It Is Time To Get Serious, It is Time To Talk Legalization

It is a difficult subject to discuss without getting a little fired up and at the same time heartbroken.  Cannabis legalization either for medical use only or for adults 21 years and older seems to be in the same category as discussing the latest pop news.  Nonchalantly, with a laugh and without much regard.  It seems that every time the subject of medical cannabis comes up it is either ignored or discussed with a laugh.  With high numbers of support and more states lined up to join the 17 states that have already approved medical cannabis legislation this subject will need to be seriously discussed.

While some have the luxury of getting stoned for the hell of it millions depend on cannabis for serious medical issues.  Many of them wish they could only use cannabis for recreation instead of the necessity with which they find themselves.  Yes cannabis can be a lot of fun to use recreationally.  Yes it can be fun to eat pizza and zone out on the couch with friends.  For those losing their livelihood, their children, their freedom or their life I am sure they have a much different outlook.

What about the cancer patient in pain?  The one who is looking death in the face and decides to take a chance with cannabis treatments to ease the pain, nausea and other horrific side effects.  The patient who uses a state legal dispensary to safely access  trusted raw cannabis or cannabis infused products.  The patient who uses the concentrated RSO oil that not only helps with the side effects but actually helps fight the cancer including inducing cancer cell death.  Is it still funny when that patients house is raided, when they are terrorized in their own home, when they are taken to jail?  Is it funny that we are keeping a PLANT from citizens who have gone through the state approved process to obtain state legal medication that not only helps cancer but hundreds of other medical issues as well?

What about the hardworking top student who gets drug tested or is caught with a small amount and loses their scholarship or funding?  What about the employee who otherwise is known as a perfect employee but comes up positive on a drug test?   There is too much known evidence to date that beyond proves cannabis has medical value.  Every week new studies are published attesting to that fact.  Should the federal government really be dictating to the states how to run a state program?  Should we still take such a hard stance against a versatile natural plant that not only helps millions but is already being used by a large percentage of the country?

We are allowed to vote, drive, consume alcohol, raise children, build large corporations and many other highly responsible activities and responsibilities so why are we not allowed to choose how to treat our illnesses or relax at the end of the day?  Why are we not allowed to choose natural cannabis instead of the more harmful choice alcohol?

Cannabis effects us not only socially but financially as well.  The cannabis related industry has grown during the recession.  We would save billions in wasted efforts trying to stifle a growing industry.  We would save lives and instead allow tax revenue and other positive residual effects to spread throughout the communities.  

We have to take a serious look at this subject and come to the table as adults.  Its time to put away the pizza, quit the giggles and other tired cliches.  This effects everyone from children losing their parents to the loved one with an illness prosecuted for using a natural herb used for thousands of years.  If we are truly free adults then we should be able to discuss this in a serious manner.  I urge all of you to speak up and let your representatives know it is time to seriously talk about cannabis legalization.

Cannabis Less Harmful Than Current Drug Therapies?

Many when faced with a serious illness fight for their life but ironically are prescribed medications that in fact not only cause harm but also are capable of taking their life.  Many prescription side effects are quite lengthy.  Those that are on prescriptions long-term end up requiring even more medication down the line to combat the side effects from the first drug.  With all that in mind patients are looking for a safer alternative solution.

From cancers to anxiety many prescribed therapies are not only dangerous but can cause death.  Chemotherapy has come a long way from the early days but it is still a drug that ravages the body.  By contrast research has shown that cannabinoid therapies induce programmed cell death in cancerous cells.  Cannabinoids as is widely known are praised for their ability to alleviate without any reported deaths throughout its historic, several thousand year use.

Although the official stance from the government is that cannabis has no accepted medical value science tells us otherwise.  Below you will see a study that weighs the harm of accepted drug therapies such as opioids.  As always I encourage all to do their own research and please feel free to share ~ Cherry Girl

Prescribing Cannabis For Harm Reduction 2012
Neuropathic pain affects between 5% and 10% of the US population and can be refractory to treatment. Opioids may be recommended as a second-line pharmacotherapy but have risks including overdose and death. Cannabis has been shown to be effective for treating nerve pain without the risk of fatal poisoning. The author suggests that physicians who treat neuropathic pain with opioids should evaluate their patients for a trial of cannabis and prescribe it when appropriate prior to using opioids. This harm reduction strategy may reduce the morbidity and mortality rates associated with prescription pain medications.

