time, believe in our organics was almost there once, then got sick. I started this little crazy diet a friend mentioned also tips from my friend Tamara she cleared her Cancer through foods just wrote a book the fist print sold out, Alternative Health Solutions. I’ll post a link with this. 12 colors a day, it was simple to me, I needed simplicity. Lost so much, reading, writing, seeing, driving, etc. The GMOs are killing us also, I hope to climate all one day, also I’ll wear only hemp once I can shop for my clothes again, using 7th generation Baby products for the skin and clothes washing, dish washing all natural stuff. There were so many scripts I had been on since the Interferon treatment. I was ready for the pills to be gone too. I became quiet good at the oil , good shit, I jacked up my dose to detox off this stuff processed foods and the rest of the meds. I was on. I didn’t think I had to tell anyone what I was doing, it was my world here. The family reacted quite different to the natural healing. They had never heard me talk about Jesus before, I dig him. What happened to my health is short of a miracle all conditions cleared, Cancer, Fibro. Chronic Pain, Fatique, high blood pressure, high sugar, Epstien Barre, angina, spastic esophagus, chronic thrush had took my taste, also candida bad on my skin, Ptsd, Anxiety, Hyper-activity I’ll get that list there are more, even have chronic marijuana abuse, I’ll keep that one. There are 2 pills I have to take, I tested it, for hyperprotienlypidemia 4, a genetic blood disorder. The only meds .I will take, or my trich
Around 2 months ago I stepped out in our World, got my hair done, new clothes, the bloat from treatments just fell off with the oil like magic! I had no idea what would come of me coming out of this Corporate Greed. I ended up with an infection, it started a change for me with our local Hospital who I had standing orders for fluids at. I usually carry a book so they can see my condition if they can’t understand me, I come around after a bag or 2. I said ” I’m not from around here, I need fluids my family has sucked me dry.” Next thing I know I was being stripped of clothes and rights, the infection or fluids not treated. They shot me up with dope and knocked me out. I awoke in what they call here the observatory, wow, worse then jail, been there one night..lol. they see if you need to be in psych. took me 2 days to get my I rights back. I cleared the infection with the veggies and water brought to me in there I made them wait on my ass hand and foot, since they had me. I had to take a drug called Septra for Schizophrenia and shut up for 3 hrs before they let me out the door I conformed. I knew an injustice had been done I was going to let it go, but they got me again.
On Dec. 2nd, my daughter, she got worried, so was I. I had did so much of my oil i need to get some more done, no one understood what I was up against, I didn’t feel I had to explain myself as long as I was getting better. The Fytanal patches, celexa they gave me for crying during chemo. , the lortabs, Valiums I was ready to get them out of my system for good. I don’t need a pain pill today for the fibromyalgia. i did show my ass, I can’t rest with knots in my gut, things I need to get out with the family and community, no one fully understand how close I’ve been to death quite many times done with that shit. Autumn hadn’t seen me since we got me thru the chemo. Placed a 911 call to my ass to check on my welfare. I was already set and at the beach with my stuff getting ready to rent a place and relax a month, yes they found me there too 4 cops and ambulance pulled in the yard. The law can do that if they feel you have a mental heath, Holistic healing is not heard here, hardly. I told that Dr. Hussini, I had stepped out of the medical society I only suffer from PTSD as far as my head is concerned. He told me I could no step out of their system. watch me.
I’m really grasping what happened next. I’ll go into more detail later but it still hurts as I saw so much brutality. I was driven and handed over to the the psych. ward. 6 cops and 2 attented to tie me down in a seclusion room and shoot me up with drugs. This went on till the 20 of Dec. I fought that stuff hard. I would no conform. I wore my Army Creed shirt, taught everyone to say Pledge allienge I had to draw it out. Talked about the Cannabis the medical bill, they lock folks in our county up if they have a narcotic benzo or cannabis in your system and dry you out. When I left there the recovery counselor who was tough..lo. I heard tell our people yes smoke a joint, its ok, That felt good, things did change up there. I did finally conform as I wasn’t going to get out, took their drugs and the lituim this time they said I was bi-polar. no labels here, a little eccentric they thought I had grandiose ideas, which I don’t think anything is impossible. We are going to free our weed in the South. I feel it. I had to eat their foods, made me sick, sleep so many hours, I’m on my own schedule is my right. I have been court ordered to take the meds. After my release 2 days later I went back. I wanted them not to keep me on those drugs, I was able to release with my signature that Observatory on the 23rd of this month with my own signature yes. I won that mess. I do feel that the Hospital will be in my lawsuit pending the county. Here is what happened while I was away from my home.
Since I wasn’t home they bursted right in my door. I don’t worry about my cannabis here, or my guns or anything for that matter I did nothing wrong. I had my Christmas weed out, maybe 10 grams, I had left buckets soaking in the bathroom, the didn’t mess with that, they were kind of freaked on my big vial of left over oil. It was empty. Many drugs in the house, a grow room my dad grew veggies in, many guns, I had my tax money put up , they took all my stuff while they figured out I was no harm to a soul not a grower or dealer of any kind. Robeson here wants this Cannabis free, its taking up their courts and recovery for the real addicts and Alcoholics. We had yet to clean out my house from all the scripts. As I sit now I’m ok with what it took to get me here. I gotta go to court to get my stuff back my guns and money. My cable which was my connection to the world all cut turned off someone didn’t pay my bills, I came home to my car egged with my own eggs, inside and out that one bit I know who did it. My dang Kloe, I lost her, 2 of my hens, I’ve been having to be on-line outside I have enjoyed the freedom.
I’d like to get the ball started rolling on education here , in my side of the State 75% are stil without internet. We have to get something to them. I was going to front this part my self financially I had 2 land sales going on. I lost them both with my phone. HB 577 needs to be in every ones face if its going to pass in a year. It should have already been 3 years ago. I have been begging for help. We are going to run a fund for now. I’m putting in about my last 100 bucks to get it rolling. That way I can get the printed material they have been begging for in their hands at least in my county Columbus and Brunswick any others can contact me. I hope to have a link for those pamphlets soon. I can’t create them on my puter don’t have the program but have help for that once I get or info. more narrow down, Also putting in about those foods and gmos just a little ed. its not available here. Very sweet runs thru veins here, dying of Cancer all over the place Genocide is what I call it. I’m leaving on that one. Have a Bless day. Peace be with you all. yes, my medicine, my Cannabis OIL! I had enough to last me for a year, til it was free to grown my own weed! My friend Donnie destroyed all for my protection. Dang, I feel I may could have beat the case and won that shit back. Out of my hands I’m ok. The foods and I smoke and eat my cookies still. Spaz is a nervous little thing she suffers from PTSD also. Do be careful with that watched a video last night out of Co. they are rushing knocked out stoned dogs to the Vets.
Magic Carpet Ride
http://www.youtube.com

It Is Time To Get Serious, It is Time To Talk Legalization

It is a difficult subject to discuss without getting a little fired up and at the same time heartbroken.  Cannabis legalization either for medical use only or for adults 21 years and older seems to be in the same category as discussing the latest pop news.  Nonchalantly, with a laugh and without much regard.  It seems that every time the subject of medical cannabis comes up it is either ignored or discussed with a laugh.  With high numbers of support and more states lined up to join the 17 states that have already approved medical cannabis legislation this subject will need to be seriously discussed.

While some have the luxury of getting stoned for the hell of it millions depend on cannabis for serious medical issues.  Many of them wish they could only use cannabis for recreation instead of the necessity with which they find themselves.  Yes cannabis can be a lot of fun to use recreationally.  Yes it can be fun to eat pizza and zone out on the couch with friends.  For those losing their livelihood, their children, their freedom or their life I am sure they have a much different outlook.

