Newly Released Studies Show Protection and Regeneration of Brain Cells with Cannabis Therapies

There are over 1.7 million cases of severe brain injury that are reported each year.  These injuries can be life altering for many but thanks to the hard work from the science and medical communities we are learning more about new treatment options.  Cannabis has been discovered to help with cell regeneration and repair in the brain.  Below you will see newly published studies where  cannabis has been applied to help with brain injuries. Truly exciting!!   As always I encourage all to do their own research as well and please feel free to share ~ Cherry Girl

Early Survival of Comatose Patients After Severe Traumatic Brain Injury With the Dual Cannabinoid CB1/CB2 Receptor Agonist KN38-7271
Despite many drug trials, no substance has yet been identified that improves the outcome of severe head injury. The dual cannabinoid CB1/CB2 receptor agonist KN38-7271 mediates potent neuroprotection in animal models. We describe here the first randomized, double-blind, prospective, placebo-controlled clinical phase IIa proof-of-concept trial to investigate the safety, pharmacokinetics, and potential efficacy of a cannabinoid receptor agonist in humans.  Conclusions KN38-7271 appeared beneficial in the acute early phase of the comatose patient after a head injury. Its use was safe and well tolerated by patients.

Cannabinoids As Neuroprotective Agents In Traumatic Brain Injury
Cannabinoids of all classes have the ability to protect neurons from a variety of insults that are believed to underlie delayed neuronal death after traumatic brain injury (TBI), including excitotoxicity, calcium influx, free radical formation and neuroinflammation.

Cannabidiol Administration After Hypoxia-Ischemia To Newborn Rats Reduces Long-Term Brain Injury and Restores Neurobehavioral Function 2012
Cannabidiol (CBD) demonstrated short-term neuroprotective effects in the immature brain following hypoxia-ischemia (HI).   In conclusion, CBD administration after HI injury to newborn rats led to long-lasting neuroprotection, with the overall effect of promoting greater functional rather than histological recovery.

Cannabidiol Reduces Brain Damage and Improves Functional Recovery After Acute Hypoxia-Ischemia In Newborn Pigs 2011
Newborn piglets exposed to acute hypoxia-ischemia (HI) received i.v. cannabidiol (HI + CBD) or vehicle (HI + VEH). In HI + VEH, 72 h post-HI brain activity as assessed by amplitude-integrated EEG (aEEG) had only recovered to 42 ± 9% of baseline, near-infrared spectroscopy (NIRS) parameters remained lower than normal, and neurobehavioral performance was abnormal (27.8 ± 2.3 points, normal 36).   In conclusion, post-HI administration of CBD protects neurons and astrocytes, leading to histological, functional, biochemical, and neurobehavioral improvements.
 

Advertisements

Never Fear Cannabis Is Here! How Cannabis Can Help With Fear, Anxiety, and Other Psychiatric Disorders

Nearly 19 million Americans suffer from a  psychiatric disorder which could include disorders such as specific phobias, generalized anxiety disorder, social anxiety disorder, panic disorder, agoraphobia, obsessive-compulsive disorder and post-traumatic stress disorder.  Many veterans returning from war have found cannabis to be a relief from PTSD.  Below you will studies where science has studied the effects of cannabis compounds when applied to psychiatric disorders.  Please feel free to share and I encourage all to do their own research as well ~ Cherry Girl

The Endocannabinoid System in the Processing of Anxiety and Fear and How CB1 Receptors May Modulate Fear Extinction 
The endocannabinoid system recently emerged as an important modulator of many neuronal functions. Among them, the control of anxiety and acquired fear represents nowadays one of the most interesting fields of research.  Finally, a neurobiological model possibly able to implement the role of the endocannabinoid system in these processes will be proposed.

CB1 Cannabinoid Receptors Modulate Kinase and Phosphatase Activity During Extinction of Conditioned Fear in Mice
Cannabinoid receptors type 1 (CB1) play a central role in both short-term and long-term extinction of auditory-cued fear memory.  We propose that the endogenous cannabinoid system modulates extinction of aversive memories, at least in part via regulation of the activity of kinases and phosphatases in a brain structure-dependent manner.

Extinction of Emotional Response As A Novel Approach of Pharmacotherapy of Anxiety Disorders 
The patogenesis of anxiety may be related to the process of an extinction of aversive memories… Studies on molecular and cellular mechanisms responsible for individual fear extinction may serve as the basis of search for more effective forms of clinical treatment… ligands stimulating endogenous cannabinoid system… these substances stimulate different central mechanisms, they appear to act synergistically, to improve the behavioural therapy.

Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear
the findings in the present study suggest that augmenting eCB-mediated neurotransmission by inhibition of eCB transport or breakdown may provide a novel mechanism for enhancing the extinction of fear. As such, eCB reuptake inhibitors may serve as useful adjuncts in the treatment of anxiety disorders (such as PTSD, panic disorder, and OCD) as well as drug addiction and other disorders that respond to behavioral treatments utilizing extinction processes.

The Endogenous Cannabinoid System Controls Extinction of Aversive Memories
Acquisition and storage of aversive memories is one of the basic principles of central nervous systems throughout the animal kingdom. In the absence of reinforcement, the resulting behavioural response will gradually diminish to be finally extinct.  We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala.

The Endocannabinoid system and Extinction Learning
As several human psychiatric disorders, such as phobia, generalized anxiety disorders, and posttraumatic stress disorder (PTSD) appear to involve aberrant memory processing and impaired adaptation to changed environmental conditions, the hope has been fuelled that the endocannabinoid system might be a valuable therapeutic target for the treatment of these disorders.

Bringing the War Back Home: Mental Health Disorders Among 103,788 US Veterans Returning From Iraq and Afghanistan Seen at Department of Veterans Affairs Facilities
Co-occurring mental health diagnoses and psychosocial problems were detected early and in primary care medical settings in a substantial proportion of OEF/OIF veterans seen at VA facilities. Targeted early detection and intervention beginning in primary care settings are needed to prevent chronic mental illness and disability.

Psychosis and Trauma. Theorical Links Between Post-Traumatic and Psychotic Symptoms
The links between psychotic and psycho-traumatic symptoms are complex and multidirectional; this co-occurrence is a factor of seriousness. The clinician, while paying attention to these symptoms, has to distinguish the structure of the personality of the subject to articulate the psychotherapy and the pharmacological treatment. Further investigational studies may determine whether antipsychotics will enhance treatment response in PTSD patients with psychotic features.

Cannabis Prohibition: Is It Really Keeping Our Children Safe?

Many a bored teen will hang out with friends and be faced with choosing to use drugs or not.  Many government officials as well as parents tout the War on Drugs as a savior to our children.  They say that it keeps the drugs out of the hands of minors, off the streets and out of schools.  With the economy shining a spotlight onto finances one can quickly see how big of a budget the War on Drugs consumes.  With taking all the different facets of this war into account some wonder if its really working.

The War on Drugs has been waging for over 40 years.  It has cost the tax-payers over $14 trillion, billions annually.  There have been surges and wanes over the 40 years in intensity in the pursuit to eradicate drug use.  Over the years we have witnessed many tragedies and successes.  We have seen harmful drug use drop among the population but especially minors.  We have also seen over the last 18 months an intensity like never before in the use of intimidation tactics, SWAT style raids against state legal patients, abuse, or lethal force when pursuing cannabis users.

With more education and information available to teens today many are able to see through the hypocrisy and lies.  Teens can see you are lying especially when they try cannabis, realize that it is not going to kill them and that they actually like the effects.  With alcohol, who’s effects are similar to cannabis but with much more harm at stake, not only available for sale but advertised everywhere including major sports events it is hard to see the difference.  When they see you are lying about cannabis they question other “truths” you have been telling them.

Simple cannabis possession or other non-violent cannabis related offenses can claim your driver’s license, student loans, subsidized housing, or federal grants.  It can jail a parent or guardian even if they are state and county legal.  With a parent jailed it costs tax-payers more to incarcerate and breaks up a family where the children are thrown into the broken foster care system.  All of us should be asking if this is really what is best for our children.

Children that go into the system cost tax-payers millions each year.  It costs the child emotionally and psychologically.   Children that grow up in the system are bounced around to different homes causing them to act out, perform poorly in school, drop out, get into legal trouble and end up repeating their parents mistakes.  Should we really treat cannabis related offenses this harshly?  Are these tactics really working?

Cannabis use was slightly higher this year but more harmful drugs, including alcohol, were reportedly down according to a recent study among teens use.  Those that take a quick look around or have a conversation with a teen will learn how easily drugs are accessible.  Each year D.E.A. officials boast of their catches but in reality they have barely scratched the surface.  Even with officials raiding and confiscating thousands of plants, California’s number one cash crop was still cannabis.  The plain truth is that it is a plant that can be grown in anyone’s home.  It can be kept from anyone’s knowledge provided the grower is smart.  It can be accessed through many avenues including access through children.

