Newly Released Studies Show Protection and Regeneration of Brain Cells with Cannabis Therapies

There are over 1.7 million cases of severe brain injury that are reported each year.  These injuries can be life altering for many but thanks to the hard work from the science and medical communities we are learning more about new treatment options.  Cannabis has been discovered to help with cell regeneration and repair in the brain.  Below you will see newly published studies where  cannabis has been applied to help with brain injuries. Truly exciting!!   As always I encourage all to do their own research as well and please feel free to share ~ Cherry Girl

Early Survival of Comatose Patients After Severe Traumatic Brain Injury With the Dual Cannabinoid CB1/CB2 Receptor Agonist KN38-7271
Despite many drug trials, no substance has yet been identified that improves the outcome of severe head injury. The dual cannabinoid CB1/CB2 receptor agonist KN38-7271 mediates potent neuroprotection in animal models. We describe here the first randomized, double-blind, prospective, placebo-controlled clinical phase IIa proof-of-concept trial to investigate the safety, pharmacokinetics, and potential efficacy of a cannabinoid receptor agonist in humans.  Conclusions KN38-7271 appeared beneficial in the acute early phase of the comatose patient after a head injury. Its use was safe and well tolerated by patients.

Cannabinoids As Neuroprotective Agents In Traumatic Brain Injury
Cannabinoids of all classes have the ability to protect neurons from a variety of insults that are believed to underlie delayed neuronal death after traumatic brain injury (TBI), including excitotoxicity, calcium influx, free radical formation and neuroinflammation.

Cannabidiol Administration After Hypoxia-Ischemia To Newborn Rats Reduces Long-Term Brain Injury and Restores Neurobehavioral Function 2012
Cannabidiol (CBD) demonstrated short-term neuroprotective effects in the immature brain following hypoxia-ischemia (HI).   In conclusion, CBD administration after HI injury to newborn rats led to long-lasting neuroprotection, with the overall effect of promoting greater functional rather than histological recovery.

Cannabidiol Reduces Brain Damage and Improves Functional Recovery After Acute Hypoxia-Ischemia In Newborn Pigs 2011
Newborn piglets exposed to acute hypoxia-ischemia (HI) received i.v. cannabidiol (HI + CBD) or vehicle (HI + VEH). In HI + VEH, 72 h post-HI brain activity as assessed by amplitude-integrated EEG (aEEG) had only recovered to 42 ± 9% of baseline, near-infrared spectroscopy (NIRS) parameters remained lower than normal, and neurobehavioral performance was abnormal (27.8 ± 2.3 points, normal 36).   In conclusion, post-HI administration of CBD protects neurons and astrocytes, leading to histological, functional, biochemical, and neurobehavioral improvements.
 

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