U.S. Government Destroying History: Why We Must Save Cannabis Plant Genetics From Extinction

Strains such as Kush have been made notorious through songs and celebrities professing their love for the strain.  Those that have experienced Kush know why it is so famous.  From Tahoe OG Kush to Afghan Kush the high is memorable.  Cannabis is not a new plant created in a lab but rather has been used for centuries as medicine, religious herb and for recreation.  Research proves more every day how vital plant genetics are in finding the right compounds to combat illnesses and find cures.  Genetics is something that isn’t often thought of when discussing the War on Drugs but it has definitely been affected by it.

Some cannabis genetics are thought to have come from Providences in China and spread throughout the Silk Road while others originate in the Middle East.  There of course was the large movement through the 60s and 70s that helped spread and create new cannabis strains through people exchanging seeds and ganja.

With new genetics infiltrating the gene pool in the States new plant strains emerged.  Hybrids also came out of the mix.  People discovered that by crossing different strains they could breed out the undesirable traits while promoting higher potency and better growth stamina.  By cross breeding not only Indica with Indica but breeding for balance we have seen hybrid strains that have the pain relief of an Indica but with the “upper” functioning high of a Sativa.  Genetics play a role in growth, mold/pest resistance and of course potency.  

Blueberry strains are known for their social anxiety and pain relief as well as helping with digestive disorders and have spawned notorious strains like Blue Cheese, Blue Dream, Old-Time Moonshine and Blue Haze .  DJ Short created the Blueberry strain by crossing his Afghani Indica, brought by some growers from California and his Purple Thai.  The female pedigree of his Purple Thai is his highly potent all-around champion, “Juicy Fruit” Highland Thai female. It packed a very sweet tropical punch and an intense high that lasted for many hours. The second plant was a Purple Thai out of Oregon, Ohio. This plant was a cross between an outstanding Highland Oaxaca Gold and a very freaky Chocolate Thai. The hybrid was very dark colored and would express a deep royal purple color at the slightest exposure to cold. The finished product was equally tasty and strong as the Juicy Fruit female.

The War on Drugs forced cannabis use underground.  Cannabis began being bred for bag appeal and what would bring the best sales.  Growers began looking for traits that would bring the biggest yield with the shortest flowering time.  Medicinal qualities were disregarded.    For decades it was thought that the compound THC was responsible for all of the effects cannabis provided.  We now know of CBD which is actually responsible for pain relief and has been found to help with insomnia, anxiety and Alzheimer’s.  CBD was another casualty of the war with most of today’s strains registering less than 0.5%.  With the War on Drugs ongoing for over 40 years countless plants have been destroyed with the government’s actions forever destroying precious genetics.

Although cannabis has been around for thousands of years it wasn’t until the summer of 2011 that the genetics of the cannabis Sativa and Indica were mapped.  We know that there are hundreds of strains that have come from the original heirloom landraces.  Today many patients and citizens alike have the option of what type of relief or high they are looking for.  From the euphoric highs of the Sativa to the amazing pain relief that Indicas bring the options are endless.

Everyday we have new research that is released that shows the anti-cancer properties of cannabinoids.  Now more than ever we understand why we need to preserve the genetics of all cannabis plants.  We know that we can use different strains to treat a wide range of illnesses and afflictions.  We also know that cannabis is not a one-size-fits-all type of plant.  You need to have the correct strain containing the right balance of compounds to reach the desired effects.

We have more proof than we have ever had before showing the medical benefits even on a molecular level.  We are beyond smoke when taking about cannabis therapies.  There are a wide range of options when talking about uses.  Tinctures, edibles, concentrates, oils, topical lotion, capsules, vaporizers and more.

Support is at an historic high with medical use over 75% and legalization for adults over 21 at 50%.  States that have enacted decriminalization have found favorable outcomes.  States that have enacted medical statues have found large increases in tax income as well as economic growth in the communities.

If cannabis is allowed to thrive imagine the possibilities.  Imagine 5, 10, 15 years from now how much we will know about genetics, compounds and treatments for cancers.  Imagine all the possibilities if we could openly and safely exchange genetics and end products.  How many people could find relief?  How many could save their life?

It is time that we stand up and protect cannabis genetics.  We need to stop the violent raids by government officials.  The government needs to change their stance on cannabis therapies.  Now more than ever it is time we stop the continual attacks on patients, crops and our heritage.  The War on Drugs needs to end.  It has been a failed war for over 40 years that has forever changed the history of cannabis.  Those that have kept cannabis genetics alive even in the face of persecution and imprisonment thus passing down history should be celebrated.  Urge your representative today to show support for ending the failed approach to dealing with cannabis.

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Cannabis, Cancer And Children:Why We Must Give Parents A Choice

There is something special about children that brings a smile.  Some parents wait a long time to be able to have that special time to cradle their child, gazing into their eyes.  Imagine being the parents faced with the reality that your child has cancer.  For over 10,000 parents each year that is the case.  Vigilantly staying by their child’s side through countless shots, painful procedures, body wrenching medications and worst of all watching as their child withers away before their eyes.  The spark slowly going out leaving behind a weak body.  Most would try anything to save their baby.  

Current therapies  such as chemotherapy are not precise measures.  Rates of success in comparisson with side effects make some wonder why alternatives are being stifled.    In contrast there is mounting evidence of the anti-tumor effects of cannabis compounds.  Cannabis has been praised for its large window of error since cannabis does not cause death.

Most in the cannabis community know who Cashy Hyde is.  He is the little boy who’s father treated him with cannabis oil and who today is cancer free.  Cashy has undergone extensive treatments that ravaged his tiny body.  His father watched as the light faded and decided to save his son.  He fed Cashy Rick Simpson Method Cannabis Oil through his feeding tube and miraculously watched his son bounce back to life.  Within days they noticed a difference.

Cashy is not alone.  There are millions of others that have been helped and cured with cannabis.  The discussion of cannabis is beyond smoke.  Cannabis research has shown that by targeting the Endocannabinoid system with the right combinations of compounds you will receive the desired effects including inducing cell death in cancer.

With so much more scientific medical research as proof the majority of the country is asking why we still pursue prohibition with a vengeance.  California has been helping patients since 1996.  Last year we saw a flood of stories where federal agencies terrorized local communities with their SWAT style raids.  In doing so they cut off supply of much needed medicine for patients just like Cashy.

We must do something to give parents an option to save their children.  When parents are told there is nothing more that can be done should we really take away hope.  Should we incarcerate parents for possessing a plant, one that science proves is lifesaving?  We need to bring sanity back into the equation.  We must change the laws.  Me must challenge the “way its always been”.  It is time to allow parents the right to decide for their children.  Several states have proposed or pending legislation.  Contact your state representatives and urge them to help change the future for our children.

Newly Released Studies Show Protection and Regeneration of Brain Cells with Cannabis Therapies

There are over 1.7 million cases of severe brain injury that are reported each year.  These injuries can be life altering for many but thanks to the hard work from the science and medical communities we are learning more about new treatment options.  Cannabis has been discovered to help with cell regeneration and repair in the brain.  Below you will see newly published studies where  cannabis has been applied to help with brain injuries. Truly exciting!!   As always I encourage all to do their own research as well and please feel free to share ~ Cherry Girl

Early Survival of Comatose Patients After Severe Traumatic Brain Injury With the Dual Cannabinoid CB1/CB2 Receptor Agonist KN38-7271
Despite many drug trials, no substance has yet been identified that improves the outcome of severe head injury. The dual cannabinoid CB1/CB2 receptor agonist KN38-7271 mediates potent neuroprotection in animal models. We describe here the first randomized, double-blind, prospective, placebo-controlled clinical phase IIa proof-of-concept trial to investigate the safety, pharmacokinetics, and potential efficacy of a cannabinoid receptor agonist in humans.  Conclusions KN38-7271 appeared beneficial in the acute early phase of the comatose patient after a head injury. Its use was safe and well tolerated by patients.