Save Your Ass, Smoke Some Grass

When people think of grass, weed, pot or cannabis they think of hippies and parties.  What most people don’t think about is that cannabis is showing real promise, on the molecular level, in fighting cancers.  People of all walks have been touched by cancer.  Most people know of someone, has had a loved one go through it or they themselves have experienced cancer.  It is no wonder then that science and medicine have been working hard to find a cure.  Cannabis research has been taking notice especially for its anti-cancer discoveries.   Over 140,000 new cases were reported for colon and rectal cancers with 51,000 reported deaths.  Below you will see studies where cannabis has been examined in the context of colorectal cancers.  As always please feel free to share and I encourage all to do their own research as well ~ Cherry Girl

Single Nucleotide Change in the Cannabinoid Receptor-1 (CNR1) Gene in Colorectal Cancer Outcome
The cannabinoid receptor-1 (CNR-1) and endogenous agonists of this receptor are present in the central and peripheral nervous systems including the gastrointestinal nervous system.Indeed nontumor paired colorectal tissues showed nucleotide change. A large number of patients with mutation in the CNR1 gene were observed. These preliminary findings highlight the importance of further studies in the use of cannabinoid analogs as receptor ligands to analyze potential therapeutic effects.

Cannabinoid Receptor Activation Induces Apoptosis(programmed cell death) through Tumor Necrosis Factor α–Mediated Ceramide De novo Synthesis in Colon Cancer Cells
We show that the CB1 receptor was mainly expressed in human normal colonic epithelium whereas tumor tissue was strongly positive for the CB2 receptor.  The present study shows that either CB1 or CB2 receptor activation induces apoptosis through ceramide de novo synthesis in colon cancer cells. Our data unveiled, for the first time, that TNF-α acts as a link between cannabinoid receptor activation and ceramide production.

Apoptosis: Programmed Cell Death At A Molecular Level
Balanced apoptosis is crucial in development and homeostasis, and all multicellular organisms have a physiologically programmed continuum of pathways to apoptotic cell death. Further studies of the control at the molecular level of key components and promoters/suppressors of apoptosis may provide better approaches to treatment of autoimmune diseases, malignancies, and neurodegenerative disorders. Many important questions remain regarding the advantages of modifying apoptotic programs in clinical situations.

Beyond The Smoke: The Anticancer Properties Of Cannabis

Cannabis has many amazing healing properties that utilize the endocannabinoid system to reach target areas.  Scientists use this knowledge to target certain aspects of a condition depending on the symptoms.  It is well known that cannabis use can help cancer patients during the course of their battle, from increased appetite to pain relief.  Scientists have been uncovering cannabis’ anticancer effects as well.  This promising research is clearing the way so that one day we will fully understand this miracle plant.  Below are studies where science has looked at cannabis therapy when applied to cancer cells.  Please feel free to share and as always I encourage all to do their own research.  Please note that a lot of these are NEW 2012 released research which is really exciting! ~ Cherry Girl

CANNABIDIOL AS POTENTIAL ANTICANCER DRUG
Over the past years, several lines of evidence support an antitumorigenic effect of cannabinoids including Δ(9) -tetrahydrocannabinol (Δ(9) -THC), synthetic agonists, endocannabinoids and endocannabinoid transport or degradation inhibitors.

Non-THC Cannabinoids Counteract Prostate Carcinoma Growth In Vitro and In Vivo: Pro-Apoptotic Effects and Underlying Mechanisms 2012
Cannabinoid receptor activation induces prostate carcinoma cell…In LNCaP cells, the pro-apoptotic effect of CBD was only partly due to TRPM8 antagonism and was accompanied by down-regulation of AR, p53 activation and elevation of reactive oxygen species. LNCaP cells differentiated to androgen-insensitive neuroendocrine-like cells were more sensitive to CBD-induced apoptosis. Conclusions. These data support the clinical testing of CBD against prostate carcinoma.

