Why We Should Pay Attention….At Least Some Of The Time

I remember as a child my grandpa talking with me about the politics of the U.S. and around the world.  I remember him rattling off different names of important people and all the scandalous things happening at the time.  My grandfather was born in 1938 and has seen a lot change in this world.  He’s followed politics longer than I have been alive and yet this passionate subject, for him, did absolutely nothing for me and felt more like a foreign language.  Once I moved out on my own and got my first real taste of freedom I thought I was free to do as I pleased.  I continued that blissful thought until my late twenties where I discovered cannabis.

I went through life not paying any attention to what was going on in politics because it wasn’t effecting me.  Then I started getting blinding intense pain headaches.  I went through a series of doctors, specialists, tests, machines, naturalists, chiropractors, medications, diets and supplements as well as a few other treatments.  For 4 years I sought out a treatment, a cause and a relief from the pain!  I subjected myself to all kinds of different prescriptions some that made my brain feel like it was on fire, made my body numb and on one occasion a near blackout on I-5 in the middle of Seattle from one drug that was supposedly safe.

It was then while at a party I discovered cannabis and all its natural benefits.  After finding cannabis I finally found relief.  I found something that not only took away the pain but lifted my spirits.  In one aspect it was a huge relief that I was not looking at a life where I had to constantly remind myself not to think of the pain always keeping myself busy to distract myself.  In the other aspect cannabis’ natural compounds helped with the depression that set in from being in pain for 4 years.  It really was a prayer answered.

I was fortunate enough to live in a state that had legalized medical marijuana so I was able to obtain a doctor’s recommendation that allowed me to purchase or grow cannabis.  It wasn’t until I walked into my first dispensary and started really talking to the cannabis community that I realized I actually needed to pay attention to politics.  Having control over your treatment, over your medication is priceless.  Having an option that is not fatal, that is natural and affordable is something everyone should enjoy.

Before legalization patients had to obtain their cannabis from the streets or risk growing it themselves.  If you buy on the black market you do not always have control over what you get and typically can not ask what strain it is, does it have molds, pests, chemicals or if its organic.  The streets also do not care if you are 37 or 15 only if you have cash.  On the other hand if a patient decides to grow they risk life as they know it.  If they are caught citizens face all kinds of situations from large legal bills, jail or prison time, losing their kids, job, house or assets as well as a stigma from society being labeled as a criminal.  Even being raided by the police is very tramatizing to the family as they typically break down the door and treat you like armed drug lords, drawing their weapons on your family.

This is why Californians passed prop 215 and later SB420.  This is just one reason why its important to at the very least check in on politics and whats going on in the world at least once in awhile.  While I was out searching for a cure to my pain trying all different kinds of legal chemical narcotics millions of Americans were being shuffled through the justice system for using, possessing or growing a plant.  Even after those two legislation were passed California patients are still having issues from the government with 2011 proving to be an aggressive year for the federal raids on patients.  

It wasn’t until I started researching cannabis that I suddenly realized we are not free at all.  When the government dictates what your medical treatment is and is not instead of you and your doctor, when they take your freedom of choice away that is not freedom and we need to ask ourselves “How can we stand by and allow it to happen?”  We as citizens need to come together and demand our freedom back.  It seems a little comical, if not for all the appalling tragedies, that we are fighting for our right to use a natural plant, one that has been used safely throughout the world for thousands of years.

I will probably never be like my grandfather rattling off names like baseball stats but I have learned to pay better attention to whats going on around me.  Financial crisis, unrest among the people in countries all over the world, everyday living prices soaring, budget cuts are everywhere and raids and arrests for simple possession of a plant are abundant.  2012 is a year to pay attention and get involved.  This year we could seize the opportunity to educate others and push for legalization and an end to this failed, immoral and unconstitutional War on Drugs.  it is time we take back our choice, our freedom, our government!  Contact your Representative or the White House and tell them its time for a real change.  Spread the word Legalization is on the horizon!

It Is Time, This Is Our Moment

Throughout history there are those moments in time that forever change our course.  Great moments where heroes stood up, fought back, and changed our destinies.  Many led ordinary lives but in that moment found the courage to do what’s right even in the face of adversity.

I believe we are at a very unique point in time.  All over the globe are seeing people wake up to the idea of a more involved society, one that gives them a voice.  We are starting to see the corruption that has been allowed to take hold.  Thanks to instant and world-wide communications we all can share an abundance of information.  The message is clear: People want freedom!

The thought of freedom of self is spreading.  People realize they have a choice.  They can be free to be responsible for themselves and their government.  With God-given free will people are seeking out the truths.  One truth that has frequently come into the spotlight, all over the globe is cannabis.  People are starting to see through the “reefer madness” and seek out the truths not only of its healing powers but of its actual harms.

The U.S. government has wasted trillions of tax-payer’s dollars pursuing a plant put here on earth for humans to use.  Beyond all its myriad of health benefits including exciting research pointing towards curing cancer, cannabis in its natural form can be looked at in the same light as drinking a beer or having a glass of wine.  Many Americans drink at the end of their day to unwind and relax from the day’s activities.  Millions of Americans use cannabis in the same way including using forms such as oils, juices, edibles and tinctures.

It is time to start taking a more serious look at what the real dangers are of cannabis prohibition.  Cannabis does not cause death, is more beneficial and is less harmful than alcohol which is a legal drug for Americans 21 and older.  We need to look at the practicality of prohibition on a national level. This is a serious issue that has devastating effects on millions of Americans.  An issue that breaks up families, bankrupts countless people, destroys American rights, costs trillions of tax-payer dollars and ruins society demands that we take a serious look at this situation and what its doing to this country.

These are the moments that history is made of.  Moments that show of courage and strength.  Times were we came together and fought back.  We need to make our voices heard loud and clear: Its time to talk about the end of prohibition!  We need to tell our representatives that its time to reschedule cannabis and repeal the prohibition.  We need to educate others on the truths.  When people see the truth we will have freedom.  This is our moment will you have the courage to change history?

Why the Prohibition of Cannabis Should End

We are witnessing the emergence of an oppressed part of society.  A community that had repeatedly been laughed at and pushed aside.  But in the last decade we have seen many breakthroughs and milestones reached.   We have also seen a very aggressive push back from the government on the fight for legalization.

The United States was attacked on Sept. 11, 2001 and since then laws and law enforcement agencies have changed.  Many expected changes but we did not expect our liberties to be eroded so much.  We have seen the militarization of local law enforcement increase with urgency.  We have seen the actions of these agencies change.

No community recognizes this more, surprisingly, than the cannabis community.  In 2011 alone thousands received threat letters from the DOJ.  Families, patients and caregivers were violently raided even though they were complying with state law.  Much of the legislation that was aimed at terrorists were actually used on Americans in the War on Drugs.  This costly war that has been going on for decades is not only a complete failure, it has misinformed millions and destroyed society.

They have squandered trillions of tax-payer dollars on this War on Drugs.  They have not only created a black market but allowed it to flourish.  Prohibition of alcohol created the rise in organized crime and prominent figures like Al Capone.  We saw prices go up, prescriptions for alcohol increase and speakeasies or clubs abound.  We have seen the same thing happen for over 75 years with cannabis with more recent increase in doctor recommendations, dispensaries in legal states and the head of a drug cartel listed on Forbes fortune 400 list.

With alcohol prohibition we saw a quicker end but we still saw the devastating effects it had in a short time.  We have had a longer period of time to take a look at the societal, emotional, economic, medical, environmental and many other impacts of prohibition and legalization.  For over 75 years we have seen families torn apart, parents lose children, people lose their wealth, their battle with their illness or their freedom.  We have seen the government tell us how cannabis is just as bad a heroin, worse than tobacco, alcohol and cocaine.  They have told us that cannabis holds no medical value.

With today’s access to information from all over the world and from many different sources many people should quickly see through the many lies of reefer madness.  There are countless medical studies backing up the medical potential of cannabis.  Last year the cannabis plants sativa and indica were genetically mapped enabling science to pinpoint the cannabinoids necessary to start using it as a therapy and cure.

With so much new data discovered, exciting breakthroughs on the horizon and the improved knowledge of society we too will see an end to cannabis prohibition.  Prohibition does not make sense as a policy or as a way to control society.  People are born with God-given free will and should be allowed to exercise it.  2012 can prove to be a momentous year if we make our voices heard.  Contact your representative today in support of legalization, rescheduling and responsible regulation.

How Technology and Medicine Are Coming Together To Legitimize Cannabis Use

In the last decade alone we have seen many advancements in technology as well as medicine.  We have seen the cell phone and subsequently smart phones and tablets held in the hands of the masses.  We have seen the access to information through use of the internet become available to the majority of the world even to far reaching places.  We have witnessed the advances in technology spill over to other industries such as medicine enabling breakthroughs.

Today with the help of technology the science, medical, technology and cannabis community are coming together.  We see doctors and scientists sharing information and ideas working collectively to cure and develop better therapies.  We see more informed patients who are working with doctors that have more access to their medical treatments (with electronic files implemented) helping to avoid the hundreds of millions of Americans that are sent to the hospital from drug reactions.

We have seen the technology that doctors use advance quickly enabling for a more pinpointed understanding of the ailment or even a patient’s specific body.  We have technology today that allows for the DNA sequencing of a cancer tumor, human and, thanks to Kevin McKernan and his team; cannabis Sativa and Indica.

In the Czech Republic they have been making advancements in the use of cannabis for medical use.  At the Konopi Je Lek (Cannabis Is Medicine) Clinic they have been working on exact strain-dependent therapeutic dosages of THC, CBD and CBN.  With the mapping of the cannabis plant along with the ability to map a human we can potentially have a quick way to match the right Cannabinoids for their particular ailment which is very exciting news.

There are millions of Americans that use cannabis in conjunction with their medication or instead of.  Many who know that cannabis works for them may not actually know why.  With the advancements in technology and medicine giving us those answers it is also making way for us to be able to better understand and therefore apply this for better therapy results.  Currently it can at times be a guessing game when trying to find the right strain or combination thereof when using cannabis therapy.  In the future you could make tinctures customized for your body.

Technology, Medicine, Science and Cannabis Community are showing people that cannabis therapy is beyond just the smoked version that comes up so frequently in debates.  Today’s cannabis therapy is far more advanced.  With British pharmaceutical products such Sativex (cannabis plant derived non-synthetic) that are seeking FDA approval it lends even more creditably to the medical uses of cannabis.  Many can see the future of cannabis as a therapy that will have legitimacy and will be taken seriously.