Cannabinoids As Neuroprotective Agents In Traumatic Brain Injury
Cannabinoids of all classes have the ability to protect neurons from a variety of insults that are believed to underlie delayed neuronal death after traumatic brain injury (TBI), including excitotoxicity, calcium influx, free radical formation and neuroinflammation.

Cannabidiol Administration After Hypoxia-Ischemia To Newborn Rats Reduces Long-Term Brain Injury and Restores Neurobehavioral Function 2012
Cannabidiol (CBD) demonstrated short-term neuroprotective effects in the immature brain following hypoxia-ischemia (HI).   In conclusion, CBD administration after HI injury to newborn rats led to long-lasting neuroprotection, with the overall effect of promoting greater functional rather than histological recovery.

Cannabidiol Reduces Brain Damage and Improves Functional Recovery After Acute Hypoxia-Ischemia In Newborn Pigs 2011
Newborn piglets exposed to acute hypoxia-ischemia (HI) received i.v. cannabidiol (HI + CBD) or vehicle (HI + VEH). In HI + VEH, 72 h post-HI brain activity as assessed by amplitude-integrated EEG (aEEG) had only recovered to 42 ± 9% of baseline, near-infrared spectroscopy (NIRS) parameters remained lower than normal, and neurobehavioral performance was abnormal (27.8 ± 2.3 points, normal 36).   In conclusion, post-HI administration of CBD protects neurons and astrocytes, leading to histological, functional, biochemical, and neurobehavioral improvements.
 

Cannabis Has Cancer In The Cross-Hairs. Utilizing The Endocannabinoid System To Kill Cancer

It seems that these days the word cancer is everywhere.  From billboards encouraging donations to charities to news headlines to loved one effected by cancer most people are familiar.  There are more than 200 different types of cancer that can develop in over 60 different organs in the body.  Current therapies include poisoning the body in hopes that it will also kill the cancer.  Cannabis is used to help counteract the side effects of these therapies.  However new research points to cannabis as the compounds that can actually cause cancer cell death, essentially curing cancer.  There are countless studies that have been published showing the benefits of using the endocannabinoid system to target cancer cells with cannabinoids.  From that research we have found where using the endocannabinoid system has proven vital in fighting cancer.  Below you will see several studies that show how using the endocannabinoid system can be used in targeting cancer.  Please feel free to share and help others see that using cannabis is beyond the smoke.  I encourage all to do their own research as well ~ Cherry Girl

The Endocannabinoid System in Cancer-Potential Therapeutic Target?
Endogenous arachidonic acid metabolites with properties similar to compounds of Cannabis sativa Linnaeus, the so-called endocannabinoids, have effects on various types of cancer.    Remarkably, these effects may be selective for the cancer cells, while normal cells and tissues are spared. Such apparent tumor cell selectivity makes the endocannabinoid system an attractive potential target for cancer therapy.

Targeting the Endocannabinoid System For the Treatment of Cancer–A Practical View
In recent years, considerable interest has been generated by findings that cannabinoids not only have useful palliative effects, but also can affect the viability and invasivity of a variety of different cancer cells.   It is concluded that cannabinoids (or agents modulating the endogenous cannabinoid system) are an attractive target for drug development in the cancer area….

The Endocannabinoid System As A Target For the Development of New Drugs For Cancer Therapy
Studies on the main bioactive components of Cannabis sativa, the cannabinoids, and particularly (THC), led to the discovery of a new endogenous signalling system that controls several physiological and pathological conditions: the endocannabinoid system. Recently, evidence has accumulated indicating that stimulation of cannabinoid receptors by either THC or the endocannabinoids influence the intracellular events controlling the proliferation and apoptosis(cell death) of numerous types of cancer cells, thereby leading to anti-tumour effects both in vitro and in vivo. This evidence is reviewed here and suggests that future anti-cancer therapy might be developed from our knowledge of how the endocannabinoid system controls the growth and metastasis of malignant cells.

Endocannabinoid System Modulation In Cancer Biology and Therapy
Endocannabinoid system modulation in cancer biology and therapy. The discovery of the endocannabinoid system… led to the development of therapeutic agents related to either the stimulation or antagonism of CB1 and CB2 cannabinoid receptors… evidence suggests that agonists of cannabinoid receptors, which share the useful property to discern between tumor cells and their non-transformed counterparts, could represent novel tumor-selective tools to treat cancer in addition to their already exploited use as palliative drugs.

Use of Cannabinoid Receptor Agonists In Cancer Therapy As Palliative and Curative Agents
“Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents… Cannabinoids (the active components of Cannabis sativa)… development, exploration and use of cannabinoid agonists for cancer therapy, not only as palliative but also as curative drugs.

Changes in the Endocannabinoid System May Give Insight into new and Effective Treatments for Cancer
Marijuana and its derivatives have been used in medicine for centuries… cannabinoids might be effective anti-tumoral agents because of their ability to inhibit the growth of various types of cancer… Evidence suggests that the endocannabinoid system may be dysregulated in a number of cancers… the endocannabinoid system exerts a myriad of effects on tumor cell growth, progression, angiogenesis, and migration. With a notable few exceptions, targeting the endocannabinoid system with agents that activate cannabinoid receptors or increase the endogenous levels of AEA may prove to have therapeutic benefit in the treatment of various cancers.

Save Your Ass, Smoke Some Grass

When people think of grass, weed, pot or cannabis they think of hippies and parties.  What most people don’t think about is that cannabis is showing real promise, on the molecular level, in fighting cancers.  People of all walks have been touched by cancer.  Most people know of someone, has had a loved one go through it or they themselves have experienced cancer.  It is no wonder then that science and medicine have been working hard to find a cure.  Cannabis research has been taking notice especially for its anti-cancer discoveries.   Over 140,000 new cases were reported for colon and rectal cancers with 51,000 reported deaths.  Below you will see studies where cannabis has been examined in the context of colorectal cancers.  As always please feel free to share and I encourage all to do their own research as well ~ Cherry Girl

Single Nucleotide Change in the Cannabinoid Receptor-1 (CNR1) Gene in Colorectal Cancer Outcome
The cannabinoid receptor-1 (CNR-1) and endogenous agonists of this receptor are present in the central and peripheral nervous systems including the gastrointestinal nervous system.Indeed nontumor paired colorectal tissues showed nucleotide change. A large number of patients with mutation in the CNR1 gene were observed. These preliminary findings highlight the importance of further studies in the use of cannabinoid analogs as receptor ligands to analyze potential therapeutic effects.

Cannabinoid Receptor Activation Induces Apoptosis(programmed cell death) through Tumor Necrosis Factor α–Mediated Ceramide De novo Synthesis in Colon Cancer Cells
We show that the CB1 receptor was mainly expressed in human normal colonic epithelium whereas tumor tissue was strongly positive for the CB2 receptor.  The present study shows that either CB1 or CB2 receptor activation induces apoptosis through ceramide de novo synthesis in colon cancer cells. Our data unveiled, for the first time, that TNF-α acts as a link between cannabinoid receptor activation and ceramide production.