What about the cancer patient in pain?  The one who is looking death in the face and decides to take a chance with cannabis treatments to ease the pain, nausea and other horrific side effects.  The patient who uses a state legal dispensary to safely access  trusted raw cannabis or cannabis infused products.  The patient who uses the concentrated RSO oil that not only helps with the side effects but actually helps fight the cancer including inducing cancer cell death.  Is it still funny when that patients house is raided, when they are terrorized in their own home, when they are taken to jail?  Is it funny that we are keeping a PLANT from citizens who have gone through the state approved process to obtain state legal medication that not only helps cancer but hundreds of other medical issues as well?

What about the hardworking top student who gets drug tested or is caught with a small amount and loses their scholarship or funding?  What about the employee who otherwise is known as a perfect employee but comes up positive on a drug test?   There is too much known evidence to date that beyond proves cannabis has medical value.  Every week new studies are published attesting to that fact.  Should the federal government really be dictating to the states how to run a state program?  Should we still take such a hard stance against a versatile natural plant that not only helps millions but is already being used by a large percentage of the country?

We are allowed to vote, drive, consume alcohol, raise children, build large corporations and many other highly responsible activities and responsibilities so why are we not allowed to choose how to treat our illnesses or relax at the end of the day?  Why are we not allowed to choose natural cannabis instead of the more harmful choice alcohol?

Cannabis effects us not only socially but financially as well.  The cannabis related industry has grown during the recession.  We would save billions in wasted efforts trying to stifle a growing industry.  We would save lives and instead allow tax revenue and other positive residual effects to spread throughout the communities.  

We have to take a serious look at this subject and come to the table as adults.  Its time to put away the pizza, quit the giggles and other tired cliches.  This effects everyone from children losing their parents to the loved one with an illness prosecuted for using a natural herb used for thousands of years.  If we are truly free adults then we should be able to discuss this in a serious manner.  I urge all of you to speak up and let your representatives know it is time to seriously talk about cannabis legalization.

U.S. Government Destroying History: Why We Must Save Cannabis Plant Genetics From Extinction

Strains such as Kush have been made notorious through songs and celebrities professing their love for the strain.  Those that have experienced Kush know why it is so famous.  From Tahoe OG Kush to Afghan Kush the high is memorable.  Cannabis is not a new plant created in a lab but rather has been used for centuries as medicine, religious herb and for recreation.  Research proves more every day how vital plant genetics are in finding the right compounds to combat illnesses and find cures.  Genetics is something that isn’t often thought of when discussing the War on Drugs but it has definitely been affected by it.

Some cannabis genetics are thought to have come from Providences in China and spread throughout the Silk Road while others originate in the Middle East.  There of course was the large movement through the 60s and 70s that helped spread and create new cannabis strains through people exchanging seeds and ganja.

With new genetics infiltrating the gene pool in the States new plant strains emerged.  Hybrids also came out of the mix.  People discovered that by crossing different strains they could breed out the undesirable traits while promoting higher potency and better growth stamina.  By cross breeding not only Indica with Indica but breeding for balance we have seen hybrid strains that have the pain relief of an Indica but with the “upper” functioning high of a Sativa.  Genetics play a role in growth, mold/pest resistance and of course potency.  

Blueberry strains are known for their social anxiety and pain relief as well as helping with digestive disorders and have spawned notorious strains like Blue Cheese, Blue Dream, Old-Time Moonshine and Blue Haze .  DJ Short created the Blueberry strain by crossing his Afghani Indica, brought by some growers from California and his Purple Thai.  The female pedigree of his Purple Thai is his highly potent all-around champion, “Juicy Fruit” Highland Thai female. It packed a very sweet tropical punch and an intense high that lasted for many hours. The second plant was a Purple Thai out of Oregon, Ohio. This plant was a cross between an outstanding Highland Oaxaca Gold and a very freaky Chocolate Thai. The hybrid was very dark colored and would express a deep royal purple color at the slightest exposure to cold. The finished product was equally tasty and strong as the Juicy Fruit female.

The War on Drugs forced cannabis use underground.  Cannabis began being bred for bag appeal and what would bring the best sales.  Growers began looking for traits that would bring the biggest yield with the shortest flowering time.  Medicinal qualities were disregarded.    For decades it was thought that the compound THC was responsible for all of the effects cannabis provided.  We now know of CBD which is actually responsible for pain relief and has been found to help with insomnia, anxiety and Alzheimer’s.  CBD was another casualty of the war with most of today’s strains registering less than 0.5%.  With the War on Drugs ongoing for over 40 years countless plants have been destroyed with the government’s actions forever destroying precious genetics.

Although cannabis has been around for thousands of years it wasn’t until the summer of 2011 that the genetics of the cannabis Sativa and Indica were mapped.  We know that there are hundreds of strains that have come from the original heirloom landraces.  Today many patients and citizens alike have the option of what type of relief or high they are looking for.  From the euphoric highs of the Sativa to the amazing pain relief that Indicas bring the options are endless.

Everyday we have new research that is released that shows the anti-cancer properties of cannabinoids.  Now more than ever we understand why we need to preserve the genetics of all cannabis plants.  We know that we can use different strains to treat a wide range of illnesses and afflictions.  We also know that cannabis is not a one-size-fits-all type of plant.  You need to have the correct strain containing the right balance of compounds to reach the desired effects.

We have more proof than we have ever had before showing the medical benefits even on a molecular level.  We are beyond smoke when taking about cannabis therapies.  There are a wide range of options when talking about uses.  Tinctures, edibles, concentrates, oils, topical lotion, capsules, vaporizers and more.

Support is at an historic high with medical use over 75% and legalization for adults over 21 at 50%.  States that have enacted decriminalization have found favorable outcomes.  States that have enacted medical statues have found large increases in tax income as well as economic growth in the communities.

If cannabis is allowed to thrive imagine the possibilities.  Imagine 5, 10, 15 years from now how much we will know about genetics, compounds and treatments for cancers.  Imagine all the possibilities if we could openly and safely exchange genetics and end products.  How many people could find relief?  How many could save their life?

It is time that we stand up and protect cannabis genetics.  We need to stop the violent raids by government officials.  The government needs to change their stance on cannabis therapies.  Now more than ever it is time we stop the continual attacks on patients, crops and our heritage.  The War on Drugs needs to end.  It has been a failed war for over 40 years that has forever changed the history of cannabis.  Those that have kept cannabis genetics alive even in the face of persecution and imprisonment thus passing down history should be celebrated.  Urge your representative today to show support for ending the failed approach to dealing with cannabis.

Ganja For Your Guts: How Cannabis Can Help IBS

No one likes dealing with an upset stomach from taco night.  Those with Irritable Bowel Syndrome or IBS deal with those symptoms and more on a frequent basis.  It is estimated that 20% of the U.S. population has IBS.  It is no wonder then why scientists would be hard at work looking for a cure.  We are seeing more and more research targeting the human Endocannabinoid system to treat illnesses.  IBS is no exception.  Below you will see studies where science has researched the role of the Endocannabinoid system with IBS and how cannabis therapy could help patients.  As always I encourage all to do their own research and please feel free to share ~ Cherry Girl

The Role of the Endocannabinoid System in the Pathophysiology and Treatment of Irritable Bowel Syndrome
Activation of cannabinoid (CB)(1) and CB(2) receptors under various circumstances reduces motility, limits secretion and decreases hypersensitivity in the gut. Drugs that alter the levels of endocannabinoids in the gut also reduce motility and attenuate inflammation. In this review, we discuss the role of the endocannabinoid system in gastrointestinal physiology. We go on to consider the involvement of the endocannabinoid system in the context of symptoms associated with IBS and a possible role of this system in the pathophysiology and treatment of IBS.