Just a few months ago we saw national support for medical legalization at 77%.  With more credible information available to the masses we see a shift in perception.  16 states along with D.C have enacted medical marijuana laws as well as several other states that have medical initiatives; with Washington, California and Colorado’s initiatives calling for legalization for adults over 21.

With the nation hurting financially it is time to look at our priorities.  So far the government has spent over $2 trillion on the war on drugs that has proven to be futile.  We need to look at reform and especially rescheduling cannabis.  This will only be accomplished if the people speak up.  We need to recognize that cannabis has medical value and that it should be decision made between a patient and doctor not the government.  Contact your local representative today and express your support for rescheduling and responsible legislation.  Many states have groups like NORML and ASA that are working on legislation so be sure to see if there is a current proposal in your state.  With everyone coming together we can see a bright future for the cannabis community as well as the nation.

Is A Win On the Horizon For the Cannabis Community?

When our parents took a stand against the government, the establishment, they had to grab the attention of the media to be heard.  They protested, burned bras and held demonstrations.  They too experienced police brutality but much of that was not covered.  They lived in a time when their generations was going through a transformation, a revolution.  As we look around today its hard not to draw parallels with where we are today.  We see critical shifts in society that give us hope for the future.  Some of these changes can be attributed to parental influence, more availability of information and a growth in enlightened thinking and perception.

The older generations who were indoctrinated with reefer madness are decreasing and we are now seeing the baby boomer generation head into the golden years.  Older Americans are finding that cannabis has come a long way from the “hippie” days and can be beneficial with ailments they are faced with today.  Discovering new methods such as edibles, tinctures and capsules spark a curiosity and give credibility to medicinal value for them.

We start to see a new generation emerge from this earlier shift in thinking and perception of the world resulting in a much more open-minded group.  With this shift in thinking we see more acceptance of non-traditional thinking, lifestyles and medical treatment options.   Along with the parental influence we see a huge influx of influence from technology and the information it provides.  This emerging group of people can search out for themselves the truth about cannabis including medicinal value.  People can connect with others, share information and even look up published medical studies.

Alternative, in some aspects, have almost become the norm.  Even something as simple as a grocery bag, ten years ago, would mostly have been used by “hippies” but now, at least on the west coast, it has become the norm.  With more education about our food and our planet we see more people choosing organic.  We are also seeing a sharp rise in acceptance and use of alternative medicine.  Polls in 2011 showed support for medical marijuana by Americans at 77%.

In the last decade we have seen a national conversation about cannabis educate and enlighten countless people about the truths and fictions surrounding it.  We have seen 16 states and the District of Columbia enact medical marijuana laws and 6 states that have regulated legalization ballot initiatives underway for 2012.  With all this progress and exposure to the topic it has brought our society to a catalyst-like moment in history.  We see the struggle that has gone on in this country with prohibition for over 75 years.  This will not have the same outcome as earlier battles, this time is different.

The new life that has impassioned the movement and helped it to gain steam, especially in the last few years, has been remarkable.  We have farther to go and still need help from all of those who believe in their right of freedom of choice and free will.  Using our voice to stand up for whats right.  Just as we saw in earlier generations we too need to stand against the establishment and fight for our rights.  We should have a natural option.  The cannabis community has been ignored, has been laughed at, as we saw heightened last year fought with and now with hopeful hearts we hope to see a win on the horizon.

Video – Cannabis Botany of Desire

Short 8 minute video on cannabis and our Endocannabinoid system.

Monumental Achievement – Cannabis Plant Genetics Mapped

In 2011 we saw cannabis all over the news.  We saw raids, booming industries, more states push for and more doctors taking a stand for legalization.  Cannabis has been in use by humans since at least 2737 BCE with Chinese Emperor Shen-Nung recorded prescribing it for a number of ailments.

There are many mysteries and controversies surrounding the cannabis plant.  Science has been trying to unravel them for years.  In 2011 we had a monumental breakthrough that quite literally could change the course of history.

Kevin McKernan has stacked up a long list of big accomplishments at just 38.  He is the owner of Medicinal Genomics with a lab in Amsterdam for researchers to freely study the cannabis plant.  Kevin was part of the Human Genome Project for four years.  He also worked on a robotic system that could handle He also developed methods to process DNA 100,000 times faster.

With a man who’s resume is that impressive you have to ask yourself why would a guy like that get into the business of studying cannabis.  He did work on mapping tumors and after working with doctors and patients started to see that many cancer patients were using cannabis.  After looking into cannabis he saw that there was much more to this plant and that it did have medicinal value.

While working with oncologist he found that if you sequence a tumors DNA as well as the patient you will discover the differences which can then become a target for drug therapies.  With cannabis being mapped the same theory could apply, instead of using Big Pharma drugs you could use Cannabinoids.

With both the Indica and Cannabis plant genetics mapped science can now start to get a better grasp on how cannabinoids interact with our bodies.  When we can successfully target each person illness with specific cannabinoids we will effectively understand the science behind the curing powers of cannabis.

Science will finally be able to confirm what millions have known for thousands of years.  Today we know more about THC, the psychoactive ingredient and the CBD, non-psychoactive ingredient and how the synthases of each are the genes that code for an enzyme that helps fold the hydrocarbons into Cannabinoids.

What controls the other 83 cannabinoids and other hundreds of terpenes is still unknown.   Many genes that were bred out in search of higher THC content since the government prohibited cannabis use, will need to be brought back through selective breading.

This is one more step in our fight for legalization.  With scientific proof the government will have no choice but to recognize cannabis has medicinal value.

Even the national Cancer Institute briefly posted a page that listed cannabis as a pain reliever and anti-nausea as well as possible anti-tumor effects.  The government made them take it down since this has only been proven in cell cultures and rats although it is currently in human clinical trials.

When dealing with chemotherapeutic drugs there is a fine line between killing the tumor and killing the patient.  Whats exciting about cannabis is that it is not fatal and very few drug therapies have such a forgiving window.

With all this new data in the coming years we will see our knowledge grow and hopefully result in legalization.  It will take all of us making our voices heard, that we should have a natural choice when treating our illnesses.  Kevin and his team have posted their findings online for all to look at.  Please feel free to share ~ Cherry Girl

Finding Pain Relief In Cannabis

This last weekend was supposed to be a mini-vacation while I Christmas shopped.  I was to stay the night in a hotel and I envisioned a fun day looking at all the Christmas displays.  In reality I was in so much pain all week I was just hoping I would be able to make it to a few stores.  My entire body was in pain with a horrible headache that radiated through my upper body.  It was hard to be in the Christmas spirit.

Fortunately by Friday I had the opportunity to visit a dispensary and picked up a new strain I had only heard about.  When I got home I was able to use some of my medicine.  I have been testing out different strains for awhile now and most I have found will give me some pain relief or complete pain relief but only briefly.  When I used the new strain I got complete pain relief for hours.  I wanted to cry.

I realized that it has been the entire year that I have spent in pain.  The year has seem to fly by and I can not believe that it is December.  It feel like it should still be early fall and I have more time left in the year.  Each month I would research more medical studies, strain lists, talk with dispensary owners, read books and test out the strains myself in search of pain relief.  Some I found would give me the giggles, make me tired, make me sick, ease anxiety, help with insomnia and now finally give me full pain relief.

It was such a strange feeling being able to enjoy the moment without trying to ignore pain.I realized how long it had been since I felt this way.  Each day I get up feeling nauseous and then a headache will set in.  Sometimes they are dull and sometimes the pain is so bad its like seeing stars before you black out.  I have not found a prescription that fully takes away the pain, doesn’t give me horrible side effects or turns me into a zombie.  I have only found that in cannabis.

This year has been a long journey that I know is just begining.  I have learned so much about cannabis and have met so many wonderful people that are doing great things for the community.  Looking back over this year I am amazed at how much I know now.  All the reading and learning that I have done has ignited a fire in me that gives me passion about this subject.  I see so many people that are suffering, that like myself, have found pain relief in cannabis.  After getting a taste of what life without pain feels like I was suddenly brought back down to earth with the realization that it could all be taken away.

Currently in California, city by city, government is banning cannabis dispensaries because of the federal crackdown that happened this year.  Real people experiencing real pain not only have to brace themselves for daily life but for the realization that they very well could be without their pain relief.  They also must face the fact that their option may be going to the corner drug dealer where no questions are asked and its a gamble of what you are actually getting.

In the country we have a very heated debate on the size of the government. We have the federal government that is imposing its view on the states.  The citizens of California voted to allow for cannabis use by patients.  In 1996 most knew of cannabis use for cancer but at that time it was not publically known to help with many other illnesses.

Now in 2011, with ABC, NBC, CNN, FOX and many other mainstream media outlets as well as organizations like NORML speaking out about the many benefits of cannabis we have a more educated public.  We still hear how California is a joke because anyone can get a recommendation for cannabis.  The truth is that many people benefit from cannabis beyond those with cancer and AIDS.

Cannabis can help from a headache, to nausea, to body aches.  It can help with many different illnesses and modern science is confirming on a continual basis the new uses for cannabis.  Many different diseases that plague millions of Americans are being treated in labs around the world with cannabis.  Scientists are hard at work to unlock the cure for cancer, Alzheimer’s, Parkinson’s, obesity, migraines, to name a few and many are finding that it may be cannabis.

Many people are starting to see the harm that prescriptions are starting to have on our bodies, our society and our government.  When looking at the side effects and the drug recalls that are regulated through the FDA we wonder why a natural plant is so evil.  We are now dealing with big drug companies controlling legislation and officials in our government.  We see users of a natural plant in its natural form imprisoned.   We see families broken up and tax payer money used against them.  We also see a rise in over use of prescription drugs and addiction and what that is doing to society.

We see what the War on Drugs has done to our society as well.  Not only has it broken families, forced those arrested to a lower standard of life but also burdened the American people with a costly system of punishment for use of a natural plant. With the raids in California we saw stories of children being awakened by DEA agents busting through their front doors and shoving a gun in their parent’s face.

We also see the black market side of things heating up.  There needs to be a balance and restoring of order.  Responsible adults should be allowed to make their own medical decisions for themselves and their family.  We should not have the federal government or any government dictating how to treat our illnesses or our bodies.  We need the black market taken down and cleaned up and the legitimate legal market allowed to flourish.

The cannabis community wants to be out in the open legally operating and paying taxes.  We want a system that supports responsible use and regulation.  We want to know that we can have safe access to safe medicine.  We want to know that we have a reliable legitimate source of pain relief.  Every citizen has the right to treat their body as they see fit. They also should have the option to treat their body with natural herbs.  As a human on this Earth we have the right to use what the planet gives us.  We have the right to use nature responsibly.

