Beyond The Smoke: The Anticancer Properties Of Cannabis

Cannabis has many amazing healing properties that utilize the endocannabinoid system to reach target areas.  Scientists use this knowledge to target certain aspects of a condition depending on the symptoms.  It is well known that cannabis use can help cancer patients during the course of their battle, from increased appetite to pain relief.  Scientists have been uncovering cannabis’ anticancer effects as well.  This promising research is clearing the way so that one day we will fully understand this miracle plant.  Below are studies where science has looked at cannabis therapy when applied to cancer cells.  Please feel free to share and as always I encourage all to do their own research.  Please note that a lot of these are NEW 2012 released research which is really exciting! ~ Cherry Girl

CANNABIDIOL AS POTENTIAL ANTICANCER DRUG
Over the past years, several lines of evidence support an antitumorigenic effect of cannabinoids including Δ(9) -tetrahydrocannabinol (Δ(9) -THC), synthetic agonists, endocannabinoids and endocannabinoid transport or degradation inhibitors.

Non-THC Cannabinoids Counteract Prostate Carcinoma Growth In Vitro and In Vivo: Pro-Apoptotic Effects and Underlying Mechanisms 2012
Cannabinoid receptor activation induces prostate carcinoma cell…In LNCaP cells, the pro-apoptotic effect of CBD was only partly due to TRPM8 antagonism and was accompanied by down-regulation of AR, p53 activation and elevation of reactive oxygen species. LNCaP cells differentiated to androgen-insensitive neuroendocrine-like cells were more sensitive to CBD-induced apoptosis. Conclusions. These data support the clinical testing of CBD against prostate carcinoma.

Role of Lipid Rafts/Caveolae in the Anticancer Effect of Endocannabinoids 2012
The endocannabinoid system comprises the cannabinoid receptors type 1 (CB1) and type 2 (CB2), their endogenous ligands (endocannabinoids) and the whole apparatus… drugs targeting the endocannabinoid system might be used to retard or block cancer growth… Perturbation of lipid rafts/caveolae may in fact represent a useful tool for the development of a novel therapy for endocannabinoids-related diseases, such as cancer.

Update On the Endocannabinoid System As An Anticancer Target
Recent studies have shown that the endocannabinoid system (ECS) could offer an attractive antitumor target.  One direction that should be pursued in antitumor therapy is to select compounds with reduced psychoactivity. This is known to be connected to the CB1 receptor; thus, targeting the CB2 receptor is a popular objective. CB1 receptors could be maintained as a target to design new compounds, and mixed CB1-CB2 ligands could be effective if they are able to not cross the BBB. Furthermore, targeting the ECS with agents that activate cannabinoid receptors or inhibitors of endogenous degrading systems such as fatty acid amide hydrolase inhibitors may have relevant therapeutic impact on tumor growth. Additional studies into the downstream consequences of endocannabinoid treatment are required and may illuminate other potential therapeutic targets.

Use of Cannabinoid Receptor Agonists In Cancer Therapy As Palliative and Curative Agents
Emerging evidence suggests that agonists of cannabinoid receptors expressed by tumour cells may offer a novel strategy to treat cancer. In this chapter we review the more recent results generating interest in the field of cannabinoids and cancer, and provide novel suggestions for the development, exploration and use of cannabinoid agonists for cancer therapy, not only as palliative but also as curative drugs.

Inhibitory Effects of Cannabinoid CB1 Receptor Stimulation on Tumor Growth and Metastatic Spreading: Actions on Signals Involved in Angiogenesis and Metastasis
Stimulation of cannabinoid CB1 receptors by 2-methyl-arachidonyl-2′-fluoro-ethylamide (Met-F-AEA) inhibits the growth of a rat thyroid cancer cell-derived tumor in athymic mice by inhibiting the activity of the oncogene product p21ras.  Three weeks from the paw injection of 3LL cells, Met-F-AEA reduced significantly the number of metastatic nodes, in a way antagonized by SR141716A. Our findings indicate that CB1 receptor agonists might be used therapeutically to retard tumor growth in vivo by inhibiting at once tumor growth, angiogenesis, and metastasis.

Good News For CB1 Receptors: Endogenous Agonists Are in the Right Place
Good news for CB1 receptors: endogenous agonists are in the right place” and “CB1 receptor agonists might be used therapeutically to retard tumor growth in vivo by inhibiting at once tumor growth, angiogenesis, and metastasis.

Advertisements

Breaking News: Cashy Hyde Free From Cancer

The Cashy Hyde case has been one that has been closely followed by many in the cannabis community that believe in the healing power of cannabis.  Below is the breaking news released yesterday.