Clinical Endocannabinoid Deficiency (CECD): Can This Concept Explain Therapeutic Benefits of Cannabis In Migraine, Fibromyalgia, Irritable Bowel Syndrome and Other Treatment-Resistant Conditions?
THC modulates glutamatergic neurotransmission via NMDA receptors. Fibromyalgia is now conceived as a central sensitization state with secondary hyperalgesia. Cannabinoids have similarly demonstrated the ability to block spinal, peripheral and gastrointestinal mechanisms that promote pain in headache, fibromyalgia, IBS and related disorders. The past and potential clinical utility of cannabis-based medicines in their treatment is discussed, as are further suggestions for experimental investigation of CECD via CSF examination and neuro-imaging.

Cannabinoids For Gastrointestinal Diseases: Potential Therapeutic Applications
A pharmacological modulation of the endogenous cannabinoid system could provide new therapeutics for the treatment of a number of gastrointestinal diseases, including nausea and vomiting, gastric ulcers, irritable bowel syndrome, Crohn’s disease, secretory diarrhoea, paralytic ileus and gastroesophageal reflux disease. Some cannabinoids are already in use clinically, for example, nabilone and delta(9)-tetrahydrocannabinol are used as antiemetics.

Cannabinoids and Gastrointestinal Motility: Animal and Human Studies
Activation of prejunctional CB1 receptors reduces excitatory enteric transmission (mainly cholinergic transmission) in different regions of the gastrointestinal tract. Consistently, in vivo studies have shown that cannabinoids reduce gastrointestinal transit in rodents through activation of CB1, but not CB2, receptors. However, in pathophysiological states, both CB1 and CB2 receptors could reduce the increase of intestinal motility induced by inflammatory stimuli. Cannabinoids also reduce gastrointestinal motility in randomized clinical trials. Overall, modulation of the gut endogenous cannabinoid system may provide a useful therapeutic target for disorders of gastrointestinal motility.

Alternative Targets Within the Endocannabinoid System for Future Treatment of Gastrointestinal Diseases
Of major therapeutic interest are nonpsychoactive cannabinoids or compounds that do not directly target cannabinoid receptors but still possess cannabinoid-like properties. Drugs that inhibit endocannabinoid degradation and raise the level of endocannabinoids are becoming increasingly promising alternative therapeutic tools to manipulate the ECS.

Irritable Bowel Syndrome: A Dysfunction of the Endocannabinoid System?

Cannabis, Cancer And Children:Why We Must Give Parents A Choice

There is something special about children that brings a smile.  Some parents wait a long time to be able to have that special time to cradle their child, gazing into their eyes.  Imagine being the parents faced with the reality that your child has cancer.  For over 10,000 parents each year that is the case.  Vigilantly staying by their child’s side through countless shots, painful procedures, body wrenching medications and worst of all watching as their child withers away before their eyes.  The spark slowly going out leaving behind a weak body.  Most would try anything to save their baby.  

Current therapies  such as chemotherapy are not precise measures.  Rates of success in comparisson with side effects make some wonder why alternatives are being stifled.    In contrast there is mounting evidence of the anti-tumor effects of cannabis compounds.  Cannabis has been praised for its large window of error since cannabis does not cause death.

Most in the cannabis community know who Cashy Hyde is.  He is the little boy who’s father treated him with cannabis oil and who today is cancer free.  Cashy has undergone extensive treatments that ravaged his tiny body.  His father watched as the light faded and decided to save his son.  He fed Cashy Rick Simpson Method Cannabis Oil through his feeding tube and miraculously watched his son bounce back to life.  Within days they noticed a difference.

Cashy is not alone.  There are millions of others that have been helped and cured with cannabis.  The discussion of cannabis is beyond smoke.  Cannabis research has shown that by targeting the Endocannabinoid system with the right combinations of compounds you will receive the desired effects including inducing cell death in cancer.

With so much more scientific medical research as proof the majority of the country is asking why we still pursue prohibition with a vengeance.  California has been helping patients since 1996.  Last year we saw a flood of stories where federal agencies terrorized local communities with their SWAT style raids.  In doing so they cut off supply of much needed medicine for patients just like Cashy.

We must do something to give parents an option to save their children.  When parents are told there is nothing more that can be done should we really take away hope.  Should we incarcerate parents for possessing a plant, one that science proves is lifesaving?  We need to bring sanity back into the equation.  We must change the laws.  Me must challenge the “way its always been”.  It is time to allow parents the right to decide for their children.  Several states have proposed or pending legislation.  Contact your state representatives and urge them to help change the future for our children.

Save Your Ass, Smoke Some Grass

When people think of grass, weed, pot or cannabis they think of hippies and parties.  What most people don’t think about is that cannabis is showing real promise, on the molecular level, in fighting cancers.  People of all walks have been touched by cancer.  Most people know of someone, has had a loved one go through it or they themselves have experienced cancer.  It is no wonder then that science and medicine have been working hard to find a cure.  Cannabis research has been taking notice especially for its anti-cancer discoveries.   Over 140,000 new cases were reported for colon and rectal cancers with 51,000 reported deaths.  Below you will see studies where cannabis has been examined in the context of colorectal cancers.  As always please feel free to share and I encourage all to do their own research as well ~ Cherry Girl

Single Nucleotide Change in the Cannabinoid Receptor-1 (CNR1) Gene in Colorectal Cancer Outcome
The cannabinoid receptor-1 (CNR-1) and endogenous agonists of this receptor are present in the central and peripheral nervous systems including the gastrointestinal nervous system.Indeed nontumor paired colorectal tissues showed nucleotide change. A large number of patients with mutation in the CNR1 gene were observed. These preliminary findings highlight the importance of further studies in the use of cannabinoid analogs as receptor ligands to analyze potential therapeutic effects.

Cannabinoid Receptor Activation Induces Apoptosis(programmed cell death) through Tumor Necrosis Factor α–Mediated Ceramide De novo Synthesis in Colon Cancer Cells
We show that the CB1 receptor was mainly expressed in human normal colonic epithelium whereas tumor tissue was strongly positive for the CB2 receptor.  The present study shows that either CB1 or CB2 receptor activation induces apoptosis through ceramide de novo synthesis in colon cancer cells. Our data unveiled, for the first time, that TNF-α acts as a link between cannabinoid receptor activation and ceramide production.

Apoptosis: Programmed Cell Death At A Molecular Level
Balanced apoptosis is crucial in development and homeostasis, and all multicellular organisms have a physiologically programmed continuum of pathways to apoptotic cell death. Further studies of the control at the molecular level of key components and promoters/suppressors of apoptosis may provide better approaches to treatment of autoimmune diseases, malignancies, and neurodegenerative disorders. Many important questions remain regarding the advantages of modifying apoptotic programs in clinical situations.

Cannabis: Your Heart Hero

More and more Americans are being classified as obese.  With obesity comes other complications such as cardiovascular disease.  Cardiovascular disease refers to any disease that affects the cardiovascular system, principally cardiac disease, vascular diseases of the brain and kidney, and peripheral arterial disease.  The causes of cardiovascular disease are diverse but atherosclerosis and/or hypertension are the most common.  It is estimated that one-third of Americans die from cardiovascular disease so it is no wonder that scientists have been hard at work trying to find a cure.   Below you will see studies where science has looked at cannabis compounds when applied to CVD.  Please feel free to share and I encourage all do their own research as well ~ Cherry Girl

Targeting Cannabinoid Receptor CB(2 ) in Cardiovascular Disorders: Promises and Controversies
“Cardiovascular disease is the leading cause of death and disability worldwide, which can be largely attributed to atherosclerosis, a chronic inflammation of the arteries… the lipid endocannabinoid system has emerged as a new therapeutic target in variety of disorders associated with inflammation and tissue injury, including those of the cardiovascular system. The discovery that delta-9-tetrahydrocannabinol (Δ9-THC), the main active constituent of marijuana, inhibited atherosclerotic plaque progression via a cannabinoid 2 (CB(2) ) receptor-dependent anti-inflammatory mechanism.