It is time that we start being a more courageous nation and stand up for what is right.  We need to voice our opinions and start working together to solve these issues.  Turn off the TV, look away from the IPhone and start talking to one another to begin the repair work for this country.  We need responsibility put back on the shoulders of the American people.  We need to roll up our sleeves and get the job done.  The government is not the answer, we are.  2012 is only weeks away how will you make a difference?

Treating Obesity and Diabetes With Cannabis

It is estimated that about one-third of Americans are clinically obese, with 25.8 million diagnosed with diabetes.  It is no secret that the American culture has encouraged obesity and as a result reported cases of diabetes is on the rise.

Scientists are still hard at work looking for a cure to both epidemics.  One therapy looked at is using cannabinoids.  Below you will see studies that back up the strongly held belief that cannabis is a natural cure to many illnesses that should be legalized for all.  Please feel free to spread the truth ~ Cherry Girl

The Endocannabinoid System As A Target For Obesity Treatment 
Overweight and obesity are major factors contributing to the development of type 2 diabetes mellitus (DM) and cardiovascular disease (CVD)… researchers and clinicians continue to explore pharmacotherapy, with intense efforts being directed toward the development of agents that will reduce weight and simultaneously reduce or eliminate modifiable cardiovascular and metabolic risk factors. Amongthe promising new agents are the CB(1) receptor antagonists. These agents target receptors of the endocannabinoid system, a neuromodulatory system recently found to influence energy balance, eating behavior, and metabolic homeostasis via central and peripheral mechanisms. In animal and clinical studies, antagonism of CB(1) receptors has resulted in meaningful weight loss and improvement of lipid and glycemic profiles.

ANTIOBESITY EFFICACY OF LH-21, A CANNABINOID CB(1) RECEPTOR ANTAGONIST WITH POOR BRAIN PENETRATION, IN DIET-INDUCED OBESE RATS
The peripheral blockade of cannabinoid CB(1) receptors has been proposed as a safe and effective therapy against obesity, putatively devoid of the adverse psychiatric side effects…Conclusions and implications: These results support the hypothesis that the treatment with the peripherally neutral acting cannabinoid CB(1) receptor antagonist, LH-21, may promote weight loss through modulation of visceral adipose tissue.

The Endocannabinoid System: A Promising Target For The Management Of Type 2 Diabetes
The endoCANNABINOID system “regulates the intake of nutrients through central mechanisms located within the hypothalamus and limbic area, but also intervenes in transport, metabolism and deposit of the nutrients in the digestive tract, liver, adipose tissue, skeletal muscle, and possibly pancreas. Activation of both central and peripheral CB1 receptors promotes weight gain and associated metabolicchanges. Conversely, selective CB(1) receptor antagonists, have been shown to reduce body weight, waist circumference, triglycerides, blood pressure, insulin resistance and C-reactive protein levels, and to increase HDL cholesterol and adiponectin concentrations in both non-diabetic and diabetic overweight/obese patients.

The Implication of CNR1 Gene’s Polymorphisms In The Modulation Of Endocannabinoid System Effects
The endocannabinoid system (ECS) represents one of the most important physiologic systems involved in organism homeostasis…The discovery of ECS and its signaling pathways opens a door towards the understanding of several important physiologic processes regarding appetite, food intake, metabolism, weight gain, motor control, memory, learning, drug addiction and nociception. The detailed analysis and validation of the ECS functioning can bring us very close to the discovery of new diagnosis and treatment methods for obesity, drugs abuse and numerous psychic diseases.

Rehashing Endocannabinoid Antagonists: Can We Selectively Target The Periphery To Safely Treat Obesity And Type 2 Diabetes?
A growing body of evidence supports an important role for the endocannabinoid system as a regulator of appetite, body weight, and systemic metabolism, which is overactive in obesity and type 2 diabetes. While initial attempts to target this system using rimonabant were successful in producing weight loss and improving obesity-related metabolic complications in humans, adverse central nervous system side effects precluded introduction of this drug into clinical practice. However, new data, presented by Tam and colleagues, demonstrate that selective blockade of peripheral cannabinoid receptors may be a novel successful therapeutic approach.

Pharmacotherapeutic Targeting Of The Endocannabinoid Signaling System: Drugs For Obesity And The Metabolic Syndrome.
Endogenous signaling lipids (“endocannabinoids”) functionally related to Delta(9)-tetrahydrocannabinol, the psychoactive ingredient of marijuana (Cannabis), are important biomediators and metabolic regulators critical to mammalian (patho)physiology.More recent data support the concept that the endocananbinoid system may be modulated for therapeutic gain at discrete pharmacological targets with safety and efficacy.Pressing worldwide healthcare needs and increasing appreciation of endocannabinoid biology make the rational design and refinement of targeted CB1 receptor modulators a promising route to future medications with significant therapeutic impact against overweight, obesity, obesity-related cardiometabolic dysregulation, and, more generally, maladies having a reward-supported appetitive component.

How Cannabis Prohibition Effects All of Us

Unraveling the web of lies and corruption tied to cannabis can be a very daunting task.  Its no wonder that the government has taken a sweeping action all across the board.  Political, racial, economic  status or geography can all play a role when the government attacks.  Many do not realize how they are impacted by the administrations view on cannabis.  Prohibition does not create a safer world, ironically it creates the opposite.

Americans love their vices with cannabis being a favorite choice for many but prohibition has made it tougher to obtain as well as intimidating with its stiff punishments.  The cost of the judicial process, incarceration, loss of jobs and all other residual effects is astounding!  These costs come at the taxpayer’s expense.

Americans instead have turned to prescription drugs many that have serious side effects. They say that sham doctors give out recommendations for cannabis to anyone but that is exactly what is happening with prescription drugs.  Americans consume 80% of the worlds pain killers.  These drugs like hydrocodone or oxycodone are just as addictive as heroin and they are legally prescribed.  In 2008 15,000 Americans died from legal pain killers.

After learning about the benefits of cannabis many Americans have switched from prescription drugs to medical cannabis with improvements to their quality of life.  Its not just switching one addiction for another but rather finding a natural option for pain relief.  It can help with not only the pain but possibly help in curing the source.  Many are finding that their condition improves with cannabis use and they can stop taking multiple prescriptions.

Cannabis can be used in many ways.  Ingesting cannabis can be used for spiritual, social, or medical purposes.  Sharing a pipe with friends can be a very enjoyable experience and can bond people together.  Tribes have used it for thousands of years spiritually and socially.  For thousands of years the cannabis plant has been used to treat many illnesses.  The hemp seed also has nutritional  value and is some of the best protein you can consume; a great option for vegetarians.

The cannabis plant itself has many ecological benefits as well.  It can be grown Eco-friendly with all parts of the plant being used; some of which provide material for clothes, rope and paper.  It would be a good replacement for a paper source with cannabis yielding more paper from the same acreage as one would from trees. It also can be regrown in 6 months with no harm done to the earth.

The social and economic impacts reverberate throughout our communities.  We all suffer from the effects of cannabis prohibition even if you do not consume it.   When law enforcement is more focused on a plant they are less focused on more serious crimes. When a loved one is suffering from pain and they are faced with the choice of relief from cannabis or constant pain it will effect you.  Cannabis patients are not just hippies getting high all day.  They are someones son, daughter, mother, father, grandmother, someone’s loved one.  They are a free American citizen, some of which are faced everyday with pain.  We all deserve a choice in our treatment without fear from the government. Imagine instead a world where we would be free to grow our own Eco-friendly source of medicine, clothing material, paper, spiritual and social aid.  One where law enforcement and the judicial system were prosecuting actual criminals.

How the law is used to destroy equality and protect the powerful
http://www.youtube.com/watch?v=7NCoR1YEGgY&feature=share

A Natural Choice For Pain Management

Most people do not know what it is like to be in pain every day but for the millions of Americans that do it can be difficult to live with.  When you wake up and go to sleep in pain it wears on you.  It can cause depression to set in.  When the pain is constant people seek out relief but sometimes find there is no easy answer.

Many seek help from traditional medicine only to find that it is costly, makes symptoms worse or causes unwanted side effects.   Pain management is a booming industry.  America is addicted to pain medications.  15,000 people in 2008 died from overdoses of legal prescription painkillers — more than died from heroin and cocaine overdoses combined.

But there is a natural way to relieve pain and modern science is slowly figuring out what millions already know.  Cannabis is not a new designer drug but has been around for thousands of years.  It was once used medicinally for a myriad of reasons.  With prohibitions for the last 75 years it has been difficult for science to unravel the mysteries.  Below you will see studies that show how cannabis can help with pain management.  Please Share with truth about the CURE!

Cannabinoid Receptors and Pain
The discovery of this ‘endocannabinoid system’ has prompted the development of a range of novel cannabinoid receptor agonists and antagonists, including several that show marked selectivity for CB(1) or CB(2) receptors. The endocannabinoid system has physiological and/or pathophysiological roles in the modulation of pain.”
Cannabinoid receptors and pain.
Pertwee RG. SourceDepartment of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, Aberdeen, UK. rgp@aberdeen.ac.uk

Abstract
Mammalian tissues contain at least two types of cannabinoid receptor, CB(1) and CB(2), both coupled to G proteins. CB(1) receptors are expressed mainly by neurones of the central and peripheral nervous system whereas CB(2) receptors occur centrally and peripherally in certain non-neuronal tissues, particularly in immune cells. The existence of endogenous ligands for cannabinoid receptors has also been demonstrated. The discovery of this ‘endocannabinoid system’ has prompted the development of a range of novel cannabinoid receptor agonists and antagonists, including several that show marked selectivity for CB(1) or CB(2) receptors. It has also been paralleled by a renewed interest in cannabinoid-induced antinociception. This review summarizes current knowledge about the ability of cannabinoids to produce antinociception in animal models of acute pain as well as about the ability of these drugs to suppress signs of tonic pain induced in animals by nerve damage or by the injection of an inflammatory agent. Particular attention is paid to the types of pain against which cannabinoids may be effective, the distribution pattern of cannabinoid receptors in central and peripheral pain pathways and the part that these receptors play in cannabinoid-induced antinociception. The possibility that antinociception can be mediated by cannabinoid receptors other than CB(1) and CB(2) receptors, for example CB(2)-like receptors, is also discussed as is the evidence firstly that one endogenous cannabinoid, anandamide, produces antinociception through mechanisms that differ from those of other types of cannabinoid, for example by acting on vanilloid receptors, and secondly that the endocannabinoid system has physiological and/or pathophysiological roles in the modulation of pain.
http://www.ncbi.nlm.nih.gov/pubmed/11164622 