Apoptosis: Programmed Cell Death At A Molecular Level
Balanced apoptosis is crucial in development and homeostasis, and all multicellular organisms have a physiologically programmed continuum of pathways to apoptotic cell death. Further studies of the control at the molecular level of key components and promoters/suppressors of apoptosis may provide better approaches to treatment of autoimmune diseases, malignancies, and neurodegenerative disorders. Many important questions remain regarding the advantages of modifying apoptotic programs in clinical situations.

Cannabis: Your Heart Hero

More and more Americans are being classified as obese.  With obesity comes other complications such as cardiovascular disease.  Cardiovascular disease refers to any disease that affects the cardiovascular system, principally cardiac disease, vascular diseases of the brain and kidney, and peripheral arterial disease.  The causes of cardiovascular disease are diverse but atherosclerosis and/or hypertension are the most common.  It is estimated that one-third of Americans die from cardiovascular disease so it is no wonder that scientists have been hard at work trying to find a cure.   Below you will see studies where science has looked at cannabis compounds when applied to CVD.  Please feel free to share and I encourage all do their own research as well ~ Cherry Girl

Targeting Cannabinoid Receptor CB(2 ) in Cardiovascular Disorders: Promises and Controversies
“Cardiovascular disease is the leading cause of death and disability worldwide, which can be largely attributed to atherosclerosis, a chronic inflammation of the arteries… the lipid endocannabinoid system has emerged as a new therapeutic target in variety of disorders associated with inflammation and tissue injury, including those of the cardiovascular system. The discovery that delta-9-tetrahydrocannabinol (Δ9-THC), the main active constituent of marijuana, inhibited atherosclerotic plaque progression via a cannabinoid 2 (CB(2) ) receptor-dependent anti-inflammatory mechanism.

Endocannabinoid System in Cardiovascular Disorders – New Pharmacotherapeutic Opportunities
The evidence so far gathered shows that the modulation of ECS (as agonism or antagonism of its receptors) is an enormous potential field for research and intervention in multiple areas of human pathophysiology. The development of selective drugs for the CB1 and CB2 receptors may open a door to new therapeutic regimens.

Never Fear Cannabis Is Here! How Cannabis Can Help With Fear, Anxiety, and Other Psychiatric Disorders

Nearly 19 million Americans suffer from a  psychiatric disorder which could include disorders such as specific phobias, generalized anxiety disorder, social anxiety disorder, panic disorder, agoraphobia, obsessive-compulsive disorder and post-traumatic stress disorder.  Many veterans returning from war have found cannabis to be a relief from PTSD.  Below you will studies where science has studied the effects of cannabis compounds when applied to psychiatric disorders.  Please feel free to share and I encourage all to do their own research as well ~ Cherry Girl

The Endocannabinoid System in the Processing of Anxiety and Fear and How CB1 Receptors May Modulate Fear Extinction 
The endocannabinoid system recently emerged as an important modulator of many neuronal functions. Among them, the control of anxiety and acquired fear represents nowadays one of the most interesting fields of research.  Finally, a neurobiological model possibly able to implement the role of the endocannabinoid system in these processes will be proposed.

CB1 Cannabinoid Receptors Modulate Kinase and Phosphatase Activity During Extinction of Conditioned Fear in Mice
Cannabinoid receptors type 1 (CB1) play a central role in both short-term and long-term extinction of auditory-cued fear memory.  We propose that the endogenous cannabinoid system modulates extinction of aversive memories, at least in part via regulation of the activity of kinases and phosphatases in a brain structure-dependent manner.

Extinction of Emotional Response As A Novel Approach of Pharmacotherapy of Anxiety Disorders 
The patogenesis of anxiety may be related to the process of an extinction of aversive memories… Studies on molecular and cellular mechanisms responsible for individual fear extinction may serve as the basis of search for more effective forms of clinical treatment… ligands stimulating endogenous cannabinoid system… these substances stimulate different central mechanisms, they appear to act synergistically, to improve the behavioural therapy.

Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear
the findings in the present study suggest that augmenting eCB-mediated neurotransmission by inhibition of eCB transport or breakdown may provide a novel mechanism for enhancing the extinction of fear. As such, eCB reuptake inhibitors may serve as useful adjuncts in the treatment of anxiety disorders (such as PTSD, panic disorder, and OCD) as well as drug addiction and other disorders that respond to behavioral treatments utilizing extinction processes.

The Endogenous Cannabinoid System Controls Extinction of Aversive Memories
Acquisition and storage of aversive memories is one of the basic principles of central nervous systems throughout the animal kingdom. In the absence of reinforcement, the resulting behavioural response will gradually diminish to be finally extinct.  We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala.

The Endocannabinoid system and Extinction Learning
As several human psychiatric disorders, such as phobia, generalized anxiety disorders, and posttraumatic stress disorder (PTSD) appear to involve aberrant memory processing and impaired adaptation to changed environmental conditions, the hope has been fuelled that the endocannabinoid system might be a valuable therapeutic target for the treatment of these disorders.

Bringing the War Back Home: Mental Health Disorders Among 103,788 US Veterans Returning From Iraq and Afghanistan Seen at Department of Veterans Affairs Facilities
Co-occurring mental health diagnoses and psychosocial problems were detected early and in primary care medical settings in a substantial proportion of OEF/OIF veterans seen at VA facilities. Targeted early detection and intervention beginning in primary care settings are needed to prevent chronic mental illness and disability.

Psychosis and Trauma. Theorical Links Between Post-Traumatic and Psychotic Symptoms
The links between psychotic and psycho-traumatic symptoms are complex and multidirectional; this co-occurrence is a factor of seriousness. The clinician, while paying attention to these symptoms, has to distinguish the structure of the personality of the subject to articulate the psychotherapy and the pharmacological treatment. Further investigational studies may determine whether antipsychotics will enhance treatment response in PTSD patients with psychotic features.

How Some Green Can Help The Blues

Americans across the nation are facing mounting pressure from the economy and many other challenges.  Many are also suffering with depression and mood disorders along with added pressures.  The average American who has tried cannabis well knows the mood elevating effects which include uncontrollable giggling or laughter.  Of course it is also dependent on the right strain but that is where science comes in.  Below you will see studies where scientists have discovered why our moods are altered as well as further the knowledge we have on the interactions of cannabis’ compounds and our bodies.  Please feel free to share and I encourage all to do their own research as well ~ Cherry Girl

The Dopamine and Cannabinoid Interaction in the Modulation of Emotions and Cognition: Assessing the Role of Cannabinoid CB1 Receptor in Neurons Expressing Dopamine D1 Receptors
Although cannabinoid CB1 receptors (CB1Rs) are densely expressed in neurons expressing dopamine D1 receptors (D1Rs), it is not fully understood to what extent they modulate emotional behaviors…….These results provided first direct evidence for a cross-talk between dopaminergic D1Rs and endocannabinoid system in terms of controlling negative affect.

Effects of Cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic Acid and Cannabidiol in MPP(+) Affected Murine Mesencephalic Cultures
Cannabinoids derived from Cannabis sativa demonstrate neuroprotective properties… Therefore we studied some major cannabinoids, i.e. delta-9-tetrahydrocannabinolic acid (THCA), delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in mice mesencephalic cultures for their protective capacities… our data show that cannabinoids THC and THCA protect dopaminergic neurons against MPP(+) induced cell death.” (Possibly due to the cross-talk between  the dopamine and cannabinoid systems as seen in the study above)

Antidepressant-like Effect of Δ9-tetrahydrocannabinol and Other Cannabinoids Isolated From Cannabis
Results of this study show that Δ9-THC and other cannabinoids exert antidepressant-like actions, and thus may contribute to the overall mood-elevating properties of cannabis.

 

Cannabis: Part Of A Healthy Diet?