Endocannabinoid System in Cardiovascular Disorders – New Pharmacotherapeutic Opportunities
The evidence so far gathered shows that the modulation of ECS (as agonism or antagonism of its receptors) is an enormous potential field for research and intervention in multiple areas of human pathophysiology. The development of selective drugs for the CB1 and CB2 receptors may open a door to new therapeutic regimens.

Never Fear Cannabis Is Here! How Cannabis Can Help With Fear, Anxiety, and Other Psychiatric Disorders

Nearly 19 million Americans suffer from a  psychiatric disorder which could include disorders such as specific phobias, generalized anxiety disorder, social anxiety disorder, panic disorder, agoraphobia, obsessive-compulsive disorder and post-traumatic stress disorder.  Many veterans returning from war have found cannabis to be a relief from PTSD.  Below you will studies where science has studied the effects of cannabis compounds when applied to psychiatric disorders.  Please feel free to share and I encourage all to do their own research as well ~ Cherry Girl

The Endocannabinoid System in the Processing of Anxiety and Fear and How CB1 Receptors May Modulate Fear Extinction 
The endocannabinoid system recently emerged as an important modulator of many neuronal functions. Among them, the control of anxiety and acquired fear represents nowadays one of the most interesting fields of research.  Finally, a neurobiological model possibly able to implement the role of the endocannabinoid system in these processes will be proposed.

CB1 Cannabinoid Receptors Modulate Kinase and Phosphatase Activity During Extinction of Conditioned Fear in Mice
Cannabinoid receptors type 1 (CB1) play a central role in both short-term and long-term extinction of auditory-cued fear memory.  We propose that the endogenous cannabinoid system modulates extinction of aversive memories, at least in part via regulation of the activity of kinases and phosphatases in a brain structure-dependent manner.

Extinction of Emotional Response As A Novel Approach of Pharmacotherapy of Anxiety Disorders 
The patogenesis of anxiety may be related to the process of an extinction of aversive memories… Studies on molecular and cellular mechanisms responsible for individual fear extinction may serve as the basis of search for more effective forms of clinical treatment… ligands stimulating endogenous cannabinoid system… these substances stimulate different central mechanisms, they appear to act synergistically, to improve the behavioural therapy.

Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear
the findings in the present study suggest that augmenting eCB-mediated neurotransmission by inhibition of eCB transport or breakdown may provide a novel mechanism for enhancing the extinction of fear. As such, eCB reuptake inhibitors may serve as useful adjuncts in the treatment of anxiety disorders (such as PTSD, panic disorder, and OCD) as well as drug addiction and other disorders that respond to behavioral treatments utilizing extinction processes.

The Endogenous Cannabinoid System Controls Extinction of Aversive Memories
Acquisition and storage of aversive memories is one of the basic principles of central nervous systems throughout the animal kingdom. In the absence of reinforcement, the resulting behavioural response will gradually diminish to be finally extinct.  We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala.

The Endocannabinoid system and Extinction Learning
As several human psychiatric disorders, such as phobia, generalized anxiety disorders, and posttraumatic stress disorder (PTSD) appear to involve aberrant memory processing and impaired adaptation to changed environmental conditions, the hope has been fuelled that the endocannabinoid system might be a valuable therapeutic target for the treatment of these disorders.

Bringing the War Back Home: Mental Health Disorders Among 103,788 US Veterans Returning From Iraq and Afghanistan Seen at Department of Veterans Affairs Facilities
Co-occurring mental health diagnoses and psychosocial problems were detected early and in primary care medical settings in a substantial proportion of OEF/OIF veterans seen at VA facilities. Targeted early detection and intervention beginning in primary care settings are needed to prevent chronic mental illness and disability.

Psychosis and Trauma. Theorical Links Between Post-Traumatic and Psychotic Symptoms
The links between psychotic and psycho-traumatic symptoms are complex and multidirectional; this co-occurrence is a factor of seriousness. The clinician, while paying attention to these symptoms, has to distinguish the structure of the personality of the subject to articulate the psychotherapy and the pharmacological treatment. Further investigational studies may determine whether antipsychotics will enhance treatment response in PTSD patients with psychotic features.

How Some Green Can Help The Blues

Americans across the nation are facing mounting pressure from the economy and many other challenges.  Many are also suffering with depression and mood disorders along with added pressures.  The average American who has tried cannabis well knows the mood elevating effects which include uncontrollable giggling or laughter.  Of course it is also dependent on the right strain but that is where science comes in.  Below you will see studies where scientists have discovered why our moods are altered as well as further the knowledge we have on the interactions of cannabis’ compounds and our bodies.  Please feel free to share and I encourage all to do their own research as well ~ Cherry Girl

The Dopamine and Cannabinoid Interaction in the Modulation of Emotions and Cognition: Assessing the Role of Cannabinoid CB1 Receptor in Neurons Expressing Dopamine D1 Receptors
Although cannabinoid CB1 receptors (CB1Rs) are densely expressed in neurons expressing dopamine D1 receptors (D1Rs), it is not fully understood to what extent they modulate emotional behaviors…….These results provided first direct evidence for a cross-talk between dopaminergic D1Rs and endocannabinoid system in terms of controlling negative affect.

Effects of Cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic Acid and Cannabidiol in MPP(+) Affected Murine Mesencephalic Cultures
Cannabinoids derived from Cannabis sativa demonstrate neuroprotective properties… Therefore we studied some major cannabinoids, i.e. delta-9-tetrahydrocannabinolic acid (THCA), delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in mice mesencephalic cultures for their protective capacities… our data show that cannabinoids THC and THCA protect dopaminergic neurons against MPP(+) induced cell death.” (Possibly due to the cross-talk between  the dopamine and cannabinoid systems as seen in the study above)

Antidepressant-like Effect of Δ9-tetrahydrocannabinol and Other Cannabinoids Isolated From Cannabis
Results of this study show that Δ9-THC and other cannabinoids exert antidepressant-like actions, and thus may contribute to the overall mood-elevating properties of cannabis.

 

Cannabis: Part Of A Healthy Diet?

Cannabis has been used in a variety of ways for thousands of years.  One of the unique things about the cannabis plant is how versatile and green the plant truly is.  It can be grown organically leaving behind virtually no footprint as well as being used in whole when harvested.  Many people believe in the power of natural remedies including a natural foods diet.  Cannabis, especially the seeds are known for their nutritional value including antioxidants.  Below you will find studies that look at the dietary value of cannabis as well as helpful side effects.  Please feel free to share ~ Cherry Girl

Antioxidant Activities and Oxidative Stabilities of Some Unconventional Oilseeds
“Hempseed (Cannabis sativa), in addition to its nutritional value, has demonstrated positive health benefits, including the lowering of cholesterol and high blood pressure… As a result of the present research, the analyzed oils could be evaluated as an alternative to traditionally consumed vegetable oils…

Health Benefits of Herbs and Spices: the Past, the Present, the Future
Health benefits of herbs and spices: the past, the present, the future… The real challenge lies not in proving whether foods, such as herbs and spices, have health benefits, but in defining what these benefits are… At present, recommendations are warranted to support the consumption of foods rich in bioactive components, such as herbs and spices. With time, we can expect to see a greater body of scientific evidence supporting the benefits of herbs and spices in the overall maintenance of health and protection from disease.