On Wednesday, February 22, 2012 Cash Michael Hyde was in Salt Lake City for a follow up MRI to check the status of his brain tumor. A PNET brain tumor he has been battling for almost 2 years.

For the second time in a row, Cashy has beat his tumor, and is in remission.

The Boy of Steel is Cancer Free!

How many people do you know that beat cancer once, nonetheless twice?

At THREE years of age?

Congratulations and hugest of blessing upon his parents Mike and Kalli for being the strong parents they are, and fighting so diligently to save their son’s life with an alternative option.

Thank heavens for the cannabis oil that saves Cashy’s life.

Be vigilant in your duties Pioneers……your efforts are important to people just like Cashy and his family EVERY day! Act responsibly! Keep up the great work!

And to all the politicians out there…….please support the Hyde family, and many other families out there just like them.

We are here to save children’s lives, not take them away.

Love and blessings to all…..I’m off to celebrate on the ride back to Montana with the Hyde’s.

I love them all so very much. Better be a BIG box of Kleenex on board as we will all be so HAPPY!

For more information please view original source or visit The Cash Hyde Foundation.

Children’s Cancer and Cannabis

The words children and cannabis sound very uncomfortable to many but to parents who want to see their child thrive, for some, it sounds like a prayer answered.  It is a very controversial subject but a very important one to discuss.  In the United States over 10,000 children under the age of 15 are diagnosed with cancer each year.  One of the most famous cases of a child with cancer being treated with cannabis is Cashy Hyde.  Many know the story of how the frail little boy bounced back with the help of Rick Simpson Oil.  Below you will see studies on how cannabis has been looked at for childhood cancers.  I encourage all to do their own research and seek out the truth! ~ Cherry Girl

An Efficient New Cannabinoid Antiemetic in Pediatric Oncology
An efficient new cannabinoid antiemetic in pediatric oncology…Delta-8-tetrahydrocannabinol (delta-8-THC), a cannabinoid with lower psychotropic potency than the main Cannabis constituent, delta-9-tetrahydrocannabinol (delta-9-THC), was administered to eight children, aged 3-13 years with various hematologic cancers, treated with different antineoplastic drugs… The THC treatment started two hours before each antineoplastic treatment… Vomiting was completely prevented.

Cannabis-Induced Cytotoxicity in Leukemic Cell Lines: The Role of the Cannabinoid Receptors and the MAPK Pathway
Delta9-Tetrahydrocannabinol (THC) is the active metabolite of cannabis… We investigated the role of the CB-Rs (cannabinoid receptors) in mediating apoptosis (cell death) in 3 leukemic cell lines… We have shown that THC is a potent inducer of apoptosis (cell death/cell suicide)…Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway.

Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of P22phox and Nox4 Expression
2006: “Cannabidiol-induced apoptosis (cell death) in human leukemia cells… results from this study reveal that cannabidiol, acting through CB2 and regulation of Nox4 and p22(phox) expression, may be a novel and highly selective treatment for leukemia.”— I believe cannabidiol is a non-psychoactive cannabinoid from cannabis.

The CB2 Cannabinoid Receptor Signals Apoptosis Via Ceramide-Dependent Activation of the Mitochondrial Intrinsic Pathway
2006: “Delta9-tetrahydrocannabinol and other cannabinoids exert pro-apoptotic actions in tumor cells via the CB2 cannabinoid receptor… the molecular mechanism involved in this effect has remained elusive. Here we used the human leukemia cell line Jurkat-that expresses CB2 as the unique CB receptor-to investigate this mechanism…results presented here show that CB2 receptor activation signals apoptosis (cell death).

Medical Marijuana: Should Minors Have the Same Rights As Adults?
“Failure to give an effective therapy to seriously ill patients, either adults or children, violates the core principles of both medicine and ethics. Medically, to deny physicians the right to prescribe to their patients a therapy that relieves pain and suffering violates the physician-patient relationship. Ethically, failure to offer an available therapy that has proven to be effective violates the basic ethical principle of nonmaleficence, which prohibits the infliction of harm, injury, or death and is related to the maxim primum non nocere (‘above all, or first, do no harm’)… Therefore, in the patient’s best interest, patients and parents/surrogates, have the right to request medical marijuana under certain circumstances and physicians have the duty to disclose medical marijuana as an option and prescribe it when appropriate. The right to an effective medical therapy, whose benefits clearly outweigh the burdens, must be available to all patients including children. To deny children the use of medical marijuana when appropriate is a grave injustice which violates the basic foundational beliefs of both medicine and… ” — ethics?