Cannabis has been used in a variety of ways for thousands of years.  One of the unique things about the cannabis plant is how versatile and green the plant truly is.  It can be grown organically leaving behind virtually no footprint as well as being used in whole when harvested.  Many people believe in the power of natural remedies including a natural foods diet.  Cannabis, especially the seeds are known for their nutritional value including antioxidants.  Below you will find studies that look at the dietary value of cannabis as well as helpful side effects.  Please feel free to share ~ Cherry Girl

Antioxidant Activities and Oxidative Stabilities of Some Unconventional Oilseeds
“Hempseed (Cannabis sativa), in addition to its nutritional value, has demonstrated positive health benefits, including the lowering of cholesterol and high blood pressure… As a result of the present research, the analyzed oils could be evaluated as an alternative to traditionally consumed vegetable oils…

Health Benefits of Herbs and Spices: the Past, the Present, the Future
Health benefits of herbs and spices: the past, the present, the future… The real challenge lies not in proving whether foods, such as herbs and spices, have health benefits, but in defining what these benefits are… At present, recommendations are warranted to support the consumption of foods rich in bioactive components, such as herbs and spices. With time, we can expect to see a greater body of scientific evidence supporting the benefits of herbs and spices in the overall maintenance of health and protection from disease.

Several Culinary and Medicinal Herbs Are Important Sources of Dietary Antioxidants
In a normal diet, intake of herbs may therefore contribute significantly to the total intake of plant antioxidants, and be an even better source of dietary antioxidants than many other food groups such as fruits, berries, cereals and vegetables.

Neuroprotective Antioxidants From Marijuana
As evidence that cannabinoids can act as an antioxidants in neuronal cultures, cannabidiol was demonstrated to reduce hydroperoxide toxicity in neurons. In a head to head trial of the abilities of various antioxidants to prevent glutamate toxicity, cannabidiol was superior to both alpha-tocopherol and ascorbate in protective capacity. Recent preliminary studies in a rat model of focal cerebral ischemia suggest that cannabidiol may be at least as effective in vivo as seen in these in vitro studies.

Cannabidiol and (-)Delta9-Tetrahydrocannabinol Are Neuroprotective Antioxidants
Cannabidiol was more protective against glutamate neurotoxicity than either ascorbate or alpha-tocopherol, indicating it to be a potent antioxidant. These data also suggest that the naturally occurring, nonpsychotropic cannabinoid, cannabidiol, may be a potentially useful therapeutic agent for the treatment of oxidative neurological disorders such as cerebral ischemia. 

 

Cannabis Prohibition: Is It Really Keeping Our Children Safe?

Many a bored teen will hang out with friends and be faced with choosing to use drugs or not.  Many government officials as well as parents tout the War on Drugs as a savior to our children.  They say that it keeps the drugs out of the hands of minors, off the streets and out of schools.  With the economy shining a spotlight onto finances one can quickly see how big of a budget the War on Drugs consumes.  With taking all the different facets of this war into account some wonder if its really working.

The War on Drugs has been waging for over 40 years.  It has cost the tax-payers over $14 trillion, billions annually.  There have been surges and wanes over the 40 years in intensity in the pursuit to eradicate drug use.  Over the years we have witnessed many tragedies and successes.  We have seen harmful drug use drop among the population but especially minors.  We have also seen over the last 18 months an intensity like never before in the use of intimidation tactics, SWAT style raids against state legal patients, abuse, or lethal force when pursuing cannabis users.

With more education and information available to teens today many are able to see through the hypocrisy and lies.  Teens can see you are lying especially when they try cannabis, realize that it is not going to kill them and that they actually like the effects.  With alcohol, who’s effects are similar to cannabis but with much more harm at stake, not only available for sale but advertised everywhere including major sports events it is hard to see the difference.  When they see you are lying about cannabis they question other “truths” you have been telling them.

Simple cannabis possession or other non-violent cannabis related offenses can claim your driver’s license, student loans, subsidized housing, or federal grants.  It can jail a parent or guardian even if they are state and county legal.  With a parent jailed it costs tax-payers more to incarcerate and breaks up a family where the children are thrown into the broken foster care system.  All of us should be asking if this is really what is best for our children.

Children that go into the system cost tax-payers millions each year.  It costs the child emotionally and psychologically.   Children that grow up in the system are bounced around to different homes causing them to act out, perform poorly in school, drop out, get into legal trouble and end up repeating their parents mistakes.  Should we really treat cannabis related offenses this harshly?  Are these tactics really working?

Cannabis use was slightly higher this year but more harmful drugs, including alcohol, were reportedly down according to a recent study among teens use.  Those that take a quick look around or have a conversation with a teen will learn how easily drugs are accessible.  Each year D.E.A. officials boast of their catches but in reality they have barely scratched the surface.  Even with officials raiding and confiscating thousands of plants, California’s number one cash crop was still cannabis.  The plain truth is that it is a plant that can be grown in anyone’s home.  It can be kept from anyone’s knowledge provided the grower is smart.  It can be accessed through many avenues including access through children.

Drug cartels have taken notice of America’s love of drugs and has very outstretched networks that effect our children.  The violence and corruption that comes along with the cartels are infiltrating our schools.  The cartels lure children with money or threats using them as drug runners, smugglers or sellers.  They know that if children are caught the punishment is less.  The also know that it takes less money to impress children.  In this way they have been able to utilize children to sell to others including their peers thus spurring not only more drug use but recruiting even more children.

California has a heavily burdened prison and welfare system.  They have a large amount of incarcerated inmates for cannabis related crimes.  Our nation has been fighting this war for far too long.  Even our children see the truth about cannabis.  Isn’t it time we started talking about this subject from a new perspective?  Our law enforcement agencies have received cuts across the states including here in California.  Our streets are not safer.  Drug use has not been eradicated even after over 40 years.  Families are broken, children are effected, states are bankrupt and in the end drugs are still easily accessible at any school.  Isn’t it time we end the War on Drugs and start with a new approach?

Cannabis and Teens

Since 1975 the “Monitoring the Future” study has recorded the self-reported use of various substances by middle and high school students. Each year it reveals what is really going on with teen drug use.  In 2011 47,000 teens participated with interesting results. Although many, including the US Drug Czar, took the findings as negative and just one more way to attack cannabis use what it revealed was more proof that teens just like most of us want to do what is best for our bodies.

Many Americans today have tried or use cannabis with no adverse side effects.  During the 90s there was a huge push with D.A.R.E. and other programs that educated school children on all dangers of drugs.  With the population becoming more educated on the actual dangers associated with cigarettes, alcohol and other harmful substances we have seen a shift in use.  People including teens  have also realized the real harms and benefits of cannabis as well.

With this realization people have turned to cannabis with its relatively mild side effects and no lasting damage or threat of death.  Data backs up that use of harmful substances such as cocaine, steroids and heroin have steadily fallen down almost 50% from peak.  Alcohol and tobacco use is down 50% as well actually reaching historic lows.  It would seem that the population of teens have weighed out the dangers and chosen for themselves.

Cannabis use by contrast in the last four years has increased but not noticeably.  Some wonder then why many saw this report as a call to action against cannabis.    Some blamed the medical use movement for not only exposure but access as well.  This argument does not entirely hold up.  Medical marijuana was in the mainstream media and nation-wide topic in 1996 when CA first tried to legalize for patients.  Access for minors in states that have legalized has been restricted and taken crime off the streets.