Several Culinary and Medicinal Herbs Are Important Sources of Dietary Antioxidants
In a normal diet, intake of herbs may therefore contribute significantly to the total intake of plant antioxidants, and be an even better source of dietary antioxidants than many other food groups such as fruits, berries, cereals and vegetables.

Neuroprotective Antioxidants From Marijuana
As evidence that cannabinoids can act as an antioxidants in neuronal cultures, cannabidiol was demonstrated to reduce hydroperoxide toxicity in neurons. In a head to head trial of the abilities of various antioxidants to prevent glutamate toxicity, cannabidiol was superior to both alpha-tocopherol and ascorbate in protective capacity. Recent preliminary studies in a rat model of focal cerebral ischemia suggest that cannabidiol may be at least as effective in vivo as seen in these in vitro studies.

Cannabidiol and (-)Delta9-Tetrahydrocannabinol Are Neuroprotective Antioxidants
Cannabidiol was more protective against glutamate neurotoxicity than either ascorbate or alpha-tocopherol, indicating it to be a potent antioxidant. These data also suggest that the naturally occurring, nonpsychotropic cannabinoid, cannabidiol, may be a potentially useful therapeutic agent for the treatment of oxidative neurological disorders such as cerebral ischemia. 

 

Cannabis Prohibition: Is It Really Keeping Our Children Safe?

Many a bored teen will hang out with friends and be faced with choosing to use drugs or not.  Many government officials as well as parents tout the War on Drugs as a savior to our children.  They say that it keeps the drugs out of the hands of minors, off the streets and out of schools.  With the economy shining a spotlight onto finances one can quickly see how big of a budget the War on Drugs consumes.  With taking all the different facets of this war into account some wonder if its really working.

The War on Drugs has been waging for over 40 years.  It has cost the tax-payers over $14 trillion, billions annually.  There have been surges and wanes over the 40 years in intensity in the pursuit to eradicate drug use.  Over the years we have witnessed many tragedies and successes.  We have seen harmful drug use drop among the population but especially minors.  We have also seen over the last 18 months an intensity like never before in the use of intimidation tactics, SWAT style raids against state legal patients, abuse, or lethal force when pursuing cannabis users.

With more education and information available to teens today many are able to see through the hypocrisy and lies.  Teens can see you are lying especially when they try cannabis, realize that it is not going to kill them and that they actually like the effects.  With alcohol, who’s effects are similar to cannabis but with much more harm at stake, not only available for sale but advertised everywhere including major sports events it is hard to see the difference.  When they see you are lying about cannabis they question other “truths” you have been telling them.

Simple cannabis possession or other non-violent cannabis related offenses can claim your driver’s license, student loans, subsidized housing, or federal grants.  It can jail a parent or guardian even if they are state and county legal.  With a parent jailed it costs tax-payers more to incarcerate and breaks up a family where the children are thrown into the broken foster care system.  All of us should be asking if this is really what is best for our children.

Children that go into the system cost tax-payers millions each year.  It costs the child emotionally and psychologically.   Children that grow up in the system are bounced around to different homes causing them to act out, perform poorly in school, drop out, get into legal trouble and end up repeating their parents mistakes.  Should we really treat cannabis related offenses this harshly?  Are these tactics really working?

Cannabis use was slightly higher this year but more harmful drugs, including alcohol, were reportedly down according to a recent study among teens use.  Those that take a quick look around or have a conversation with a teen will learn how easily drugs are accessible.  Each year D.E.A. officials boast of their catches but in reality they have barely scratched the surface.  Even with officials raiding and confiscating thousands of plants, California’s number one cash crop was still cannabis.  The plain truth is that it is a plant that can be grown in anyone’s home.  It can be kept from anyone’s knowledge provided the grower is smart.  It can be accessed through many avenues including access through children.

Drug cartels have taken notice of America’s love of drugs and has very outstretched networks that effect our children.  The violence and corruption that comes along with the cartels are infiltrating our schools.  The cartels lure children with money or threats using them as drug runners, smugglers or sellers.  They know that if children are caught the punishment is less.  The also know that it takes less money to impress children.  In this way they have been able to utilize children to sell to others including their peers thus spurring not only more drug use but recruiting even more children.

California has a heavily burdened prison and welfare system.  They have a large amount of incarcerated inmates for cannabis related crimes.  Our nation has been fighting this war for far too long.  Even our children see the truth about cannabis.  Isn’t it time we started talking about this subject from a new perspective?  Our law enforcement agencies have received cuts across the states including here in California.  Our streets are not safer.  Drug use has not been eradicated even after over 40 years.  Families are broken, children are effected, states are bankrupt and in the end drugs are still easily accessible at any school.  Isn’t it time we end the War on Drugs and start with a new approach?

Interactions With Cannabis Compounds and the Human Endocannabinoid System in the Brain

We have know about the endocannabinoid system since the 60’s but we have only begun to scratch the surface of what our system is capable of.  This of course include the interaction with compounds found in the cannabis plant.  Below are studies that deal with the interaction of cannabis compounds and our endocannabinoid system in our brain.  Please feel free to share and spread the truth ~ Cherry Gurl

Multiple Functions of Endocannabinoid Signaling in the Brain 2012
Despite being regarded as a hippie science for decades, cannabinoid research has finally found its well-deserved position in mainstream neuroscience. A series of groundbreaking discoveries revealed that endocannabinoid molecules are as widespread and important as conventional neurotransmitters such as glutamate or GABA, yet they act in profoundly unconventional ways. We aim to illustrate how uncovering the molecular, anatomical, and physiological characteristics of endocannabinoid signaling has revealed new mechanistic insights into several fundamental phenomena in synaptic physiology.

Clinical Efficacy and Effectiveness of Sativex(®), A Combined Cannabinoid Medicine, in Multiple Sclerosis-Related Spasticity 2012
Results from randomized, controlled trials have reported a reduction in the severity of symptoms associated with spasticity, leading to a better ability to perform daily activities and an improved perception of patients and their carers regarding functional status. These are highly encouraging findings that provide some much needed optimism for the treatment of this disabling and often painful symptom of MS.

Cannabidiol Exerts Anti-Convulsant Effects in Animal Models of Temporal Lobe and Partial Seizures 2012
We have recently shown that the phytocannabinoid cannabidiol (CBD) reduces seizure severity and lethality in the well-established in vivo model of pentylenetetrazole-induced generalised seizures… this evidence strongly supports CBD as a therapeutic candidate for a diverse range of human epilepsies.

The Cannabinoid Receptor-2 is Involved in Allergic Inflammation 2012
These results clearly demonstrate that CB2 and its endogenous ligands participate not only in the acute, edematous phase of allergic dermatitis, but also in the chronic irreversible acanthosis reaction.

The Direct Pro-Fibrotic and Indirect Immune Anti-Fibrotic Balance of Blocking the Cannabinoid CB2 Receptor 2012
Naïve CB2(-/-) mice had significantly decreased T-cell subsets. (II) Adoptive transfer of CB2(-/-) lymphocytes led to decreased fibrosis in the irradiated WT recipient as compared to animals receiving WT lymphocytes. Moreover, necro-inflammation also tended to decrease. (III) In-vitro, a CB2-antagonist directly increased human HSCs activation and increased apoptosis, decreased proliferation of mice/ human T-cells (healthy/ fibrotic) and their phagocytosis. Conclusions: CB2(-/-) lymphocytes exert an anti-fibrotic activity while lack of CB2-receptor in HSCs promotes fibrosis. These findings broaden our understanding of cannabinoid signaling in hepatic fibrosis beyond their activity solely in HSCs.