The Future of Cannabinoids As Analgesic Agents: A Pharmacologic, Pharmacokinetic, and Pharmacodynamic Overview
Cannabinoid receptor agonists and/or molecules that affect the modulation of endocannabinoid synthesis, metabolism, and transport may, in the future, offer extremely valuable tools for the treatment of a number of currently intractable disorders.”— So, in the future, cannabis will be an “extremely valuable tool for treating a number of currently intractable disorders.
The future of cannabinoids as analgesic agents: a pharmacologic, pharmacokinetic, and pharmacodynamic overview. McCarberg BH, Barkin RL. SourceFamily Medicine Kaiser Permanente, Escondido, California, USA. Bill.H.Mccarberg@kp.org

Abstract
For thousands of years, physicians and their patients employed cannabis as a therapeutic agent. Despite this extensive historical usage, in the Western world, cannabis fell into disfavor among medical professionals because the technology available in the 1800s and early 1900s did not permit reliable, standardized preparations to be developed. However, since the discovery and cloning of cannabinoid receptors (CB1 and CB2) in the 1990s, scientific interest in the area has burgeoned, and the complexities of this fascinating receptor system, and its endogenous ligands, have been actively explored. Recent studies reveal that cannabinoids have a rich pharmacology and may interact with a number of other receptor systems-as well as with other cannabinoids-to produce potential synergies. Cannabinoids-endocannabinoids, phytocannabinoids, and synthetic cannabinoids-affect numerous bodily functions and have indicated efficacy of varying degrees in a number of serious medical conditions. Nevertheless, despite promising preclinical and early clinical data, particularly in the areas of inflammation and nociception, development challenges abound. Tetrahydrocannabinol (THC) and other CB1 receptor agonists can have an undesirable CNS impact, and, in many cases, dose optimization may not be realizable before onset of excessive side effects. In addition, complex botanically derived cannabinoid products must satisfy the demanding criteria of the U.S. Food and Drug Association’s approval process. Recent agency guidance suggests that these obstacles are not insurmountable, although cannabis herbal material (“medical marijuana”) may present fatal uncertainties of quality control and dosage standardization. Therefore, formulation, composition, and delivery system issues will affect the extent to which a particular cannabinoid product may have a desirable risk-benefit profile and acceptable abuse liability potential. Cannabinoid receptor agonists and/or molecules that affect the modulation of endocannabinoid synthesis, metabolism, and transport may, in the future, offer extremely valuable tools for the treatment of a number of currently intractable disorders. Further research is warranted to explore the therapeutic potential of this area.
http://www.ncbi.nlm.nih.gov/pubmed/17890938

Role of Cannabinoids in the Treatment of Pain and (Painful) Spasticity
In chronic pain and (painful) spasticity, an increasing number of randomized, double-blind, placebo-controlled studies have shown the efficacy of cannabinoids. Patients with unsatisfactory response to other methods of pain therapy and who were characterized by failed stress adaptation particularly benefited from treatment with cannabinoids. Different methods of administration and other types of cannabinoids, such as endocannabinoid modulators, should be tested in future trials.
Role of cannabinoids in the treatment of pain and (painful) spasticity.
Karst M, Wippermann S, Ahrens J. SourceDepartment of Anaesthesiology, Pain Clinic, Hannover Medical School, Hannover, Germany. karst.matthias@mh-hannover.de

Abstract
Both the discovery of the endocannabinoid system (ECS) and its role in the control of pain and habituation to stress, as well as the significant analgesic and antihyperalgesic effects in animal studies, suggest the usefulness of cannabinoids in pain conditions. However, in human experimental or clinical trials, no convincing reduction of acute pain, which may be caused by a pronociceptive, ECS-triggered mechanism on the level of the spinal cord, has been demonstrated. In contrast, in chronic pain and (painful) spasticity, an increasing number of randomized, double-blind, placebo-controlled studies have shown the efficacy of cannabinoids, which is combined with a narrow therapeutic index. Patients with unsatisfactory response to other methods of pain therapy and who were characterized by failed stress adaptation particularly benefited from treatment with cannabinoids. None of the attempts to overcome the disadvantage of the narrow therapeutic index, either by changing the route of application or by formulating balanced cannabinoid preparations, have resulted in a major breakthrough. Therefore, different methods of administration and other types of cannabinoids, such as endocannabinoid modulators, should be tested in future trials.
http://www.ncbi.nlm.nih.gov/pubmed/21142261

The Role of Endocannabinoids in Pain Modulation and the Therapeutic Potential of Inhibiting Their Enzymatic Degradation
The EndoCANNABINOID SYSTEM modulates pain. Cannabinoids inhibit FAAH and MAGL.
The Role of Endocannabinoids in Pain Modulation and the Therapeutic Potential of Inhibiting their Enzymatic Degradation. Alvarez-Jaimes LJ, Palmer JA. SourceJohnson and Johnson Pharmaceutical Research and Development, LLC, 3210 Merryfield Row,San Diego, CA 92121, USA. jpalmer9@its.jnj.co.

Abstract
The need for new pain therapies that provide greater relief without unwanted side-effects drives the search for new drug targets. The identification of endogenous lipid ligands for the two known cannabinoid receptors (CB(1) and CB(2)) has led to numerous studies investigating the role of these endocannabinoids in pain processes. The two most widely studied endocannabinoids are anandamide (AEA; arachidonoyl ethanolamide) and 2-arachidonoylglycerol (2 AG), but there are also a number of structurally related endogenous lipid signaling molecules that are agonists at cannabinoid and non-cannabinoid receptors. These lipid signaling molecules are not stored in synaptic vesicles, but are synthesized and released on-demand and act locally, as they are rapidly inactivated. This suggests that there may be therapeutic potential in modulating levels of these ligands to only have effects in active neural pathways, thereby reducing the potential for side-effects that result from widespread systemic cannabinoid receptor activation. One approach to modulate the levels and duration of action of these lipid signaling molecules is to target the enzymes responsible for their hydrolysis. The two main enzymes responsible for hydrolysis of these lipid signaling molecules are fatty acid amide hydrolase (FAAH) and monoacylglyceride lipase (MGL). This article will discuss the role of the endocannabinoid system in the modulation of pain and will review the current understanding of the properties of the hydrolytic enzymes and the recent advances in developing inhibitors for these targets, with particular relevance to the treatment of pain.”
http://www.ncbi.nlm.nih.gov/pubmed/21466449

Cannabinoids For Pain Management
Cannabinoids have been used for thousands of years to provide relief from suffering. Adverse effects are not uncommon with cannabinoids, though most are not serious and self-limiting. In view of the limited effect size and low but not inconsequential risk of serious adverse events, cannabinoids should be employed as analgesics only when safer and more effective medication trials have failed, or as part of a multimodal treatment regimen-In other words: Cannabinoids, which are safe and effective for pain, should only be used after you’ve tried all of Big Phama’s failed drugs, or in combination with Big Pharma.
Cannabinoids for pain management. Thaler A, Gupta A, Cohen SP.
SourcePain Management Division, Department of Anesthesiology, University of Pennsylvania School of Medicine, Philadelphia, PA 21029, USA.

Abstract
Cannabinoids have been used for thousands of years to provide relief from suffering, but only recently have they been critically evaluated in clinical trials. This review provides an in-depth examination of the evidence supporting cannabinoids in various pain states, along with an overview of potential adverse effects. In summary, there is strong evidence for a moderate analgesic effect in peripheral neuropathic and central pain conditions, and conflicting evidence for their use in nociceptive pain. For spasticity, most controlled studies demonstrate significant improvement. Adverse effects are not uncommon with cannabinoids, though most are not serious and self-limiting. In view of the limited effect size and low but not inconsequential risk of serious adverse events, cannabinoids should be employed as analgesics only when safer and more effective medication trials have failed, or as part of a multimodal treatment regimen.
http://www.ncbi.nlm.nih.gov/pubmed/21508629

The Role of Central and Peripheral Cannabinoid1 Receptors In the Antihyperalgesic Activity of Cannabinoids In A Model of Neuropathic Pain 
These data show that cannabinoids are highly potent and efficacious antihyperalgesic agents in a model of neuropathic pain. This activity is likely to be mediated via an action in both the CNS and in the periphery.
The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain.
Fox A, Kesingland A, Gentry C, McNair K, Patel S, Urban L, James I.
SourceNovartis Institute for Medical Sciences, 5 Gower Place, WC1E 6BN, London, UK. alyson.fox@pharma.novartis.com

Abstract
We have examined the effects of cannabinoid agonists on hyperalgesia in a model of neuropathic pain in the rat and investigated the possible sites of action. The antihyperalgesic activity of the cannabinoids was compared with their ability to elicit behavioural effects characteristic of central cannabinoid activity. WIN55,212-2 (0.3-10 mg kg(-1)), CP-55,940 (0.03-1 mg kg(-1)) and HU-210 (0.001-0.03 mg kg(-1)) were all active in a ‘tetrad’ of tests consisting of tail-flick, catalepsy, rotarod and hypothermia following subcutaneous administration, with a rank order of potency in each of HU-210 > CP-55,940 > WIN55,212-2. The effects of WIN55,212-2 in each assay were blocked by the Cannabinoid1 (CB1) antagonist SR141716A. In the partial sciatic ligation model of neuropathic pain WIN55,212-2, CP-55,940 and HU-210 produced complete reversal of mechanical hyperalgesia within 3 h of subcutaneous administration with D50 values of 0.52, 0.08 and 0.005 mg kg(-1), respectively. In this model WIN55,212-2 was also effective against thermal hyperalgesia and mechanical allodynia. WIN55,212-2 produced pronounced reversal of mechanical hyperalgesia following intrathecal administration that was blocked by the CB1 antagonist SR141716A. Following intraplantar administration into the ipsilateral hindpaw, WIN55,212-2 produced up to 70% reversal of mechanical hyperalgesia, although activity was also observed at high doses following injection into the contralateral paw. The antihyperalgesic effect of WIN55,212-2 injected into the ipsilateral paw was blocked by subcutaneously administered SR141716A, but was not affected by intrathecally administered SR141716A. These data show that cannabinoids are highly potent and efficacious antihyperalgesic agents in a model of neuropathic pain. This activity is likely to be mediated via an action in both the CNS and in the periphery.
http://www.ncbi.nlm.nih.gov/pubmed/11323130

 