Drug cartels have taken notice of America’s love of drugs and has very outstretched networks that effect our children.  The violence and corruption that comes along with the cartels are infiltrating our schools.  The cartels lure children with money or threats using them as drug runners, smugglers or sellers.  They know that if children are caught the punishment is less.  The also know that it takes less money to impress children.  In this way they have been able to utilize children to sell to others including their peers thus spurring not only more drug use but recruiting even more children.

California has a heavily burdened prison and welfare system.  They have a large amount of incarcerated inmates for cannabis related crimes.  Our nation has been fighting this war for far too long.  Even our children see the truth about cannabis.  Isn’t it time we started talking about this subject from a new perspective?  Our law enforcement agencies have received cuts across the states including here in California.  Our streets are not safer.  Drug use has not been eradicated even after over 40 years.  Families are broken, children are effected, states are bankrupt and in the end drugs are still easily accessible at any school.  Isn’t it time we end the War on Drugs and start with a new approach?

Dear Mr. President

I know this year is a very important year for you.  It is just as important for millions of Americans across the nation.  I write to ask you a question.  In an election year that many feel is vital we would like to know why the issue of cannabis has not been properly discussed?  I have read the releases from the administration but it fails to properly address our concerns.  The issue has been ignored at many venues where it was the leading question.

After 40 years of this War on Drugs where have we gotten and was it worth it?  In this economy many people are hurting and everyone is looking for ways to save money.  The War on Drugs cost taxpayers billions of dollars each year and is responsible for many tragic stories.

Not only has it cost us money but it has cost us as a society as well.  Millions of Americans have been shuffled through the judicial system destroying their lives many for simple possession.  This problem has also exposed racial divides and furthered the tension in the country.  People have lost faith in law enforcement in many cities.  In Mexico over 50,000 have died in the last 6 years directly resulting from this war.  The Cartels are getting richer and the demand is still there.

There is a sizable and growing group of supporters across the nation.  75% support medical use and the number for legalization for adults over 21 is rapidly growing.  In this economy where many are downsizing the cannabis industry is booming.  The states that have legalized cannabis have seen a sharp increase in revenue both in taxes and fees as well as residual income for local communities.  When properly regulated and implemented we have seen excellent examples shine through.

Consumers no longer want to go to the street corner dealer but instead enjoy the safety and security of dispensaries.  There patients can find natural, organic strain choices with professional help and options in consumption.  They can feel confident that they are paying taxes and contributing towards the community instead of the black market.

With legalization comes regulation which assists in restricting access to minors.  Today minors are restricted from buying and accessing alcohol on their own due to strict regulations.  We have seen the devastating effects that alcohol prohibition caused.  Since its repeal we have also seen the effects that it has had on this nation.  From responsible use to fatalities from car accidents, consumption and domestic violence alcohol has been responsible.  Today alcohol is advertised during major sporting events, radio, TV, movies billboards and more exposing children at a young age.

There is too much proof both in scientific studies and in testimonies to deny the many benefits of cannabis.   With the knowledge we have gained so far patients of all kinds have found relief with cannabis.  We have also seen miraculous cases such as Cash Hyde overcome childhood cancer.  We have come much further than smoking on a Friday night but rather uncovered just the surface of what looks to be exciting and promising discoveries.

With all these factors in mind our community is wondering why our our President and candidates, who are vying for the highest power in the country for the next four years  and who directly effect this issue, continue to ignore us?  We want to know why an issue that directly effects millions and indirectly effects us all would not be considered?

We are looking for a leader who is willing to stand up to the opposition and show people that legalization can be done responsibly with regulations and state approval.  We need a leader who will take us seriously and address our needs.  We are looking for that leader this year and it is for that reason it needs to be addressed.  Millions of voters are waiting it is time to address cannabis.

We Can Not Afford To Continue The War On Drugs

The Vice President visited with South American leaders but continued the hardened stance against drug legalization despite opposing opinions from the other side.  While the US government, in their fight against drugs, has proven its disregard for its own citizens they have also shown that they are willing to sacrifice over 50,000 Mexicans as well as thousands in other Latin countries, murdered, some decapitated and dumped in public streets.  By continuing this costly, bloody and utterly disastrous War on Drugs they have proven that they will stop at nothing to continue their agenda.    Over 40 years of continual war on drugs has cost this country dearly and many ask is it really worth it?