Therapeutic Use of Cannabis 2012
Evidence on the therapeutic use of cannabis suggests it may produce improvements in quality of life, which has led to increased use among people with life-limiting illnesses. The cannabis used is usually obtained illegally, which can have consequences for both those who use it and nurses who provide treatment in the community.

Endocannabinoids Regulate Growth and Survival of Human Eccrine Sweat Gland-Derived Epithelial Cells 2012
The endocannabinoids selectively activated the mitogen-activated protein kinase signaling pathway. Finally, other elements of the ECS (i.e., enzymes involved in the synthesis and degradation of endocannabinoids) were also identified on NCL-SG3 cells. These results collectively suggest that cannabinoids exert a profound regulatory role in the biology of the appendage. Therefore, from a therapeutic point of view, upregulation of endocannabinoid levels might help to manage certain sweat gland-derived disorders (e.g., tumors) characterized by unwanted growth.Journal of Investigative Dermatology advance online publication.

 

Cannabis and Teens

Since 1975 the “Monitoring the Future” study has recorded the self-reported use of various substances by middle and high school students. Each year it reveals what is really going on with teen drug use.  In 2011 47,000 teens participated with interesting results. Although many, including the US Drug Czar, took the findings as negative and just one more way to attack cannabis use what it revealed was more proof that teens just like most of us want to do what is best for our bodies.

Many Americans today have tried or use cannabis with no adverse side effects.  During the 90s there was a huge push with D.A.R.E. and other programs that educated school children on all dangers of drugs.  With the population becoming more educated on the actual dangers associated with cigarettes, alcohol and other harmful substances we have seen a shift in use.  People including teens  have also realized the real harms and benefits of cannabis as well.

With this realization people have turned to cannabis with its relatively mild side effects and no lasting damage or threat of death.  Data backs up that use of harmful substances such as cocaine, steroids and heroin have steadily fallen down almost 50% from peak.  Alcohol and tobacco use is down 50% as well actually reaching historic lows.  It would seem that the population of teens have weighed out the dangers and chosen for themselves.

Cannabis use by contrast in the last four years has increased but not noticeably.  Some wonder then why many saw this report as a call to action against cannabis.    Some blamed the medical use movement for not only exposure but access as well.  This argument does not entirely hold up.  Medical marijuana was in the mainstream media and nation-wide topic in 1996 when CA first tried to legalize for patients.  Access for minors in states that have legalized has been restricted and taken crime off the streets.

In 2011 it was reported that 6.6% reported consuming cannabis daily which is greater than previously reported.   The attitude towards cannabis by teens as a whole has also changed with about 45% of them viewing cannabis as harmful.  That is a huge difference considering in the early 90s it was at 80%.  One caveat is that during the time from the early 90s and throughout most of 2000 teen use of cannabis also fell.

Anyone who lives in the real world will attest that you can only shield your children for so long before you have to let go and let them make their own choices.  When it comes to that point all the training that they have received will guide them.  Teens will always party and always break the rules.  We will never live in a society where there is not a teenage party going on somewhere.  While I don’t support teen use of cannabis, when weighing out the harms against use of alcohol and other harmful substances I would rather see teens choose a natural plant that does not cause death.

There of course are risks with using cannabis not only from using the drug but also the consequential side effects and one’s actions.  The earlier in one’s life cannabis is used the more potential there is for risks.  With that, when weighing out the cons, the potential risks of using cannabis is far less severe than many other substances including prescriptions.

While Drug Czar Gil Kerlikowske and other national media look negatively at the study others walk away with a sense of pride that our nation’s youth are choosing more wisely.  Today more people, including teens, perceive cannabis to be less harmful than alcohol and tobacco.  Someday our leaders will see the light and come to the same conclusion as the rest of us.  The War on Drugs has made cannabis an evil that is not neccessary.

The Human Prenatal Endocannabinoid System

Since the discovery of the human endocannabinoid system science has been busy trying to unlock the mysteries of this complex system.  Science has uncovered many interesting features of this system.  This includes the presence of this multi-function system in fetuses.   Below you will see studies on how science has uncovered in-dept knowledge of the endocannabinoid system in pre and post natal subjects.  I encourage all to do their own research and please feel free to share the TRUTH ~ Cherry Girl

Multiple Roles For the Endocannabinoid System During the Earliest Stages Of Life: Pre- and Postnatal Development
The endocannabinoid system, including its receptors (CB(1) and CB(2)), endogenous ligands (‘endocannabinoids’), synthesising and degrading enzymes, as well as transporter molecules, has been detected from the earliest stages of embryonic development and throughout pre- and postnatal development.  Multiple roles for the endocannabinoid system during the earliest stages of life: pre- and postnatal development…the endocannabinoid system appears to play an essential role for development and survival… the endocannabinoid system plays several key roles in pre- and postnatal development. Future studies should further clarify the mechanisms involved… in order to design strategies for the treatment of conditions such as infertility, mental retardation and failure-to-thrive.

The Endocannabinoid-CB Receptor System: Importance For Development and In Pediatric Disease
The endocannabinoid-CB receptor system: Importance for development and in pediatric disease… it is suggested that children may respond positively to medicinal applications of cannabinoids without undesirable central effects. Excellent clinical results have previously been reported in pediatric oncology and in case studies of children with severe neurological disease or brain trauma. We suggest cannabinoid treatment for children or young adults with cystic fibrosis in order to achieve an improvement of their health condition including improved food intake and reduced inflammatory exacerbations.

On the Application of Cannabis In Paediatrics and Epileptology
An initial report on the therapeutic application of delta 9-THC (THC) (Dronabinol, Marinol) in 8 children resp. adolescents suffering from the following conditions, is given: neurodegenerative disease, mitochondriopathy, posthypoxic state, epilepsy, posttraumatic reaction. THC effected reduced spasticity, improved dystonia, increased initiative, increased interest in the surroundings, and anticonvulsive action…possibility that THC-induced effects on ion channels and transmitters may explain its therapeutic activity seen in epileptic patients.

The Endocannabinoid-CB(1) Receptor System In Pre- and Postnatal Life
The endocannabinoid-CB(1) receptor system in pre- and postnatal life.. CB(1) receptors display a transient presence in white matter areas of the pre- and postnatal nervous system, suggesting a role for CB(1) receptors in brain development…Further observations suggest that children may be less prone to psychoactive side effects of Delta(9)-tetrahydrocannabinol or endocannabinoids than adults. The medical implications of these novel developments are far reaching and suggest a promising future for cannabinoids in pediatric medicine for conditions including “non-organic failure-to-thrive” and cystic fibrosis.

Endocannabinoids and Food Intake: Newborn Suckling and Appetite Regulation In Adulthood
The appetite-stimulating effects of the cannabis plant (Cannabis sativa) have been known since ancient times, and appear to be effected through the incentive and rewarding properties of foods. Investigations into the biological basis of the multiple effects of cannabis have yielded important breakthroughs in recent years… exciting progress in the understanding of how the endocannabinoid CB receptor systems influence appetite and body weight is stimulating the development of therapeutic orexigenic and anorectic agents. Furthermore, the role of cannabinoid CB1 receptor activation for milk suckling in newborns may open new doors toward understanding nonorganic failure-to-thrive in infants, who display growth failure without known organic cause.