Therapeutic Potential of Cannabinoid Receptor Agonists As Analgesic Agents
Increasing data emerging from controlled clinical trials support an analgesic activity of cannabinoids. However, the psychotropic side effects associated with tetrahydrocannabinol or synthetic derivatives essentially puts a brake on their use.”– In other words: Cannabinoids CURE pain, but we cannot have THe Cure because of the side-effects of THC, such as euphoria (feeling good), increased appetite, and temporary memory loss.
Therapeutic potential of cannabinoid receptor agonists as analgesic agents.
Fox A, Bevan S. SourceNovartis Institutes for Biomedical Research, Chronic Pain Unit, 5 Gower Place, London WC1E 6BS, UK. alyson.fox@.novartis.com

Abstract
Increasing data emerging from controlled clinical trials support an analgesic activity of cannabinoids. However, the psychotropic side effects associated with tetrahydrocannabinol or synthetic derivatives essentially puts a brake on their use, possibly limiting the degree of analgesia that can be achieved as well as providing regulatory hurdles. Animal studies show that although these side effects are mediated via central cannabinoid type 1 (CB(1)) receptors, the analgesic activity in chronic pain states may be mediated via spinal CB(1) and potentially CB(2) receptors, as well as peripheral CB(1) and CB2 receptors on sensory nerves or immune cells. The design of novel compounds that either specifically target peripheral CB(1) receptors or display high selectivity for CB(2) receptors may offer avenues for harnessing the analgesic effect of CB receptor agonists while avoiding the central adverse events seen with cannabinoid structures. Clinical trials with such compounds are required to determine whether either approach can provide the level of analgesia required to fulfil the unmet medical need left by current therapies for chronic pain.
http://www.ncbi.nlm.nih.gov/pubmed/16004597


We’re Fed Up! – An Open Letter From 30,000,000 Marijuana Smokers Who Vote

I found this post while researching and wanted to share:

Because of our diversity and direct democracy, California has always been a “test state” for many new ideas and political reforms. The Federal government is now targeting California and its Medical Marijuana patients to create a test case out of us.

They are afraid to change the status quo. But it is not just Medical Marijuana patients, or even marijuana smokers they are targeting.

The people of the state of California are the ones who voted for Medical Marijuana. We did this by direct democracy, by voting to change our own laws with Proposition 215, rather than have legislators write them for us. This is the essence of a democratic republic at its best.

By attacking Medical Marijuana in the State of California, the Federal government is attacking and disrespecting the people of California. They’re effectively saying, “We don’t recognize your authority over your own lives. We want to control you and force you to use only the medicines that we approve. We don’t care about your actual health. And we really don’t want you to get the idea that you can change things by voting.”

The Feds are very afraid of direct democracy because it challenges the power of the bloated, monolithic central government. All the career politicians are afraid of what can happen when people realize the power they have. Remember the 1960s rallying cry Power To the People? We have the power and we’re not planning to give it up.

“They got the guns, but we got the numbers.” — Jim Morrison

We are tired of being persecuted and mistreated simply because of our choice of medicine.

Marijuana users are treated as a laughingstock, even by a president that publicly claimed to be one of us.

We are sought out, profiled, and arrested.

We are imprisoned.

We are called drug addicts and losers by our own government.

Even the most unfortunate among us — who have cancer, AIDS, MS, depression, and intractable pain of all kinds — are treated in much the same manner, sometimes even judicially murdered.

Would the American public put up with this treatment if it was happening to gay and lesbian people? To Jews? To Muslims? Certainly not!

Each of those groups have suffered persecution in the past, gotten organized, and either aroused public sensibilities about their treatment to the point where it was made socially unacceptable, or gotten laws passed or changed to insure that it wouldn’t happen again.

But we have something special that these other groups don’t have.

We outnumber them all put together.

That’s right. There are 30 million people who regularly smoke marijuana in the United States. That’s about 10% of the population.

About 5% of Americans are gay or lesbian (so 15 million in round numbers), around 5 million are Jewish, 7 million are Muslim. We could easily throw other often oppressed groups in here, such as the Sikhs, without changing the equation.

The nation’s marijuana smokers need to unite for real change.

We must get organized.

We must arouse public sensibilities about our treatment and make it socially unacceptable to laugh at medical marijuana patients as well as recreational users.

The American public must understand that we – medical marijuana patients and users – are not anonymous drug-addled strangers. We are their sons and daughters, their brothers and sisters, their fathers and mothers, their grandfathers and grandmothers.

Marijuana prohibition is a failure based on lies, bad science, and racism. Millions upon millions of people have had their lives ruined – not by the harmless cannabis plant, but by the laws, arrests, lost jobs, and denied medical treatment.

75 years of marijuana prohibition is long enough for us, as a nation, to calmly sit down and acknowledge that the experiment of making a medicinal plant illegal is unconstitutional, morally wrong, and destructive to our society. It’s time to change things to insure that it won’t happen again.

We have the organizations — NORML, ASA, MPP, and others. We have our own media: The 420 Times, High Times, Kush, Skunk, Cannabis Culture, Treating Yourself, Toke Of the Town, and plenty more. But all of us have tended to work separately. Now it is time for laser focus.

We now call upon all of these organizations and publications, and all of us – patients and caregivers and recreational smokers alike – to unite behind a single, attainable goal:

Reschedule Marijuana Out Of Category I

Doing this can be a face-saver for the Federal government. No laws need be changed, no “embarrassing” Congressional debates over “pot”. No high-level politician even has to take “the blame” for it. It just becomes a simple administrative change in a database, but it will allow open medical research and actual legal prescriptions by doctors. It’s also about time that the Federal government acknowledges that cannabis actually is an effective medicine that is safely used every day by millions of people…since they already know that.

Let’s all take the time to help them help us.

Our first step: support CA NORML’s Call The White House campaign set for Tuesday, October 11.

Our second step: sign this online petition directly to the White House to address rescheduling marijuana out of Category I.

Our third step: we will be working with these other organizations and publications to organize a National Day Of Protest to call attention to this problem.

And for heaven’s sake, vote.

(Signed)

N.B. This manifesto does not intend to minimize the oppression that these and all other minorities (including women and people of color) have suffered in the past and present in this country and elsewhere. But the point is that the oppression of marijuana patients and users is official government policy to this very day, and we must not be satisfied until it ends forever.

http://the420times.com/2011/10/were-fed-up-an-open-letter-from-30000000-marijuana-smokers-who-vote/

Why More Americans Support Legalization of Marijuana

Gallup Poll released yesterday showed American support for the legalization of marijuana has risen to 50%. What might have caused this surge in support and made Americans take a second look at cannabis? Have Americans finally seen what a waste the War on Drugs is? Media coverage has become more common and less taboo enabling more people to become enlightened to the many benefits of cannabis as well as the corruption and lies surrounding it. There are 16 states that have set up some sort of medical marijuana program. More doctors and medical studies have emerged that support the medical benefits of cannabis.  There is also anger in the nation at corruption and Big Pharma is one target.

We have seen several reports lately that have showed medical advancements and new knowledge of the powers of cannabis.  We have seen them not only in expected media like High Times but also on news channels ranging from local to MSNBC.  We have seen many reports of patients that cannabis has helped or cured them as well as scientists discovering why cannabis works.

16 states enacted some sort of medical marijuana program. California was the first to enact legislation and has run a medical marijuana program for 15 years.  Colorado is one state that is allowing for-profit dispensaries to operate.  Reports have shown how revenue from taxes and fees as well as the residual business that benefits are seen throughout the community.  In a time when the economy is slow its hard to ignore the fact that cannabis is a booming industry.  With more states challenging the federal government’s stand on cannabis we have this industry brought to the forefront.

Politics has affected this issue extensively.  Many times politicians are focused on their career and not on the issues that need to be addressed.  Instead they continue to follow the failed policies of the Drug War that has been failing for the last 70 plus years.  The current Obama administration has promised one thing while doing a completely opposite action.  Recently attacks from the federal government against California patients has become severe.  With many more urgent issues that need to be addressed many Americans see this use of government spending wasteful.

 

People have seen the costs associated with processing criminals for small amounts of marijuana as well as the search for marijuana grows.  In a time where everyone is scrutinizing government spending people have turned their attention to the money wasted on the War on Drugs.  The recent attacks on medical marijuana dispensaries in California have put federal government spending in the spotlight.

Although Occupy Wall St is disorganized one thing you can glean from the people is the frustration over corruption.  We have seen how Big Pharma has control over the industry.  People want affordable, quality medicine, and with more information emerging on the health risks of prescription medications as well as the up rise in addiction rates more people are looking for a natural solution.

Some other points that might explain the increase in support is the spotlight that has been shown on NYC and the racially profiled marijuana arrests, that are prevalent not only in NYC but all over the country.  In 2010 NYC spent $75 million arresting and jailing 50,000 people for possessing small amounts of marijuana.  Most of them were in their late teens or early twenties and nearly 90% of them were of color.  This is something that has caught the attention of the NAACP who has spoke out in support of legalization of marijuana.

 

With so many factors working for us there are just as many if not more working against the legalization for marijuana. There is legislation currently being processed  HR 2306: The Ending Federal Marijuana Prohibition Act of 2011 which you can request your representative to support.  There is also a proposed ballot that has support of private citizens, celebrities, law enforcement and judges.  Its called the Regulate Marijuana Like Wine Act of 2012.  Now is our opportunity to change history and right a wrong.  Reefer madness and all the ridiculous claims against cannabis have had their claim on Americans for far too long.  Now is the time to take a second look at cannabis.  Now is the time to act and help legalize a natural safe alternative!

Prostate Cancer and Cannabis:Cause and CURE

Cannabis has been used for thousands of years as a natural remedy for many ailments but only recently has modern science began to recognize the curing power of cannabis.  In 2011 alone there were about 240,890 new cases and about 33,720 deaths from prostate cancer.  Below are studies that show how cannabis can be an effective therapy for prostate cancer.   With more research we can prove that cannabis does have medicinal value and can greatly aid or cure many ailments.  These are published medical studies that I encourage you to research and share your findings with everyone.  Spread the truth!
Information gathered by David Worrell edited by Cherry Girl

Cause:

CXCL12 / CXCR4 / CXCR7 Chemokine Axis And Cancer Progression
‎”CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression.” Sun X, Cheng G, Hao M, Zheng J, Zhou X, Zhang J, Taichman RS, Pienta KJ, Wang J. SourceDepartment of Biochemistry and Molecular & Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Institute of Medical Science, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, People’s Republic of China. Erratum in Cancer Metastasis Rev. 2011 Jun;30(2):269-70.