With all that is going on in the country today it’s no wonder that people start to ignore some issues and continue on with more pressing matters. But when taking a further look into the cannabis issue it has more to do with every day life than what appears at face value.  There are multiple layers to this complex issue.  Cannabis and the War on Drugs impacts the economy, citizen’s rights, society, families, the individual user and much more.  It impacts all of us in one way or another many without us realizing it.

With the economy in the shape that it’s currently in, budget cuts rampant, layoffs, department downsizing; cities across the country are having to prioritize and make cuts often deciding which cases are the most important and letting others slide including violent crimes.  With cuts to law enforcement cities across the nation see crimes rates rise and the value decrease which impacts us all.  Each year the government spends billions fighting the War on Drugs. That money could instead be used more wisely.  One wonders then with these limited resources why cannabis, a non lethal plant,  continues to top their priorities list despite saying the administration would do otherwise?

We have spent trillions of dollars fighting this War on Drugs and what we have ended with is a broken country both financially and socially.  The government has criminalized a natural plant and taken a hardened stance against it despite the growing support nationally for legalization especially for medical reasons.  The government has continued to deny any benefits of cannabis and still stands by its classification of it as a scheduled 1 substance along side such hard drugs as heroin and deemed harsher than cocaine.  The government needs to wake up and realize that this war is not worth the cost and needs to end.   That will happen when we come together and make our voices heard.  We need to take this issue to the forefront and make people, make the president, address it.

In the last three years we saw more attacks from the federal government during the Obama administration than those of Presidents Bush and Clinton.  We saw federal raids on legitimate patients and their caregivers.  We saw taxpayer’s money wasted fueling this war on citizens.  We saw the federal government trample all over our rights in its search for criminals, millions who’s only crime was simple possession.

The laws that were passed soon after the 9/11 attacks, that were thought to be used only for the protection against terrorists attacks, have continuously been used in the War against Drugs and American citizens.  The laws have been used more in the search for drugs than for terrorists.  We need to stand up for our rights and demand that use of a plant should not constitute giving up our constitutional rights.

Currently schools across the country are in need of funding and money spent on the War on Drugs could instead go to make our schools excellent again.  By having smart regulations, correct zoning in cities and responsible use, children will not be effected in the manner everyone fears.  Instead of an underground network of criminals you would have a respected cannabis community that is not selling your children drugs. 

The argument for denying legalization for the sake of children may at face value have merit but when looking closer is ridiculous.  Parents need to take a leading role in teaching their children about cannabis, responsibility for choices and the pros and cons of drug use.  This issue of children’s use of cannabis or not is not a government decision but a parental one.  Parents play a huge role in their child’s influences, view towards drugs, access and more.  They should be the one making that decision to restrict cannabis or drug use.

By keeping cannabis illegal you keep it from being regulated which means that the product is out there with no one saying who can and can not have it.  Which also means that the person selling it doesn’t necessarily care how old your kid is when they try to buy pot only if they have the right amount of cash.  Alcohol by contrast, which consequently can be fatal especially to children and teens, is legal, regulated and not readily accessible to children.  Those worried about dispensary signs keep in mind that alcohol is advertised during national sporting events, local radio, TV, movies, billboards and more, giving children much more exposure.

In states across the US there is pending legislation for cannabis use with some aiming to take control and address the obvious problems caused by the War on Drugs.  The state of Washington has a great set up already in place for alcohol which would nicely accommodate the cannabis industry as well.  The citizens have gotten the necessary signatures validated for a legalization initiative for adults 21 and older to consume cannabis to appear before the voters in the November 2012 ballots. This has a great potential for a positive financial impact on the local and state economy allowing for more income, a much-needed relief especially in these times.

With all the facts stacking up against the War on Drugs and the hardened stance against legalization you have to ask yourself why are we continuing this costly war?  We need to address this issue and demand and end to this war.  We must urge our representatives to support rescheduling cannabis and repealing the devastating effects of prohibition.  The fight for legalization has been a long one but with quick action we can take hold of this opportunity and finally achieve our goals.

This guy can afford the War on Drugs (head of Sinola cartel)

Why We Should Pay Attention….At Least Some Of The Time

I remember as a child my grandpa talking with me about the politics of the U.S. and around the world.  I remember him rattling off different names of important people and all the scandalous things happening at the time.  My grandfather was born in 1938 and has seen a lot change in this world.  He’s followed politics longer than I have been alive and yet this passionate subject, for him, did absolutely nothing for me and felt more like a foreign language.  Once I moved out on my own and got my first real taste of freedom I thought I was free to do as I pleased.  I continued that blissful thought until my late twenties where I discovered cannabis.