In 2011 it was reported that 6.6% reported consuming cannabis daily which is greater than previously reported.   The attitude towards cannabis by teens as a whole has also changed with about 45% of them viewing cannabis as harmful.  That is a huge difference considering in the early 90s it was at 80%.  One caveat is that during the time from the early 90s and throughout most of 2000 teen use of cannabis also fell.

Anyone who lives in the real world will attest that you can only shield your children for so long before you have to let go and let them make their own choices.  When it comes to that point all the training that they have received will guide them.  Teens will always party and always break the rules.  We will never live in a society where there is not a teenage party going on somewhere.  While I don’t support teen use of cannabis, when weighing out the harms against use of alcohol and other harmful substances I would rather see teens choose a natural plant that does not cause death.

There of course are risks with using cannabis not only from using the drug but also the consequential side effects and one’s actions.  The earlier in one’s life cannabis is used the more potential there is for risks.  With that, when weighing out the cons, the potential risks of using cannabis is far less severe than many other substances including prescriptions.

While Drug Czar Gil Kerlikowske and other national media look negatively at the study others walk away with a sense of pride that our nation’s youth are choosing more wisely.  Today more people, including teens, perceive cannabis to be less harmful than alcohol and tobacco.  Someday our leaders will see the light and come to the same conclusion as the rest of us.  The War on Drugs has made cannabis an evil that is not neccessary.

The Human Prenatal Endocannabinoid System

Since the discovery of the human endocannabinoid system science has been busy trying to unlock the mysteries of this complex system.  Science has uncovered many interesting features of this system.  This includes the presence of this multi-function system in fetuses.   Below you will see studies on how science has uncovered in-dept knowledge of the endocannabinoid system in pre and post natal subjects.  I encourage all to do their own research and please feel free to share the TRUTH ~ Cherry Girl

Multiple Roles For the Endocannabinoid System During the Earliest Stages Of Life: Pre- and Postnatal Development
The endocannabinoid system, including its receptors (CB(1) and CB(2)), endogenous ligands (‘endocannabinoids’), synthesising and degrading enzymes, as well as transporter molecules, has been detected from the earliest stages of embryonic development and throughout pre- and postnatal development.  Multiple roles for the endocannabinoid system during the earliest stages of life: pre- and postnatal development…the endocannabinoid system appears to play an essential role for development and survival… the endocannabinoid system plays several key roles in pre- and postnatal development. Future studies should further clarify the mechanisms involved… in order to design strategies for the treatment of conditions such as infertility, mental retardation and failure-to-thrive.

The Endocannabinoid-CB Receptor System: Importance For Development and In Pediatric Disease
The endocannabinoid-CB receptor system: Importance for development and in pediatric disease… it is suggested that children may respond positively to medicinal applications of cannabinoids without undesirable central effects. Excellent clinical results have previously been reported in pediatric oncology and in case studies of children with severe neurological disease or brain trauma. We suggest cannabinoid treatment for children or young adults with cystic fibrosis in order to achieve an improvement of their health condition including improved food intake and reduced inflammatory exacerbations.

On the Application of Cannabis In Paediatrics and Epileptology
An initial report on the therapeutic application of delta 9-THC (THC) (Dronabinol, Marinol) in 8 children resp. adolescents suffering from the following conditions, is given: neurodegenerative disease, mitochondriopathy, posthypoxic state, epilepsy, posttraumatic reaction. THC effected reduced spasticity, improved dystonia, increased initiative, increased interest in the surroundings, and anticonvulsive action…possibility that THC-induced effects on ion channels and transmitters may explain its therapeutic activity seen in epileptic patients.

The Endocannabinoid-CB(1) Receptor System In Pre- and Postnatal Life
The endocannabinoid-CB(1) receptor system in pre- and postnatal life.. CB(1) receptors display a transient presence in white matter areas of the pre- and postnatal nervous system, suggesting a role for CB(1) receptors in brain development…Further observations suggest that children may be less prone to psychoactive side effects of Delta(9)-tetrahydrocannabinol or endocannabinoids than adults. The medical implications of these novel developments are far reaching and suggest a promising future for cannabinoids in pediatric medicine for conditions including “non-organic failure-to-thrive” and cystic fibrosis.

Endocannabinoids and Food Intake: Newborn Suckling and Appetite Regulation In Adulthood
The appetite-stimulating effects of the cannabis plant (Cannabis sativa) have been known since ancient times, and appear to be effected through the incentive and rewarding properties of foods. Investigations into the biological basis of the multiple effects of cannabis have yielded important breakthroughs in recent years… exciting progress in the understanding of how the endocannabinoid CB receptor systems influence appetite and body weight is stimulating the development of therapeutic orexigenic and anorectic agents. Furthermore, the role of cannabinoid CB1 receptor activation for milk suckling in newborns may open new doors toward understanding nonorganic failure-to-thrive in infants, who display growth failure without known organic cause.

Ontogenetic Development of Cannabinoid Receptor Expression and Signal Transduction Functionality in the Human Brain
Previous evidence suggests that the endogenous cannabinoid system emerges relatively early during brain development in the rat. However, the pre- and postnatal pattern of appearance of CB1 cannabinoid receptors in humans has not been analysed in detail.   This early pattern of expression of functionally active cannabinoid receptors, along with the transient and atypical localization of these proteins in white matter areas during the prenatal stages, suggest an specific role of the endocannabinoid system in the events related to human neural development.

 

Dear Mr. President

I know this year is a very important year for you.  It is just as important for millions of Americans across the nation.  I write to ask you a question.  In an election year that many feel is vital we would like to know why the issue of cannabis has not been properly discussed?  I have read the releases from the administration but it fails to properly address our concerns.  The issue has been ignored at many venues where it was the leading question.

After 40 years of this War on Drugs where have we gotten and was it worth it?  In this economy many people are hurting and everyone is looking for ways to save money.  The War on Drugs cost taxpayers billions of dollars each year and is responsible for many tragic stories.

Not only has it cost us money but it has cost us as a society as well.  Millions of Americans have been shuffled through the judicial system destroying their lives many for simple possession.  This problem has also exposed racial divides and furthered the tension in the country.  People have lost faith in law enforcement in many cities.  In Mexico over 50,000 have died in the last 6 years directly resulting from this war.  The Cartels are getting richer and the demand is still there.

There is a sizable and growing group of supporters across the nation.  75% support medical use and the number for legalization for adults over 21 is rapidly growing.  In this economy where many are downsizing the cannabis industry is booming.  The states that have legalized cannabis have seen a sharp increase in revenue both in taxes and fees as well as residual income for local communities.  When properly regulated and implemented we have seen excellent examples shine through.

Consumers no longer want to go to the street corner dealer but instead enjoy the safety and security of dispensaries.  There patients can find natural, organic strain choices with professional help and options in consumption.  They can feel confident that they are paying taxes and contributing towards the community instead of the black market.

With legalization comes regulation which assists in restricting access to minors.  Today minors are restricted from buying and accessing alcohol on their own due to strict regulations.  We have seen the devastating effects that alcohol prohibition caused.  Since its repeal we have also seen the effects that it has had on this nation.  From responsible use to fatalities from car accidents, consumption and domestic violence alcohol has been responsible.  Today alcohol is advertised during major sporting events, radio, TV, movies billboards and more exposing children at a young age.

There is too much proof both in scientific studies and in testimonies to deny the many benefits of cannabis.   With the knowledge we have gained so far patients of all kinds have found relief with cannabis.  We have also seen miraculous cases such as Cash Hyde overcome childhood cancer.  We have come much further than smoking on a Friday night but rather uncovered just the surface of what looks to be exciting and promising discoveries.