Chemokine Family and Their Cognate Receptors

Abstract
Chemokines, small pro-inflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The chemokine CXCL12 (also called stromal-derived factor-1) is an important α-chemokine that binds primarily to its cognate receptor CXCR4 and thus regulates the trafficking of normal and malignant cells. For many years, it was believed that CXCR4 was the only receptor for CXCL12. Yet, recent work has demonstrated that CXCL12 also binds to another seven-transmembrane span receptor called CXCR7. Our group and others have established critical roles for CXCR4 and CXCR7 on mediating tumor metastasis in several types of cancers, in addition to their contributions as biomarkers of tumor behavior as well as potential therapeutic targets. Here, we review the current concepts regarding the role of CXCL12 / CXCR4 / CXCR7 axis activation, which regulates the pattern of tumor growth and metastatic spread to organs expressing high levels of CXCL12 to develop secondary tumors. We also summarize recent therapeutic approaches to target these receptors and/or their ligands.”
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175097/?tool=pubmed 

Schematic representation showing the role of microenvironment in tumor cell CXCR4 receptor activation in both the primary and metastatic sites.

CURE:

Cannabinoid Receptor CB2 Modulates the CXCL12/CXCR4-Mediated Chemotaxis of T Lymphocytes
‎”Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes.
Ghosh S, Preet A, Groopman JE, Ganju RK.
SourceDivision of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

Abstract
Cannabinoids have been shown to influence the immune system. However, their immunomodulatory effects have not been extensively studied. In this investigation, we have observed that both primary and Jurkat T cells express a functional cannabinoid receptor 2 (CB(2)). Furthermore, both the synthetic cannabinoids CP55,940 and WIN55,212-2, as well as the CB(2)-selective agonist JWH-015, caused a significant inhibition of the chemokine CXCL12-induced and CXCR4-mediated chemotaxis of Jurkat T cells, as well as their transendothelial migration. Involvement of the CB(2) receptor was further confirmed by partial reversal of the inhibition using the CB(2)-specific antagonist, AM630. Similarly, CP55,940 and JWH-015 inhibited the CXCL12-induced chemotaxis of primary CD4(+) and CD8(+) T lymphocytes. Further investigation of signaling studies to delineate the mechanism of inhibition revealed that cannabinoids enhance CXCL12-induced p44/42 MAP kinase activity. However, enhanced MAP kinase activity was not responsible for the inhibition of chemotaxis. This suggests that cannabinoids differentially regulate CXCR4-mediated migration and MAP kinase activation in T cells. Cannabinoids were also found to downregulate the PMA-enhanced enzyme activity of matrix metalloproteinase-9, which is known to play an important role in transendothelial migration. This study provides novel information regarding cannabinoid modulation of functional effects in T cells.”
http://www.ncbi.nlm.nih.gov/pubmed/16503355

The importance of the CXCL12-CXCR4 chemokine ligand-receptor interaction in prostate cancer metastasis
“These results suggest prostate cancers may be influenced by the CXCL12:CXCR4 pathway during metastasis. This pathway would provide a novel target for therapeutic intervention.”
‎”The importance of the CXCL12-CXCR4 chemokine ligand-receptor interaction in prostate cancer metastasis.  Arya M, Patel HR, McGurk C, Tatoud R, Klocker H, Masters J, Williamson M.  Source Prostate Cancer Research Centre, Institute of Urology,University College London, UK. manit_arya@hotmail.com

Abstract
AIM: Chemokines or chemotactic cytokines are known to be important in the directional migration or chemotaxis of leucocytes in conditions of homeostasis and in inflammatory or immunological responses. However, the role of chemokines is extending beyond their involvement in mediating leucocyte trafficking with an increasing body of evidence suggesting these proteins are intimately involved in many stages of tumour development and progression. Our aim was to study the role of the CXCL12:CXCR4 chemokine ligand:receptor complex in determining the organ-specific metastasis of prostate cancer. MATERIALS and

METHODS: CXCR4 mRNA expression was determined by RT-PCR in 3 metastatic prostate cancer cell lines DU145, LNCaP and PC3, the primary prostate cancer cell line 1542 CPT3X and the normal prostate epithelial cell lines 1542 NPTX and Pre 2.8. This was followed by Taqman quantitative PCR analysis of CXCR4 mRNA in these cell lines. Flow cytometry analysis was then used to measure the expression of the CXCR4 receptor protein on the cell surface. The influence of the receptor on cell migration was studied using Transwell, Migration Assays. Finally, Taqman quantitative PCR was performed on RNA obtained from laser microdissected fresh primary prostate tumour and benign tissue samples from patients.

RESULTS: In DU145, LNCaP and PC3 CXCR4 mRNA expression was approximately 1000, 400 and 21 times respectively that of 1542 NPTX, Pre 2.8 and 1542 CPT3X. In patient primary tumour samples and patient benign tissue specimens CXCR4 mRNA expression was similar to that of the metastatic cell line DU145. Flow cytometry analysis showed that significantly higher levels of the CXCR4 receptor were present on the cell surface of the 3 metastatic cell lines. Migration studies revealed that chemotaxis of the metastatic cell lines PC3 and DU145 was enhanced by CXCL12 ligand and inhibited by antibody to CXCR4. CXCL12 did not influence the migration of the normal prostate epithelial cell line 1542 NPTX.

CONCLUSIONS: We have demonstrated that human prostate cell lines derived from metastases express functional CXCR4 receptor and that CXCL12 ligand enhances their migratory capabilities. Also, laser microdissected primary patient tumours and patient benign tissue specimens express CXCR4 mRNA at high levels (it is suggested that post-transcriptional modification of the CXCR4 receptor plays a major role in regulating protein expression). These results suggest prostate cancers may be influenced by the CXCL12:CXCR4 pathway during metastasis. This pathway would provide a novel target for therapeutic intervention.”
http://www.ncbi.nlm.nih.gov/pubmed/15844659

The Regulate Marijuana Like Wine Act 2012

Imagine a day when a property owner can look out over his cannabis crops just like a vinyard owner.  That day may be much closer with a proposed ballot in California.  Its call The Regulate Marijuana Like Wine Act 2012 and it has a lot of good points to it.  If passed it could change countless lives and challenge the federal government, something that is long overdue.

It also boasts some impressive supporters.  You can find more information on their website.  The launch of the petition drive will be November 1, 2011. They have volunteering opportunities on their website as well.

In Short – This California Voter Intitiative for 2012 intends to:

  •  Repeal prohibition of marijuana for adults
  •  Strictly regulates marijuana, just like the wine industry
  •  Allows hemp agriculture and products
  •  Does not change laws regarding

medical marijuana
impairment
workplace
vehicle operation
use by minors under 21 years old

  •  Provides specific personal possession exemptions
  •  Requires dismissal of pending court cases
  •  Defense against all related litigation
  •  Prevents California from supporting federal enforcements that conflict with this law and requires the State to petition the Feds to remove marijuana from Schedule One
  •  Prohibits commercial advertising of non-medical marijuana
  •  Generates new revenue from sales taxes, while creating no new taxes
SPONSORED BY
THE REGULATE MARIJUANA LIKE WINE COMMITTEE

JAMES P. GRAY, CHIEF PROPONENT 
Retired Superior Court Judge and author
STEVE KUBBY, CHIEF OFFICER 
Managing Partner and CEO, Kubby Patents and Licenses
WILLIAM McPIKE,  COUNSEL  
Nationally recognized attorney and legal authority
STEVE COLLETT, TREASURER 
President, Collett & Company, Inc., Certified Public Accountants
For more information visit their site at

Now Is the Time To Act! Medical Marijuana On the Defense

With all the protests and grumbling from the every day American I know that we are at a pivotal point in history that we are at a point where they could go either way.  I believe we are at that point with Medical Marijuana.  It has been state legal in CA since 1996 but only in the past few years has it really exploded.  A quick search on weedmaps or any other like website and you will see thousands of dispensaries dotted all over California.  While for cannabis consumers its a dream come true for officials its a nightmare.

With their experience only while the black market still exists, law enforcement and like minded people’s point of view on the violence and corruption that seems to follow I can see how they can be fearful of the whole industry. But just like with like with prohibition, not all of us are Al Capone.  There will always be criminals but it is wrong to punish us all for a few and in turn create more criminals.

Cannabis patients truly are an oppressed people.  The government has sought after marijuana with the same vivaciousness of a murderer manhunt. It has been unrelenting in its pursuit of even simple possession.  They wasted billions of hard earned taxpayer’s money at the drop of a hat over a simple plant.

There are hundreds of other top priority issues that are being negleted to go after this plant and its consumers.  It makes me angry to see stories where domestic violence is decriminalized because they ran out of money to prosecute but they have plenty of money to go after medical marijuana patients.

Thankfully the Alcohol Prohibition Era lasted a relatively short time but it still gives us a great look into a failed policy that applies to us today.  We saw how crime and general chaos ensued after prohibition took place.  We also saw crime organized for the first time on a larger scale.  Mass murders took place with bodies being dumped in the streets.  Even with the it being illegal people still drank.

We are at a time in history with some of the same things taking place.  We have dispensaries and patients being robbed.  We have gang violence still trying to control whats left of the black market.  We have Mexican cartels taking over our forests and killing thousands in their country.  We have decapitated heads being found on children’s school playgrounds.

The underground black market for Marijuana is organized.  It has its roots deep throughout the country.  Here in California especially it has spilled out into almost every county.  The gang violence can be seen in the streets as well as the size of the prison population.  It has been a very lucrative business for them.  The sad thing is that some marijuana patients are forced to fuel this economy.

With regulation and legislation passed we have seen the legal medical marijuana population rise to the top and be on display for the world to see.  They have shown how dispensaries can be run responsibly and in the compassionate manner originally intended.  We have seen the standards of cannabis rise not only with potency but in growing and quality.

We have heard thousands of success stories from patients living a better life thanks to cannabis.  When pulled into the light and operated legally we see a change.  I have visited locations that are similar to a doctor’s office with a staff that are professional and knowledgeable.  They pay taxes, bring revenue into the county and provide jobs.

In Colorado, where the medical marijuana industry is for-profit, we have seen the amount collected in business licenses and the like in the millions.  We see how even in a bad economy that is one industry that is booming.  It is exploding right in the face of the federal government and they’re not happy about it.

Today we saw a crack down in California from the federal government.  They put it under the guise of criminal activity but in their eyes all of it is illegal.  The Attorney General’s office sent out letters to property owners bullying them by saying they would lose their property if they continued to allow a dispensary to operate.  By doing this they are strong arming the entire industry.