Ontogenetic Development of Cannabinoid Receptor Expression and Signal Transduction Functionality in the Human Brain
Previous evidence suggests that the endogenous cannabinoid system emerges relatively early during brain development in the rat. However, the pre- and postnatal pattern of appearance of CB1 cannabinoid receptors in humans has not been analysed in detail.   This early pattern of expression of functionally active cannabinoid receptors, along with the transient and atypical localization of these proteins in white matter areas during the prenatal stages, suggest an specific role of the endocannabinoid system in the events related to human neural development.

 

Individualized Treatments: Key To Cannabis’ Success

With so many new scientific discoveries published for the world to see many patients are now gaining a better understanding of how cannabis actually helps them.  Millions of patients have found relief in cannabis for a wide range of afflictions with millions more that have found relaxation.  Cannabis has been used for medicinal, religious and recreation purposes for thousands of years.  But it wasn’t until the 60s when the endocannabinoid system was discovered that we really began to understand the effects.  In 2011 the genetics of the cannabis plant was mapped with that we found that it was not just a plant but a complex world filled with compounds that have many applications.

Patients now have the option of learning what compounds exist in the cannabis plant and how that can help them personally.  Currently there are companies one in particular, GW Pharmaceuticalsthat is seeking FDA approval of a new drug that contains actual cannabinoids, not synthetic, which is currently approved and on the market.  Their mouth spray contains a blend of cannabinoids that they have found to commonly bring relief.

The problem is now that patients are armed with more in-dept information of not only their illness but of cannabis and its compounds they are no longer happy with a “one size fits all” treatment.  Why and how cannabis interacts with our system is becoming more widely known.  With this comes the knowledge that when using cannabis the key to its success is using the right mix of compounds.  Many studies point to the fact that you can not just isolate THC or just CBD but  that its the correct balance of multiple compounds that achieves the desired effect.  This is important to keep in mind when researching your ailment.  Looking for strains that match up with your needs can be very tricky so it is recommended that you seek help when undertaking this.

This is just one more reason why legalization is important.  In states that have legalized medical use of cannabis, dispensaries have flourished.  This allows first-time patients to be guided through the process with experienced patients and experts.  This also allows for supervision of a professional doctor instead of just yourself.  Dispensaries offer a wide array of strain choices within sativa, indica and hybrid varieties.  Professionals also help with choosing the right delivery method for you.

Cannabis use has come a long way since the casual days of the 60s.  Today patients are faced with many choices from natural buds,concentrates, tinctures, edibles and more.  In the states that have passed medical use laws patients standards have been raised.  Gone are the days when people were satisfied with whatever the guy on the corner had that day, no questions asked.  Today patients can inquire about anything from if a bud is organic to what the percentage of THC, CBD or CBN a product contains.

Many dispensaries are now testing their products to not only raise industry standards but to educate patients and promote their best buds.  In today’s market we see dispensaries competing for business giving patients the best selection.  Patients are becoming more educated on the differences between not only the strains but the major compound contents.  With the database of knowledge on individual strains and their compounds becoming not only ever increasing but more accessible it is only a matter of time before we have a better grasp to really start helping patients.

One of the largest shortfalls of today’s medical community is individualized care.  Many times patients are quickly shuffled through their appointment with their doctor trying out different therapies that have worked for other patients.  We do not have the availability of affordable technology to scan or sequence every patients illness or cancer.  Someday we will have wide-spread use of technology that allows doctors to give patients exactly what their bodies need.  Gone will be the days when doctors guess if a medication will work or kill you.  We know today that the technology exists to DNA sequence a cancerous tumor.  We already know that if we have the right combination of cannabis compounds it can shrink a tumor.  Think of all the loved ones that we could save with the right individualized care.

Today’s medications can cause many side effects including respiratory failure, liver damage and even death.  Many times patients are left with the option of doctors guessing which medication will be most helpful with the least damage and many times are prescribed more medication later on to combat damaged caused by previous treatments.  Cannabis has been praised for its forgiving window for patients in regards to damage from side effects.  Common knowledge of no reported overdoses or deaths from cannabis is another appealing factor.  Many have discovered that the benefits of cannabis outweigh the non-lethal side effects and have stopped taking all other medications.

With patients today educated on not only their illness but the available treatment options it is no wonder that they no longer want to accept only what the industry is willing to provide.  Many have taken their health into their own hands.  We have discovered how vital individualized care is when dealing with cannabis and hopefully have sparked interest into other avenues where this can be applied.  It is no longer in the best interest of the nation to rely so heavily on the current industries but instead look for not only natural options but ones that will not do harm.  We can look to the future for the technologies that can one day save us but for today we need to keep our option of being able to choose our own strain combination for ourselves until we all can have individualized care.  To do this we must continue in our fight for legalization.

Dear Mr. President

I know this year is a very important year for you.  It is just as important for millions of Americans across the nation.  I write to ask you a question.  In an election year that many feel is vital we would like to know why the issue of cannabis has not been properly discussed?  I have read the releases from the administration but it fails to properly address our concerns.  The issue has been ignored at many venues where it was the leading question.

After 40 years of this War on Drugs where have we gotten and was it worth it?  In this economy many people are hurting and everyone is looking for ways to save money.  The War on Drugs cost taxpayers billions of dollars each year and is responsible for many tragic stories.

Not only has it cost us money but it has cost us as a society as well.  Millions of Americans have been shuffled through the judicial system destroying their lives many for simple possession.  This problem has also exposed racial divides and furthered the tension in the country.  People have lost faith in law enforcement in many cities.  In Mexico over 50,000 have died in the last 6 years directly resulting from this war.  The Cartels are getting richer and the demand is still there.

There is a sizable and growing group of supporters across the nation.  75% support medical use and the number for legalization for adults over 21 is rapidly growing.  In this economy where many are downsizing the cannabis industry is booming.  The states that have legalized cannabis have seen a sharp increase in revenue both in taxes and fees as well as residual income for local communities.  When properly regulated and implemented we have seen excellent examples shine through.

Consumers no longer want to go to the street corner dealer but instead enjoy the safety and security of dispensaries.  There patients can find natural, organic strain choices with professional help and options in consumption.  They can feel confident that they are paying taxes and contributing towards the community instead of the black market.

With legalization comes regulation which assists in restricting access to minors.  Today minors are restricted from buying and accessing alcohol on their own due to strict regulations.  We have seen the devastating effects that alcohol prohibition caused.  Since its repeal we have also seen the effects that it has had on this nation.  From responsible use to fatalities from car accidents, consumption and domestic violence alcohol has been responsible.  Today alcohol is advertised during major sporting events, radio, TV, movies billboards and more exposing children at a young age.

There is too much proof both in scientific studies and in testimonies to deny the many benefits of cannabis.   With the knowledge we have gained so far patients of all kinds have found relief with cannabis.  We have also seen miraculous cases such as Cash Hyde overcome childhood cancer.  We have come much further than smoking on a Friday night but rather uncovered just the surface of what looks to be exciting and promising discoveries.

With all these factors in mind our community is wondering why our our President and candidates, who are vying for the highest power in the country for the next four years  and who directly effect this issue, continue to ignore us?  We want to know why an issue that directly effects millions and indirectly effects us all would not be considered?

We are looking for a leader who is willing to stand up to the opposition and show people that legalization can be done responsibly with regulations and state approval.  We need a leader who will take us seriously and address our needs.  We are looking for that leader this year and it is for that reason it needs to be addressed.  Millions of voters are waiting it is time to address cannabis.