With all these factors in mind our community is wondering why our our President and candidates, who are vying for the highest power in the country for the next four years  and who directly effect this issue, continue to ignore us?  We want to know why an issue that directly effects millions and indirectly effects us all would not be considered?

We are looking for a leader who is willing to stand up to the opposition and show people that legalization can be done responsibly with regulations and state approval.  We need a leader who will take us seriously and address our needs.  We are looking for that leader this year and it is for that reason it needs to be addressed.  Millions of voters are waiting it is time to address cannabis.

Why We Should Pay Attention….At Least Some Of The Time

I remember as a child my grandpa talking with me about the politics of the U.S. and around the world.  I remember him rattling off different names of important people and all the scandalous things happening at the time.  My grandfather was born in 1938 and has seen a lot change in this world.  He’s followed politics longer than I have been alive and yet this passionate subject, for him, did absolutely nothing for me and felt more like a foreign language.  Once I moved out on my own and got my first real taste of freedom I thought I was free to do as I pleased.  I continued that blissful thought until my late twenties where I discovered cannabis.

I went through life not paying any attention to what was going on in politics because it wasn’t effecting me.  Then I started getting blinding intense pain headaches.  I went through a series of doctors, specialists, tests, machines, naturalists, chiropractors, medications, diets and supplements as well as a few other treatments.  For 4 years I sought out a treatment, a cause and a relief from the pain!  I subjected myself to all kinds of different prescriptions some that made my brain feel like it was on fire, made my body numb and on one occasion a near blackout on I-5 in the middle of Seattle from one drug that was supposedly safe.

It was then while at a party I discovered cannabis and all its natural benefits.  After finding cannabis I finally found relief.  I found something that not only took away the pain but lifted my spirits.  In one aspect it was a huge relief that I was not looking at a life where I had to constantly remind myself not to think of the pain always keeping myself busy to distract myself.  In the other aspect cannabis’ natural compounds helped with the depression that set in from being in pain for 4 years.  It really was a prayer answered.

I was fortunate enough to live in a state that had legalized medical marijuana so I was able to obtain a doctor’s recommendation that allowed me to purchase or grow cannabis.  It wasn’t until I walked into my first dispensary and started really talking to the cannabis community that I realized I actually needed to pay attention to politics.  Having control over your treatment, over your medication is priceless.  Having an option that is not fatal, that is natural and affordable is something everyone should enjoy.

Before legalization patients had to obtain their cannabis from the streets or risk growing it themselves.  If you buy on the black market you do not always have control over what you get and typically can not ask what strain it is, does it have molds, pests, chemicals or if its organic.  The streets also do not care if you are 37 or 15 only if you have cash.  On the other hand if a patient decides to grow they risk life as they know it.  If they are caught citizens face all kinds of situations from large legal bills, jail or prison time, losing their kids, job, house or assets as well as a stigma from society being labeled as a criminal.  Even being raided by the police is very tramatizing to the family as they typically break down the door and treat you like armed drug lords, drawing their weapons on your family.

This is why Californians passed prop 215 and later SB420.  This is just one reason why its important to at the very least check in on politics and whats going on in the world at least once in awhile.  While I was out searching for a cure to my pain trying all different kinds of legal chemical narcotics millions of Americans were being shuffled through the justice system for using, possessing or growing a plant.  Even after those two legislation were passed California patients are still having issues from the government with 2011 proving to be an aggressive year for the federal raids on patients.  

It wasn’t until I started researching cannabis that I suddenly realized we are not free at all.  When the government dictates what your medical treatment is and is not instead of you and your doctor, when they take your freedom of choice away that is not freedom and we need to ask ourselves “How can we stand by and allow it to happen?”  We as citizens need to come together and demand our freedom back.  It seems a little comical, if not for all the appalling tragedies, that we are fighting for our right to use a natural plant, one that has been used safely throughout the world for thousands of years.

I will probably never be like my grandfather rattling off names like baseball stats but I have learned to pay better attention to whats going on around me.  Financial crisis, unrest among the people in countries all over the world, everyday living prices soaring, budget cuts are everywhere and raids and arrests for simple possession of a plant are abundant.  2012 is a year to pay attention and get involved.  This year we could seize the opportunity to educate others and push for legalization and an end to this failed, immoral and unconstitutional War on Drugs.  it is time we take back our choice, our freedom, our government!  Contact your Representative or the White House and tell them its time for a real change.  Spread the word Legalization is on the horizon!

Breaking News: Cashy Hyde Free From Cancer

The Cashy Hyde case has been one that has been closely followed by many in the cannabis community that believe in the healing power of cannabis.  Below is the breaking news released yesterday.

On Wednesday, February 22, 2012 Cash Michael Hyde was in Salt Lake City for a follow up MRI to check the status of his brain tumor. A PNET brain tumor he has been battling for almost 2 years.

For the second time in a row, Cashy has beat his tumor, and is in remission.

The Boy of Steel is Cancer Free!

How many people do you know that beat cancer once, nonetheless twice?

At THREE years of age?

Congratulations and hugest of blessing upon his parents Mike and Kalli for being the strong parents they are, and fighting so diligently to save their son’s life with an alternative option.

Thank heavens for the cannabis oil that saves Cashy’s life.

Be vigilant in your duties Pioneers……your efforts are important to people just like Cashy and his family EVERY day! Act responsibly! Keep up the great work!

And to all the politicians out there…….please support the Hyde family, and many other families out there just like them.

We are here to save children’s lives, not take them away.

Love and blessings to all…..I’m off to celebrate on the ride back to Montana with the Hyde’s.

I love them all so very much. Better be a BIG box of Kleenex on board as we will all be so HAPPY!

For more information please view original source or visit The Cash Hyde Foundation.

It Is Time, This Is Our Moment

Throughout history there are those moments in time that forever change our course.  Great moments where heroes stood up, fought back, and changed our destinies.  Many led ordinary lives but in that moment found the courage to do what’s right even in the face of adversity.

I believe we are at a very unique point in time.  All over the globe are seeing people wake up to the idea of a more involved society, one that gives them a voice.  We are starting to see the corruption that has been allowed to take hold.  Thanks to instant and world-wide communications we all can share an abundance of information.  The message is clear: People want freedom!

The thought of freedom of self is spreading.  People realize they have a choice.  They can be free to be responsible for themselves and their government.  With God-given free will people are seeking out the truths.  One truth that has frequently come into the spotlight, all over the globe is cannabis.  People are starting to see through the “reefer madness” and seek out the truths not only of its healing powers but of its actual harms.

The U.S. government has wasted trillions of tax-payer’s dollars pursuing a plant put here on earth for humans to use.  Beyond all its myriad of health benefits including exciting research pointing towards curing cancer, cannabis in its natural form can be looked at in the same light as drinking a beer or having a glass of wine.  Many Americans drink at the end of their day to unwind and relax from the day’s activities.  Millions of Americans use cannabis in the same way including using forms such as oils, juices, edibles and tinctures.

It is time to start taking a more serious look at what the real dangers are of cannabis prohibition.  Cannabis does not cause death, is more beneficial and is less harmful than alcohol which is a legal drug for Americans 21 and older.  We need to look at the practicality of prohibition on a national level. This is a serious issue that has devastating effects on millions of Americans.  An issue that breaks up families, bankrupts countless people, destroys American rights, costs trillions of tax-payer dollars and ruins society demands that we take a serious look at this situation and what its doing to this country.

These are the moments that history is made of.  Moments that show of courage and strength.  Times were we came together and fought back.  We need to make our voices heard loud and clear: Its time to talk about the end of prohibition!  We need to tell our representatives that its time to reschedule cannabis and repeal the prohibition.  We need to educate others on the truths.  When people see the truth we will have freedom.  This is our moment will you have the courage to change history?