Role of Lipid Rafts/Caveolae in the Anticancer Effect of Endocannabinoids 2012
The endocannabinoid system comprises the cannabinoid receptors type 1 (CB1) and type 2 (CB2), their endogenous ligands (endocannabinoids) and the whole apparatus… drugs targeting the endocannabinoid system might be used to retard or block cancer growth… Perturbation of lipid rafts/caveolae may in fact represent a useful tool for the development of a novel therapy for endocannabinoids-related diseases, such as cancer.

Update On the Endocannabinoid System As An Anticancer Target
Recent studies have shown that the endocannabinoid system (ECS) could offer an attractive antitumor target.  One direction that should be pursued in antitumor therapy is to select compounds with reduced psychoactivity. This is known to be connected to the CB1 receptor; thus, targeting the CB2 receptor is a popular objective. CB1 receptors could be maintained as a target to design new compounds, and mixed CB1-CB2 ligands could be effective if they are able to not cross the BBB. Furthermore, targeting the ECS with agents that activate cannabinoid receptors or inhibitors of endogenous degrading systems such as fatty acid amide hydrolase inhibitors may have relevant therapeutic impact on tumor growth. Additional studies into the downstream consequences of endocannabinoid treatment are required and may illuminate other potential therapeutic targets.

Use of Cannabinoid Receptor Agonists In Cancer Therapy As Palliative and Curative Agents
Emerging evidence suggests that agonists of cannabinoid receptors expressed by tumour cells may offer a novel strategy to treat cancer. In this chapter we review the more recent results generating interest in the field of cannabinoids and cancer, and provide novel suggestions for the development, exploration and use of cannabinoid agonists for cancer therapy, not only as palliative but also as curative drugs.

Inhibitory Effects of Cannabinoid CB1 Receptor Stimulation on Tumor Growth and Metastatic Spreading: Actions on Signals Involved in Angiogenesis and Metastasis
Stimulation of cannabinoid CB1 receptors by 2-methyl-arachidonyl-2′-fluoro-ethylamide (Met-F-AEA) inhibits the growth of a rat thyroid cancer cell-derived tumor in athymic mice by inhibiting the activity of the oncogene product p21ras.  Three weeks from the paw injection of 3LL cells, Met-F-AEA reduced significantly the number of metastatic nodes, in a way antagonized by SR141716A. Our findings indicate that CB1 receptor agonists might be used therapeutically to retard tumor growth in vivo by inhibiting at once tumor growth, angiogenesis, and metastasis.

Good News For CB1 Receptors: Endogenous Agonists Are in the Right Place
Good news for CB1 receptors: endogenous agonists are in the right place” and “CB1 receptor agonists might be used therapeutically to retard tumor growth in vivo by inhibiting at once tumor growth, angiogenesis, and metastasis.

Never Fear Cannabis Is Here! How Cannabis Can Help With Fear, Anxiety, and Other Psychiatric Disorders

Nearly 19 million Americans suffer from a  psychiatric disorder which could include disorders such as specific phobias, generalized anxiety disorder, social anxiety disorder, panic disorder, agoraphobia, obsessive-compulsive disorder and post-traumatic stress disorder.  Many veterans returning from war have found cannabis to be a relief from PTSD.  Below you will studies where science has studied the effects of cannabis compounds when applied to psychiatric disorders.  Please feel free to share and I encourage all to do their own research as well ~ Cherry Girl

The Endocannabinoid System in the Processing of Anxiety and Fear and How CB1 Receptors May Modulate Fear Extinction 
The endocannabinoid system recently emerged as an important modulator of many neuronal functions. Among them, the control of anxiety and acquired fear represents nowadays one of the most interesting fields of research.  Finally, a neurobiological model possibly able to implement the role of the endocannabinoid system in these processes will be proposed.