Not everyone can grow their own medicine but they still need it.  Even when the government says they are not going after the sick, by attacking the source of our medicine, they are attacking patients.  Once again they are reacting towards everyone instead of the problem.  Somehow they still do not seem to get that while a black market exists, while the unsuccessful and costly drug war exists, while prohibition exists we will always have these issues.

If it was not illegal you would not have mass amounts of undocumented marijuana transferred between states but instead a regulated system that would generate billions if not trillions in revenue.  The Mexican cartels, US gangs and the black market would not have the funding nor the power it currently does.

Instead license fees, taxes and other revenue would be pumped into the local, state and federal governments.  Patients would have access to quality medicine without fear.  With a law enforcement that back the marijuana industry and instead targets only true criminal activity I believe we would see an industry much like alcohol or tobacco.

With over 70 years of failed policy and crime stats supporting the evidence its time to repeal the prohibition of marijuana is it not time to act?  One can not be heard but many they will take notice.  How much longer can we stand by while the government attacks patients?

Even if you can’t actively participate educating and informing people of the benefits of cannabis is one way to be active.  There are hundreds of medical studies, thousands of survivor stories and millions of consumers.  There is mounting evidence of the powers of cannabis.  It is time for us to educate the government and others so that all can be free to medicate.

If you can be active get involved and contact your representitive and the presidential hotline.  Supporters are urged to call on the President to respect state marijuana laws – White House Hotline:202 -456-1111  show your support for a bill to let states regulate medical marijuana legally, H.R. 2306, has been introduced by Rep. Barney Frank and has several co-sponsors from California.

And in the great words of Thomas Jefferson:
When, in the course of human events, it becomes necessary for one people to dissolve the political bands which have connected them with another, and to assume among the powers of the earth the separate and equal station to which the laws of nature and of nature’s God entitle them, a decent respect to the opinions of mankind requires that they should declare the causes which impel them to the separation. We hold these truths to be self-evident; that all men are created equal; that they are endowed by their creator with certain inalienable rights; that among these are life, liberty, and the pursuit of happiness; that to secure these rights, governments are instituted among men, deriving their just powers from the consent of the governed; that whenever any form of government becomes destructive to these ends, it is the right of the people to alter or abolish it, and to institute new government, laying its foundation on such principles, and organizing its powers in such form, as to them shall seem most likely to effect their safety and happiness.

What country can preserve its liberties if its rulers are not warned from time to time that their people preserve the spirit of resistance?-Thomas Jefferson

POT-TAX

How Do You Approach Medicine? Cannabis As A Treatment Option

How each of us approaches medicine is as unique as our life experiences. Some are skeptical of medicine and are reluctant to experiment with many drugs or therapies while others fully embrace medication and are willing to put themselves through many side effects to find the right drug.

When put in a difficult and stressful situation such as being told you have diabetes, heart disease or cancer it can be hard to make a decision.  When given news as well as options at once it can be difficult to remember your values or views on medical therapies.

With the government only allowing therapies and medication that they approve and Doctors being dazzled by the pharmaceutical companies it can be hard to get an unbiased opinion.  Even at home we are bombarded with commercials for the pharmaceutical companies.  With all these opinions being thrown at you it can be hard to come up with an opinion of your own.  Just remember ultimately it is your body.

Cannabis has been proven, not only through individual personal trials but also through medical studies, to process medicinal value.  It helps with nausea, tremors, bipolar disorder, headaches, insomnia and recently found to slow tumor growth in cancer.

Cannabis is no longer just the party drug of the past but recognized by millions as a medicinal plant.  Only recently have people discovered what has been known for thousands of years.  Cannabis can take away a headache, calm tremors, stimulate appetite, mellow anxiety along with hundreds of other uses.

Cannabis can be organically grown with very little if any environmental impact. It can also be at home dropping the price of medication drastically.  Cannabis is all natural organic meaning no chemicals will be entering your body. Finally Cannabis does not have a long list of side effects like many drugs.

Instead of blindly going along with whatever your Doctor recommends do your homework.  Research your ailment, look up treatments, side effects and weigh drug therapies against others.  The easy way is not always the best way and pharmaceuticals are not always the answer.  Cannabis can be a great alternative to conventional medicine in both cost and health. Before reaching for the pill bottle see if cannabis could be right for you.

Cannabis and Brain Disorders: Cannabinoids Targeting the Endocannabinoid System and Receptors As A Means to CURE

Below are studies that show how cannabis affects the central nervous system.  These studies suggest that cannabis can aid in treating brain disorders.  With more research we can prove that marijuana does have medicinal value and can greatly aid or cure many ailments.  These are published medical studies that I encourage you to research and share your findings with everyone.  Spread the truth!
Information gathered by David Worrell edited by Cherry Girl

It is not important that you fully understand all the scientific mumbo-jumbo. What is important, what you need to understand, is that there are “Functional Neuronal CB2 Cannabinoid Receptors in the Central Nervous System”  ~ D.W.

Functional Neuronal CB2 Cannabinoid Receptors in the Central Nervous System
“Cannabinoids are the constituents of the marijuana plant (Cannabis sativa). The recent progress in marijuana-cannabinoid research include the discovery of an endocannabinoid system with specific genes coding for cannabinoid receptors (CBRs) that are activated by smoking marijuana, and that the human body and brain makes its own marijuana-like substances called endocannabinoids that also activate CBRs.”
‎”Commentary: Functional Neuronal CB2 Cannabinoid Receptors in the CNS.
Onaivi ES.  SourceWilliam Paterson University, Wayne NJ and Molecular Neurobiology Branch, National Institute on Drug Abuse, NIH, Baltimore, USA.

Abstract
Cannabinoids are the constituents of the marijuana plant (Cannabis sativa). There are numerous cannabinoids and other natural compounds that have been reported in the cannabis plant. The recent progress in marijuana-cannabinoid research include the discovery of an endocannabinoid system with specific genes coding for cannabinoid receptors (CBRs) that are activated by smoking marijuana, and that the human body and brain makes its own marijuana-like substances called endocannabinoids that also activate CBRs. This new knowledge and progress about cannabinoids and endocannabinoids indicate that a balanced level of endocannabinoids is important for pregnancy and that the breast milk in animals and humans has endocannabinoids for the growth and development of the new born. There are two well characterized cannabinoid receptors termed CB1-Rs and CB2-Rs and these CBRs are perhaps the most abundant G-protein coupled receptors that are expressed at high levels in many regions of the mammalian brain. The expression of CB1-Rs in the brain and periphery and the identification of CB2-Rs in immune cells and during inflammation has been extensively studied and characterized. However, the expression of functional neuronal CB2-Rs in the CNS has been much less well established and characterized in comparison to the expression of abundant brain CB1-Rs and functional neuronal CB2-Rs has ignited debate and controversy. While the issue of the specificity of CB2-R antibodies remains, many recent studies have reported the discovery and functional characterization of functional neuronal CB2-Rs in the CNS beyond neuro-immuno cannabinoid activity.”   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137183/?tool=pubmed


Targeting the Endocannabinoid System in Treating Brain Disorders.
“Many studies on cannabinoids indicate important progress for protection against several neurodegenerative disorders.This review highlights recent studies implicating the endocannabinoid system in neuroprotection against different disorders of the CNS.” (Central Nervous System)
‎”Targeting the endocannabinoid system in treating brain disorders.Bahr BA, Karanian DA, Makanji SS, Makriyannis A. SourceDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA. Bahr@uconn.edu

Abstract
Recent cannabinoid research has a primary focus on developing therapeutics against human diseases. Many studies on Cannabinoids indicate important progress for protection against several Neurodegenerative disorders.  Agonists of cannabinoid receptors activate signalling pathways in the brain that are linked to neuronal repair and cell maintenance, and endogenous ligands can also activate neuroprotective responses. These endocannabinoids are bioactive fatty acid amides and esters that are synthesised in the brain and include arachidonoyl ethanolamide (anandamide) and 2-arachidonoyl glycerol. Endocannabinoids are released in response to pathogenic events, thus representing a potential compensatory repair mechanism. Enhancing this on-demand action of endocannabinoids is a strategy with which to promote endogenous repair signalling. For such enhancement, considerable work has gone into modulating the availability of endocannabinoids by blocking the processes of their deactivation. The targets include the anandamide-hydrolysing enzyme fatty acid amide hydrolase, the carrier-mediated anandamide transport system and 2-arachidonoyl glycerol-deactivating enzyme monoacylglycerol lipase. The activity of endocannabinoids is terminated through transport and degradation and, accordingly, selective inhibitors of these processes effectively exploit the protective nature of cannabinergic responses. This review highlights recent studies implicating the endocannabinoid system in neuroprotection against different disorders of the Central Nervous System.”  http://www.ncbi.nlm.nih.gov/pubmed/16548785

Cannabinoids: A New Group of Agonists of PPARs
Cannabinoids have been used medicinally for thousands of years. In preclinical studies cannabinoids displayed many of the characteristics of nonsteroidal anti-inflammatory drugs (NSAIDs) and seem to be free of unwanted side effects. An increasing number of therapeutic actions of cannabinoids are being reported…
Sun Y, Bennett A.  SourceSchool of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK. stxys3@nottingham.ac.uk

Abstract
Cannabinoids have been used medicinally and recreationally for thousands of years and their effects were proposed to occur mainly via activation of the G-protein-coupled receptor CB1/CB2 (cannabinoid receptor 1/2). Discovery of potent synthetic analogs of the natural cannabinoids as clinically useful drugs is the sustained aim of cannabinoid research. This demands that these new compounds be free of the psychotropic effects that connected with the recreational use of cannabinoids. In preclinical studies cannabinoids displayed many of the characteristics of nonsteroidal anti-inflammatory drugs (NSAIDs) and it seems to be free of unwanted side effects. An increasing number of therapeutic actions of cannabinoid are being reported that do not appear to be mediated by either CB1 or CB2, and recently nuclear receptor superfamily PPARs (peroxisome-proliferator-activated receptors) have been suggested as the target of certain cannabinoids. This review summarizes the evidence for cannabinoid activation on PPARs and possible associated remedial potentials.”
‎”In summary, there is strong evidence to suggest that some cannabinoids can act on PPARs through either direct or indirect pathways. These discoveries not only broaden the promising usage of cannabinoids as therapeutic agents, but also support PPARs as new targets for some neuroprotective treatment.”  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220031/?tool=pubmed

Cannabinoid Activation of PPARα; A Novel Neuroprotective Mechanism
“Conclusions and implications:These data demonstrate the potential for a range of cannabinoid compounds, of diverse structures, to activate PPAR alpha and suggest that at least some of the neuroprotective properties of these agents could be mediated by nuclear receptor activation.”
‎”Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism.
Sun Y, Alexander SP, Garle MJ, Gibson CL, Hewitt K, Murphy SP, Kendall DA, Bennett AJ.
SourceSchool of Biomedical Sciences, University of Nottingham Medical School, Nottingham, UK.