How Technology and Medicine Are Coming Together To Legitimize Cannabis Use

In the last decade alone we have seen many advancements in technology as well as medicine.  We have seen the cell phone and subsequently smart phones and tablets held in the hands of the masses.  We have seen the access to information through use of the internet become available to the majority of the world even to far reaching places.  We have witnessed the advances in technology spill over to other industries such as medicine enabling breakthroughs.

Today with the help of technology the science, medical, technology and cannabis community are coming together.  We see doctors and scientists sharing information and ideas working collectively to cure and develop better therapies.  We see more informed patients who are working with doctors that have more access to their medical treatments (with electronic files implemented) helping to avoid the hundreds of millions of Americans that are sent to the hospital from drug reactions.

We have seen the technology that doctors use advance quickly enabling for a more pinpointed understanding of the ailment or even a patient’s specific body.  We have technology today that allows for the DNA sequencing of a cancer tumor, human and, thanks to Kevin McKernan and his team; cannabis Sativa and Indica.

In the Czech Republic they have been making advancements in the use of cannabis for medical use.  At the Konopi Je Lek (Cannabis Is Medicine) Clinic they have been working on exact strain-dependent therapeutic dosages of THC, CBD and CBN.  With the mapping of the cannabis plant along with the ability to map a human we can potentially have a quick way to match the right Cannabinoids for their particular ailment which is very exciting news.

There are millions of Americans that use cannabis in conjunction with their medication or instead of.  Many who know that cannabis works for them may not actually know why.  With the advancements in technology and medicine giving us those answers it is also making way for us to be able to better understand and therefore apply this for better therapy results.  Currently it can at times be a guessing game when trying to find the right strain or combination thereof when using cannabis therapy.  In the future you could make tinctures customized for your body.

Technology, Medicine, Science and Cannabis Community are showing people that cannabis therapy is beyond just the smoked version that comes up so frequently in debates.  Today’s cannabis therapy is far more advanced.  With British pharmaceutical products such Sativex (cannabis plant derived non-synthetic) that are seeking FDA approval it lends even more creditably to the medical uses of cannabis.  Many can see the future of cannabis as a therapy that will have legitimacy and will be taken seriously.

Just a few months ago we saw national support for medical legalization at 77%.  With more credible information available to the masses we see a shift in perception.  16 states along with D.C have enacted medical marijuana laws as well as several other states that have medical initiatives; with Washington, California and Colorado’s initiatives calling for legalization for adults over 21.

With the nation hurting financially it is time to look at our priorities.  So far the government has spent over $2 trillion on the war on drugs that has proven to be futile.  We need to look at reform and especially rescheduling cannabis.  This will only be accomplished if the people speak up.  We need to recognize that cannabis has medical value and that it should be decision made between a patient and doctor not the government.  Contact your local representative today and express your support for rescheduling and responsible legislation.  Many states have groups like NORML and ASA that are working on legislation so be sure to see if there is a current proposal in your state.  With everyone coming together we can see a bright future for the cannabis community as well as the nation.

Finding Pain Relief In Cannabis

This last weekend was supposed to be a mini-vacation while I Christmas shopped.  I was to stay the night in a hotel and I envisioned a fun day looking at all the Christmas displays.  In reality I was in so much pain all week I was just hoping I would be able to make it to a few stores.  My entire body was in pain with a horrible headache that radiated through my upper body.  It was hard to be in the Christmas spirit.

Fortunately by Friday I had the opportunity to visit a dispensary and picked up a new strain I had only heard about.  When I got home I was able to use some of my medicine.  I have been testing out different strains for awhile now and most I have found will give me some pain relief or complete pain relief but only briefly.  When I used the new strain I got complete pain relief for hours.  I wanted to cry.

I realized that it has been the entire year that I have spent in pain.  The year has seem to fly by and I can not believe that it is December.  It feel like it should still be early fall and I have more time left in the year.  Each month I would research more medical studies, strain lists, talk with dispensary owners, read books and test out the strains myself in search of pain relief.  Some I found would give me the giggles, make me tired, make me sick, ease anxiety, help with insomnia and now finally give me full pain relief.

It was such a strange feeling being able to enjoy the moment without trying to ignore pain.I realized how long it had been since I felt this way.  Each day I get up feeling nauseous and then a headache will set in.  Sometimes they are dull and sometimes the pain is so bad its like seeing stars before you black out.  I have not found a prescription that fully takes away the pain, doesn’t give me horrible side effects or turns me into a zombie.  I have only found that in cannabis.

This year has been a long journey that I know is just begining.  I have learned so much about cannabis and have met so many wonderful people that are doing great things for the community.  Looking back over this year I am amazed at how much I know now.  All the reading and learning that I have done has ignited a fire in me that gives me passion about this subject.  I see so many people that are suffering, that like myself, have found pain relief in cannabis.  After getting a taste of what life without pain feels like I was suddenly brought back down to earth with the realization that it could all be taken away.

Currently in California, city by city, government is banning cannabis dispensaries because of the federal crackdown that happened this year.  Real people experiencing real pain not only have to brace themselves for daily life but for the realization that they very well could be without their pain relief.  They also must face the fact that their option may be going to the corner drug dealer where no questions are asked and its a gamble of what you are actually getting.

In the country we have a very heated debate on the size of the government. We have the federal government that is imposing its view on the states.  The citizens of California voted to allow for cannabis use by patients.  In 1996 most knew of cannabis use for cancer but at that time it was not publically known to help with many other illnesses.

Now in 2011, with ABC, NBC, CNN, FOX and many other mainstream media outlets as well as organizations like NORML speaking out about the many benefits of cannabis we have a more educated public.  We still hear how California is a joke because anyone can get a recommendation for cannabis.  The truth is that many people benefit from cannabis beyond those with cancer and AIDS.

Cannabis can help from a headache, to nausea, to body aches.  It can help with many different illnesses and modern science is confirming on a continual basis the new uses for cannabis.  Many different diseases that plague millions of Americans are being treated in labs around the world with cannabis.  Scientists are hard at work to unlock the cure for cancer, Alzheimer’s, Parkinson’s, obesity, migraines, to name a few and many are finding that it may be cannabis.

Many people are starting to see the harm that prescriptions are starting to have on our bodies, our society and our government.  When looking at the side effects and the drug recalls that are regulated through the FDA we wonder why a natural plant is so evil.  We are now dealing with big drug companies controlling legislation and officials in our government.  We see users of a natural plant in its natural form imprisoned.   We see families broken up and tax payer money used against them.  We also see a rise in over use of prescription drugs and addiction and what that is doing to society.

We see what the War on Drugs has done to our society as well.  Not only has it broken families, forced those arrested to a lower standard of life but also burdened the American people with a costly system of punishment for use of a natural plant. With the raids in California we saw stories of children being awakened by DEA agents busting through their front doors and shoving a gun in their parent’s face.

We also see the black market side of things heating up.  There needs to be a balance and restoring of order.  Responsible adults should be allowed to make their own medical decisions for themselves and their family.  We should not have the federal government or any government dictating how to treat our illnesses or our bodies.  We need the black market taken down and cleaned up and the legitimate legal market allowed to flourish.

The cannabis community wants to be out in the open legally operating and paying taxes.  We want a system that supports responsible use and regulation.  We want to know that we can have safe access to safe medicine.  We want to know that we have a reliable legitimate source of pain relief.  Every citizen has the right to treat their body as they see fit. They also should have the option to treat their body with natural herbs.  As a human on this Earth we have the right to use what the planet gives us.  We have the right to use nature responsibly.