CB1 Cannabinoid Receptors Modulate Kinase and Phosphatase Activity During Extinction of Conditioned Fear in Mice
Cannabinoid receptors type 1 (CB1) play a central role in both short-term and long-term extinction of auditory-cued fear memory.  We propose that the endogenous cannabinoid system modulates extinction of aversive memories, at least in part via regulation of the activity of kinases and phosphatases in a brain structure-dependent manner.

Extinction of Emotional Response As A Novel Approach of Pharmacotherapy of Anxiety Disorders 
The patogenesis of anxiety may be related to the process of an extinction of aversive memories… Studies on molecular and cellular mechanisms responsible for individual fear extinction may serve as the basis of search for more effective forms of clinical treatment… ligands stimulating endogenous cannabinoid system… these substances stimulate different central mechanisms, they appear to act synergistically, to improve the behavioural therapy.

Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear
the findings in the present study suggest that augmenting eCB-mediated neurotransmission by inhibition of eCB transport or breakdown may provide a novel mechanism for enhancing the extinction of fear. As such, eCB reuptake inhibitors may serve as useful adjuncts in the treatment of anxiety disorders (such as PTSD, panic disorder, and OCD) as well as drug addiction and other disorders that respond to behavioral treatments utilizing extinction processes.

The Endogenous Cannabinoid System Controls Extinction of Aversive Memories
Acquisition and storage of aversive memories is one of the basic principles of central nervous systems throughout the animal kingdom. In the absence of reinforcement, the resulting behavioural response will gradually diminish to be finally extinct.  We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala.

The Endocannabinoid system and Extinction Learning
As several human psychiatric disorders, such as phobia, generalized anxiety disorders, and posttraumatic stress disorder (PTSD) appear to involve aberrant memory processing and impaired adaptation to changed environmental conditions, the hope has been fuelled that the endocannabinoid system might be a valuable therapeutic target for the treatment of these disorders.

Bringing the War Back Home: Mental Health Disorders Among 103,788 US Veterans Returning From Iraq and Afghanistan Seen at Department of Veterans Affairs Facilities
Co-occurring mental health diagnoses and psychosocial problems were detected early and in primary care medical settings in a substantial proportion of OEF/OIF veterans seen at VA facilities. Targeted early detection and intervention beginning in primary care settings are needed to prevent chronic mental illness and disability.

Psychosis and Trauma. Theorical Links Between Post-Traumatic and Psychotic Symptoms
The links between psychotic and psycho-traumatic symptoms are complex and multidirectional; this co-occurrence is a factor of seriousness. The clinician, while paying attention to these symptoms, has to distinguish the structure of the personality of the subject to articulate the psychotherapy and the pharmacological treatment. Further investigational studies may determine whether antipsychotics will enhance treatment response in PTSD patients with psychotic features.

Citizens Drive, Consume Alcohol, Use Tobacco And Take Prescriptions So Why Not Cannabis?

With all the heated debates over cannabis legalization going on around the country one would wonder why there is so much buzz over a plant.  Cannabis, specifically medical cannabis, has been at the forefront of discussions all around the country.  The federal government has continued its harsh stance against legalization despite the mounting evidence of its benefits, as backed up by the Vice President’s actions in Latin America this week.

We have looked at the issue of legalization in many lights but one way that has not been discussed is that of the individual.  Legally we are given responsibility for our actions and our bodies when we drive, consume alcohol, tobacco or prescriptions despite deaths each year.  Most of us are reasonably responsible adults who are depended upon to carry out many important tasks and make many important decisions including raising children.  Doctors are entrusted with our lives including cancer treatments and brain surgeries but they are not trusted to prescribe cannabis medicinally.

We are each supposed to be responsible for ourselves including the care of our bodies.  With this it would naturally be assumed that one would also have control of what goes into one’s body and what treatments or relaxations methods one chooses to use.  Americans range from lawyers, doctors, congresspeople, CEO s, mothers or any other law abiding citizens.  Why are we not trusted to make a responsible decision when it comes to cannabis?