Abstract
BACKGROUND AND PURPOSE: Although CB(1) receptor activation evokes neuroprotection in response to cannabinoids, some cannabinoids have been reported to be peroxisome proliferator activated receptor (PPAR) ligands, offering an alternative protective mechanism. We have, therefore, investigated the ability of a range of cannabinoids to activate PPAR alpha and for N-oleoylethanolamine (OEA), an endogenous cannabinoid-like compound (ECL), to evoke neuroprotection.

EXPERIMENTAL APPROACH:
Assays of PPAR alpha occupancy and gene transactivation potential were conducted in cell-free and transfected HeLa cell preparations, respectively. In vivo estimates of PPAR alpha activation through fat mobilization and gene transcription were conducted in mice. Neuroprotection in vivo was investigated in wild-type and PPAR alpha gene-disrupted mice.

KEY RESULTS: The ECLs OEA, anandamide, noladin ether and virodhamine were found to bind to the purified PPAR alpha ligand binding domain and to increase PPAR alpha-driven transcriptional activity. The high affinity synthetic CB(1/2) cannabinoid agonist WIN 55212-2 bound to PPAR alpha equipotently with the PPARalpha agonist fenofibrate, and stimulated PPARalpha-mediated gene transcription. The phytocannabinoid delta 9 tetrahydrocannabinol was without effect. OEA and WIN 55212-2 induced lipolysis in vivo, while OEA pre-treatment reduced infarct volume from middle cerebral artery occlusion in wild-type, but not in PPAR alpha-null mice. OEA treatment also led to increased expression of the NFkappa B-inhibitory protein, Ikappa B, in mouse cerebral cortex, while expression of the NFkappa B-regulated protein COX-2 was inhibited. Conclusions and implications:These data demonstrate the potential for a range of cannabinoid compounds, of diverse structures, to activate PPAR alpha and suggest that at least some of the neuroprotective properties of these agents could be mediated by nuclear receptor activation.”

‎”In summary, the data presented here provide strong evidence that selected cannabinoids (WIN 55212-2, OEA, noladin ether and virodhamine) are PPARα agonists, and suggest a novel means by which the multiple effects of cannabinoids, in boththe CNS and periphery, could be brought about. In addition to its well-recognized role in lipid metabolism, PPARα activation showed obvious beneficial effects in ischaemic brain damage, which is likely to be connected with its anti-inflammatory action through the NF–κB pathway. These discoveries not only broaden the potential use of cannabinoids as therapeutic agents, but also support PPARα as a new target for neuroprotectiv treatment.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190030/?tool=pubmed


Cannabinoids and PPARalpha Signalling

“Cannabinoids have been shown to possess anti-inflammatory and neuroprotective properties.This review summarizes the evidence for cannabinoid activation of PPARs and identifies a new intracellular target for cannabinoids as therapeutic agents for neuroprotective treatment.”
‎”Cannabinoids and PPARalpha signalling. Sun Y, Alexander SP, Kendall DA, Bennett AJ. SourceSchool of Biomedical Sciences, University of Nottingham, Nottingham NG7 2UH, UK. stxys3@nottingham.ac.uk

Abstract
Cannabinoids have been shown to possess anti-inflammatory and neuroprotective properties, which were proposed to occur mainly via activation of the G-protein-coupled receptor CB(1) (cannabinoid receptor 1). Recently, certain cannabinoids have been reported to be ligands for members of the nuclear receptor transcription factor superfamily known as PPARs (peroxisome-proliferator-activated receptors). This review summarizes the evidence for cannabinoid activation of PPARs and identifies a new intracellular target for cannabinoids as therapeutic agents for neuroprotective treatment.”
http://www.ncbi.nlm.nih.gov/pubmed/17073758

Cooking with Cannabis

Image

Most people have heard of pot brownies.  They are often talked about in movies, songs and TV.  Cooking with cannabis today extends beyond brownies although you can still make a mean batch!  There are hundreds of recipes and techniques for cooking with cannabis.  Whether you have a sweet tooth or are hungry for dinner you will be sure to find a recipe.

Using edibles as a way to ingest medical marijuana is a healthy alternative to smoking.  Many find that their medical condition or personal preference works better with eating cannabis.  Today there are many options when looking to cook edibles.  You can use different parts of the plant and in different ways depending on the use.

Popular ways are making butter, infused oils, honey, hash oil, and infused alcohol.  With a quick Google search you can find hundred of ways to cook with cannabis.  Butter or cannabutter is a very popular method because of the versatility.   It allows you to use it in your favorite recipes as you normally would.  Letting you enjoy each bite while you medicate.

Some can find it daunting when first cooking with cannabis but you will soon learn that it will become second nature.  Who knows you could have a secret talent for it.  Get in the kitchen and find out!

Cannabutter  

The basic ratio is ~20 grams of butter per every gram of cannabis. The awesome bonus of cannabutter is you can use schwag, stems and shake (leaves) you’d normally discard for this recipe.

  1. Grind up your cannabis until it is very, very fine – far finer than if your were going to smoke it. You want to turn it into a fine powder, and an electric or manual coffee grider could work. Your best bet would be a cannabis grinder.
  2. Heat the water over a low to medium heat in a pan or double boiler. Add butter. Once the butter has completely melted, add the cannabis powder, stir well and turn heat down to low.
  3. Stir constantly and be sure the butter does not burn!
  4. Cook on low heat. The marijuana cookbook recommends cooking over a low heat for two to three hours. Do not overcook the THC will degrade and your butter will be bitter.  Be sure to stir periodically and keep an eye on it!
  5. When your mixture has cooked sufficiently, carefully strain the mixture with cheese cloth into a container appropriate for cooling and storage. Seal up the container and put in the refrigerator.
  6. As the mixture cools, a layer of butter will begin to solidify above the water. Remove the butter, throw out the water, and your butter is ready to use!
  7. Now you can use your thc butter in any baking recipe that requires butter.

Did you know you can Flavor your cannabutter?

Cannabutter can be enhanced with sweets, fruits, spices, savory, herbs and exotic flavors. Sweet cannabutter ingredients include brown sugar, stevia, chocolate or cocoa, crushed candy, and minced candied fruit. Fruity cannabutter ingredients are lemons, oranges, apple and coconut. Spicy marijuana butter additives come from whole hot peppers, hot sauce, Chinese 5 spice, or Jamaican jerk spice. The savory marijuana butter favorite flavor is garlic, making a very versatile condiment. Herb cannabutter best flavors with oregano, basil, thyme and rosemary. Exotic marijuana butter loves lemon grass. Simply experiment to find your favorite intensities. The fun part is many other cannabutter flavors to discover.

Cannabrownies

Ingredients

  1. 1/4 cup THC butter with 1/4 cup regular butter
  2. 1 cup chocolate chips
  3. 1 cup sugar2 eggs
  4. 3/4 cup self-rising flour
  5. 1 1/2 teaspoon vanilla
  6. 3/4 cup chopped pecans

Directions

  1. Preheat oven to 350° Fahrenheit. Grease a 9 inch square baking pan.
  2. Melt THC butter, regular butter and chocolate chips in a large sauce pan or double boiler over low heat.
  3. When melted, remove from heat and stir in remaining ingredients in order listed, mixing well.
  4. Pour into pan and bake for 25-30 minutes. Let cool, cut into squares and enjoy!

Things to remember when eating Cannabis:

It usually takes longer for relief when eating cannabis compared to other methods of intake. It may also take longer for you to learn what dose is appropriate for you when eating and the side effects of using cannabis may be stronger = than those felt by smoking. You cannot overdose on cannabis, however side effects can be intense and overwhelming. Use caution when trying edible products especially if you did not make them. Try small doses at first and give yourself a few days to figure out the correct titration.

Ever Wonder If Your Illness Could Be Treated With Cannabis?

When I was first introduced to cannabis it was in a party setting.  I just knew that if I smoked it I would feel good.  The only way to get it was by calling up a guy who would bring you a plastic bag of green stuff.  There was no talk of what strain, how it was grown or where it came from.  Each week would be a surprise as to what you were going to get.  Sometimes it would make you sleepy, sometimes it would make you giggle till your sides hurt.

After dealing with debilitating headaches for a few years I decided to try cannabis as a treatment option.  I had a Dr. that was prescribing me medication after medication that would cause side effects like making my brain feel like it was on fire.  I was getting frustrated with reading all the side effects or worse feeling them.  I finally drew the line after they suggested that I try injections at the base of my head.  I knew I needed to find a safer, natural remedy.

Once I started doing research I learned that cannabis wasn’t green stuff in a bag but a natural wonder plant.  Not only was there more than one type but hundreds each with its own miracle properties.  Its not only the strain but the location of where or even how its grown that determines its usefulness.  When determining which strain is right for you there are some things to keep in mind.

There are two main categories that cannabis fall into although there are more.  Indica strains typically are the strains that will give you that drowsy body stoned feeling.  By contrast a sativa strain typically is a cerberal or head high.  Hybrids are quite common and depending on the percentage of indica to sativa can make a nice combination high.

There are strains that help with a variety of illnesses.  There are even studies that are suggesting that cannabis can reduce or shrink cancer cells.  Cancer patients find comfort from strains that aid with nausea and appetite while chronic pain sufferers find solace in it’s pain relief properties.

Cannabis needs to be grown properly and preferably by a quality grower who puts attention to detail as a priority.  One thing that should be on your mind when choosing cannabis is that you will be ingesting this product so why not know more about it?  Fertilizers and other chemicals being used during the growing process can effect the end product.  Even things like proper drying and handling can change how effective your medicine is.

One of the best ways to ensure that you are getting quality product is to grow it yourself.  There are plenty of books and online help to assist in growing your own medicine.  If growing is not an option the next best thing is buying your medicine through a dispensary or collective.  There you will have the option of choosing quality medicine that is safer.  If your state offers a medical marijuana program it is definitely worth the time to research and see if its an option for you.  So before passing off the option of using cannabis as a natural option do a little research and see that there is more to it than some green stuff in a bag.

We have selfless people who are willing to put in the time to compile a list of illness and their known treatments with cannabis as well as studies to back it up.  This is just a guide and as with anything you should seek professional opinions first.

Click Below to download PDF list
Granny Storm Crow’s MMJ Reference List- July 2011