I went through life not paying any attention to what was going on in politics because it wasn’t effecting me.  Then I started getting blinding intense pain headaches.  I went through a series of doctors, specialists, tests, machines, naturalists, chiropractors, medications, diets and supplements as well as a few other treatments.  For 4 years I sought out a treatment, a cause and a relief from the pain!  I subjected myself to all kinds of different prescriptions some that made my brain feel like it was on fire, made my body numb and on one occasion a near blackout on I-5 in the middle of Seattle from one drug that was supposedly safe.

It was then while at a party I discovered cannabis and all its natural benefits.  After finding cannabis I finally found relief.  I found something that not only took away the pain but lifted my spirits.  In one aspect it was a huge relief that I was not looking at a life where I had to constantly remind myself not to think of the pain always keeping myself busy to distract myself.  In the other aspect cannabis’ natural compounds helped with the depression that set in from being in pain for 4 years.  It really was a prayer answered.

I was fortunate enough to live in a state that had legalized medical marijuana so I was able to obtain a doctor’s recommendation that allowed me to purchase or grow cannabis.  It wasn’t until I walked into my first dispensary and started really talking to the cannabis community that I realized I actually needed to pay attention to politics.  Having control over your treatment, over your medication is priceless.  Having an option that is not fatal, that is natural and affordable is something everyone should enjoy.

Before legalization patients had to obtain their cannabis from the streets or risk growing it themselves.  If you buy on the black market you do not always have control over what you get and typically can not ask what strain it is, does it have molds, pests, chemicals or if its organic.  The streets also do not care if you are 37 or 15 only if you have cash.  On the other hand if a patient decides to grow they risk life as they know it.  If they are caught citizens face all kinds of situations from large legal bills, jail or prison time, losing their kids, job, house or assets as well as a stigma from society being labeled as a criminal.  Even being raided by the police is very tramatizing to the family as they typically break down the door and treat you like armed drug lords, drawing their weapons on your family.

This is why Californians passed prop 215 and later SB420.  This is just one reason why its important to at the very least check in on politics and whats going on in the world at least once in awhile.  While I was out searching for a cure to my pain trying all different kinds of legal chemical narcotics millions of Americans were being shuffled through the justice system for using, possessing or growing a plant.  Even after those two legislation were passed California patients are still having issues from the government with 2011 proving to be an aggressive year for the federal raids on patients.  

It wasn’t until I started researching cannabis that I suddenly realized we are not free at all.  When the government dictates what your medical treatment is and is not instead of you and your doctor, when they take your freedom of choice away that is not freedom and we need to ask ourselves “How can we stand by and allow it to happen?”  We as citizens need to come together and demand our freedom back.  It seems a little comical, if not for all the appalling tragedies, that we are fighting for our right to use a natural plant, one that has been used safely throughout the world for thousands of years.

I will probably never be like my grandfather rattling off names like baseball stats but I have learned to pay better attention to whats going on around me.  Financial crisis, unrest among the people in countries all over the world, everyday living prices soaring, budget cuts are everywhere and raids and arrests for simple possession of a plant are abundant.  2012 is a year to pay attention and get involved.  This year we could seize the opportunity to educate others and push for legalization and an end to this failed, immoral and unconstitutional War on Drugs.  it is time we take back our choice, our freedom, our government!  Contact your Representative or the White House and tell them its time for a real change.  Spread the word Legalization is on the horizon!

Corruption Through the Ages

It is said that if history is not learned it is doomed to repeat itself.  It is important to look back and know how we got here today.  We have looked at how Prohibition of Alcohol can be applied to today’s War on Drugs.  We have also looked at the current Drug War in terms of stats on arrests and how much money is wasted.  Now we will take a look at how the Banking System has played a role in the drug trade and the War on Drugs. If you study the timeline below you will see how corruption has a firm grip where ever there is money. In the past 10 years there has been major corruption linking the banking system and drug cartels.  This is just one key point in the War on Drugs and our fight for legalization.  Money does have control and it is vital to know all aspects when fighting for legalization.  In the timeline you will notice underline text.  These are areas that I encourage to be further researched as there is a lot of interesting history to be discovered.  Please Share: just click on the image below to read~ Cherry Girl

Also available in High Resolution

Adapted from “Banking Laid Bare” Steven Hager ~ High Times Dec 2011

Wachovia and J.P. Morgan connection to Slave Trade: http://www.ushistory.org/presidentshouse/news/ww061005.htm