This leaves one to wonder in regards to cannabis when did the government decide we were incapable of making such a personal decision?  When did they decide that they know more about whats better for each of us individually than we do ourselves?  It is insulting when you look at it in this light; that the government does not feel that each of us are capable of self-control.  As a parent I am insulted that they question my parenting abilities to raise a competent person capable of choosing wisely for themselves including refraining from letting cannabis “take over their lives” as the government wants us to believe happens all the time.  In reality each of us are capable of deciding how to, when to and how much to use cannabis if at all.  Each of us are capable of researching and talking with our doctors to see if cannabis is right for us.

The government allows drivers 16 and older to get behind the wheel of a car despite the harm drivers cause all across the nation.  There are over 40,000 deaths a year as a result of vehicles and their drivers.  People now more than ever are distracted with texting, videos, talking, browsing and more making them even more dangerous.

The government also allows for adults 21 and older to consume alcohol even though it causes over 750,000 deaths a year, domestic violence, rise in crime rates, child abuse, liver damage and many more tragedies.  The government feels that you can responsibly use and monitor your consumption of alcohol even though there are over 17 million alcoholics in the US.

The government allow adults 18 and older to use tobacco even after concrete evidence that it causes cancer and death not only to the user but those around them that are exposed.  Cigarettes have been linked to lung cancer, emphysema and more.  Each year it is estimated that 443,000 die from tobacco related issues.

Each year over 100,000 Americans die from medication by overdose, interactions or other medication related issues.  Citizens are entrusted with sometimes fatal medications monitored only by themselves and some doctor supervision.  Doctors on the whole still do not have sophisticated systems between themselves and pharmacies to prevent drug interactions or overdose.

There are many larger responsibilities we handle than a personal choice of using cannabis or not.  Even legally we are given much larger responsibilities so with that in mind the obvious question is why would using this plant in a responsible manner not be one our responsibilities as well?

Despite all the mounting evidence of the beneficial properties of cannabis and the fact there has never been a reported case of overdose, the government refuses to recognize that Americans are responsible enough and should have control over their decision concerning cannabis.  The decision to use or not to use cannabis is a personal choice and one that should be used with facts in hand and government nowhere in sight.

Although cannabis does not cause death, people still do.  People need to live up to that responsibility by using cannabis wisely and responsibly.  We shouldn’t have to prove anything to the government but if we are going to change things in this country being a good example is the first step.  This includes responsibly using cannabis and restricting access to children.

Educating others is the second step.  We need to show others that cannabis is not the evil drug that the government has made it out to be but instead a healing plant.  It can be used responsibly to wind down at the end of a long day much like wine or beer or in more potent version medicinally for patients.  In the end this is just a plant and one that can be used naturally without changing its form which can not be said for many other drugs legal or not.

Educating others is key to our success in legalization.  Others need to know the truth and I encourage all to go out and seek the truth.  Learn the real facts of cannabis.  Then contact your representative and ask for their support in repealing cannabis prohibition.  There are several pending legislation all over the country.  Help 2012 be a monumental year, one that we reach our goal!

Corruption Through the Ages

It is said that if history is not learned it is doomed to repeat itself.  It is important to look back and know how we got here today.  We have looked at how Prohibition of Alcohol can be applied to today’s War on Drugs.  We have also looked at the current Drug War in terms of stats on arrests and how much money is wasted.  Now we will take a look at how the Banking System has played a role in the drug trade and the War on Drugs. If you study the timeline below you will see how corruption has a firm grip where ever there is money. In the past 10 years there has been major corruption linking the banking system and drug cartels.  This is just one key point in the War on Drugs and our fight for legalization.  Money does have control and it is vital to know all aspects when fighting for legalization.  In the timeline you will notice underline text.  These are areas that I encourage to be further researched as there is a lot of interesting history to be discovered.  Please Share: just click on the image below to read~ Cherry Girl

Also available in High Resolution

Adapted from “Banking Laid Bare” Steven Hager ~ High Times Dec 2011

Wachovia and J.P. Morgan connection to Slave Trade: http://www.ushistory.org/presidentshouse/news/ww061005.htm