It is time that we start being a more courageous nation and stand up for what is right.  We need to voice our opinions and start working together to solve these issues.  Turn off the TV, look away from the IPhone and start talking to one another to begin the repair work for this country.  We need responsibility put back on the shoulders of the American people.  We need to roll up our sleeves and get the job done.  The government is not the answer, we are.  2012 is only weeks away how will you make a difference?

Treating Obesity and Diabetes With Cannabis

It is estimated that about one-third of Americans are clinically obese, with 25.8 million diagnosed with diabetes.  It is no secret that the American culture has encouraged obesity and as a result reported cases of diabetes is on the rise.

Scientists are still hard at work looking for a cure to both epidemics.  One therapy looked at is using cannabinoids.  Below you will see studies that back up the strongly held belief that cannabis is a natural cure to many illnesses that should be legalized for all.  Please feel free to spread the truth ~ Cherry Girl

The Endocannabinoid System As A Target For Obesity Treatment 
Overweight and obesity are major factors contributing to the development of type 2 diabetes mellitus (DM) and cardiovascular disease (CVD)… researchers and clinicians continue to explore pharmacotherapy, with intense efforts being directed toward the development of agents that will reduce weight and simultaneously reduce or eliminate modifiable cardiovascular and metabolic risk factors. Amongthe promising new agents are the CB(1) receptor antagonists. These agents target receptors of the endocannabinoid system, a neuromodulatory system recently found to influence energy balance, eating behavior, and metabolic homeostasis via central and peripheral mechanisms. In animal and clinical studies, antagonism of CB(1) receptors has resulted in meaningful weight loss and improvement of lipid and glycemic profiles.

ANTIOBESITY EFFICACY OF LH-21, A CANNABINOID CB(1) RECEPTOR ANTAGONIST WITH POOR BRAIN PENETRATION, IN DIET-INDUCED OBESE RATS
The peripheral blockade of cannabinoid CB(1) receptors has been proposed as a safe and effective therapy against obesity, putatively devoid of the adverse psychiatric side effects…Conclusions and implications: These results support the hypothesis that the treatment with the peripherally neutral acting cannabinoid CB(1) receptor antagonist, LH-21, may promote weight loss through modulation of visceral adipose tissue.

The Endocannabinoid System: A Promising Target For The Management Of Type 2 Diabetes
The endoCANNABINOID system “regulates the intake of nutrients through central mechanisms located within the hypothalamus and limbic area, but also intervenes in transport, metabolism and deposit of the nutrients in the digestive tract, liver, adipose tissue, skeletal muscle, and possibly pancreas. Activation of both central and peripheral CB1 receptors promotes weight gain and associated metabolicchanges. Conversely, selective CB(1) receptor antagonists, have been shown to reduce body weight, waist circumference, triglycerides, blood pressure, insulin resistance and C-reactive protein levels, and to increase HDL cholesterol and adiponectin concentrations in both non-diabetic and diabetic overweight/obese patients.

The Implication of CNR1 Gene’s Polymorphisms In The Modulation Of Endocannabinoid System Effects
The endocannabinoid system (ECS) represents one of the most important physiologic systems involved in organism homeostasis…The discovery of ECS and its signaling pathways opens a door towards the understanding of several important physiologic processes regarding appetite, food intake, metabolism, weight gain, motor control, memory, learning, drug addiction and nociception. The detailed analysis and validation of the ECS functioning can bring us very close to the discovery of new diagnosis and treatment methods for obesity, drugs abuse and numerous psychic diseases.

Rehashing Endocannabinoid Antagonists: Can We Selectively Target The Periphery To Safely Treat Obesity And Type 2 Diabetes?
A growing body of evidence supports an important role for the endocannabinoid system as a regulator of appetite, body weight, and systemic metabolism, which is overactive in obesity and type 2 diabetes. While initial attempts to target this system using rimonabant were successful in producing weight loss and improving obesity-related metabolic complications in humans, adverse central nervous system side effects precluded introduction of this drug into clinical practice. However, new data, presented by Tam and colleagues, demonstrate that selective blockade of peripheral cannabinoid receptors may be a novel successful therapeutic approach.

Pharmacotherapeutic Targeting Of The Endocannabinoid Signaling System: Drugs For Obesity And The Metabolic Syndrome.
Endogenous signaling lipids (“endocannabinoids”) functionally related to Delta(9)-tetrahydrocannabinol, the psychoactive ingredient of marijuana (Cannabis), are important biomediators and metabolic regulators critical to mammalian (patho)physiology.More recent data support the concept that the endocananbinoid system may be modulated for therapeutic gain at discrete pharmacological targets with safety and efficacy.Pressing worldwide healthcare needs and increasing appreciation of endocannabinoid biology make the rational design and refinement of targeted CB1 receptor modulators a promising route to future medications with significant therapeutic impact against overweight, obesity, obesity-related cardiometabolic dysregulation, and, more generally, maladies having a reward-supported appetitive component.

No Connection Found Between Marijuana and Cancer

This was an article I came across about a study done on the association of cannabis and cancer.

The largest study of its kind has unexpectedly concluded that smoking marijuana, even regularly and heavily, does not lead to lung cancer.

The new findings “were against our expectations,” said Donald Tashkin of the University of California at Los Angeles, a pulmonologist who has studied marijuana for 30 years.

“We hypothesized that there would be a positive association between marijuana use and lung cancer, and that the association would be more positive with heavier use,” he said. “What we found instead was no association at all, and even a suggestion of some protective effect.”

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Federal health and drug enforcement officials have widely used Tashkin’s previous work on marijuana to make the case that the drug is dangerous. Tashkin said that while he still believes marijuana is potentially harmful, its cancer-causing effects appear to be of less concern than previously thought.

Earlier work established that marijuana does contain cancer-causing chemicals as potentially harmful as those in tobacco, he said. However, marijuana also contains the chemical THC, which he said may kill aging cells and keep them from becoming cancerous.

Tashkin’s study, funded by the National Institutes of Health’s National Institute on Drug Abuse, involved 1,200 people in Los Angeles who had lung, neck or head cancer and an additional 1,040 people without cancer matched by age, sex and neighborhood.

They were all asked about their lifetime use of marijuana, tobacco and alcohol. The heaviest marijuana smokers had lighted up more than 22,000 times, while moderately heavy usage was defined as smoking 11,000 to 22,000 marijuana cigarettes. Tashkin found that even the very heavy marijuana smokers showed no increased incidence of the three cancers studied.

“This is the largest case-control study ever done, and everyone had to fill out a very extensive questionnaire about marijuana use,” he said. “Bias can creep into any research, but we controlled for as many confounding factors as we could, and so I believe these results have real meaning.”

Tashkin’s group at the David Geffen School of Medicine at UCLA had hypothesized that marijuana would raise the risk of cancer on the basis of earlier small human studies, lab studies of animals, and the fact that marijuana users inhale more deeply and generally hold smoke in their lungs longer than tobacco smokers — exposing them to the dangerous chemicals for a longer time. In addition, Tashkin said, previous studies found that marijuana tar has 50 percent higher concentrations of chemicals linked to cancer than tobacco cigarette tar.

While no association between marijuana smoking and cancer was found, the study findings, presented to the American Thoracic Society International Conference this week, did find a 20-fold increase in lung cancer among people who smoked two or more packs of cigarettes a day.

The study was limited to people younger than 60 because those older than that were generally not exposed to marijuana in their youth, when it is most often tried.

http://www.washingtonpost.com/wp-dyn/content/article/2006/05/25/AR2006052501729.html