Cannabis And The Human Immune System

For over 50 years science has been trying to unravel the questions that surround our endocannabinoid system.  Science has discovered many exciting breakthroughs including how cannabis, our endocannabinoid stem and our immune system work together.  below you will see studies on how this has been studied.  Please feel free to do your own research, seek out and share the truth ~ Cherry Girl

Immune Control By Endocannabinoids – New Mechanisms of Neuroprotection?
The endocannabinoid system consists of cannabinoid receptors, their endogenous ligands and enzymes for synthesis and degradation of endocannabinoids and represents a local messenger system within and between the nervous and immune system. Apparently, the endocannabinoid system is involved in immune control and neuroprotection.

Cannabinoid Treatment Suppresses the T-helper Cell-Polarizing Function of Mouse Dendritic Cells Stimulated With Legionella Pneumophila Infection
“In conclusion, our results show that a major cellular target of THC-induced immune suppression of Th1 immunity is the dendritic cell and that the drug attenuates polarizing function… THC… might be of use in the treatment of chronic inflammatory diseases, such as celiac disease and Crohn’s disease, rheumatoid arthritis, and systemic lupus, and therefore might be in the class of anti-inflammatory drugs recognized to interfere with earlier stages of immunity by suppressing DC activation.

Role of Cannabinoid Receptors In Delta-9-Tetrahydrocannabinol Suppression of IL-12p40 In Mouse Bone Marrow-Derived Dendritic Cells Infected With Legionella Pneumophila
These results suggest that THC-induced suppression of serum IL-12 is partly due to a suppression of IL-12 production by dendritic cells and that G(i) signaling and cannabinoid receptors, but not TRPV1, are involved in this suppressive effect.

The Endogenous Cannabinoid 2-Arachidonoyl Glycerol As In Vivo Chemoattractant For Dendritic Cells and Adjuvant For Th1 Response To A Soluble Protein
The decision-making mechanisms that determine the choice of the appropriate effector immune response to a microbial challenge are poorly understood. The endocannabinoid 2-arachidonoylglycerol (2-AG), injected intradermally in mice together with a soluble protein and a T helper-2 (Th2) priming Toll-like receptors (TLRs) agonist during primary immunization, shifts the memory response to the Th1 type. As 2-AG may be induced in tissues by various stimuli at concentrations similar to that used in our study, this evidence might be of a wide-ranging pathophysiological relevance.

Presence and Regulation of the Endocannabinoid System In Human Dendritic Cells
Cannabinoid receptors and their endogenous ligands, the endocannabinoids, have been detected in several blood immune cells, including monocytes/macrophages, basophils and lymphocytes. However, their presence in dendritic cells, which play a key role in the initiation and development of the immune response, has never been investigated.  These findings demonstrate for the first time that the endogenous cannabinoid system is present in human dendritic cells and can be regulated by cell activation.

The Endocannabinoid System: Mechanisms Behind Metabolic Homeostasis and Imbalance
The endocannabinoid system: mechanisms behind metabolic homeostasis and imbalance…EC agonists and receptors have been identified in the brain, liver, and peripheral adipose tissue, and the EC system is known to affect metabolism in these areas and others through neuromodulatory signals. Meal size, body weight, and numerous metabolic factors such as triglyceride and cholesterol levels, insulin resistance, and glucose intolerance can be affected via the EC system.

Delta 9-Tetrahydrocannabinol Modulates Antigen Processing By Macrophages
THC differentially modulates the capacity of macrophages to process antigens that is necessary for the activation of CD4+ T cells… delta 9-Tetrahydrocannabinol modulates antigen processing by macrophages.

Citizens Drive, Consume Alcohol, Use Tobacco And Take Prescriptions So Why Not Cannabis?

With all the heated debates over cannabis legalization going on around the country one would wonder why there is so much buzz over a plant.  Cannabis, specifically medical cannabis, has been at the forefront of discussions all around the country.  The federal government has continued its harsh stance against legalization despite the mounting evidence of its benefits, as backed up by the Vice President’s actions in Latin America this week.

We have looked at the issue of legalization in many lights but one way that has not been discussed is that of the individual.  Legally we are given responsibility for our actions and our bodies when we drive, consume alcohol, tobacco or prescriptions despite deaths each year.  Most of us are reasonably responsible adults who are depended upon to carry out many important tasks and make many important decisions including raising children.  Doctors are entrusted with our lives including cancer treatments and brain surgeries but they are not trusted to prescribe cannabis medicinally.

We are each supposed to be responsible for ourselves including the care of our bodies.  With this it would naturally be assumed that one would also have control of what goes into one’s body and what treatments or relaxations methods one chooses to use.  Americans range from lawyers, doctors, congresspeople, CEO s, mothers or any other law abiding citizens.  Why are we not trusted to make a responsible decision when it comes to cannabis?

This leaves one to wonder in regards to cannabis when did the government decide we were incapable of making such a personal decision?  When did they decide that they know more about whats better for each of us individually than we do ourselves?  It is insulting when you look at it in this light; that the government does not feel that each of us are capable of self-control.  As a parent I am insulted that they question my parenting abilities to raise a competent person capable of choosing wisely for themselves including refraining from letting cannabis “take over their lives” as the government wants us to believe happens all the time.  In reality each of us are capable of deciding how to, when to and how much to use cannabis if at all.  Each of us are capable of researching and talking with our doctors to see if cannabis is right for us.

The government allows drivers 16 and older to get behind the wheel of a car despite the harm drivers cause all across the nation.  There are over 40,000 deaths a year as a result of vehicles and their drivers.  People now more than ever are distracted with texting, videos, talking, browsing and more making them even more dangerous.

The government also allows for adults 21 and older to consume alcohol even though it causes over 750,000 deaths a year, domestic violence, rise in crime rates, child abuse, liver damage and many more tragedies.  The government feels that you can responsibly use and monitor your consumption of alcohol even though there are over 17 million alcoholics in the US.

The government allow adults 18 and older to use tobacco even after concrete evidence that it causes cancer and death not only to the user but those around them that are exposed.  Cigarettes have been linked to lung cancer, emphysema and more.  Each year it is estimated that 443,000 die from tobacco related issues.

Each year over 100,000 Americans die from medication by overdose, interactions or other medication related issues.  Citizens are entrusted with sometimes fatal medications monitored only by themselves and some doctor supervision.  Doctors on the whole still do not have sophisticated systems between themselves and pharmacies to prevent drug interactions or overdose.

There are many larger responsibilities we handle than a personal choice of using cannabis or not.  Even legally we are given much larger responsibilities so with that in mind the obvious question is why would using this plant in a responsible manner not be one our responsibilities as well?

Despite all the mounting evidence of the beneficial properties of cannabis and the fact there has never been a reported case of overdose, the government refuses to recognize that Americans are responsible enough and should have control over their decision concerning cannabis.  The decision to use or not to use cannabis is a personal choice and one that should be used with facts in hand and government nowhere in sight.

Although cannabis does not cause death, people still do.  People need to live up to that responsibility by using cannabis wisely and responsibly.  We shouldn’t have to prove anything to the government but if we are going to change things in this country being a good example is the first step.  This includes responsibly using cannabis and restricting access to children.

Educating others is the second step.  We need to show others that cannabis is not the evil drug that the government has made it out to be but instead a healing plant.  It can be used responsibly to wind down at the end of a long day much like wine or beer or in more potent version medicinally for patients.  In the end this is just a plant and one that can be used naturally without changing its form which can not be said for many other drugs legal or not.

Educating others is key to our success in legalization.  Others need to know the truth and I encourage all to go out and seek the truth.  Learn the real facts of cannabis.  Then contact your representative and ask for their support in repealing cannabis prohibition.  There are several pending legislation all over the country.  Help 2012 be a monumental year, one that we reach our goal!